21 withdrawn. 21 Phase 2, 4 Phase 1, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 21 | Withdrawn 21 |
| Phase 1 | 4 | Withdrawn 4 |
| Phase 3 | 2 | Withdrawn 2 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Trifecta Research Study Hormone Replacement Therapy (HRT), Magnetic Resonance Therapy (MeRT), ibogaine with magnesium treatment - PTSD - Post Traumatic Stress Disorder, Cognitive Dysfunction | Phase 2 | Withdrawn | Johns Hopkins University | 2025-09-01 | 2025-08-22 | |
| Trial Investigating the Safety and Efficacy of BRC-003 in Refractory Post-Traumatic Epilepsy PO BRC-003 (High Cannabidiol Cannabis Extract), Placebo - Post-traumatic Epilepsy | Phase 2 | Withdrawn | Dr. Paul Lyons | 2024-11-01 | 2025-04-24 | |
| Promoting Upright Mobility in Infants With Cerebral Palsy Using a Robotic Unweighting System BabyG - Cerebral Palsy, Physical Therapy Modalities | Phase 2 | Withdrawn | National Institutes of Health Clinical Center (CC) | 2024-09-11 | 2025-08-05 | |
| Exercise as Concussion Therapy Trial- 2 Graded Exercise Therapy: ClearPlay(TM) - Mild Traumatic Brain Injury, Concussion, Mild | Phase 2 | Withdrawn | ANSwers Neuroscience, Inc. | 2020-10-01 | 2022-03-03 | |
| Exogenous Sodium Lactate Infusion in Traumatic Brain Injury (ELI-TBI) Sodium Lactate, Placebo - Brain Injuries, Traumatic | Phase 2 | Withdrawn | University of California, Los Angeles | 2020-09-01 | 2021-11-15 | |
| Anti-secretory Factor as a Treatment for Adults With Severe Traumatic Head Injury Salovum - Head Trauma, Intensive Care Neurological Disorder | Phase 2 | Withdrawn | Peter Siesjö | 2018-03-01 | 2018-12-12 | |
| Traumatic Brain Injury and Effects of Acute Cyclosporine A Cyclosporine A, Placebo - Traumatic Brain Injury | Phase 1 / Phase 2 | Withdrawn | Edward Hall,PhD | 2017-08-07 | 2017-10-26 | |
| Impact of GHRH on Sleep Promotion and Endocrine Regulation in Service Members Who Sustained a Traumatic Brain Injury and Have Current Insomnia Tesamorelin, Placebo - Sleep Disorder, Traumatic Brain Injury | Phase 2 | Withdrawn | National Institute of Nursing Research (NINR) | 2016-10-06 | 2019-11-19 | |
| Ibuprofen Versus Acetaminophen for Treatment of Mild Traumatic Brain Injury Ibuprofen, Acetaminophen - Brain Concussion | Phase 2 | Withdrawn | Northwestern University | 2015-05-01 | 2020-11-13 | |
| Effect of Recombinant Erythropoietin on Numbers of Circulating Endothelial Progenitor Cells in Subacute TBI Erythropoietin - Traumatic Brain Injury | Phase 2 | Withdrawn | Uniformed Services University of the Health Sciences | 2014-09-01 | 2019-01-18 | |
| Effect of Recombinant Erythropoietin on Numbers of Circulating Endothelial Progenitor Cells in People With Persistent Symptoms During the Subacute Period After Traumatic Brain Injury Erythropoeitin - Traumatic Brain Injury | Phase 2 | Withdrawn | National Institute of Neurological Disorders and Stroke (NINDS) | 2014-08-15 | 2018-07-05 | |
| Hypernatremia for the Prevention and Treatment of Cerebral Edema in Traumatic Brain Injury Induced, sustained hypernatremia using hypertonic saline, Standard of care (hypertonic saline and mannitol; serum sodium) - Traumatic Brain Injury, Subdural Hematoma | Phase 1 / Phase 2 | Withdrawn | Massachusetts General Hospital | 2012-07-01 | 2016-12-12 | |
| A Pilot Trial of Citicoline in Individuals With Mild Traumatic Brain Injury (mTBI) Citicoline, Placebo - Traumatic Brain Injury | Phase 2 | Withdrawn | Mclean Hospital | 2012-04-01 | 2014-04-23 | |
| Evaluation of Pediatric Procedural Sedation With Rectal Chloral Hydrate or Intranasal Midazolam Midazolam, Chloral Hydrate - Traumatic Brain Injury, Computed Tomography | Phase 2 | Withdrawn | University of Sao Paulo | 2011-08-01 | 2013-06-20 | |
| Controlling Hyperadrenergic Activity in Neurologic Injury Esmolol, Propranolol - Traumatic Brain Injury, Dysautonomia | Phase 1 / Phase 2 | Withdrawn | Johns Hopkins University | 2011-07-01 | 2017-04-20 | |
| Safety Study of Umbilical Cord Blood To Treat Pediatric Traumatic Brain Injury Autologous cord blood - Traumatic Brain Injury | Phase 1 / Phase 2 | Withdrawn | Charles Cox | 2011-01-01 | 2015-12-10 | |
| Vagus Nerve Stimulation to Augment Recovery From Minimally Conscious or Persistently Vegetative States After Traumatic Brain Injury Vagus nerve stimulation;, No stimulation - Minimally Conscious States Due to Traumatic Brain Injury, Persistently Vegetative States Due to Traumatic Brain Injury | Phase 2 / Phase 3 | Withdrawn | VA New York Harbor Healthcare System | 2011-01-01 | 2023-04-27 | |
| Safety of Dexmedetomidine in Severe Traumatic Brain Injury Precedex, Propofol, Fentanyl - Traumatic Brain Injury | Phase 2 | Withdrawn | University of Maryland, Baltimore | 2010-01-01 | 2023-09-13 | |
| Botulinum Toxin and Saliva Management in Tracheotomised Patients Botulinum Toxin - Traumatic Brain Injury | Phase 2 | Withdrawn | HCA International Limited | 2009-09-01 | 2012-09-06 | |
| Efficacy of Ketamine in Children With Severe Brain Injury for Brain Cell Protection saline, Ketamine - Traumatic Brain Injury | Phase 2 | Withdrawn | University of Arkansas | 2008-12-01 | 2013-11-01 |
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Brain Injuries, Traumatic (17) · Brain Concussion (2) · Brain Edema (2) · Craniocerebral Trauma (2) · Autonomic Nervous System Diseases (1) · Brain Contusion (1) · Brain Diseases (1) · Bronchiolitis Obliterans Syndrome (1) · Central Nervous System Diseases (1) · Cerebral Palsy (1) · Cognitive Dysfunction (1) · Combat Disorders (1) · Emergencies (1) · Epilepsy, Post-Traumatic (1)
Trauma, Nervous System (21) · Brain Diseases (20) · Central Nervous System Diseases (20) · Nervous System Diseases (20) · Wounds and Injuries (20) · Craniocerebral Trauma (19) · Pathological Conditions, Signs and Symptoms (4) · Wounds, Nonpenetrating (3) · Brain Damage, Chronic (2) · Brain Injuries, Traumatic (2) · Head Injuries, Closed (2) · Mental Disorders (2) · Neurologic Manifestations (2) · Pathologic Processes (2)
Acetaminophen (1) · Botulinum Toxins (1) · Cannabinoids (1) · Chloral Hydrate (1) · Cyclosporine (1) · Cytidine Diphosphate Choline (1) · Dexmedetomidine (1) · Epoetin Alfa (1) · Erythropoietin (1) · Fentanyl (1) · Hormone Replacement Therapy (1) · Ibogaine (1) · Ibuprofen (1) · Ketamine (1) · Mannitol (1)
Johns Hopkins University (2) · ANSwers Neuroscience, Inc. (1) · Charles Cox (1) · Dr. Paul Lyons (1) · Edward Hall,PhD (1) · HCA International Limited (1) · Massachusetts General Hospital (1) · Mclean Hospital (1) · Medical College of Wisconsin (1) · National Institute of Neurological Disorders and Stroke (NINDS) (1) · National Institute of Nursing Research (NINR) (1) · National Institutes of Health Clinical Center (CC) (1) · Northwestern University (1) · Peter Siesjö (1) · Uniformed Services University of the Health Sciences (1)
United States (13) · Australia (1) · Brazil (1) · United Kingdom (1)
Brian P Walcott, MD (1) · Brian V Nahed, MD (1) · Charles S Cox, Jr., MD (1) · Chetan Vyas, BSc, MSc (1) · Christina Master, MD (1) · David Cederberg, Consultant (1) · Deborah Stein, MD (1) · Demetrios N. Kyriacou, MD,PhD (1) · Diane L Damiano, Ph.D. (1) · Eduardo Mekitarian Filho, MSc (1) · Edward Hall, PhD (1) · Eric M Wassermann, M.D. (1) · Eric Wassermann, MD (1) · Jessica Gill, Ph.D. (1) · Muayyad Tailounie, MD (1)