115 completed, 21 terminated, 14 recruiting, 11 withdrawn. 177 Phase 2, 22 Phase 3, 21 Phase 1.
Follow Bipolar Disorder: new trials by email Literature Review of Bipolar Disorder trials Research Report on Bipolar Disorder
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| N-Acetylcysteine for Bipolar and Alcohol Use Disorders N-acetyl cysteine, Placebo - Bipolar Disorder, Alcohol Use Disorder | Phase 2 | Not yet recruiting | Medical University of South Carolina | 70 | 2027-01-01 | 2026-11-03 |
| Ketamine With Dialectical Behavioural Therapy (DBT) for Suicidality in Individuals With Treatment-Resistant Depression and Borderline Personality Disorder (KET-DBT) Ketamine Hydrochloride, Midazolam Hydrochloride, Dialectical Behavioral Therapy (DBT) - Borderline Personality Disorder (BPD), Treatment-Resistant Major Depressive Disorder | Phase 2 | Recruiting | Joshua Rosenblat | 120 | 2026-07-16 | 2026-07-29 |
| Efficacy and Mechanism of IPSRT for Bipolar II Disorder Quetiapine (drug), Psychopharmacological treatment - Bipolar Disorder II | Phase 2 | Not yet recruiting | First Affiliated Hospital of Zhejiang University | 216 | 2026-07-01 | 2026-06-17 |
| Psilocybin-Assisted Therapy for Treatment-Resistant Depression in Bipolar II Disorder psilocybin (25 mg), psilocybin 1mg micro-dose - Bipolar II Depression | Phase 2 | Recruiting | Lakshmi N Yatham | 90 | 2026-06-15 | 2026-09-15 |
| Melatonin Versus Placebo for Bipolar Disorder Melatonin, Placebo - Bipolar Affective Disorder | Phase 2 | Recruiting | Lars Vedel Kessing | 200 | 2026-05-08 | 2026-05-12 |
| A Study to Assess Adverse Events and Change in Disease Activity of Oral Icalcaprant in Adult Participants With Bipolar I or II Disorder Icalcaprant, Placebo for Icalcaprant - Bipolar I Disorder, Bipolar II Disorder | Phase 2 | Recruiting | AbbVie | 195 | 2026-02-03 | 2026-08-14 |
| The PEDAL Intervention - Reducing Affective Lability in Bipolar Disorder Traditional group psychoeducation for bipolar disorder, Group psychoeducation with digital elements and focus on affective lability - Bipolar Disorder (BD) | Phase 2 | Recruiting | Oslo University Hospital | 120 | 2025-12-01 | 2026-09-04 |
| A Study of Brenipatide in Adult Participants With Bipolar Disorder (RENEW-Bipolar-1) Brenipatide, Placebo - Bipolar Disorder | Phase 2 | Recruiting | Eli Lilly and Company | 400 | 2025-11-24 | 2026-11-04 |
| Adaptation and Validation of the Hypomanic Personality Scale (HPS-6) to Romanian Hypomanic Personality Scale - 6 - Bipolar Disorder (BD) | Phase 1 / Phase 2 | Recruiting | Babes-Bolyai University | 50 | 2025-09-22 | 2026-02-10 |
| Acceptability & Safety of Two Sequential Doses of Psilocybin in Bipolar Disorder II Depression and Suicidality Psilocybin, Therapeutic Support - Bipolar II Disorder, Depression, Bipolar | Phase 2 | Recruiting | The University of Texas Health Science Center, Houston | 10 | 2025-07-07 | 2026-08-12 |
| Assessment of Acute Psychomotor Agitation Measures Associated With Schizophrenia and Bipolar Disorder BXCL501 Sublingual Film - Bipolar I Disorder, Bipolar II Disorder | Phase 2 | Completed | BioXcel Therapeutics Inc | 33 | 2025-06-19 | 2026-10-05 |
| Study of ABX-002 for the Adjunctive Treatment of Depressive Episodes Associated With Bipolar Disorder in Adults ABX-002 - Bipolar Disorder Depression | Phase 2 | Active not recruiting | Autobahn Therapeutics, Inc. | 35 | 2025-03-28 | 2026-05-26 |
| FMRI of Patients Receiving IV Ketamine for Treatment Resistant Bipolar Depression Ketamine, Functional magnetic resonance imaging (fMRI) - Bipolar Depression, Treatment Resistant Bipolar Depression | Phase 2 | Completed | Drew Cumming | 20 | 2024-11-12 | 2026-10-15 |
| Study of Oral ABBV-932 to Assess Adverse Events and Change in Disease Activity in Adult Participants With Bipolar I or II Disorder ABBV-932, Placebo for ABBV-932 - Bipolar I Disorder, Bipolar II Disorder | Phase 2 | Completed | AbbVie | 161 | 2024-10-15 | 2026-10-14 |
| Correcting Circadian Rhythms to Breakthrough in Bipolar Disorder Melatonin, Placebo, Behavioral sleep intervention - Bipolar Disorder, Delayed Sleep-Wake Phase Disorder | Phase 2 | Recruiting | Leslie Swanson | 50 | 2024-08-13 | 2026-05-11 |
| Low Amplitude Pulse Seizure Therapy Versus Standard Ultra-Brief Right Unilateral Electroconvulsive Therapy Sigma-Stim, RUL LAP-ST (Low-Amplitude Pulse Seizure Therapy - Right Unilateral) - Suicidal Ideation, Major Depressive Disorder | Phase 2 / Phase 3 | Active not recruiting | Michigan State University | 30 | 2024-07-03 | 2026-11-02 |
| BHV-7000 Open-Label Extension Bipolar Mania Study BHV-7000 - Bipolar Disorder | Phase 2 | Terminated | Biohaven Therapeutics Ltd. | 94 | 2024-06-24 | 2025-12-16 |
| BHV-7000 Acute Treatment of Bipolar Mania BHV-7000, Placebo - Bipolar Disorder | Phase 2 / Phase 3 | Completed | Biohaven Therapeutics Ltd. | 274 | 2024-05-28 | 2025-12-16 |
| To Evaluate the Effects of NMRA-335140 on Symptoms of Major Depression in Participants With Bipolar II Disorder. NMRA-335140 80 mg, Placebo - Major Depressive Episode Associated With Bipolar II Disorder | Phase 2 | Completed | Neumora Therapeutics, Inc. | 18 | 2024-05-13 | 2026-03-30 |
| Effects of Acute Exercise and Ibuprofen on Symptoms, Immunity, and Neural Circuits in Bipolar Depression Exercise Session, Ibuprofen 800 mg, Rest - Bipolar Depression | Phase 1 / Phase 2 | Recruiting | Laureate Institute for Brain Research, Inc. | 20 | 2024-03-12 | 2025-05-23 |
Showing 20 of 177. Sign in to see all of them.
Depression (54) · Mood Disorders (20) · Psychotic Disorders (20) · Depressive Disorder, Major (19) · Mania (19) · Schizophrenia (14) · Depressive Disorder (11) · Mental Disorders (9) · Suicidal Ideation (8) · Alcoholism (6) · Anxiety Disorders (6) · Depressive Disorder, Treatment-Resistant (4) · Suicide (4) · Smoking Cessation (3)
Bipolar and Related Disorders (176) · Mental Disorders (168) · Mood Disorders (157) · Behavior (67) · Behavioral Symptoms (62) · Pathological Conditions, Signs and Symptoms (30) · Nervous System Diseases (28) · Signs and Symptoms (28) · Neurologic Manifestations (26) · Neurobehavioral Manifestations (22) · Schizophrenia Spectrum and Other Psychotic Disorders (22) · Depressive Disorder (18) · Chemically-Induced Disorders (11) · Self-Injurious Behavior (9) · Substance-Related Disorders (8)
Ketamine (10) · Lithium (6) · Quetiapine Fumarate (6) · Valproic Acid (6) · Acetylcysteine (5) · Lamotrigine (5) · Gabapentin (4) · Lurasidone Hydrochloride (4) · Memantine (4) · Midazolam (4) · Sodium Chloride (4) · Therapeutics (4) · Transcranial Direct Current Stimulation (4) · Epoetin Alfa (3) · Erythropoietin (3)
National Institute of Mental Health (NIMH) (17) · Mclean Hospital (7) · Medical University of South Carolina (6) · The University of New South Wales (5) · Forest Laboratories (4) · Massachusetts General Hospital (4) · The University of Texas Health Science Center, Houston (4) · University of Sao Paulo (4) · Joshua Rosenblat (3) · Lars Vedel Kessing (3) · NeuroRx, Inc. (3) · University of British Columbia (3) · University of California, Los Angeles (3) · VA Office of Research and Development (3) · Yale University (3)
United States (118) · Canada (21) · Australia (7) · Brazil (6) · Denmark (6) · France (5) · Germany (4) · Poland (4) · South Korea (4) · Taiwan (4) · Japan (3) · Sweden (3) · United Kingdom (3) · Bulgaria (2) · China (2)
Beth L Murphy, MD, PhD (3) · Ihsan M Salloum, MD, MPH (3) · Benjamin I Goldstein, MD (2) · Carlos A Zarate, M.D. (2) · Colleen Loo (2) · James J Prisciandaro, PhD (2) · Jennifer L Payne, MD (2) · Joshua Rosenblat, MD, MSc (2) · Kamilla W. Miskowiak, Prof. (2) · Nassir Ghaemi, MD, MPH (2) · Roy H Perlis, MD, MSc (2) · Albert J Arias, MD (1)
PMID 31969269, PMID 34510411, PMID 15630071, PMID 17897484, PMID 18762591, PMID 19422756, PMID 19454920, PMID 20074703, PMID 20810586, PMID 20816040, PMID 20942940, PMID 21029512, PMID 21486171, PMID 22215866, PMID 22420597, PMID 22545088, PMID 22926607, PMID 23364679, PMID 23826157, PMID 23870798, PMID 24103632, PMID 24345793, PMID 25099079, PMID 25313530, PMID 25641635, PMID 26011424, PMID 26457385, PMID 26459650, PMID 26541814, PMID 26996196, PMID 27259062, PMID 27366831, PMID 27371157, PMID 27835716, PMID 28338546, PMID 28351410, PMID 29017067, PMID 29111077, PMID 29282470, PMID 29480043, PMID 29619634, PMID 29673379, PMID 30172724, PMID 30184133, PMID 30400939, PMID 30466205, PMID 30524702, PMID 30549489, PMID 30738555, PMID 31066887
2016 (2), 2015 (1), 2017 (1), 2018 (1), 2019 (1), K23AA017689 (1), K24DA000435 (1), R01AA015385 (1), R01AA025365 (1), R01DA019992 (1), R01DA054275 (1), R01MH058681 (1), R01MH072556 (1), R01MH078060 (1), R01MH080150 (1)