51 completed, 9 terminated, 6 unknown, 5 recruiting. 76 Phase 1, 21 Phase 2.
Follow Bipolar Disorder: new trials by email Literature Review of Bipolar Disorder trials Research Report on Bipolar Disorder
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Pharmacokinetics and Relative Bioavailability of Intranasal vs Intramuscular Olanzapine in Healthy Adult Participants NRL-1004 2.5 mg, ZYPREXA IM 10mg, NRL-1004 5.0 mg - Healthy Adult Participants | Phase 1 | Not yet recruiting | Neurelis, Inc. | 24 | 2026-10-16 | 2026-11-06 |
| A Study to Assess Adverse Events and How Oral ABBV-932 Moves Through the Body When Given With Oral Itraconazole in Adult Participants With Bipolar Disorder ABBV-932, Itraconazole - Bipolar Disorder | Phase 1 | Recruiting | AbbVie | 20 | 2026-08-20 | 2026-09-16 |
| Adaptation and Validation of the Hypomanic Personality Scale (HPS-6) to Romanian Hypomanic Personality Scale - 6 - Bipolar Disorder (BD) | Phase 1 / Phase 2 | Recruiting | Babes-Bolyai University | 50 | 2025-09-22 | 2026-02-10 |
| The Combination of Pharmacotherapy and Cognitive Behavioral Psychotherapy Under the Recovery Perspective. Group A. The combination of pharmacotherapy and individual cognitive behavioral psychotherapy by anxiety disorders and depression., Group B. The combination of pharmacotherapy and individual cognitive behavioral psychotherapy by PTSD, Group C. The combination of pharmacotherapy and individual cognitive behavioral psychotherapy by obsessive-compulsive disorder. - Anxiety, Depression | Phase 1 | Completed | Rakitzi, Stavroula | 107 | 2025-06-02 | 2026-08-04 |
| A Study of SEP-380135 in Adults With Schizophrenia or Major Depressive Episode SEP-380135, Placebo - Schizophrenia, Major Depressive Disorder (MDD) | Phase 1 | Completed | Otsuka Pharmaceutical Development & Commercialization, Inc. | 43 | 2024-11-07 | 2026-04-24 |
| Neurobiological Effects of Psilocybin in Treatment Resistant Bipolar Depression Psilocybin, Functional MRI - Bipolar Depression | Phase 1 | Active not recruiting | University Health Network, Toronto | 30 | 2024-10-09 | 2026-08-10 |
| Effects of Acute Exercise and Ibuprofen on Symptoms, Immunity, and Neural Circuits in Bipolar Depression Exercise Session, Ibuprofen 800 mg, Rest - Bipolar Depression | Phase 1 / Phase 2 | Recruiting | Laureate Institute for Brain Research, Inc. | 20 | 2024-03-12 | 2025-05-23 |
| Alexithymia Intervention for Suicide Affective Awareness - Suicide, Schizophrenia | Phase 1 | Terminated | VA Office of Research and Development | 11 | 2023-10-01 | 2026-03-27 |
| A Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of ABBV-932 in Healthy Adult Participants, Participants With Generalized Anxiety Disorder (GAD) and Participants With Bipolar Disorder (BPD) ABBV-932, Placebo for ABBV-932 - Healthy Volunteers, Generalized Anxiety Disorder (GAD) | Phase 1 | Completed | AbbVie | 72 | 2023-08-31 | 2025-03-17 |
| Inositol for Comorbid Anxiety in Children and Adolescents With Bipolar Disorder Inositol - Bipolar Disorder, Anxiety Disorders | Phase 1 / Phase 2 | Withdrawn | Ronald M. Glick, MD | 2023-08-01 | 2023-10-06 | |
| Adjunctive Allogeneic Mesenchymal Stem Cells for Treatment-resistant Bipolar Depression Allogeneic Bone Marrow Derived Multipotent Mesenchymal Stromal Cells (MSCs), Placebo - Treatment-resistant Bipolar Depression | Phase 1 | Recruiting | The University of Texas Health Science Center, Houston | 30 | 2022-04-20 | 2025-06-22 |
| Pentoxifylline for Treatment of Resistant Major Depression Pentoxifylline, Placebo - Resistant Major Depression | Phase 1 / Phase 2 | Completed | Hawler Medical University | 60 | 2021-12-15 | 2022-09-07 |
| Brain Insulin Resistance in Mood Disorders Humulin R, Diluent - Major Depressive Disorder, Bipolar Disorder | Phase 1 / Phase 2 | Unknown | University Health Network, Toronto | 150 | 2021-10-06 | 2023-12-15 |
| Determining Efficacy and Safety of BXCL501 in Agitation Associated With Pediatric Schizophrenia and Bipolar Disorder BXCL501 80 Micrograms, Placebo Film, BXCL501 120 Micrograms - Schizophrenia, Schizo-Affective Disorder | Phase 1 | Recruiting | BioXcel Therapeutics Inc | 140 | 2021-08-27 | 2026-08-11 |
| Recovering Damaged Cells for Sequelae Caused by COVID-19, SARS-CoV-2 PurWet, FurFat, PurApo - Sequelae of; Infection, Post Infection Glomerulonephritis | Phase 1 / Phase 2 | Unknown | All Natural Medicine Clinic, LLC | 2000 | 2021-03-01 | 2021-05-26 |
| Bright Light Therapy in the Treatment of Non-seasonal Bipolar Depression Light - Bipolar Depression | Phase 1 / Phase 2 | Unknown | Assistance Publique - Hôpitaux de Paris | 45 | 2019-09-30 | 2020-02-10 |
| Modeling Mood Course to Detect Markers for Effective Adaptive Interventions- Aim 3 Mobile intervention - Bipolar Disorder, Psychosocial Intervention | Phase 1 | Completed | University of Wisconsin, Madison | 30 | 2019-09-13 | 2022-01-03 |
| Trial to Assess the Bioavailability of Quetiapine Versus Seroquel® in Subjects With Schizophrenia or Bipolar Disorder Seroquel IR 300mg, Seroquel IR 25mg, Quetiapine Formulation A 300mg - Bipolar Disorder, Schizophrenia | Phase 1 | Completed | Otsuka Pharmaceutical Development & Commercialization, Inc. | 58 | 2019-03-27 | 2020-09-02 |
| Alpha-Amino-3-Hydroxy-5-Methyl-4- Isoxazole Propionic Acid Receptor Components of the Anti-Depressant Ketamine Response, Pilot Trial Ketamine, Perampanel, Placebo - Depressive Disorder, Major, Post Traumatic Stress Disorder | Phase 1 | Completed | Yale University | 13 | 2018-11-29 | 2025-02-07 |
| Technology Enhanced Family Treatment Family-Focused Treatment with MCC App - Mood Disorders, Bipolar Disorder | Phase 1 / Phase 2 | Completed | University of California, Los Angeles | 65 | 2018-11-15 | 2024-05-28 |
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Schizophrenia (16) · Depression (12) · Depressive Disorder, Major (9) · Psychotic Disorders (8) · Anxiety Disorders (4) · Depressive Disorder (4) · Stress Disorders, Post-Traumatic (4) · Alcoholism (3) · Epilepsy (3) · Mania (3) · Mood Disorders (2) · Seizures (2) · Substance-Related Disorders (2) · Suicide (2)
Bipolar and Related Disorders (76) · Mental Disorders (76) · Mood Disorders (74) · Behavior (17) · Schizophrenia Spectrum and Other Psychotic Disorders (17) · Behavioral Symptoms (14) · Nervous System Diseases (11) · Depressive Disorder (9) · Neurologic Manifestations (9) · Pathological Conditions, Signs and Symptoms (9) · Signs and Symptoms (9) · Chemically-Induced Disorders (5) · Neurobehavioral Manifestations (5) · Stress Disorders, Traumatic (4) · Trauma and Stressor Related Disorders (4)
Lamotrigine (4) · Valproic Acid (4) · 2-methyl-N-((2'-(pyrrolidin-1-ylsulfonyl)biphenyl-4-yl)methyl)propan-1-amine (3) · Ketamine (3) · Aripiprazole (2) · Lithium (2) · Midazolam (2) · Paliperidone Palmitate (2) · Risperidone (2) · Therapeutics (2) · Topiramate (2) · vixotrigine (2) · 3-(6-p-tolylpyridin-3-yloxy)-1-azabicyclo(2.2.2)octane (1) · Acamprosate (1) · Bupropion (1)
GlaxoSmithKline (4) · Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (4) · New York State Psychiatric Institute (3) · Otsuka Pharmaceutical Development & Commercialization, Inc. (3) · Pfizer (3) · University of California, Los Angeles (3) · University of Miami (3) · Yale University (3) · AbbVie (2) · Biogen (2) · Eli Lilly and Company (2) · Massachusetts General Hospital (2) · Sandoz (2) · The University of New South Wales (2) · University Health Network, Toronto (2)
United States (48) · Canada (4) · United Kingdom (4) · Singapore (3) · Australia (2) · Brazil (2) · Germany (2) · Argentina (1) · Belgium (1) · Bulgaria (1) · China (1) · France (1) · Greece (1) · Iraq (1) · Ireland (1)
Ihsan M Salloum, MD, MPH (2) · Armen Arevian, MD (1) · Aude Henin, Ph.D. (1) · Barry F Chaitin, M.D. (1) · Beny Lafer, Professor (1) · BioXcel MM, MD (1) · Bryan K. Tolliver, M.D., Ph.D. (1)
PMID 14702256, PMID 15780843, PMID 18762591, PMID 19454920, PMID 20854181, PMID 26187603, PMID 26682997, PMID 27371157, PMID 28351410, PMID 28379964, PMID 29063592, PMID 29578646, PMID 30466205, PMID 32965227, PMID 33360365, PMID 34131914, PMID 35036831, PMID 37079363, PMID 38094620, PMID 39428602, PMID 40109484, PMID 40494497, PMID 40608475
2016 (1), K01MH112876 (1), K24DA000435 (1), R01AA015385 (1), R01DA019992 (1), R01MH059710 (1), R21MH062555 (1), R21MH096850 (1), R33MH096850 (1), R34MH081335 (1), R34MH083894 (1), R34MH090148 (1), R34MH117200 (1), UL1TR000067 (1)