60 completed, 18 unknown, 17 recruiting, 8 withdrawn. 118 Phase 1, 41 Phase 2.
Follow Brain Injuries: new trials by email Literature Review of Brain Injuries trials Research Report on Brain Injuries
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Safety of Cultured Allogeneic Adult Umbilical Cord or Placental Derived Mesenchymal Stem Cell Intravenous Infusion for TBI cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cells - Traumatic Brain Injury | Phase 1 | Not yet recruiting | The Foundation for Orthopaedics and Regenerative Medicine | 20 | 2026-12-01 | 2026-10-16 |
| Rehabilitation Through Virtual Immersion & Integrated Exposure for Mild Traumatic Brain Injury (ReVIVE for mTBI) Virtual Reality, Standard Psychotherapy - Traumatic Brain Injuries, TBI (Traumatic Brain Injury) | Phase 1 | Recruiting | Johns Hopkins University | 30 | 2026-10-01 | 2026-10-26 |
| Nanopulse Laser Therapy Nano-Pulsed Laser Therapy (NPLT) - TBI (Traumatic Brain Injury) | Phase 1 | Not yet recruiting | The University of Texas Medical Branch, Galveston | 30 | 2026-10-01 | 2026-09-18 |
| Mesenchymal Stem Cells With Cooling Therapy for Infants With Hypoxic-Ischemic Encephalopathy Wharton's jelly-derived mesenchymal stem cells, 0.9 % Normal Saline - Hypoxic-Ischemic Encephalopathy, Neonatal, Brain Injuries, Hypoxic-Ischemic | Phase 1 / Phase 2 | Not yet recruiting | Mahidol University | 40 | 2026-09-15 | 2026-09-02 |
| ENGAGE-TBI Feasibility Study Social intervention study for TBI survivors - TBI (Traumatic Brain Injury) | Phase 1 | Recruiting | Washington University School of Medicine | 30 | 2026-08-17 | 2026-08-18 |
| Feasibility of SUPPORT-TBI SUPPORT-TBI - TBI Traumatic Brain Injury | Phase 1 | Recruiting | Washington University School of Medicine | 60 | 2026-08-17 | 2026-08-19 |
| Neonatal White Matter Injury Trial (WRAP) Clemastine fumarate - White Matter Injury, Brain Injury, Fetus and Neonate | Phase 1 | Recruiting | Bridget LaMonica Ostrem, M.D., Ph.D. | 24 | 2026-07-26 | 2026-07-28 |
| Psychologically Informed Cervicovestibular Rehabilitation (PIC Rehab) for Mild Traumatic Brain Injury: A Feasibility Trial Psychologically Informed CVPT (PIC) Rehab, Cervicovestibular Rehabilitation (CVPT) - Mild Traumatic Brain Injury, Concussion | Phase 1 | Not yet recruiting | Sport Injury Prevention Research Centre | 34 | 2026-06-01 | 2026-06-01 |
| Monitoring Patients With Repetitive Head Impact With Gamma-glutamylcysteine Supplementation Gamma-glutamylcysteine (GGC) - Repetitive Head Impacts | Phase 1 | Recruiting | Pravat Mandal | 30 | 2026-05-01 | 2026-06-03 |
| Hydrogen In Neonatal Encephalopathy (HIE) Trial Hydrogen Gas (H2) - HIE, Hypoxic-Ischemic Encephalopathy | Phase 1 | Not yet recruiting | Boston Children's Hospital | 54 | 2026-03-01 | 2026-02-17 |
| Low-Tech Treatments for Obstructive Sleep Apnea High-Resistance Breathing and Drinking Exercises, Low-Resistance Breathing and Drinking Exercises - Obstructive Sleep Apnea (OSA), Traumatic Brain Injury (TBI) | Phase 1 / Phase 2 | Recruiting | Uniformed Services University of the Health Sciences | 60 | 2026-01-29 | 2026-09-10 |
| A Safety and Feasibility Trial Protocol of Metformin in Infants After Perinatal Brain Injury Metformin - Hypoxic-Ischemic Encephalopathy, HIE | Phase 1 | Enrolling by invitation | Boston Children's Hospital | 30 | 2025-10-01 | 2026-02-17 |
| Treatment of Persisting Symptoms After Concussion With Psilocybin Assisted Therapy Psilocybin - Persisting Symptoms After Concussion | Phase 1 | Recruiting | University of Calgary | 40 | 2025-05-27 | 2026-09-09 |
| Regulation of Emotion, Sleep Extension, and mTBI Sleep Extension - Mild Traumatic Brain Injury | Phase 1 | Recruiting | Merrimack College | 60 | 2025-02-01 | 2025-04-09 |
| Evaluating the Impact of Adjuvant Use of Beta Blockers on Clinical Outcomes in Patients With Traumatic Brain Injury control, propranolol, Carvedilol - TBI Traumatic Brain Injury | Phase 1 / Phase 2 | Recruiting | Mansoura University | 100 | 2025-01-20 | 2025-04-02 |
| DBS for Cognitive Deficits After Traumatic Brain Injury Deep Brain Stimulation - TBI Traumatic Brain Injury | Phase 1 | Recruiting | Sunnybrook Health Sciences Centre | 10 | 2024-11-01 | 2025-02-11 |
| Safety and Efficacy of Angiotensin (1-7) in Persons With Moderate to Severe Traumatic Brain Injury Angiotensin (1-7), Sterile saline - Traumatic Brain Injury | Phase 1 / Phase 2 | Recruiting | University of Arizona | 90 | 2024-05-28 | 2026-08-11 |
| Frontal iTBS for Impulsivity and Suicidal Ideation in Veterans With Mild Traumatic Brain Injury intermittent theta burst stimulation, placebo intermittent theta burst stimulation - Mild Traumatic Brain Injury, Suicidal Ideation | Phase 1 | Recruiting | VA Office of Research and Development | 55 | 2024-05-20 | 2026-04-14 |
| Evaluating the Effect of Tranexamic Acid on the Clinical Outcomes in Patients With Traumatic Brain Injury Tranexamic Acid (TXA), Normal saline - Traumatic Brain Injury | Phase 1 / Phase 2 | Unknown | Mansoura University | 90 | 2024-03-25 | 2024-05-10 |
| Greater Occipital Nerve Blockade in Veterans With Post-concussion Headache: Sub-study 1 Bupivacaine Injection - Post-Traumatic Headache | Phase 1 | Completed | Yale University | 10 | 2024-01-26 | 2026-08-20 |
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Brain Injuries, Traumatic (78) · Brain Concussion (21) · Post-Concussion Syndrome (6) · Stroke (6) · Cerebral Palsy (5) · Stress Disorders, Post-Traumatic (5) · Hypoxia-Ischemia, Brain (4) · Alzheimer Disease (3) · Brain Diseases (3) · Chronic Traumatic Encephalopathy (3) · Craniocerebral Trauma (3) · Fatigue (3) · Headache (3) · Inflammation (3)
Nervous System Diseases (117) · Trauma, Nervous System (117) · Central Nervous System Diseases (116) · Wounds and Injuries (116) · Craniocerebral Trauma (115) · Brain Diseases (114) · Pathological Conditions, Signs and Symptoms (35) · Signs and Symptoms (24) · Wounds, Nonpenetrating (24) · Head Injuries, Closed (22) · Mental Disorders (18) · Cardiovascular Diseases (17) · Vascular Diseases (16) · Cerebrovascular Disorders (15)
Rehabilitation (4) · Sodium Chloride (4) · 7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole (3) · Exercise (3) · Hyperbaric Oxygenation (3) · Saline Solution (3) · Acetylcysteine (2) · Glyburide (2) · Human Growth Hormone (2) · Injections (2) · Mannitol (2) · Minocycline (2) · Oxygen (2) · Propranolol (2) · Sildenafil Citrate (2)
VA Office of Research and Development (4) · National Institute of Neurological Disorders and Stroke (NINDS) (3) · Paul G. Harch, M.D. (3) · Boston Children's Hospital (2) · Centre for Neuro Skills (2) · Johns Hopkins University (2) · Mansoura University (2) · Massachusetts General Hospital (2) · National Institutes of Health Clinical Center (CC) (2) · Neuren Pharmaceuticals Limited (2) · The University of Texas Health Science Center, Houston (2) · The University of Texas Medical Branch, Galveston (2) · University of Calgary (2) · University of California, Davis (2) · University of Colorado, Denver (2)
United States (77) · Canada (7) · Australia (4) · China (3) · South Korea (3) · Egypt (2) · France (2) · Iran (2) · Israel (2) · Russia (2) · Antigua and Barbuda (1) · Austria (1) · Belgium (1) · Bulgaria (1) · Czechia (1)
Paul G Harch, M.D. (3) · Brian Kalish, MD (2) · David R Howell, PhD (2) · Eric M Wassermann, M.D. (2) · Grace S Griesbach, PhD (2) · Alexander A Ostanin, MD, PhD (1) · Alexandra L Aaronson, MD (1) · Alison C Bested, MD FRCPC (1) · Allen Lamb, DO (1) · Alok K Sharma, M.S., M.Ch (1) · Andrew P Carlson, MD (1) · Arlene Schmid, PhD (1) · Arthur L Kellermann, MD, MPH (1) · Avraam Ploumis (1) · Barry Miskin, MD (1)
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1DP2NS148743-01 (1), 1IK2RX001136-01A2 (1), KL2TR002346 (1), R01HD070792 (1), R01HD108133 (1), R01NS039097 (1), R01NS052448 (1), R01NS069247 (1), R15MH136612 (1), R21HD042659 (1)