127 completed, 50 unknown, 37 recruiting, 20 not yet recruiting. 127 Not applicable, 84 Phase 4, 18 Phase 3, 10 Phase 2, 4 Phase 1.
Follow Dexmedetomidine: new trials by email Literature Review of Dexmedetomidine trials Research Report on Dexmedetomidine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Long-term Follow-up of Dexmedetomidine-esketamine and tDCS for Neurocognitive Complications After Surgery Dex-Esk, Placebo, Active tDCS - Older Patients, Surgery | Phase 4 | Not yet recruiting | Peking University First Hospital | 1996 | 2026-10-01 | 2026-10-13 |
| Dexmedetomidine for Prevention of Delirium After Hip Fracture Surgery Delirium - Postoperative, Delirium Prevention | Recruiting | Peter Gaarsdal Uhrbrand | 242 | 2026-10-01 | 2026-10-09 | |
| Dexmedetomidine-esketamine and tDCS for Prevention of Neurocognitive Complications After Surgery Dex-Esk, Placebo, Active tDCS - Older Patients, Surgery | Phase 4 | Not yet recruiting | Peking University First Hospital | 1996 | 2026-10-01 | 2026-10-13 |
| Safety and Efficacy of Esketamine - Dexmedetomidine Combination Versus Dexmedetomidine Monotherapy for Hyperactive Delirium in ICU Patients on Non-Invasive Respiratory Support (SEED-NIRS Trial): Study Protocol of a Randomized Controlled Trial Esketamine combined with dexmedetomidine, Dexmedetomidine - Dexmedetomidine, Ketamine | Phase 4 | Not yet recruiting | The First Affiliated Hospital with Nanjing Medical University | 356 | 2026-09-28 | 2026-09-03 |
| The Impact of Dexmedetomidine Nasal Spray on Perioperative Anxiety in Neurosurgical Patients Dexmedetomidine - Anxiety, Dexmedetomidine | Not applicable | Not yet recruiting | Beijing Tiantan Hospital | 114 | 2026-09-15 | 2026-09-02 |
| Dexmedetomidine Combined With Transcutaneous Vagus Nerve Stimulation (taVNS) Can Reduce the Incidence of PTSD in Trauma Patients After Surgery Dexmedetomidine 0.1μg/kg/h, tavns - PTSD - Post Traumatic Stress Disorder, taVNS | Not applicable | Recruiting | Affiliated Hospital of Nantong University | 300 | 2026-09-12 | 2026-09-17 |
| Dexmedetomidine-Esketamine Combination on Depression and Anxiety After Laparoscopic Ureteral Reconstruction Combined dexmedetomidine-esketamine administration, Placebo administration - Ureteral Stricture, Dexmedetomidine | Phase 4 | Not yet recruiting | Peking University First Hospital | 658 | 2026-08-01 | 2026-08-14 |
| Intranasal Dexmedetomidine and Perioperative Myocardial Injury Intranasal Dexmedetomidine, Normal saline - Coronary Heart Disease, Myocardial Injury | Phase 4 | Not yet recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 140 | 2026-08-01 | 2026-07-30 |
| Esmolol Versus Dexmedetomidine for Opioid-sparing in Laparoscopic Gynecological Surgery Esmolol hydrochloride, Dexmedetomidine, Normal (0.9%) saline - Pain, Acute Post-Operative, Dexmedetomidine | Not applicable | Recruiting | Vasiliki Samartzi | 90 | 2026-07-15 | 2026-09-29 |
| Propofol-Only Versus Dexmedetomidine-Propofol in Children Undergoing Magnetic Resonance Imaging Dexmedetomidine (IV) 0.5 mcg/kg, Propofol (IV) 2-4 mg/kg, Dexmedetomidine (IV) 1 mcg/kg - MRI Sedation, Pediatric Sedation | Phase 4 | Recruiting | Boston Children's Hospital | 105 | 2026-06-30 | 2026-09-21 |
| Intranasal Dexmedetomidine-esketamine on Sleep and Cognition in Older Adults With Mild-to-moderate Cognitive Impairment Dexmedetomidine-esketamine combination, Placebo - Older Adults, Cognitive Impairment | Phase 4 | Not yet recruiting | Peking University First Hospital | 60 | 2026-06-01 | 2026-06-01 |
| Intranasal Esketamine-dexmedetomidine Combination and Postpartum Depression Esketamine-dexmedetomidine combination, Placebo - Parturients, Depressive Symptoms | Phase 4 | Not yet recruiting | Peking University First Hospital | 164 | 2026-06-01 | 2026-06-15 |
| Adding Dexmedetomidine or Clonidine to Spinal Anesthesia for Cesarean Delivery Clonidine, Dexmedetomidine - Cesarean Delivery, Cesarean Delivery; Neuraxial Opioids | Phase 4 | Not yet recruiting | Columbia University | 150 | 2026-06-01 | 2026-05-05 |
| Dexmedetomidine vs Lignocaine for Reducing Intubation-Induced Hemodynamic Responses in Cardiac Surgery: A Randomized Controlled Trial IV dexmedetomidine, IV Lignocaine - Laryngoscopic Stress Response, Dexmedetomidine | Phase 4 | Recruiting | Rawalpindi Institute of Cardiology | 70 | 2026-05-21 | 2026-05-28 |
| Hemodynamic Effect of Dexmedetomidine Versus Magnesium Sulphate as an Adjuvant to Lidocaine in Preemptive Peribulbar Block in Patients Undergoing Dacryocystorhinostomy Under General Anesthesia Lidocaine + Dexmedetomidine, Lidocaine + Magnesium sulphate, Lidocaine - Hemodynamic Effect, Dexmedetomidine | Not applicable | Recruiting | Cairo University | 60 | 2026-05-16 | 2026-06-30 |
| Intraperitoneal Dexmedetomidine Versus Magnesium as Adjuvants to Bupivacaine in Laparoscopic Cholecystectomy Bupivacaine 100 mg + dexmedetomidine 1 µg/kg, Bupivacaine 100 mg + magnesium sulphate 50 mg/kg - Dexmedetomidine, Magnesium Sulfate | Not applicable | Recruiting | Alexandria University | 80 | 2026-05-03 | 2026-07-09 |
| Intranasal Dexmedetomidine-esketamine Administration and Postoperative Pain in Pediatric Patients Intranasal dexmedetomidine-esketamine, Intranasal placebo (normal saline) - Adenotonsillectomy, Children | Phase 4 | Recruiting | Peking University First Hospital | 160 | 2026-04-07 | 2026-04-09 |
| Effect of Intranasal Dexmedetomidine on the Incidence of Emergence Agitation in Children Undergoing Strabismus Surgery high dex group, low dex group - Dexmedetomidine, Emergence Agitation | Not applicable | Completed | Alexandria University | 150 | 2026-04-06 | 2026-10-22 |
| Dexmedetomidine-esketamine Combination and Chronic Postsurgical Pain After Spinal Surgery Combined dexmedetomidine-esketamine administration, Placebo administration - Spinal Surgery, Pain Intensity | Phase 4 | Not yet recruiting | Peking University First Hospital | 274 | 2026-04-01 | 2026-04-16 |
| Dexmedetomidine-esketamine Combination and Moderate-to-severe Pain After Spinal Surgery Combined dexmedetomidine-esketamine administration, Placebo administration - Spinal Surgery, Pain Intensity | Phase 4 | Not yet recruiting | Peking University First Hospital | 274 | 2026-04-01 | 2026-04-14 |
Showing 20 of 249. Sign in to see all of them.
Agnosia (25) · Emergence Delirium (18) · Delirium (17) · Pain, Postoperative (16) · Chronic Pain (7) · Pain (7) · Postoperative Complications (7) · Sleep Initiation and Maintenance Disorders (7) · Acute Pain (5) · Nociceptive Pain (4) · Cognitive Dysfunction (3) · Depression (3) · Obesity, Morbid (3) · Pulmonary Disease, Chronic Obstructive (3) · Sleep Wake Disorders (3)
Pathological Conditions, Signs and Symptoms (102) · Signs and Symptoms (87) · Neurologic Manifestations (80) · Nervous System Diseases (75) · Neurobehavioral Manifestations (58) · Pathologic Processes (57) · Mental Disorders (51) · Postoperative Complications (37) · Confusion (34) · Neurocognitive Disorders (34) · Perceptual Disorders (25) · Pain (19) · Delirium (18) · Cardiovascular Diseases (11) · Respiratory Tract Diseases (10)
Dexmedetomidine (182) · Saline Solution (45) · Sodium Chloride (21) · Bupivacaine (15) · Esketamine (15) · Propofol (14) · Fentanyl (13) · Lidocaine (13) · Control Groups (10) · Dexamethasone (9) · Magnesium Sulfate (9) · Midazolam (9) · Remifentanil (6) · Ropivacaine (5) · Sufentanil (5)
Peking University First Hospital (44) · Tanta University (35) · Cairo University (11) · Kafrelsheikh University (11) · Beijing Tiantan Hospital (9) · Ain Shams University (7) · Alexandria University (4) · Aretaieion University Hospital (4) · Assiut University (4) · Anqing Municipal Hospital (3) · Ajou University School of Medicine (2) · Ankara Etlik City Hospital (2) · Aswan University (2) · Benha University (2) · Boston Children's Hospital (2)
Egypt (84) · China (82) · South Korea (11) · Turkey (Türkiye) (10) · United States (9) · Canada (7) · Greece (7) · Pakistan (6) · Nepal (3) · Hong Kong (2) · Belgium (1) · Brazil (1) · Chile (1) · Denmark (1) · France (1)
Dong-Xin Wang, MD, PhD (28) · Dong-Xin Wang, MD,PhD (11) · Yuming Peng, MD,Ph.D (4) · Dong-Xin Wang (3) · Huacheng Liu (2) · Kassiani Theodoraki (2) · Stephen Choi, MD,MSc,FRCPC (2) · Abdelhamed I Badreldin, MBBCH (1) · Ahmed A Mahmoud, MD (1) · Ayman A Yousef, Professor (1) · Ayman M Eldemrdash (1) · Ayman M Eldemrdash, MD (1) · Bidur K Baral, MBBS,MD (1)
PMID 37302963, PMID 11936706, PMID 16192522, PMID 16415311, PMID 16531445, PMID 17299013, PMID 17563882, PMID 18156878, PMID 18653496, PMID 19713256, PMID 20345866, PMID 21277735, PMID 21818162, PMID 21903640, PMID 22436955, PMID 23160979, PMID 23355160, PMID 23389068, PMID 23748199, PMID 23820102, PMID 23881255, PMID 23893490, PMID 24785989, PMID 25038833, PMID 25207314, PMID 25335575, PMID 26142712, PMID 26264382, PMID 26739975, PMID 26832926, PMID 27252089, PMID 27607187, PMID 28100530, PMID 28314555, PMID 28625441, PMID 28760515, PMID 29068980, PMID 29279832, PMID 29656663, PMID 29736744, PMID 29947681, PMID 30041987, PMID 30570761, PMID 30603826, PMID 31260468, PMID 31908520, PMID 32265584, PMID 32975624, PMID 33011083, PMID 33078536
2018 (1), U24TR001608 (1)