47 completed, 20 terminated, 16 recruiting, 14 unknown. 114 Phase 3, 24 Phase 2.
Follow Brain Injuries: new trials by email Literature Review of Brain Injuries trials Research Report on Brain Injuries
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Valproic AcId for Traumatic BRAin INjury Trial Valproic Acid (VPA), Standard of care treatment + normal saline - Moderate Traumatic Brain Injury (TBI), Severe Traumatic Brain Injury | Phase 2 / Phase 3 | Not yet recruiting | Northwestern University | 432 | 2027-05-01 | 2026-11-05 |
| Sovateltide for the Treatment of Acute Traumatic Brain Injury Placebo, Sovateltide - Traumatic Brain Injury | Phase 3 | Not yet recruiting | Pharmazz, Inc. | 214 | 2026-12-01 | 2026-10-13 |
| Traumatic Injury Clinical Trial Evaluating Tranexamic Acid in Children: An Efficacy Study Tranexamic acid injection - Brain Injuries, Traumatic, Wounds and Injury | Phase 3 | Not yet recruiting | Daniel Nishijima, MD, MAS | 2000 | 2026-10-01 | 2025-12-15 |
| Optimized, Neuroplasticity-Enhanced-Depression (ONE-D) Transcranial Magnetic Stimulation (TMS) Treatment for Female Athletes With Co-morbid Depression and Concussion ONE-D TMS protocol and d-cycloserine (125 mg) - Concussion, Depression | Phase 2 / Phase 3 | Not yet recruiting | University of Florida | 35 | 2026-09-01 | 2026-08-18 |
| Efficacy of Propranolol in Traumatic Brain Injury Patients Admitted to the ICU: A Prospective, Randomized, Triple-Blind Study Propranolol + Placebo - Traumatic Brain Injury (TBI) Patients | Phase 3 | Recruiting | Fundació d'investigació Sanitària de les Illes Balears | 536 | 2026-06-01 | 2026-10-27 |
| Efficacy of Early Continuous Infusion of HSS on the Neurological Outcome at 6 Months in TBI Patients. Hypertonic saline solution - TBI Traumatic Brain Injury | Phase 3 | Recruiting | Nantes University Hospital | 760 | 2026-04-21 | 2026-07-29 |
| Xenon for Neuroprotection During Post-Cardiac Arrest Syndrome in Comatose Survivors of an Out of Hospital Cardiac Arrest Xenon - Post-Cardiac Arrest Syndrome | Phase 3 | Not yet recruiting | Invero Pharma, Inc. | 1436 | 2026-03-01 | 2025-04-03 |
| FFP In Traumatic BRAin INjury (FIT-BRAIN) Trial Fresh Frozen Plasma (FFP) - Moderate to Severe Traumatic Brain Injury | Phase 2 / Phase 3 | Recruiting | Northwestern University | 357 | 2026-02-01 | 2026-02-11 |
| PRophylaxis Against Early VENTilator-associated Infections in Acute Brain Injury Ceftriaxone 2g diluted in >200ml 0.9%sodium chloride, Placebo comparator - no ceftriaxone - All-cause Mortality, Quality of Life | Phase 3 | Recruiting | The George Institute | 3300 | 2025-10-30 | 2026-08-28 |
| Role of Non-Selective Beta-Adrenergic Blocker in Severe TBI propranolol, normal saline IV - Traumatic Brain Injury (TBI) Patients, Intracranial Pressure | Phase 3 | Not yet recruiting | Tanta University | 60 | 2025-09-20 | 2025-03-11 |
| Randomized Controlled Trial of Treatment to Optimize Heart Rate Variability for Persistent Post-Concussion Symptoms HRV Coherence Ratio, NSI, Pittsburgh Sleep Quality Index (PSQI) - Autonomic Nervous System Disease, Concussive Injury | Phase 2 / Phase 3 | Recruiting | Virginia Commonwealth University | 148 | 2025-09-02 | 2026-09-22 |
| Visualizing Brain Proteinopathies Using [F-18]Flornaptitril-PET in the Prediction of Clinical Progression of Mild Cognitive Impairment With Either Suspected Chronic Traumatic Encephalopathy or Alzheimer's Disease [F-18]Flornaptitril - Alzheimer Disease, Chronic Traumatic Encephalopathy | Phase 3 | Recruiting | CereMark Pharma, LLC | 230 | 2025-07-01 | 2025-07-30 |
| Saline Versus Balanced Crystalloid in Traumatic Brain Injury Normal Saline (0.9% NaCl), balanced crystalloid - Traumatic Brain Injury (TBI) Patients | Phase 3 | Recruiting | University of Louisville | 600 | 2025-06-01 | 2026-08-26 |
| Memantine as an Additive Therapy in Patients With Traumatic Brain Injury Memantine, Mannitol - Mild Traumatic Brain Injury, Moderate Traumatic Brain Injury (TBI) | Phase 2 / Phase 3 | Not yet recruiting | Mansoura University | 80 | 2025-03-25 | 2025-04-06 |
| Walking With Overground Robotic Exoskeletons to Improve Arrousal in Individuals With Disorders of Consciousness Overground Walking - Traumatic Brain Injuries | Phase 2 / Phase 3 | Not yet recruiting | Craig Hospital | 25 | 2025-03-20 | 2025-02-24 |
| Growth Hormone Replacement Therapy in Veterans With Mild Traumatic Brain Injury (mTBI) and Adult Growth Hormone Deficiency (AGHD) Somatropin, Placebo - Adult Growth Hormone Deficiency, Mild Traumatic Brain Injury | Phase 3 | Recruiting | VA Office of Research and Development | 172 | 2025-01-13 | 2026-10-13 |
| Effects of Dexmedetomidine on Agitation in Critically Ill TBI Patients Dexmedetomidine, Placebo - Traumatic Brain Injury, Agitation,Psychomotor | Phase 2 / Phase 3 | Not yet recruiting | Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal | 72 | 2024-10-01 | 2024-10-01 |
| Hyperbaric Oxygen Treatment for Veterans With Traumatic Brain Injury Oxygen 99.7 %, Oxygen 21 % - Traumatic Brain Injury, Military Operations | Phase 3 | Recruiting | University of South Florida | 420 | 2024-09-18 | 2026-07-15 |
| Pilot Study of Whole Blood Transfusion for Trauma Brain Injury (TBI) Whole blood transfusion, Blood components transfusion - Traumatic Brain Injury | Phase 3 | Unknown | Oregon Health and Science University | 100 | 2024-08-01 | 2024-04-02 |
| Quetiapine to Reduce Post Concussive Syndrome After Mild Traumatic Brain Injury (mTBI) Quetiapine Fumarate, TAU - Mild Traumatic Brain Injury | Phase 3 | Recruiting | Foundation for Advancing Veterans' Health Research | 146 | 2024-07-09 | 2025-07-11 |
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Brain Injuries, Traumatic (91) · Brain Concussion (12) · Stroke (10) · Wounds and Injuries (9) · Craniocerebral Trauma (6) · Hypothermia (5) · Cerebral Palsy (4) · Cognitive Dysfunction (4) · Epilepsy, Post-Traumatic (4) · Multiple Sclerosis (4) · Stress Disorders, Post-Traumatic (4) · Consciousness Disorders (3) · Intellectual Disability (3) · Muscle Spasticity (3)
Brain Diseases (114) · Central Nervous System Diseases (114) · Nervous System Diseases (112) · Trauma, Nervous System (111) · Craniocerebral Trauma (105) · Wounds and Injuries (102) · Pathological Conditions, Signs and Symptoms (34) · Signs and Symptoms (26) · Mental Disorders (22) · Cardiovascular Diseases (18) · Vascular Diseases (18) · Neurologic Manifestations (17) · Cerebrovascular Disorders (14) · Pathologic Processes (14)
Sodium Chloride (8) · Saline Solution (7) · Mannitol (6) · Tranexamic Acid (5) · Botulinum Toxins, Type A (4) · Magnesium Sulfate (4) · Saline Solution, Hypertonic (4) · Hypothermia, Induced (3) · Propranolol (3) · Valproic Acid (3) · incobotulinumtoxinA (3) · Amantadine (2) · Biperiden (2) · Clinical Trials, Phase II as Topic (2) · Clinical Trials, Phase III as Topic (2)
University of Washington (4) · Merz Pharmaceuticals GmbH (3) · VA Office of Research and Development (3) · Apurano Pharmaceuticals GmbH (2) · Assiut University (2) · Australian and New Zealand Intensive Care Research Centre (2) · Baylor College of Medicine (2) · Cephalon, Inc. (2) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (2) · London School of Hygiene and Tropical Medicine (2) · Nantes University Hospital (2) · Northwestern University (2) · RenJi Hospital (2) · Rennes University Hospital (2) · Solstice Neurosciences, LLC, a subsidiary of MDD US Operations, LLC (2)
United States (49) · France (12) · Germany (11) · Canada (10) · Egypt (8) · Spain (7) · Australia (6) · New Zealand (6) · Hungary (5) · Poland (5) · Russia (5) · United Kingdom (5) · Belgium (3) · Denmark (3) · Finland (3)
Bruno Laviolle, MD (2) · Hasan Alam, MD (2) · Joseph T Hull, PhD (2) · Abeer Salamah, Lecturer (1) · Adriaan J Vlok, Professor (1) · Akshitkumar Mistry, MD (1) · Alexander V Savello, Prof (1) · Alistair D Nichol, MD (1) · Allen W Brown, MD (1) · Andreas Bender, Prof.Dr. (1) · Andrew Maas, M.D. (1) · Andrew Udy, Prof (1) · Angelle Sander, PhD (1)
PMID 25325609, PMID 26452709, PMID 10625862, PMID 12114906, PMID 15756405, PMID 16361021, PMID 17166799, PMID 18759980, PMID 19930566, PMID 20082712, PMID 20554319, PMID 20924011, PMID 21169065, PMID 21675055, PMID 22375973, PMID 22446155, PMID 22721545, PMID 22839656, PMID 23168823, PMID 23234472, PMID 23664370, PMID 23895556, PMID 24686108, PMID 24701988, PMID 24731434, PMID 24842590, PMID 25058216, PMID 25062507, PMID 25066331, PMID 25072443, PMID 25493974, PMID 25493978, PMID 25528574, PMID 25884605, PMID 26464429, PMID 26491799, PMID 26496111, PMID 27433815, PMID 27626622, PMID 27630085, PMID 28693604, PMID 28716153, PMID 29370008, PMID 30132785, PMID 30175246, PMID 30184559, PMID 30583957, PMID 30918101, PMID 31271691, PMID 31299040
2018 (2), 2009 (1), 2017 (1), 2019 (1), 2025 (1), M01RR000070 (1), M01RR000750 (1), M01RR000997 (1), M01RR006022 (1), M01RR008084 (1), P01NS038660 (1), R01HD021453 (1), R01NS055827 (1), R01NS058302 (1), U01HD019897 (1)