14 completed, 3 terminated, 3 withdrawn. 12 Phase 1, 6 Phase 2, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 12 | Completed 10, Terminated 1, Withdrawn 1 |
| Phase 2 | 6 | Completed 4, Terminated 2 |
| Phase 3 | 2 | Withdrawn 2 |
Follow vixotrigine: new trials by email Literature Review of vixotrigine trials Research Report on vixotrigine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| 802NP301 Efficacy and Safety Study of BIIB074 in Participants With Trigeminal Neuralgia BIIB074, Placebo - Trigeminal Neuralgia | Phase 3 | Withdrawn | Biogen | 2023-04-19 | 2023-05-06 | |
| 802NP302 Efficacy and Safety Study of BIIB074 in Participants With Trigeminal Neuralgia BIIB074, Placebo - Trigeminal Neuralgia | Phase 3 | Withdrawn | Biogen | 2023-03-01 | 2023-05-06 | |
| Pharmacodynamic Study of BIIB095 and BIIB074 in Healthy Participants and Participants With Painful Diabetic Polyneuropathy BIIB095, BIIB074, Placebo - Healthy Volunteers, Diabetic Neuropathies | Phase 1 | Withdrawn | Biogen | 2020-09-30 | 2021-03-22 | |
| Efficacy and Safety Study of BIIB074 in Participants With Small Fiber Neuropathy BIIB074, Placebo - Small Fiber Neuropathy, Diabetes Mellitus | Phase 2 | Terminated | Biogen | 265 | 2018-05-31 | 2021-05-05 |
| A Drug Interaction Study of BIIB074 and an Oral Contraceptive Regimen BIIB074, OC (ethinyl estradiol and levonorgestrel) - Drug Interactions | Phase 1 | Completed | Biogen | 36 | 2017-11-11 | 2018-09-25 |
| Study to Evaluate the Effect of UGT Inhibition by Valproic Acid on the Pharmacokinetics of BIIB074 BIIB074, Valproic Acid - Drug Interaction | Phase 1 | Completed | Biogen | 30 | 2017-09-12 | 2018-04-20 |
| Extension Study to Evaluate the Long-Term Safety, Tolerability, and Maintenance of Effect of BIIB074 BIIB074 - Neuropathic Pain From Lumbosacral Radiculopathy | Phase 2 | Terminated | Biogen | 302 | 2017-02-10 | 2019-02-25 |
| Study to Evaluate the Efficacy and Safety of BIIB074 in Neuropathic Pain From Lumbosacral Radiculopathy BIIB074, Placebo - Lumbosacral Radiculopathy | Phase 2 | Completed | Biogen | 502 | 2016-10-31 | 2018-08-15 |
| A Phase 2a Study of BIIB074 in the Treatment of Erythromelalgia BIIB074, Placebo - Primary Inherited Erythromelalgia | Phase 2 | Completed | Biogen | 8 | 2016-09-09 | 2018-01-10 |
| PK and Safety Study of BIIB074 in Healthy Japanese and Caucasian Participants BIIB074, Placebo - Healthy, Trigeminal Neuralgia | Phase 1 | Completed | Biogen | 64 | 2016-08-01 | 2017-03-09 |
| Absorption, Metabolism, and Excretion Study of BIIB074 BIIB074 - Neuropathic Pain | Phase 1 | Completed | Biogen | 6 | 2016-04-01 | 2016-06-16 |
| Effect of Itraconazole on the Pharmacokinetics of BIIB074 BIIB074, Itraconazole - Neuropathic Pain | Phase 1 | Completed | Biogen | 16 | 2016-02-01 | 2016-06-09 |
| Study to Evaluate the Interaction Between a Drug and CNV1014802 in Healthy Subjects CNV1014802 - Healthy | Phase 1 | Completed | Biogen | 36 | 2015-04-30 | 2017-10-16 |
| PK & Tolerability of CNV1014802 in Young and Elderly Healthy Volunteers CNV1014802, Placebo - Trigeminal Neuralgia | Phase 1 | Completed | Biogen | 32 | 2015-02-03 | 2017-10-12 |
| A Phase IIa Withdrawal Study of CNV1014802 in Patients With Trigeminal Neuralgia CNV1014802, Placebo - Trigeminal Neuralgia | Phase 2 | Completed | Biogen | 67 | 2012-03-31 | 2019-01-10 |
| Crossover Study of CNV1014802 in Subjects With Neuropathic Pain From Lumbosacral Radiculopathy CNV1014802, Placebo - Lumbosacral Radiculopathy | Phase 2 | Completed | Biogen | 82 | 2011-04-30 | 2017-10-13 |
| Effect of GSK1014802 on Electrical Hyperalgesia and Threshold Tracking in Healthy Subjects GSK1014802 low dose, Lidocaine, GSK1014802 high dose - Pain, Neuropathic, Neuropathic Pain | Phase 1 | Terminated | Biogen | 16 | 2009-07-31 | 2017-10-26 |
| Study to Investigate the Effect of GSK1014802 on Ambulatory Blood Pressure GSK1014802, Placebo - Healthy Volunteer | Phase 1 | Completed | Biogen | 60 | 2009-07-31 | 2017-10-16 |
| Safety, Tolerability and Pharmacokinetics of Repeat Doses of GSK1014802. Placebo, GSK1014802 - Bipolar Depression, Bipolar Disorder | Phase 1 | Completed | Biogen | 51 | 2008-05-31 | 2017-10-30 |
| GSK Drug Single Dose Escalation And Their Effect On Resting Motor Threshold In Healthy Volunteers GSK drug, Placebo, Lamictal - Bipolar Disorder | Phase 1 | Completed | Biogen | 50 | 2007-05-31 | 2017-10-26 |
Trigeminal Neuralgia (5) · Neuralgia (3) · Bipolar Disorder (2) · Diabetes Mellitus (1) · Diabetic Neuropathies (1) · Pain (1) · Small Fiber Neuropathy (1)
Biogen (20)
United Kingdom (10) · United States (5) · Czechia (4) · France (4) · Bulgaria (3) · Italy (3) · Spain (3) · Austria (2) · Belgium (2) · Denmark (2) · Georgia (2) · Latvia (2) · Netherlands (2) · Romania (2) · Serbia (2)
PMID 28216232, PMID 30587219, PMID 32564301, PMID 36045316, PMID 37152360
2015 (4), 2016 (3), 2014 (1), 2017 (1), 2019 (1)