45 completed, 16 unknown, 10 not yet recruiting, 10 withdrawn. 31 Not applicable, 18 Phase 2, 9 Phase 3, 8 Phase 1, 6 Phase 4.
Follow Brain Edema: new trials by email Literature Review of Brain Edema trials Research Report on Brain Edema
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| TENS of Auricular Vagal Nerve for Radiation Necrosis Transcutaneous auricular vagal nerve stimulation (taVNS), Sham - Radiation Necrosis, Cerebral Edema | Not applicable | Not yet recruiting | Virginia Commonwealth University | 40 | 2026-11-30 | 2026-09-04 |
| Modulating Inflammation in Neuro-Trauma Nurosym taVNS, Nurosym (sham) - Traumatic Brain Injury | Not applicable | Not yet recruiting | The University of Texas Health Science Center at San Antonio | 16 | 2026-11-01 | 2026-10-05 |
| Decompressive Craniectomy After Aneurysmal Subarachnoid Hemorrhage (DECIDE-SAH) Decompressive craniectomy - Aneurysmal Subarachnoid Hemorrhage | Not yet recruiting | University Hospital, Essen | 10000 | 2026-11-01 | 2026-10-14 | |
| Bedside Ultrasound Measurement of Optic Nerve Sheath Diameter for Detecting Raised Intracranial Pressure Intracranial Hypertension, Increased Intracranial Pressure | Not yet recruiting | Assiut University | 85 | 2026-10-01 | 2026-09-02 | |
| ONSD Trajectory in Rebound ICH Optic Nerve Sheath Diameter Ultrasonography - Traumatic Brain Injury, Rebound Intracranial Hypertension | Not yet recruiting | Benha University | 100 | 2026-09-01 | 2026-07-23 | |
| Transcranial Doppler Evaluation After Endovascular Thrombectomy for Acute Ischemic Stroke (PRECISE-TCD) Transcranial Doppler (TCD) examination - Anterior Cerebral Artery Syndrome, Anterior Cerebral Artery Stroke | Not yet recruiting | Virginia Commonwealth University | 100 | 2026-09-01 | 2026-09-14 | |
| Early Prophylactic Versus Late Salvage Recombinant Human Endostatin in Managing Radiosurgery-Induced Brain Injury for NSCLC Brain Metastases Recombinant Human Endostatin (Endostar) - Lung Cancer (Non-Small Cell), Radiation | Phase 2 | Not yet recruiting | Jiangmen Central Hospital | 49 | 2026-09-01 | 2026-10-01 |
| A Trial of Adacolumn on Cerebral Edema After Anterior Circulation Ischemic Stroke Adacolumn®, Standard Reperfusion Therapy, Standard Medical Management - Cerebral Edema, Ischemic Stroke, Acute | Not applicable | Not yet recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 10 | 2026-08-10 | 2026-08-07 |
| Butylphthalide for Brain Edema After Endovascular Treatment Butylphthalide, Placebo - Acute Ischemic Stroke | Phase 4 | Not yet recruiting | Nanfang Hospital, Southern Medical University | 100 | 2026-04-01 | 2026-04-14 |
| High-volume Versus Standard Volume Plasma Exchange in Patients With Acute Liver Failure With Cerebral Edema High Volume Therapeutic Plasma Exchange, Standard volume therapeutic plasma exchange - Acute Liver Failure, Cerebral Edema | Not applicable | Not yet recruiting | Institute of Liver and Biliary Sciences, India | 60 | 2025-12-01 | 2025-09-19 |
| Early Prophylactic Decompressive Hemicraniectomy Following Endovascular Therapy in Large Hemispheric Infarct Trial Early prophylactic decompressive hemicraniectomy - Stroke, Ischemic, Cerebral Edema | Not applicable | Recruiting | Xuanwu Hospital, Beijing | 380 | 2025-07-19 | 2026-01-26 |
| Effect of Volatile- Based Versus Total Intravenous Anesthesia on Brain Homeostasis and Neurocognitive Outcome Sevoflurane, Desflurane - Brain Edema Caused by Drugs, Cerebral Oxygenation | Phase 4 | Recruiting | Georgia Tsaousi | 84 | 2025-05-12 | 2025-10-01 |
| Local Ischemic Postconditioning in Acute Ischemic Stroke rapid local ischemic postconditioning - Acute Ischemic Stroke, Mechanical Thrombectomy | Not applicable | Completed | Shanghai Jiao Tong University Affiliated Sixth People's Hospital | 25 | 2024-10-14 | 2025-11-28 |
| "The Effect of Trimetazidine on the Clinical Outcome of Acute Ischemic Stroke Patients" Trimetazidine - Acute Ischemic Stroke | Phase 3 | Completed | Ain Shams University | 60 | 2024-09-01 | 2025-09-08 |
| Early Identification of Malignant Brain Edema in laRge Artery oCclusive Stroke After Endovascular Therapy (EMBRACE Study) Endovascular Therapy, Brain Edema | Recruiting | Zhejiang Provincial People's Hospital | 1950 | 2024-04-01 | 2024-06-11 | |
| Rapid Local Ischemic Postconditioning in Acute Ischemic Stroke rapid local ischemic postconditioning - Acute Ischemic Stroke, Mechanical Thrombectomy | Not applicable | Unknown | Shanghai Jiao Tong University Affiliated Sixth People's Hospital | 135 | 2024-03-15 | 2024-03-13 |
| Impact of Salovum® and SPC® Flakes on Brain Tumor Induced Edema Salovum/SPC flakes - Glioblastoma, Cerebral Metastases | Phase 2 | Recruiting | Peter Siesjö | 20 | 2024-01-27 | 2025-01-27 |
| Safety and Efficacy of ABX-101 in Participants Aged 18 to 50 Years of Age With Moderate to Severe Traumatic Brain Injury ABX-101 1mg, ABX-101 2mg - Traumatic Brain Injury, Cerebral Edema | Phase 2 | Unknown | Abalonex, LLC | 45 | 2023-12-01 | 2023-10-23 |
| International Multi-center Retrospective Study of Patients With Serum Sodium ≤110 mmol/L to Determine the Relationship Between Osmotic Demyelination Syndrome (ODS) and Rapid Correction of Hyponatremia Hypertonic 3% saline - Hyponatremia Symptomatic, Osmotic Demyelination Syndrome | Enrolling by invitation | Rochester General Hospital | 800 | 2023-11-01 | 2026-08-26 | |
| Non-invasive Monitoring and Serum Marker Study in Children With Cerebral Edema Exposure factors - Brain Edema | Unknown | Qilu Hospital of Shandong University | 264 | 2023-08-31 | 2023-08-30 |
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Brain Injuries, Traumatic (20) · Ischemic Stroke (16) · Brain Injuries (12) · Craniocerebral Trauma (12) · Stroke (11) · Intracranial Hypertension (10) · Head Injuries, Closed (9) · Brain Hemorrhage, Traumatic (8) · Brain Neoplasms (8) · Hematoma, Subdural (8) · Brain Concussion (7) · Brain Contusion (7) · Cerebral Hemorrhage (7) · Edema (7)
Nervous System Diseases (98) · Central Nervous System Diseases (97) · Brain Diseases (96) · Cardiovascular Diseases (46) · Vascular Diseases (45) · Cerebrovascular Disorders (43) · Pathological Conditions, Signs and Symptoms (42) · Pathologic Processes (36) · Trauma, Nervous System (22) · Hemorrhage (20) · Wounds and Injuries (20) · Intracranial Hemorrhages (19) · Stroke (17) · Craniocerebral Trauma (15) · Brain Injuries (13)
Sodium Chloride (7) · Mannitol (6) · Saline Solution, Hypertonic (6) · Corticotropin-Releasing Hormone (4) · Glyburide (3) · AER-271 (2) · Acetazolamide (2) · Injections (2) · Sevoflurane (2) · TOPS (2) · Ultrasonography, Doppler, Transcranial (2) · antisecretory factor (2) · conivaptan (2) · sodium aescinate (2) · 3-n-butylphthalide (1)
Children's Hospital Medical Center, Cincinnati (8) · Celtic Pharma Development Services (4) · Peter Siesjö (4) · Nanfang Hospital, Southern Medical University (3) · Second Affiliated Hospital, Zhejiang University, School of Medicine (3) · Xuanwu Hospital, Beijing (3) · Ain Shams University (2) · Aristotle University Of Thessaloniki (2) · Beijing Tiantan Hospital (2) · Shanghai Jiao Tong University Affiliated Sixth People's Hospital (2) · Ting Li (2) · University of California, Davis (2) · University of Florida (2) · University of Zurich (2) · Virginia Commonwealth University (2)
United States (34) · China (22) · Canada (4) · Italy (4) · Sweden (4) · Switzerland (4) · United Kingdom (4) · Egypt (3) · Germany (3) · Greece (3) · Czechia (2) · Denmark (2) · France (2) · India (2) · Israel (2)
Shari L Wade, PhD (3) · William Shapiro, MD (3) · Shari L. Wade, PhD (2) · Shari Wade, PhD (2) · Yueqi Zhu, MD (2) · Aarti Sarwal (1) · Achikam Oren-Grinberg, MD (1) · Alex King, MD (1) · Alex Novak, MSc (1) · Alexander Lyon, BCh PhD FRCP (1) · Andreas Raabe, MD (1) · Anna Letizia Allegra Mascaro, PhD (1) · Benedetta Piccardi, MD, PhD (1)
PMID 30413559, PMID 31405391, PMID 35170571, PMID 11077095, PMID 14238966, PMID 15145991, PMID 15243684, PMID 16703877, PMID 17041512, PMID 17210899, PMID 17303527, PMID 17522793, PMID 18173315, PMID 19372001, PMID 19715392, PMID 19726011, PMID 19934980, PMID 21505900, PMID 22746261, PMID 22943271, PMID 23095732, PMID 23234472, PMID 23330995, PMID 23382470, PMID 2350622, PMID 23640543, PMID 23753094, PMID 23790158, PMID 24481284, PMID 24760352, PMID 24781374, PMID 25208667, PMID 25208677, PMID 25541084, PMID 25583911, PMID 25738891, PMID 26445777, PMID 26461100, PMID 26755455, PMID 27654000, PMID 28389109, PMID 28548592, PMID 28687281, PMID 28836809, PMID 28919116, PMID 29088962, PMID 29096775, PMID 29097272, PMID 29148904, PMID 29617953
2019 (2), 2017 (1), R01AG069930 (1), R01NS052592 (1), R01NS052619 (1), R21CA107277 (1), U01HD062417 (1), UL1TR001420 (1)