545 completed, 256 unknown, 218 recruiting, 101 not yet recruiting. 664 Not applicable, 46 Phase 2, 24 Phase 1, 15 Phase 3, 14 Phase 4.
Follow this condition Literature Review of Frailty trials Research Report on Frailty
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Frailty Improvement Through Technology With Informal Caregiver Supported Exercise (FITWISE) for Pre-frail and Frail Community-dwelling Older Adults FITWISE, Psychosocial support, Health education control - Frailty, Pre-Frailty | Not applicable | Not yet recruiting | National University of Singapore | 60 | 2027-02-01 | 2026-04-09 |
| VOCALE: A Digital Intervention to Improve Quality of Life and Reduce Frailty Among Older Adults in Retirement Communities VOCALE Healthy Aging Online Program - Frailty, Quality of Life | Not applicable | Not yet recruiting | University of Washington | 128 | 2027-01-15 | 2026-10-06 |
| ENRICH Study: A Mixed-methods Feasibility Study of a Nurse-led Model of Care for Social Frailty in Philippine Primary Care Group activities (i.e., low impact exercise), peer counseling, volunteering, Social Frailty Care Bundle (SFCB) - Frailty, Frailty in Older Adults | Not applicable | Not yet recruiting | The Hong Kong Polytechnic University | 30 | 2027-01-01 | 2026-10-06 |
| Safety and Tolerability Study of Mesenchymal Stem Cells, HeXell-2020, in Elderly Subjects With Mild to Moderate Frailty Syndrome HeXell-2020 - Frailty in Older Adults | Phase 1 | Not yet recruiting | Hexun Biosciences Co., LTD. | 12 | 2026-12-31 | 2026-09-25 |
| Safety Study of Intravenous MiraMSC in Older Adults With Mild to Moderate Frailty Syndrome MiraMSC-FS-001 - Frailty | Phase 1 | Not yet recruiting | Miracle Biomedical Co., Ltd. | 12 | 2026-12-01 | 2026-07-15 |
| Longitudinal Tracking and Intervention Platform for Medicare Advantage Patients Longitudinal Tracking and Intervention Platform for Medicare Advantage Patients - Frailty | Not applicable | Not yet recruiting | Stanford University | 1000 | 2026-12-01 | 2026-02-27 |
| Frailty and Outcomes in Critically Ill Patients Receiving CRRT Acute Kidney Injury | Not yet recruiting | Karolinska Institutet | 22000 | 2026-11-01 | 2026-09-28 | |
| Exercise-based Frailty Intervention in Lung Transplantation (XFIT) XFIT - Frailty, Lung Tranplant Candidate | Not applicable | Recruiting | University of California, San Francisco | 70 | 2026-10-22 | 2026-10-16 |
| Immune Aging and Advanced Therapy Outcomes in Older Adults With IBD Inflammatory Bowel Disease (Crohn's Disease and Ulcerative Colitis), Frailty | Not yet recruiting | First Affiliated Hospital, Sun Yat-Sen University | 300 | 2026-10-12 | 2026-10-13 | |
| Whole-Body Point-of-Care Ultrasound in Older Adults Presenting to the Emergency Department After a Fall Whole-body point-of-care ultrasound (POCUS) - Accidental Falls, Aged | Recruiting | Kocaeli City Hospital | 105 | 2026-10-12 | 2026-10-21 | |
| Patients With Long-stay at ICU: Factors and Evaluation - Feasibility Study Frailty, Delirium Confusional State | Not yet recruiting | Uppsala University | 300 | 2026-10-01 | 2026-10-01 | |
| Safety and Preliminary Efficacy of Adipose-Derived Stem Cell Secretome in Frailty (VinVital) VinVital - Frailty Syndrome, Aging | Phase 1 | Not yet recruiting | Vinmec Research Institute of Stem Cell and Gene Technology | 20 | 2026-10-01 | 2026-10-02 |
| AI-Supported Physiotherapy After Hip Fracture in Frail Older Adults Conventional hospital physiotherapy, Automated motivational support and movement-capture system - Hip Fractures, Frailty | Not applicable | Not yet recruiting | Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal | 48 | 2026-10-01 | 2026-10-05 |
| Effects of a Community-based Multicomponent Physical Exercise Program on Physical Function, Frailty, and Sarcopenia in Older Adults From the Municipality of Santoña: a Quasi-experimental Study. Multicomponent Exercise Program (Vivifrail-based) - Frailty/Sarcopenia, Frailty in Older Adults | Not applicable | Not yet recruiting | Universidad de Granada | 300 | 2026-10-01 | 2026-07-30 |
| Improving Shared DECISion-making in oldEr Hip Fracture Patients Living With Frailty Hip Fractures (i.e. Femoral Neck or Intertrochanteric Hip Fractures), Hip Fractures (ICD-10 72.01-72.2) | Not yet recruiting | University of Southampton | 42 | 2026-10-01 | 2026-07-07 | |
| Older Adults' Recovery Dynamics After Cardiac Surgery Frailty, Resilience | Not yet recruiting | University of Chile | 75 | 2026-10-01 | 2026-08-28 | |
| Targeting HealthY Eating to Maintain Energy While Living With Cancer Nutrition counseling, Time-restricted eating - Fatigue in Cancer Survivors | Phase 2 | Not yet recruiting | University of Maryland, Baltimore | 132 | 2026-10-01 | 2026-09-17 |
| A Pilot Study to Explore the Feasibility of Navigator and Coach Support for Community Participation by Older People Navigation support, Coaching support - Frailty, Social Isolation in Older Adults | Not applicable | Not yet recruiting | Bastiaan Van Grootven | 45 | 2026-10-01 | 2026-09-23 |
| Integrating Geriatric 8 (G8) Screening and Cancer and Age Research Group (CARG) Toxicity Assessment Score Into Routine Care for Older Adults With Cancer Solid Neoplasms, Solid Tumors | Not yet recruiting | Assiut University | 100 | 2026-10-01 | 2026-09-23 | |
| Frailty, Geriatric Syndromes and Care Pathways of Older Adults Living With HIV in West Africa Older Adults | Recruiting | ANRS, Emerging Infectious Diseases | 600 | 2026-09-28 | 2026-10-02 |
Showing 20 of 1234. Sign in to see all of them.
Sarcopenia (162) · Motor Activity (142) · Cognitive Dysfunction (61) · Neoplasms (37) · Heart Failure (36) · Malnutrition (34) · Depression (33) · Cardiovascular Diseases (26) · Dementia (26) · Postoperative Complications (24) · Sedentary Behavior (24) · Hip Fractures (22) · Renal Insufficiency, Chronic (22) · Emergencies (21)
Pathological Conditions, Signs and Symptoms (1234) · Pathologic Processes (1233) · Nervous System Diseases (274) · Signs and Symptoms (254) · Behavior (229) · Neurologic Manifestations (221) · Neuromuscular Manifestations (175) · Pathological Conditions, Anatomical (169) · Atrophy (162) · Muscular Atrophy (150) · Mental Disorders (124) · Cardiovascular Diseases (117) · Nutritional and Metabolic Diseases (108) · Neurocognitive Disorders (107) · Disease Attributes (98)
Exercise (54) · Geriatric Assessment (24) · Resistance Training (22) · Preoperative Exercise (13) · Dietary Supplements (12) · Standard of Care (12) · Control Groups (10) · Nutritional Status (9) · Blood Specimen Collection (8) · Observation (8) · Methods (7) · Aging (6) · Metformin (6) · Testosterone (6) · Diet (5)
National Taiwan University Hospital (14) · The Hong Kong Polytechnic University (12) · VA Office of Research and Development (12) · Fundacion Miguel Servet (11) · Jewish General Hospital (10) · The University of Hong Kong (10) · Charite University, Berlin, Germany (9) · Mayo Clinic (9) · National Yang Ming Chiao Tung University (9) · University Hospital, Toulouse (9) · University of Valencia (9) · McGill University Health Centre/Research Institute of the McGill University Health Centre (8) · McMaster University (8) · University of Limerick (8) · National Institute on Aging (NIA) (7)
United States (179) · Spain (129) · Canada (82) · Turkey (Türkiye) (77) · Taiwan (66) · United Kingdom (62) · China (60) · France (57) · Italy (44) · Denmark (33) · Germany (33) · Sweden (31) · Singapore (27) · Hong Kong (25) · Belgium (24)
Dennis T Villareal, MD (4) · Ai-Fu Chiou, PhD (3) · Anne Kenny, MD (3) · Bruce R. Troen, MD (3) · Dae Hyun Kim, MD, MPH, ScD (3) · Doris Sau Fung YU, PhD (3) · Jonathan Afilalo, MD, MSc (3) · Mohammad Ali Tabibi, Dr (3) · Olivier Beauchet, MD (3) · Alexandra Papaioannou, MD, MSc (2) · Annie-Claire Nadeau-Fredette, MD (2) · Bella Azaria, Doctor (2) · Catherine Ludwig, PhD (2) · Cecilia M Lund, MD, PhD (2)
PMID 11253156, PMID 17634318, PMID 20392703, PMID 22511289, PMID 26947059, PMID 27507236, PMID 28724351, PMID 30312372, PMID 30419096, PMID 30885132, PMID 31189323, PMID 32033532, PMID 32033882, PMID 33962483, PMID 35870875, PMID 36070134, PMID 38730363, PMID 39053972, PMID 39360568, PMID 42814673, PMID 10109801, PMID 10201543, PMID 10522957, PMID 10904038, PMID 11217890, PMID 11322678, PMID 11328886, PMID 11480531, PMID 11815695, PMID 12456735, PMID 12766979, PMID 12844499, PMID 12900694, PMID 1425649, PMID 14552938, PMID 15031310, PMID 15135914, PMID 15304540, PMID 15514517, PMID 15674925, PMID 15763418, PMID 15860469, PMID 15907642, PMID 16076854, PMID 16129869, PMID 16636211, PMID 16645293, PMID 16776798, PMID 16821500, PMID 16913163
2023 (6), 2019 (5), P30AG021334 (2), 2016 (1), 2017 (1), 2025 (1), I01HX003215 (1), I21RX002562 (1), I21RX004420 (1), K00AG076123 (1), K01AG076967 (1), K01AG080164 (1), K12CA138464 (1), K12HD001262 (1), K23AG045560 (1)