68 completed, 15 terminated, 8 unknown, 4 recruiting. 31 Phase 2, 20 Phase 1, 18 Phase 3, 14 Phase 4, 3 Not applicable.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Senicapoc and Perampanel for Newly Diagnosed Glioblastoma senicapoc, Perampanel - Glioblastoma | Early Phase 1 | Recruiting | Aarhus University Hospital | 36 | 2026-03-01 | 2026-05-07 |
| Efficacy and Safety of Perampanel in the Treatment of Refractory Status Epilepticus Perampanel - Refractory Status Epilepticus | Phase 4 | Terminated | Wayne State University | 1 | 2025-10-10 | 2025-10-14 |
| PeRampanel fOr Status ePilEpticus pRophylaxis Post-cardiac Arrest Perampanel, Placebo - Heart Arrest, Seizures | Phase 2 | Recruiting | University of California, San Francisco | 52 | 2024-05-20 | 2026-07-29 |
| Bioequivalence Assessment Between Two Perampanel Oral Suspension Formulations Lepsiramp, 0.5 Mg/mL Oral Suspension, Fycompa, 0.5 Mg/mL Oral Suspension - Bioequivalence Study in Healthy Subjects | Phase 1 | Completed | Aya Mohammed Abdel Magid Abdel Hamid | 26 | 2024-03-07 | 2025-08-20 |
| Bioequivalence Study of Perampanel Tablets 10 mg Perampanel 10 MG, Fycompa 10Mg Tablet - Epilepsy | Phase 1 | Completed | Humanis Saglık Anonim Sirketi | 30 | 2023-11-22 | 2024-06-10 |
| Bioequivalence Study of Perampanel Tablets 12 mg Perampanel 12 MG, Fycompa 12 mg film-coated tablets - Epilepsy | Phase 1 | Completed | Humanis Saglık Anonim Sirketi | 30 | 2023-09-14 | 2024-06-12 |
| Alpha-Amino-3-Hydroxy-5-Methyl-4- Isoxazole Propionic Acid Receptor Components of the Anti-Depressant Ketamine Response Ketamine, Perampanel, Placebo - Depressive Disorder, Major, Post Traumatic Stress Disorder | Phase 1 | Recruiting | Yale University | 50 | 2023-09-07 | 2026-05-06 |
| The Impact of AMPA Receptor Blockade on Ketamine's Anti-Suicidal Effects Perampanel 6 MG, Ketamine, Placebo - Depressive Disorder, Major Depressive Disorder | Phase 2 | Recruiting | Yale University | 30 | 2023-04-03 | 2026-05-06 |
| Perampanel in Focal Status Epilepticus Perampanel, Placebo - Epilepticus; Status, Focal Motor | Phase 3 | Terminated | Assistance Publique - Hôpitaux de Paris | 1 | 2022-11-02 | 2023-12-14 |
| A Study to Evaluate the Efficacy and Safety of Perampanel Monotherapy in Untreated Participants With Focal Onset Seizures With or Without Focal to Bilateral Tonic-clonic Seizures Perampanel - Epilepsy | Phase 4 | Completed | Eisai Korea Inc. | 125 | 2022-10-19 | 2025-03-07 |
| Fycompa in Catamenial Epilepsy Fycompa, Fycompa with a boost - Catamenial Epilepsy | Phase 4 | Terminated | University of Florida | 7 | 2022-03-09 | 2024-07-31 |
| Dual Anti-glutamate Therapy in Super-refractory Status Epilepticus After Cardiac Arrest Ketamine, Any anti-epileptic and anesthetic therapy, excluding Ketamine and Perampanel - Status Epilepticus, Cardiac Arrest | Completed | University of Milano Bicocca | 84 | 2022-01-15 | 2026-07-14 | |
| Perampanel Titration and Cognitive Effects Perampanel 1 week titration, Perampanel 2 week titration, Perampanel 4mg - Epilepsy | Phase 4 | Terminated | Kimford Jay Meador | 29 | 2021-10-20 | 2024-06-06 |
| A Multi-center RWS of Perampanel as an add-on Treatment for Epileptic Seizures in Chinese Children Perampanel - Epilepsy | Unknown | Beijing Children's Hospital | 1000 | 2021-07-02 | 2022-03-25 | |
| Clinical Efficacy and Safety of Perampanel Monotherapy in the Treatment of Children With Focal Epilepsy perampanel - Focal Epilepsy | Unknown | Yang Xinwei | 280 | 2021-07-01 | 2022-08-11 | |
| Efficacy and Safety of Perampanel in Combination in Glioma-refractory Epilepsy Perampanel, conventional antiepileptic treatment - Refractory Epilepsy | Not applicable | Withdrawn | Assistance Publique Hopitaux De Marseille | 2021-02-15 | 2022-06-27 | |
| A China RWS to Evaluate the Effectiveness and Safety of Perampanel as an add-on Treatment for Epileptic Seizure Perampanel - Epilepsy | Unknown | Beijing Children's Hospital | 600 | 2021-01-01 | 2022-02-25 | |
| Perampanel for the Reduction of Seizure Frequency in Patients With High-grade Glioma and Focal Epilepsy Anticonvulsant Agent, Perampanel, Quality-of-Life Assessment - Intractable Epilepsy, Malignant Glioma | Phase 4 | Terminated | Mayo Clinic | 4 | 2020-12-04 | 2023-06-22 |
| Effect of Perampanel on Peritumoral Hyperexcitability in HGG Perampanel, Standard of Care - Glioma, Malignant, Surgery | Phase 1 / Phase 2 | Completed | Dana-Farber Cancer Institute | 12 | 2020-11-05 | 2024-08-05 |
| Open Label Pilot Study of Perampanel for the Treatment of Alcohol Use Disorder Perampanel Tablet, Disulfiram - Alcohol Disorders | Phase 1 / Phase 2 | Completed | Virginia Commonwealth University | 4 | 2020-10-15 | 2022-10-07 |
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Epilepsy (37) · Seizures (26) · Parkinson Disease (11) · Epilepsies, Partial (4) · Amyotrophic Lateral Sclerosis (3) · Depressive Disorder, Major (3) · Drug Resistant Epilepsy (3) · Status Epilepticus (3) · Stress Disorders, Post-Traumatic (3) · Bipolar Disorder (2) · Glioma (2) · Heart Arrest (2) · Lennox Gastaut Syndrome (2) · Neuralgia (2) · Alcohol-Related Disorders (1)
Eisai Inc. (37) · Eisai Co., Ltd. (14) · Eisai Limited (7) · Yale University (3) · Assistance Publique - Hôpitaux de Paris (2) · Beijing Children's Hospital (2) · Eisai Korea Inc. (2) · Humanis Saglık Anonim Sirketi (2) · Mayo Clinic (2) · Virginia Commonwealth University (2) · Aarhus University Hospital (1) · American University of Beirut Medical Center (1) · Assistance Publique Hopitaux De Marseille (1) · Aya Mohammed Abdel Magid Abdel Hamid (1) · Carilion Clinic (1)
United States (46) · France (14) · Czechia (12) · Germany (12) · Japan (12) · Belgium (11) · South Korea (11) · Spain (11) · Italy (10) · Latvia (9) · India (8) · United Kingdom (8) · Australia (7) · Canada (7) · Hungary (7)
David Squillacote, M.D. (6) · David Squillacote, MD (2) · Fang Fang (2) · John Krystal, MD (2) · Robert Cooper (2) · Aashit Shah, MD (1) · Albert Arias, MD (1) · Albert Arias, MD, PhD (1) · Alessia Nicotra, M.D., Ph.D. (1) · Alessia Nicotra, MD, PhD, DIC (1) · Allison Mann, MD (1) · Antonio Laurenza, M. D. (1) · Antonio Laurenza, M.D. (1) · Bjorn E Oskarsson, MD (1) · Charles A Handforth, M.D. (1)
PMID 35305920, PMID 37059702, PMID 25823975, PMID 23663001, PMID 25878175, PMID 21883097, PMID 22517103, PMID 22843280, PMID 22905857, PMID 22913800, PMID 24867391, PMID 26296511, PMID 26724782, PMID 29250772, PMID 29574701, PMID 29653338, PMID 30739576, PMID 31912493, PMID 33681651, PMID 33825230, PMID 33839450, PMID 34657389, PMID 34782307, PMID 34942053, PMID 34953337, PMID 34994582, PMID 35453064, PMID 35596529, PMID 35792849, PMID 36106379, PMID 36746851, PMID 37999939, PMID 39499201, PMID 41249688, PMID 41724127, PMID 42837646
2005 (2), 2014 (2), R21AA026681 (2), 2004 (1), 2017 (1), 2018 (1), 2019 (1), 2025 (1), P50CA165962 (1), R01MH129371 (1)