23 completed, 15 recruiting, 13 unknown, 5 terminated. 28 Not applicable, 4 Phase 2, 3 Phase 4, 2 Phase 1, 2 Phase 3.
Follow Epilepsy, Temporal Lobe: new trials by email Literature Review of Epilepsy, Temporal Lobe trials Research Report on Epilepsy, Temporal Lobe
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Studying Heart Rhythms With a Wearable Sensor to Detect and Predict Seizures in People With Epilepsy Textile-based wearable electrocardiography - Epilepsy, Temporal Lobe, Drug Resistant Epilepsy | Not yet recruiting | Acibadem University | 40 | 2026-10-15 | 2026-09-23 | |
| Overnight TI in TLE Non-invasive Temporal Interference (TI) Stimulation Targeting Bilateral Hippocampi - Temporal Lobe Epilepsy (TLE), Drug Resistant Epilepsy | Not applicable | Recruiting | Duke University | 20 | 2026-10-15 | 2026-10-16 |
| MRI Volumetry and Diffusion Tensor Imaging in Temporal Lobe Epilepsy MRI - Temporal Lobe Epilepsy (TLE) | Not yet recruiting | Assiut University | 78 | 2026-04-01 | 2026-02-03 | |
| MRgLITT for mTLE: A PROBE Trial Resonance-guided Laser Interstitial Thermal Therapy (MRgLITT), Open Surgery - Temporal Lobe Epilepsy (TLE) | Not applicable | Recruiting | Beijing Tiantan Hospital | 120 | 2025-07-21 | 2026-01-21 |
| Integrating Metabolism, Connectivity, and Mesoscale Imaging at Ultra-high Field to Decipher Mechanisms of Resilience and Neurodegeneration in Neurological Diseases and Healthy Aging Imaging Techniques (MRI 3T & 7T, Functional, Structural, and Metabolic Imaging) - Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorders | Recruiting | Assistance Publique Hopitaux De Marseille | 700 | 2025-05-19 | 2025-10-01 | |
| Enhanced MRI Imaging in Healthy Participants and Participants With Epilepsy Ferumoxytol - Epilepsy, Temporal Lobe | Phase 2 | Recruiting | University of Alberta | 50 | 2025-05-01 | 2026-05-08 |
| Spatial Memory and Temporal Lobe Epilepsy spatial memory test - Epilepsy Lobe Temporal, Healthy | Not applicable | Completed | Centre Hospitalier Metropole Savoie | 60 | 2025-02-26 | 2026-10-07 |
| A Phase 1/2 Study of NRTX-1001 Neuronal Cell Therapy in Drug-Resistant Bilateral Mesial Temporal Lobe Epilepsy (MTLE) NRTX-1001 - Epilepsy, Temporal Lobe | Phase 1 / Phase 2 | Recruiting | Neurona Therapeutics | 10 | 2024-11-14 | 2026-01-07 |
| Innovative MRI to Localize the Epileptic Zone mqMRI and GABA-MRS - Epilepsy, Temporal Lobe | Not yet recruiting | University Hospital, Grenoble | 40 | 2024-10-01 | 2024-08-23 | |
| A Pilot Study to Evaluate the Efficacy and Safety of NaviFUS™ System Neuromodulating Treatment for Patients With Drug Resistant Epilepsy Focused ultrasound (FUS) treatment - Drug Resistant Epilepsy, Epilepsy | Not applicable | Recruiting | NaviFUS Corporation | 16 | 2024-09-01 | 2026-04-09 |
| Spatial Scene Recognition Memory in Epilepsy Surgery Virtual Tour Recognition Memory Task, Intracranial EEG Recording with Research Electrodes (Aim III only), MRI Neuroimaging and Neuropsychological Assessment (Aim I) - Focal Epilepsy, Temporal Lobe Epilepsy | Not applicable | Recruiting | University of California, Davis | 620 | 2024-07-01 | 2026-05-12 |
| Transcranial Electrical Stimulation Targeting the Cerebellum for the Treatment of Refractory Temporal Lobe Epilepsy Transcranial Alternating Current Stimulation - Transcranial Electrical Stimulation, Temporal Lobe Epilepsy | Not applicable | Unknown | Xijing Hospital | 60 | 2024-06-08 | 2024-08-19 |
| Changes in Attentional Control After a Focal Seizure. All included subjects - Temporal Lobe Epilepsy, Frontal Lobe Epilepsy | Recruiting | University Hospital, Lille | 100 | 2024-03-04 | 2026-04-27 | |
| Evaluation of the NaviFUS System in Drug Resistant Epilepsy NaviFUS System - Epilepsy, Temporal Lobe, Drug Resistant Epilepsy | Not applicable | Recruiting | Genovate-NaviFUS (Australia) Pty Ltd. | 18 | 2023-10-02 | 2026-09-10 |
| A New Approach in Intensive Care Unit Consciousness Assessment: FIVE Score Postoperative Intracranial Hematoma, Postoperative Intracranial Haemorrhage | Unknown | Istanbul University - Cerrahpasa | 223 | 2023-10-01 | 2023-09-14 | |
| Minimally Invasive Surgical Epilepsy Trial for Temporal Lobe Epilepsy Functional anterior temporal lobectomy (FATL), Anterior temporal lobectomy (ATL) - Temporal Lobe Epilepsy, Open Surgery | Not applicable | Unknown | First Affiliated Hospital Xi'an Jiaotong University | 120 | 2023-04-25 | 2022-12-30 |
| Intensive Preoperative Speech Rehabilitation in Drug-Resistant Temporal Epilepsy Speech therapy, Speech therapy assessment - Epilepsy, Anomia | Not applicable | Recruiting | Assistance Publique Hopitaux De Marseille | 214 | 2023-03-30 | 2024-07-18 |
| Autonomic Dysfunction in Temporal Lobe Epilepsy and SUDEP Sympathetic skin response, heart rate variability test, quantitative EEG - Temporal Lobe Epilepsy | Completed | Cairo University | 54 | 2022-09-01 | 2024-02-21 | |
| Exercise for Brain Regeneration in Epilepsy High-Impact Aerobic Exercise, Low-Impact Aerobic Exercise - Temporal Lobe Epilepsy | Phase 1 | Unknown | University of Southern California | 10 | 2022-08-20 | 2023-12-06 |
| Pre-operative Mapping of the Anterior Temporal Lobe Using Functional MRI Innovative Techniques in in Drug-resistant Epileptic Patients functional MRI - Epilepsy, Temporal Lobe, Cognitive Decline | Not applicable | Recruiting | Central Hospital, Nancy, France | 30 | 2022-06-10 | 2025-07-01 |
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Epilepsy (27) · Epilepsies, Partial (8) · Seizures (8) · Drug Resistant Epilepsy (7) · Depression (5) · Epilepsy, Frontal Lobe (3) · Alzheimer Disease (2) · Amyotrophic Lateral Sclerosis (2) · Anxiety Disorders (2) · Cognitive Dysfunction (2) · Depressive Disorder, Major (2) · Language (2) · Stress Disorders, Post-Traumatic (2) · Anomia (1)
Central Nervous System Diseases (62) · Epileptic Syndromes (62) · Nervous System Diseases (62) · Brain Diseases (61) · Epilepsies, Partial (54) · Epilepsy (35) · Neurologic Manifestations (14) · Pathological Conditions, Signs and Symptoms (13) · Signs and Symptoms (13) · Behavior (9) · Mental Disorders (8) · Behavioral Symptoms (5) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (3) · Neurobehavioral Manifestations (3) · Neurocognitive Disorders (3)
Anterior Temporal Lobectomy (2) · 4-(N-methylamino)-4'-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)stilbene (1) · Amitriptyline (1) · Anticonvulsants (1) · Antidepressive Agents (1) · Buspirone (1) · Cognitive Behavioral Therapy (1) · Conversion to Open Surgery (1) · Deep Brain Stimulation (1) · Escitalopram (1) · Ferrosoferric Oxide (1) · Functional Status (1) · Lovastatin (1) · Magnetic Resonance Spectroscopy (1) · Neuronavigation (1)
National Institute of Neurological Disorders and Stroke (NINDS) (11) · Assistance Publique Hopitaux De Marseille (2) · Assiut University (2) · Central Hospital, Nancy, France (2) · Duke University (2) · Second Affiliated Hospital, Zhejiang University, School of Medicine (2) · Xijing Hospital (2) · Acibadem University (1) · Andrew Parrent (1) · Assistance Publique - Hôpitaux de Paris (1) · Beijing Tiantan Hospital (1) · Beth Israel Deaconess Medical Center (1) · BrainSonix Inc. (1) · Cairo University (1) · Cardiff and Vale University Health Board (1)
United States (27) · France (9) · China (7) · Canada (2) · Egypt (2) · Turkey (Türkiye) (2) · Australia (1) · Brazil (1) · Denmark (1) · Germany (1) · Mexico (1) · Norway (1) · Portugal (1) · Switzerland (1) · Taiwan (1)
William H Theodore, M.D. (4) · Adam Williamson, PhD (1) · Andrew Parrent (1) · Barbara Jobst, MD, PhD (1) · Bernard S Chang, MD, MMSc (1) · Birgit Frauscher, MD / PD (1) · Daniel Crail-Melendez, MD (1) · Donald Gross, MD (1) · Eduardo Dunayevich, MD (1) · Eli B Kyte, Cand.psych (1) · Erich J Conrad, M.D (1) · Fatma Eren Akcil, MD (1) · Filiz Onat, MD, PhD (1)
PMID 20331461, PMID 21391767, PMID 22396514, PMID 25564232, PMID 25663221, PMID 26143305, PMID 27354526, PMID 29208571, PMID 29502144, PMID 31666082, PMID 32496194, PMID 33420912, PMID 33860531, PMID 34187524, PMID 34198105, PMID 34955774, PMID 40543839, PMID 42425569
1UG3NS112826-01 (1), DP1MH116506 (1)