552 completed, 254 unknown, 220 recruiting, 104 not yet recruiting. 672 Not applicable, 46 Phase 2, 24 Phase 1, 15 Phase 3, 14 Phase 4.
Follow Frailty: new trials by email Literature Review of Frailty trials Research Report on Frailty
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Adapting an Evidence-Based Physical Activity Intervention to Prevent Frailty and Functional Decline in Older Women Living With HIV Positively Fit and Strong! - Mobility Impairment, Frailty | Not applicable | Not yet recruiting | University of Illinois Chicago | 210 | 2027-06-01 | 2026-11-06 |
| Frailty Improvement Through Technology With Informal Caregiver Supported Exercise (FITWISE) for Pre-frail and Frail Community-dwelling Older Adults FITWISE, Psychosocial support, Health education control - Frailty, Pre-Frailty | Not applicable | Not yet recruiting | National University of Singapore | 60 | 2027-02-01 | 2026-04-09 |
| VOCALE: A Digital Intervention to Improve Quality of Life and Reduce Frailty Among Older Adults in Retirement Communities VOCALE Healthy Aging Online Program - Frailty, Quality of Life | Not applicable | Not yet recruiting | University of Washington | 128 | 2027-01-15 | 2026-10-06 |
| ENRICH Study: A Mixed-methods Feasibility Study of a Nurse-led Model of Care for Social Frailty in Philippine Primary Care Group activities (i.e., low impact exercise), peer counseling, volunteering, Social Frailty Care Bundle (SFCB) - Frailty, Frailty in Older Adults | Not applicable | Not yet recruiting | The Hong Kong Polytechnic University | 30 | 2027-01-01 | 2026-10-06 |
| Assessment of Transnational Performance of the Universal Cardiac Surgical Risk Score Across International Sites Risk score calculation - Heart Valve Diseases, Cardiac Surgical Procedures | Not yet recruiting | Union Health System | 5000 | 2027-01-01 | 2026-11-05 | |
| Safety and Tolerability Study of Mesenchymal Stem Cells, HeXell-2020, in Elderly Subjects With Mild to Moderate Frailty Syndrome HeXell-2020 - Frailty in Older Adults | Phase 1 | Not yet recruiting | Hexun Biosciences Co., LTD. | 12 | 2026-12-31 | 2026-09-25 |
| Safety Study of Intravenous MiraMSC in Older Adults With Mild to Moderate Frailty Syndrome MiraMSC-FS-001 - Frailty | Phase 1 | Not yet recruiting | Miracle Biomedical Co., Ltd. | 12 | 2026-12-01 | 2026-07-15 |
| Longitudinal Tracking and Intervention Platform for Medicare Advantage Patients Longitudinal Tracking and Intervention Platform for Medicare Advantage Patients - Frailty | Not applicable | Not yet recruiting | Stanford University | 1000 | 2026-12-01 | 2026-02-27 |
| Effect of Animation-Based Digital Education on Risk Knowledge and Frailty in Older Adults Branching Scenario Animation Education - Aging, Frail Elderly | Not applicable | Not yet recruiting | Saglik Bilimleri Universitesi | 66 | 2026-12-01 | 2026-11-03 |
| Eccentric Exercise in Community-dwelling Older Adults Eccentric exercise intervention - Ageing Well | Not applicable | Not yet recruiting | The University of Northampton | 30 | 2026-11-23 | 2026-11-04 |
| PROfiles of FGF-19 Post-prandial Secretion in Older Adults With Frailty and Without Frailty FLEXMEAL : post-prandial blood sampling - Frailty, Sarcopenia | Not applicable | Not yet recruiting | Hospices Civils de Lyon | 30 | 2026-11-19 | 2026-11-10 |
| Postprandial Hypotension, Frailty and Post-Induction Hypotension in Older Patients Undergoing Noncardiac Surgery Post-induction Hypotension (PIH), Postprandial Hypotension | Recruiting | Konya City Hospital | 200 | 2026-11-05 | 2026-11-10 | |
| Preoperative Frailty and Suboptimal Mask Ventilation in Cardiac Surgery Patients Mask Ventilation During Routine Anesthesia Induction - Frailty, Suboptimal Mask Ventilation | Not yet recruiting | Ankara City Hospital Bilkent | 450 | 2026-11-03 | 2026-11-04 | |
| Frailty and Outcomes in Critically Ill Patients Receiving CRRT Acute Kidney Injury | Not yet recruiting | Karolinska Institutet | 22000 | 2026-11-01 | 2026-09-28 | |
| Targeting HealthY Eating to Maintain Energy While Living With Cancer Nutrition counseling, Time-restricted eating - Fatigue in Cancer Survivors | Phase 2 | Recruiting | University of Maryland, Baltimore | 132 | 2026-11-01 | 2026-11-03 |
| Online Exercise Program for Transplant Patients: A Pilot Study Online Therapeutic Exercise Programme, Usual Care Control Group - Kidney Transplantation, Physical Function | Not applicable | Enrolling by invitation | Cardenal Herrera University | 20 | 2026-11-01 | 2026-11-06 |
| Creatine and Beta-Hydroxy-Beta-Methylbutyrate (HMB) Supplementation Plus Home-Based Exercise for Sarcopenia in Huntington's Disease Creatine monohydrate, Beta-hydroxy-beta-methylbutyrate (HMB), Placebo (microcrystalline cellulose) - Huntington Disease, Sarcopenia | Not applicable | Not yet recruiting | Universidad de Burgos | 88 | 2026-11-01 | 2026-10-28 |
| Prognostic Value of Functional-Nutritional Status in Older Adults With Acute Coronary Syndrome Functional-Nutritional Burden - Acute Coronary Syndromes (ACS) | Not yet recruiting | Samara State Medical University | 270 | 2026-11-01 | 2026-10-28 | |
| Exercise-based Frailty Intervention in Lung Transplantation (XFIT) XFIT - Frailty, Lung Tranplant Candidate | Not applicable | Recruiting | University of California, San Francisco | 70 | 2026-10-22 | 2026-10-16 |
| Immune Aging and Advanced Therapy Outcomes in Older Adults With IBD Inflammatory Bowel Disease (Crohn's Disease and Ulcerative Colitis), Frailty | Not yet recruiting | First Affiliated Hospital, Sun Yat-Sen University | 300 | 2026-10-12 | 2026-10-13 |
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Sarcopenia (168) · Motor Activity (143) · Cognitive Dysfunction (61) · Heart Failure (37) · Neoplasms (37) · Malnutrition (35) · Depression (33) · Cardiovascular Diseases (26) · Dementia (26) · Postoperative Complications (25) · Sedentary Behavior (24) · Emergencies (22) · Hip Fractures (22) · Renal Insufficiency, Chronic (22)
Pathological Conditions, Signs and Symptoms (1248) · Pathologic Processes (1247) · Nervous System Diseases (280) · Signs and Symptoms (260) · Behavior (232) · Neurologic Manifestations (227) · Neuromuscular Manifestations (181) · Pathological Conditions, Anatomical (175) · Atrophy (168) · Muscular Atrophy (156) · Mental Disorders (125) · Cardiovascular Diseases (120) · Nutritional and Metabolic Diseases (109) · Neurocognitive Disorders (108) · Disease Attributes (99)
Exercise (54) · Geriatric Assessment (24) · Resistance Training (22) · Preoperative Exercise (13) · Dietary Supplements (12) · Standard of Care (12) · Control Groups (10) · Nutritional Status (9) · Blood Specimen Collection (8) · Observation (8) · Methods (7) · Aging (6) · Metformin (6) · Testosterone (6) · Diet (5)
National Taiwan University Hospital (14) · The Hong Kong Polytechnic University (12) · VA Office of Research and Development (12) · Fundacion Miguel Servet (11) · Jewish General Hospital (10) · The University of Hong Kong (10) · Charite University, Berlin, Germany (9) · Mayo Clinic (9) · National Yang Ming Chiao Tung University (9) · University Hospital, Toulouse (9) · University of Valencia (9) · McGill University Health Centre/Research Institute of the McGill University Health Centre (8) · McMaster University (8) · University of Limerick (8) · National Institute on Aging (NIA) (7)
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Dennis T Villareal, MD (4) · Ai-Fu Chiou, PhD (3) · Anne Kenny, MD (3) · Bruce R. Troen, MD (3) · Dae Hyun Kim, MD, MPH, ScD (3) · Doris Sau Fung YU, PhD (3) · Jonathan Afilalo, MD, MSc (3) · Mohammad Ali Tabibi, Dr (3) · Olivier Beauchet, MD (3) · Alexandra Papaioannou, MD, MSc (2) · Annie-Claire Nadeau-Fredette, MD (2) · Bella Azaria, Doctor (2) · Catherine Ludwig, PhD (2) · Cecilia M Lund, MD, PhD (2)
PMID 11253156, PMID 17634318, PMID 20392703, PMID 22511289, PMID 26947059, PMID 27507236, PMID 28724351, PMID 30312372, PMID 30419096, PMID 30885132, PMID 31189323, PMID 32033532, PMID 32033882, PMID 33962483, PMID 35870875, PMID 36070134, PMID 38730363, PMID 39053972, PMID 39360568, PMID 42814673, PMID 10109801, PMID 10201543, PMID 10522957, PMID 10904038, PMID 11217890, PMID 11322678, PMID 11328886, PMID 11480531, PMID 11815695, PMID 12456735, PMID 12766979, PMID 12844499, PMID 12900694, PMID 1425649, PMID 14552938, PMID 15031310, PMID 15135914, PMID 15304540, PMID 15514517, PMID 15674925, PMID 15763418, PMID 15860469, PMID 15907642, PMID 16076854, PMID 16129869, PMID 16636211, PMID 16645293, PMID 16776798, PMID 16821500, PMID 16913163
2023 (6), 2019 (5), P30AG021334 (2), 2016 (1), 2017 (1), 2025 (1), I01HX003215 (1), I21RX002562 (1), I21RX004420 (1), K00AG076123 (1), K01AG076967 (1), K01AG080164 (1), K12CA138464 (1), K12HD001262 (1), K23AG045560 (1)