99 completed, 37 unknown, 13 withdrawn, 11 terminated. 94 Not applicable, 22 Phase 4, 9 Phase 2, 6 Phase 3, 2 Phase 1.
Follow Arthroplasty, Replacement, Knee: new trials by email Literature Review of Arthroplasty, Replacement, Knee trials Research Report on Arthroplasty, Replacement, Knee
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Tau Pathology in the Brain After Hip or Knee Replacement Surgery Hip or Knee Arthroplasty Under Spinal Anesthesia - Postoperative Cognitive Dysfunction, Alzheimer Disease | Recruiting | Uppsala University Hospital | 30 | 2029-04-01 | 2026-10-15 | |
| A Study of the Effect of a Nurse Navigator Program on High Risk Patients Nurse Navigator Program - Patient Readmission, Arthroplasty, Replacement, Knee | Not applicable | Not yet recruiting | Mayo Clinic | 300 | 2027-01-01 | 2026-03-19 |
| GENIVS Block Versus Adductor Canal Block After Total Knee Arthroplasty GENIVS block, Adductor Canal Block (ACB) Only - Arthroplasty, Replacement, Knee, Pain, Postoperative | Not applicable | Not yet recruiting | Bakirkoy Dr. Sadi Konuk Research and Training Hospital | 74 | 2026-12-01 | 2026-10-28 |
| Effect of Rebound Pain on Chronic Postsurgical Pain After Total Knee Arthroplasty Acute Pain, Postoperative, Chronic Pain | Recruiting | Konya City Hospital | 220 | 2026-08-19 | 2026-08-20 | |
| Ultrasonographic Predictors of Adductor Canal Block Effectiveness in Total Knee Arthroplasty Adductor Canal Block (ACB) Only - Arthroplasty, Replacement, Knee, Nerve Block Assessment | Recruiting | Konya City Hospital | 623 | 2026-08-09 | 2026-08-12 | |
| Early Outcome of Simultaneous Bilateral Total Knee Replacement With and Without Tourniquet Simultaneous Bilateral Total Knee Replacement with Tourniquet, Simultaneous Bilateral Total Knee Replacement without Tourniquet - Arthroplasty, Replacement, Knee, Blood Loss, Surgical | Not applicable | Enrolling by invitation | Shifa International Hospital | 84 | 2026-07-01 | 2026-10-29 |
| Sleep Patterns After Total Joint Replacement Surgery Arthroplasty, Replacement, Knee, Arthroplasty, Replacement, Hip | Withdrawn | Henry Ford Health System | 2026-06-01 | 2026-08-11 | ||
| BiFeS vs. iPACK in Postoperative Knee Arthroplasty Analgesia Biceps Femoris Short Head Block (BiFeS), Infiltration Between The Popliteal Artery and The Capsule of The Knee, Adductor Canal Block - Arthroplasty, Replacement, Knee, Pain, Postoperative | Not applicable | Recruiting | Amasya University | 88 | 2026-04-20 | 2026-04-22 |
| Comparing Different Doses of Corticosteroids in Local Infiltration Analgesia (LIA) for Total Knee Arthroplasty LIA with different doses of Diprospan - Adrenal Cortex Hormones, Arthroplasty, Replacement, Knee | Not applicable | Recruiting | First Affiliated Hospital of Fujian Medical University | 120 | 2026-02-01 | 2026-01-13 |
| Testing Regional Anesthesia Techniques for Up and Early Discharge Following Knee Arthroplasty - A Feasibility Study Ropivacaine, Normal saline - Arthroplasty, Replacement, Knee | Phase 4 | Withdrawn | McMaster University | 2026-01-15 | 2026-06-04 | |
| Comparison of BiFeS + ACB and IPACK + ACB Block Combinations for Postoperative Pain After Total Knee Arthroplasty Pain After Total Knee Arthroplasty, Pain, Postoperative | Completed | Karabuk University | 60 | 2025-10-15 | 2026-02-03 | |
| Nurse-Led Telehealth vs In-Person Follow-Up After Total Knee Replacement Nurse-Led Telehealth Consultation, Traditional In-Person Nursing Consultation - Arthroplasty, Replacement, Knee, Osteoarthritis, Knee | Not applicable | Recruiting | Hospital Authority, Hong Kong | 98 | 2025-09-10 | 2026-01-05 |
| Phase IIa Trial of Oral SSS17 for Post-Arthroplasty Anemia SSS17 Capsule (6 Dose Levels), Placebo Drug - Postoperative Anemia, Arthroplasty, Replacement, Hip | Phase 2 | Not yet recruiting | Shenyang Sunshine Pharmaceutical Co., LTD. | 90 | 2025-07-01 | 2025-06-11 |
| Comparing Local Anesthetic Injections to Nerve Blocks for Pain Control After Total Knee Replacement Continuous Femoral and Sciatic Nerve Block (Ropivacaine), Local Infiltration Analgesia (Ropivacaine, Ketorolac, Epinephrine) - Pain, Postoperative, Osteoarthritis, Knee | Not applicable | Completed | Christopher Male | 78 | 2025-06-01 | 2026-08-05 |
| Real-component vs All-cement Articulating Spacers for Periprosthetic Knee Infection All-cement articulating spacer, Durable, real-component articulating spacer, Rigid Spacer - Prosthetic-joint Infection, Knee Infection | Not applicable | Recruiting | Northwestern University | 153 | 2024-08-08 | 2026-08-24 |
| Dimolegin® (60 mg) Given Once Daily in Patients Undergoing Total Hip or Knee Replacement Compared to Enoxaparin Sodium enoxaparin, Dimolegin, Dimolegin placebo - Arthroplasty, Replacement, Hip, Arthroplasty, Replacement, Knee | Phase 3 | Completed | Avexima Diol LLC | 215 | 2024-07-22 | 2026-01-16 |
| Metal Ion Concentrations After Total Knee Arthroplasty Metal ion level testing - Arthroplasty, Replacement, Knee, Total Knee Replacement | Enrolling by invitation | Mayo Clinic | 60 | 2024-06-25 | 2026-07-13 | |
| The Role of Auricular Point Diagnosis and Treatment in ERAS During TKA Auriculotherapy - Auriculotherapy, Arthroplasty, Replacement, Knee | Completed | Peking Union Medical College | 116 | 2024-03-23 | 2025-12-17 | |
| Wearable Sensors for Monitoring Recovery After Total Knee Arthroplasty Measuring gait - Arthroplasty, Replacement, Knee | Unknown | Aalborg University Hospital | 30 | 2024-03-12 | 2025-04-10 | |
| Mepivacaine vs Bupivacaine Spinal Anesthesia for TKA Mepivacaine, Bupivacaine - Anesthesia, Spinal, Arthroplasty, Replacement, Knee | Phase 4 | Completed | Prisma Health-Upstate | 138 | 2024-02-16 | 2025-08-28 |
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Osteoarthritis, Knee (22) · Pain, Postoperative (20) · Agnosia (11) · Pain (5) · Osteoarthritis (4) · Chronic Pain (3) · Knee Injuries (3) · Thromboembolism (3) · Acute Kidney Injury (2) · Anemia (2) · Anxiety Disorders (2) · Edema (2) · Hemorrhage (2) · Motor Activity (2) · Osteoarthritis, Hip (2)
Pathological Conditions, Signs and Symptoms (41) · Signs and Symptoms (35) · Neurologic Manifestations (32) · Musculoskeletal Diseases (30) · Joint Diseases (28) · Rheumatic Diseases (28) · Arthritis (27) · Pathologic Processes (26) · Osteoarthritis (23) · Pain (23) · Postoperative Complications (22) · Nervous System Diseases (14) · Neurobehavioral Manifestations (12) · Perceptual Disorders (11) · Cardiovascular Diseases (10)
Arthroplasty, Replacement, Knee (11) · Bupivacaine (10) · Ropivacaine (8) · Epinephrine (5) · Enoxaparin (4) · Anesthesia, Conduction (3) · Ketorolac (3) · Saline Solution (3) · Anesthesia, General (2) · Anesthesia, Spinal (2) · Dabigatran (2) · Levobupivacaine (2) · Lidocaine (2) · Mepivacaine (2) · Morphine (2)
Stryker Orthopaedics (13) · Mayo Clinic (4) · Boehringer Ingelheim (3) · Sunnybrook Health Sciences Centre (3) · TriHealth Inc. (3) · Bornholms Regionskommune (2) · Bozyaka Training and Research Hospital (2) · Colorado Joint Replacement (2) · Henry Ford Health System (2) · Konya City Hospital (2) · Medical University of South Carolina (2) · Montefiore Medical Center (2) · Northwestern University (2) · Region Skane (2) · Smith & Nephew, Inc. (2)
United States (56) · Canada (16) · Denmark (13) · United Kingdom (12) · Turkey (Türkiye) (11) · Netherlands (10) · Sweden (9) · Germany (8) · Italy (8) · China (7) · Belgium (6) · Australia (5) · Austria (5) · South Korea (5) · Spain (5)
Mark Snyder, MD (3) · Carlos A Higuera, MD (2) · Hsu Ma, MD, PhD (2) · Adam I Edelstein, MD (1) · Ahmed Saeed Younis, Dr. (1) · Alvin Ong, MD (1) · Amit Atrey, MD (1) · Ammara Khalil (1) · Amr Amal Elsayed Amin, Dr. (1) · Andrew D Posner, MD (1) · Andrew Toms, FRCS (1)
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