12 completed, 4 unknown, 3 terminated, 1 recruiting. 8 Phase 3, 5 Phase 4, 4 Phase 2, 1 Not applicable, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 8 | Completed 4, Terminated 3, Withdrawn 1 |
| Phase 4 | 5 | Unknown 4, Completed 1 |
| Phase 2 | 4 | Completed 4 |
| Not applicable | 1 | Completed 1 |
| Phase 1 | 1 | Completed 1 |
Follow Clobazam: new trials by email Literature Review of Clobazam trials Research Report on Clobazam
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The Benefit and Safety of Older Generation Anti-Epileptic Drugs (AEDs) in Drug-Resistant Epilepsy Children Valproic acid, Carbamazepin, Phenytoin - Drug Resistant Epilepsy | Phase 4 | Unknown | Dr Cipto Mangunkusumo General Hospital | 100 | 2023-03-01 | 2023-01-26 |
| Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS) The POP02 study is collecting bodily fluid samples (i.e., whole blood, effluent samples) of children prescribed the following drugs of interest per standard of care: - Coronavirus Infection (COVID-19), Pulmonary Arterial Hypertension | Recruiting | Duke University | 5000 | 2020-03-05 | 2026-08-21 | |
| GABA Pathways in Autism Spectrum Disorder (ASD) AZD7325_10, AZD7325_20, Placebo - Autism Spectrum Disorder | Not applicable | Completed | King's College London | 109 | 2018-12-07 | 2025-08-26 |
| Use of Clobazam for Epilepsy and Anxiety Clobazam - Epilepsy, Anxiety | Phase 4 | Completed | Hugo W. Moser Research Institute at Kennedy Krieger, Inc. | 20 | 2017-10-01 | 2021-03-04 |
| Population Pharmacokinetics of Antiepileptic in Pediatrics Valproic acid, carbamazepine, phenobarbital - Epilepsy | Completed | Assistance Publique - Hôpitaux de Paris | 753 | 2017-06-19 | 2025-11-20 | |
| An Open-label Extension Study to Investigate Possible Drug-drug Interactions Between Clobazam and Cannabidiol GWP42003-P, Clobazam - Epilepsy | Phase 2 | Completed | Jazz Pharmaceuticals | 18 | 2016-03-11 | 2022-09-28 |
| A Randomized Controlled Trial to Investigate Possible Drug-drug Interactions Between Clobazam and Cannabidiol GWP42003-P 20 mg/kg/Day Dose, Placebo, Clobazam - Epilepsy | Phase 2 | Completed | Jazz Pharmaceuticals | 20 | 2016-01-20 | 2022-09-28 |
| Safety and Tolerability of Clobazam as Adjunctive Therapy in Paediatric Patients Aged ≥1 to ≤16 Years With Dravet Syndrome Clobazam - Dravet Syndrome | Phase 3 | Terminated | H. Lundbeck A/S | 3 | 2015-03-01 | 2017-03-27 |
| Clobazam as Adjunctive Therapy in Paediatric Patients Aged ≥1 to ≤16 Years With Dravet Syndrome Clobazam, Placebo - Dravet Syndrome | Phase 3 | Withdrawn | H. Lundbeck A/S | 2015-03-01 | 2015-09-24 | |
| Clobazam Adjunctive Treatment of Adults With Refractory Focal Epilepsy Clobazam - Epilepsy | Phase 4 | Unknown | Pavel Klein | 20 | 2015-02-01 | 2017-03-23 |
| Ketogenic Diet in Infants With Epilepsy (KIWE) Ketogenic diet, Antiepileptic drug therapy - Epilepsy | Phase 4 | Unknown | University College, London | 160 | 2015-01-01 | 2017-05-04 |
| Pharmacovigilance in Gerontopsychiatric Patients Phenobarbital, Phenytoin, Carbamazepine - Dementia, Depression | Phase 3 | Terminated | Hannover Medical School | 407 | 2015-01-01 | 2018-02-28 |
| Clobazam Use in Epilepsia Partialis Continua - Pilot Study Clobazam, Clonazepam, Lorazepam - Epilepsia Partialis Continua, Kojewnikov's Epilepsy | Phase 3 | Terminated | The Cooper Health System | 7 | 2014-07-01 | 2018-05-09 |
| Evaluation of Onfi Conversion Therapy Replacing Clonazepam in Patients With Medically Refractory Epilepsy clobazam (Onfi), Initial conversion and titration, Conversion schedule - Week 1 - Refractory Epilepsy | Phase 4 | Unknown | St. Joseph's Hospital and Medical Center, Phoenix | 21 | 2013-02-01 | 2017-03-03 |
| Electrical Status Epilepticus in Sleep: Response of Neuropsychological Deficits and Epileptiform Activity to Clobazam Treatment ESES treated with clobazam - Electrical Status Epilepticus in Sleep | Completed | Boston Children's Hospital | 17 | 2012-07-01 | 2015-07-30 | |
| Linking Altered Central Pain Processing and Genetic Polymorphism to Drug Efficacy in Chronic Low Back Pain (Predictio) Oxycodone 15mg, Clobazam, Imipramine - Low Back Pain | Phase 3 | Completed | Insel Gruppe AG, University Hospital Bern | 150 | 2010-07-01 | 2016-04-06 |
| GABAergic Modulation in Pain Transmission in Human: Effect of the GABAA Agonist Clobazam on Peripheral and Central Sensitisation Clonazepam, Tolterodine, clobazam - Neuropathic Pain | Phase 1 / Phase 2 | Completed | University Hospital, Geneva | 25 | 2010-04-01 | 2011-12-14 |
| Effects of GABA-a-Agonists on Pain Mechanisms: An Experimental Study in Healthy Volunteers clobazam, clonazepam, tolterodine - Pain | Phase 3 | Completed | Insel Gruppe AG, University Hospital Bern | 17 | 2009-12-01 | 2010-08-11 |
| Clobazam in Patients With Lennox-Gastaut Syndrome Clobazam Low Dose, Clobazam Medium Dose, Clobazam High Dose - Epilepsy, Epilepsy, Generalized | Phase 3 | Completed | Lundbeck LLC | 238 | 2007-08-01 | 2012-02-09 |
| Safety and Effectiveness of Open-Label Clobazam in Subjects With Lennox-Gastaut Syndrome Clobazam - Lennox-Gastaut Syndrome | Phase 3 | Completed | Lundbeck LLC | 267 | 2005-12-01 | 2018-03-21 |
Showing 20 of 21. Sign in to see all of them.
Epilepsy (12) · Seizures (3) · Anxiety Disorders (2) · Drug Resistant Epilepsy (2) · Epilepsies, Myoclonic (2) · Epilepsy, Generalized (2) · Lennox Gastaut Syndrome (2) · Pain (2) · Syncope (2) · Adrenal Insufficiency (1) · Arrhythmias, Cardiac (1) · Attention Deficit Disorder with Hyperactivity (1) · Autism Spectrum Disorder (1) · Bronchopulmonary Dysplasia (1) · COVID-19 (1)
Lundbeck LLC (3) · H. Lundbeck A/S (2) · Insel Gruppe AG, University Hospital Bern (2) · Jazz Pharmaceuticals (2) · Assistance Publique - Hôpitaux de Paris (1) · Boston Children's Hospital (1) · Dr Cipto Mangunkusumo General Hospital (1) · Duke University (1) · Hannover Medical School (1) · Hugo W. Moser Research Institute at Kennedy Krieger, Inc. (1) · King's College London (1) · Pavel Klein (1) · St. Joseph's Hospital and Medical Center, Phoenix (1) · The Cooper Health System (1) · University College, London (1)
United States (10) · United Kingdom (4) · Switzerland (3) · Mexico (2) · Spain (2) · Australia (1) · Belarus (1) · Canada (1) · France (1) · Germany (1) · India (1) · Indonesia (1) · Lithuania (1)
Andreas Siegenthaler, Dr Med (1) · Chi Hornik (1) · Grainne McAlonan, PhD (1) · Helen Cross, FRCP(UK) (1) · Helge Frieling, Prof., MD (1) · Jay Salpekar, MD (1) · Melissa Carran, MD (1) · Michele Curatolo, Prof (1) · Michele Curatolo, Professor (1) · Pascal H Vuilleumier, Dr Med (1) · Pascal H Vuilleumier, Dr med (1) · Pavel Klein, M.D. (1)
PMID 27683846, PMID 16215338, PMID 16616268, PMID 18654615, PMID 19380256, PMID 21956725, PMID 23141144, PMID 23554851, PMID 26376691, PMID 28446244, PMID 28850362, PMID 32652616, PMID 33825230, PMID 37609651
2014 (2)