Brain Injuries: Clinical Trials

105 completed, 34 recruiting, 29 unknown, 28 terminated. 242 Phase 2, 41 Phase 1, 24 Phase 3.

By phase and status

Phase	Trials	Status
Phase 2	242	Completed 105, Recruiting 34, Unknown 29, Terminated 28, Withdrawn 21, Not yet recruiting 15, Enrolling by invitation 5, Active not recruiting 4, Suspended 1
Phase 1	41	Completed 23, Unknown 7, Recruiting 5, Withdrawn 4, Enrolling by invitation 1, Not yet recruiting 1
Phase 3	24	Completed 11, Not yet recruiting 5, Terminated 3, Recruiting 2, Withdrawn 2, Unknown 1

Follow Brain Injuries: new trials by email Literature Review of Brain Injuries trials Research Report on Brain Injuries

Trials (filtered) newest first · largest first

All 242 trials

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Sodium Lactate in Severe TBI Sodium Lactate, placebo - Traumatic Brain Injury	Phase 2	Not yet recruiting	University of California, Los Angeles	264	2028-01-10	2026-01-16
Memantine Targeting Neurovascular Dysfunction After Mild and Moderate Traumatic Brain Injury (MEND) Memantine - Traumatic Brain Injury, Mild Traumatic Brain Injury	Phase 2	Not yet recruiting	Nova Scotia Health Authority	45	2027-06-01	2026-10-09
Remotely Administered tDCS to Improve Cognitive Function in Veterans With mTBI and PTSD Principal Investigator Transcranial direct current stimulation (tDCS), Cognitive training - Cognition, Brain Injuries	Phase 2	Not yet recruiting	VA Office of Research and Development	46	2027-05-24	2026-02-17
Valproic AcId for Traumatic BRAin INjury Trial Valproic Acid (VPA), Standard of care treatment + normal saline - Moderate Traumatic Brain Injury (TBI), Severe Traumatic Brain Injury	Phase 2 / Phase 3	Not yet recruiting	Northwestern University	432	2027-05-01	2026-11-05
Allopregnanolone in Chronic Complex Traumatic Brain Injury Placebo, Allopregnanolone - Traumatic Brain Injury (TBI)	Phase 2	Not yet recruiting	VA Office of Research and Development	132	2026-12-01	2026-10-19
Natural History of MTBI-related Convergence Insufficiency & Effectiveness of Vision Therapy for MTBI-related CI Office-Based Vergence/Accommodative Therapy with Movement (OBVAM) - Convergence Insufficiency	Phase 2	Not yet recruiting	Salus University	100	2026-11-01	2025-02-27
Repurposing Insulin With Intranasal Administration to Improve Function After Mild Traumatic Brain Injury Insulin (Humulin), Placebo - Concussion (Diagnosis), Mild Traumatic Brain Injury	Phase 2	Recruiting	HealthPartners Institute	96	2026-11-01	2026-11-13
Hyperbaric Oxygen Therapy for Veterans With TBI and PCS: A Biomarker Study Hyperbaric Oxygen Therapy (HBOT) - Traumatic Brain Injury (TBI) Patients, Post Concussive Symptoms	Phase 2	Recruiting	Summit Hyperbarics and Wellness	34	2026-10-01	2026-09-30
Mesenchymal Stem Cells With Cooling Therapy for Infants With Hypoxic-Ischemic Encephalopathy Wharton's jelly-derived mesenchymal stem cells, 0.9 % Normal Saline - Hypoxic-Ischemic Encephalopathy, Neonatal, Brain Injuries, Hypoxic-Ischemic	Phase 1 / Phase 2	Not yet recruiting	Mahidol University	40	2026-09-15	2026-09-02
HBOT Effects on First Responders' Cognition and Well-Being Hyperbaric Oxygen Therapy (HBOT) - Traumatic Brain Injury, PTSD - Post Traumatic Stress Disorder	Phase 2	Recruiting	Summit Hyperbarics and Wellness	54	2026-09-11	2026-10-01
Optimized, Neuroplasticity-Enhanced-Depression (ONE-D) Transcranial Magnetic Stimulation (TMS) Treatment for Female Athletes With Co-morbid Depression and Concussion ONE-D TMS protocol and d-cycloserine (125 mg) - Concussion, Depression	Phase 2 / Phase 3	Not yet recruiting	University of Florida	35	2026-09-01	2026-08-18
Early Prophylactic Versus Late Salvage Recombinant Human Endostatin in Managing Radiosurgery-Induced Brain Injury for NSCLC Brain Metastases Recombinant Human Endostatin (Endostar) - Lung Cancer (Non-Small Cell), Radiation	Phase 2	Not yet recruiting	Jiangmen Central Hospital	49	2026-09-01	2026-10-01
BCAAs in Concussion 3.0 BCAA, Placebo - Concussion (Diagnosis), MTBI - Mild Traumatic Brain Injury	Phase 2	Recruiting	Akiva Cohen	150	2026-08-05	2026-09-03
TRACK-TBI Precision Medicine Part 3 - Option II Cyclosporine (CsA), Placebo - Traumatic Brain Injury	Phase 2	Enrolling by invitation	University of California, San Francisco	26	2026-07-02	2026-10-22
Long-Term Outcomes Following HBOT Hyperbaric Oxygen Therapy (HBOT) - Traumatic Brain Injury, Post-Concussive Symptoms	Phase 2	Recruiting	Summit Hyperbarics and Wellness	35	2026-06-18	2026-07-28
Naturally Produced Cannabinoids for Neuroprotection From Concussion Broad spectrum cannabinoid formulation, Placebo gel capsule - Healthy	Phase 2	Recruiting	University of Regina	60	2026-06-01	2026-07-21
Vitamin D3 for Moderate to Mild Traumatic Brain Injury: A Randomized Trial on Inflammation and Recovery (VIMOT) Vitamin D3 (Cholecalciferol) - Traumatic Brain Injury (TBI) Patients, Neuroinflammation	Phase 2	Recruiting	Lagos State University	240	2026-03-02	2026-05-13
FFP In Traumatic BRAin INjury (FIT-BRAIN) Trial Fresh Frozen Plasma (FFP) - Moderate to Severe Traumatic Brain Injury	Phase 2 / Phase 3	Recruiting	Northwestern University	357	2026-02-01	2026-02-11
Low-Tech Treatments for Obstructive Sleep Apnea High-Resistance Breathing and Drinking Exercises, Low-Resistance Breathing and Drinking Exercises - Obstructive Sleep Apnea (OSA), Traumatic Brain Injury (TBI)	Phase 1 / Phase 2	Recruiting	Uniformed Services University of the Health Sciences	60	2026-01-29	2026-09-10
Precision Biomarkers to Detect Brain Injury in Active-Duty United States Special Operations Forces With Repeated Blast Exposure PBR28 TSPO PET - Blast Injury	Phase 2	Recruiting	Massachusetts General Hospital	100	2025-10-14	2025-10-31

Showing 20 of 242. Sign in to see all of them.

Narrower conditions

Brain Injuries, Traumatic (169)  ·  Brain Concussion (38)  ·  Post-Concussion Syndrome (18)  ·  Stress Disorders, Post-Traumatic (18)  ·  Depression (12)  ·  Stroke (11)  ·  Craniocerebral Trauma (8)  ·  Headache (7)  ·  Anxiety Disorders (6)  ·  Cerebral Palsy (6)  ·  Post-Traumatic Headache (6)  ·  Trauma, Nervous System (6)  ·  Wounds and Injuries (6)  ·  Brain Edema (5)

Broader conditions

Nervous System Diseases (241)  ·  Brain Diseases (240)  ·  Central Nervous System Diseases (239)  ·  Trauma, Nervous System (234)  ·  Wounds and Injuries (234)  ·  Craniocerebral Trauma (231)  ·  Pathological Conditions, Signs and Symptoms (72)  ·  Wounds, Nonpenetrating (50)  ·  Signs and Symptoms (48)  ·  Head Injuries, Closed (46)  ·  Mental Disorders (44)  ·  Neurologic Manifestations (36)  ·  Pathologic Processes (32)  ·  Brain Injuries, Traumatic (31)

Interventions

Saline Solution (12)  ·  Hyperbaric Oxygenation (9)  ·  Sodium Chloride (9)  ·  Standard of Care (5)  ·  Acetylcysteine (4)  ·  Dexmedetomidine (4)  ·  Mannitol (4)  ·  Melatonin (4)  ·  Methylphenidate (4)  ·  Propranolol (4)  ·  Sildenafil Citrate (4)  ·  7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole (3)  ·  Acetaminophen (3)  ·  Ascorbic Acid (3)  ·  Cyclosporine (3)

Sponsors

Uniformed Services University of the Health Sciences (6)  ·  VA Office of Research and Development (6)  ·  University of Pennsylvania (5)  ·  National Institutes of Health Clinical Center (CC) (4)  ·  Summit Hyperbarics and Wellness (4)  ·  The University of Texas Health Science Center, Houston (4)  ·  University of Calgary (4)  ·  University of California, San Francisco (4)  ·  University of Sao Paulo (4)  ·  University of Washington (4)  ·  Assistance Publique - Hôpitaux de Paris (3)  ·  Mansoura University (3)  ·  Neuren Pharmaceuticals Limited (3)  ·  Northwestern University (3)  ·  University of California, Los Angeles (3)

Countries

United States (156)  ·  Canada (13)  ·  France (12)  ·  Israel (6)  ·  Brazil (5)  ·  China (5)  ·  Germany (5)  ·  Spain (5)  ·  United Kingdom (5)  ·  Australia (4)  ·  Denmark (4)  ·  Egypt (4)  ·  Italy (4)  ·  Belgium (3)  ·  Hungary (3)

Top investigators

Charles S Cox, MD (4)  ·  Eric M Wassermann, M.D. (3)  ·  Eric Wassermann, MD (3)  ·  Amy A Herrold, PhD BA (2)  ·  Charles S Cox, Jr., M.D. (2)  ·  Daniel Corwin, MD (2)  ·  Hasan Alam, MD (2)  ·  Jeanne M Hoffman, PhD (2)  ·  Joseph T Hull, PhD (2)  ·  Leighton Chan, M.D. (2)  ·  Lindell K. Weaver, MD (2)  ·  Ramon Diaz-Arrastia, MD, PhD (2)  ·  Ramon R. Diaz-Arrastia, MD, PhD (2)  ·  Robert J Schloesser, MD (2)

Results publications

PMID 31394602, PMID 31394603, PMID 41114449, PMID 12411660, PMID 14526234, PMID 15199405, PMID 15901745, PMID 17011666, PMID 17143244, PMID 17188664, PMID 17370477, PMID 18234750, PMID 18418368, PMID 19172693, PMID 19255065, PMID 19406291, PMID 19883750, PMID 19930566, PMID 20082712, PMID 20571524, PMID 20631189, PMID 21468088, PMID 21897681, PMID 22375973, PMID 22446155, PMID 22771222, PMID 22777131, PMID 23013802, PMID 23106988, PMID 23133515, PMID 23140612, PMID 23510092, PMID 23682548, PMID 23771484, PMID 23876024, PMID 23895556, PMID 24504128, PMID 24686108, PMID 24701988, PMID 24831445, PMID 24842590, PMID 25058216, PMID 25064164, PMID 25401463, PMID 25438964, PMID 25594628, PMID 26314998, PMID 26376074, PMID 26394294, PMID 26438108

NIH funding

2018 (2), 2019 (2), 1IK2RD000464-01A2 (1), 1IK2RX001136-01A2 (1), 2008 (1), 2023 (1), I01RX002798 (1), I01RX002916 (1), IK2RX000949 (1), K23HD049626 (1), K23HL150229 (1), K23NS048152 (1), K23NS065132 (1), P01NS038660 (1), R01HD036075 (1)