4 completed, 3 active not recruiting, 3 recruiting, 2 terminated. 4 Phase 3, 3 Not applicable, 3 Phase 2, 1 Phase 1, 1 Phase 4.
Follow Epilepsy, Post-Traumatic: new trials by email Literature Review of Epilepsy, Post-Traumatic trials Research Report on Epilepsy, Post-Traumatic
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Early Post-Traumatic Seizures Prevention Trial (E-PTS Trial) Phenytoin, Levetiracetam, Placebo - Seizures, Traumatic Brain Injuries | Phase 4 | Recruiting | All India Institute of Medical Sciences, Jodhpur | 1260 | 2025-07-23 | 2026-10-29 |
| Trial Investigating the Safety and Efficacy of BRC-003 in Refractory Post-Traumatic Epilepsy PO BRC-003 (High Cannabidiol Cannabis Extract), Placebo - Post-traumatic Epilepsy | Phase 2 | Withdrawn | Dr. Paul Lyons | 2024-11-01 | 2025-04-24 | |
| Collaborative Care in Posttraumatic Epilepsy Neurology Based Collaborative Care, SOC Neurological care - Epilepsy, Post-Traumatic | Not applicable | Completed | Wake Forest University Health Sciences | 40 | 2023-04-30 | 2026-10-13 |
| Biperiden Trial for Epilepsy Prevention Biperiden, Placebo - Brain Injury Traumatic Moderate, Brain Injury Traumatic Severe | Phase 3 | Recruiting | Hospital Sirio-Libanes | 312 | 2023-01-10 | 2024-03-26 |
| HOme-Based Self-management and COgnitive Training CHanges Lives (HOBSCOTCH) -Post-Traumatic Epilepsy (PTE) Home Based Self-management and Cognitive Training Changes lives in post traumatic epilepsy (HOBSCOTCH-PTE), HOBSCOTCH-PTE for Caregivers - Epilepsy, Traumatic, Brain Injuries, Traumatic | Not applicable | Active not recruiting | Dartmouth-Hitchcock Medical Center | 160 | 2022-03-21 | 2026-03-19 |
| Transforming Research and Clinical Knowledge in Traumatic Brain Injury Epileptogenesis Project (TRACK-TBI EPI) In-Person Outcome Assessment, 3T Magnetic Resonance Imaging (MRI), Clinical Visit - Traumatic Brain Injury, Post-traumatic Epilepsy | Active not recruiting | University of Pennsylvania | 300 | 2022-03-01 | 2026-07-30 | |
| Imaging of Neuro-Inflammation and the Risk for Post-Traumatic Epilepsy [18F]DPA-714 Positron Emission Tomography Scan - Epilepsy, Post-Traumatic | Phase 1 | Active not recruiting | University of California, Davis | 30 | 2020-02-01 | 2026-09-14 |
| Epilepsy Learning Healthcare System (ELHS) Clinical care and quality improvement - Epilepsy, Seizure Disorder | Recruiting | Epilepsy Foundation of America | 100000 | 2019-03-20 | 2024-08-30 | |
| Use of Biperiden for the Prevention of Post-traumatic Epilepsy Biperiden Lactate, Placebo - Traumatic Brain Injury | Phase 3 | Terminated | Federal University of São Paulo | 123 | 2018-01-31 | 2023-01-31 |
| Neuroimaging Biomarker for Seizures Cognitive Behavioral Therapy for Seizures, Standard Medical Care - Seizure Disorder, Seizure Disorder, Post Traumatic | Not applicable | Unknown | Providence VA Medical Center | 224 | 2017-09-15 | 2022-04-05 |
| Allopregnanolone for the Treatment of Traumatic Brain Injury Allopregnanolone injection, Placebo injection - Traumatic Brain Injury, Posttraumatic Epilepsy | Phase 2 | Completed | Michael A. Rogawski, MD, PhD | 13 | 2013-04-01 | 2017-06-28 |
| Prevention of Post-traumatic Seizures With Levetiracetam Levetiracetam, Placebo - Epilepsy, Post-Traumatic | Phase 3 | Terminated | Rennes University Hospital | 23 | 2007-11-01 | 2012-06-21 |
| Levetiracetam to Prevent Post-Traumatic Epilepsy Levetiracetam - Epilepsy, Post-traumatic Epilepsy | Phase 2 | Completed | Pavel Klein | 126 | 2005-04-01 | 2016-01-13 |
| Phase III Double Blind Trial of Valproate Sodium for Prophylaxis of Post Traumatic Seizures phenytoin, valproate sodium - Post-Traumatic Seizure Disorder, Head Injuries | Phase 3 | Completed | National Institute of Neurological Disorders and Stroke (NINDS) | 385 | 1991-02-01 | 2005-06-24 |
| Characteristics of Blood- Brain Barrier Permeability in Neurological Patients Traumatic Brain Injury, Cerebral Infarction | Unknown | Soroka University Medical Center | 100 | 2007-01-09 |
Brain Injuries, Traumatic (9) · Epilepsy (7) · Seizures (6) · Brain Injuries (2) · Craniocerebral Trauma (2) · Rare Diseases (2) · Anxiety Disorders (1) · Brain Diseases (1) · Caregiver Burden (1) · Cerebral Hemorrhage (1) · Cerebral Infarction (1) · Chronic Disease (1) · Conversion Disorder (1) · Depression (1)
Central Nervous System Diseases (15) · Trauma, Nervous System (15) · Wounds and Injuries (15) · Brain Diseases (14) · Nervous System Diseases (14) · Brain Injuries (13) · Craniocerebral Trauma (13) · Epilepsy (8) · Pathological Conditions, Signs and Symptoms (7) · Signs and Symptoms (6) · Neurologic Manifestations (5) · Pathologic Processes (4) · Mental Disorders (3) · Behavior (2) · Behavioral Symptoms (2)
Levetiracetam (3) · Biperiden (2) · Phenytoin (2) · Blood Specimen Collection (1) · Cannabinoids (1) · Caregivers (1) · Cognitive Behavioral Therapy (1) · Injections (1) · Lactic Acid (1) · Pregnanolone (1) · Quality Improvement (1) · Saline Solution (1) · Sodium Hydroxide (1) · Sodium Lactate (1) · Therapeutics (1)
All India Institute of Medical Sciences, Jodhpur (1) · Dartmouth-Hitchcock Medical Center (1) · Dr. Paul Lyons (1) · Epilepsy Foundation of America (1) · Federal University of São Paulo (1) · Hospital Sirio-Libanes (1) · Michael A. Rogawski, MD, PhD (1) · National Institute of Neurological Disorders and Stroke (NINDS) (1) · Pavel Klein (1) · Providence VA Medical Center (1) · Rennes University Hospital (1) · Soroka University Medical Center (1) · University of California, Davis (1) · University of Pennsylvania (1) · Wake Forest University Health Sciences (1)
United States (9) · Brazil (2) · France (1) · India (1) · Israel (1)
Alon Friedman, MD/PhD (1) · Arnaud Biraben, MD (1) · Barbara C. Jobst, MD, Dr. Med. (1) · Brandy Fureman, PhD (1) · Bruno Laviolle, MD (1) · Dr Apinderpreet Singh Additional Professor, MCh Neurosugery (1) · Dr Kamlesh Bhaisora Additional Professor, MCh Neurosugery (1) · Elaine T Kiriakopoulos, MD, MSc (1) · Eliana Garzon, MD, PhD (1) · H. Richard Winn (1) · Heidi M. Munger Clary, MD, MPH (1) · Ilan Shelef, MD (1) · Jerzy Szarflarski, MD (1) · JoAnne E Natale, MD, PhD (1) · Luiz E Mello, MD, PhD (1)
PMID 22771222, PMID 22777131, PMID 23876024, PMID 36084082, PMID 39175759, PMID 39535875, PMID 40996372, PMID 42219462