2670 completed, 544 unknown, 462 recruiting, 415 terminated. 1187 Phase 2, 988 Not applicable, 715 Phase 3, 598 Phase 1, 384 Phase 4.
Follow Anemia: new trials by email Literature Review of Anemia trials Research Report on Anemia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| OPTIMAL LEAP: Optimizing Dihydroartemisinin-Piperaquine IPTsc Intervals to Advance Learning, Executive Function, Attendance, and Antimalarial Resistance Surveillance in Kenyan Schoolchildren Monthly DP, Quarterly DP - Malaria, Asymptomatic Malaria | Phase 3 | Not yet recruiting | Indiana University | 1500 | 2028-01-01 | 2026-09-01 |
| Methadone as an Alternative Treatment for Children Underdoing HSCT PCA plus methadone (Experimental), PCA Alone (SOC) - Leukemia, Aplastic Anemia | Phase 3 | Suspended | University of Texas Southwestern Medical Center | 60 | 2028-01-01 | 2025-10-23 |
| Prenatal Transplantation for Fetuses With Fanconi Anemia IUHSCT for FA-affected fetuses - Fanconi Anemia, Anemia, Hypoplastic, Congenital | Phase 1 / Phase 2 | Not yet recruiting | Agnieszka Czechowicz | 12 | 2028-01-01 | 2026-06-16 |
| Study of NM8074 in Patients With aHUS With Evidence of Ongoing Thrombotic Microangiopathy NM8074 - aHUS - Atypical Hemolytic Uremic Syndrome | Phase 2 | Not yet recruiting | NovelMed Therapeutics | 12 | 2027-11-01 | 2026-04-13 |
| Self-administered Acupressure in Patients With Sickle Cell Disease Verum Acupressure (using AcuWand), Sham Acupressure (using AcuWand) - Sickle Cell Disease (SCD) | Not applicable | Not yet recruiting | University of Cincinnati | 300 | 2027-10-01 | 2026-10-15 |
| Development of a Provider-Focused Intervention to Improve Health Outcomes in Pediatric Sickle Cell Disease Individuation and Perspective-Taking (IPT), pediatric SCD pain management education session - Sickle Cell Disease, Sickle Cell Anemia in Children | Not applicable | Not yet recruiting | Connecticut Children's Medical Center | 30 | 2027-09-01 | 2026-04-29 |
| Conditioning Regimen Containing Low-Dose ATG for the Treatment of AA Receiving sUCBT Anti-Thymocyte Globulin (Rabbit) (Thymoglobulin®) - Aplastic Anaemia | Phase 2 | Not yet recruiting | Anhui Provincial Hospital | 59 | 2027-08-01 | 2026-10-21 |
| Evaluation of Efficacy and Safety of a Single Dose of Exa-cel in Participants With Severe Sickle Cell Disease, βS/ βC Genotype Exa-cel - Sickle Cell Disease | Phase 3 | Withdrawn | Vertex Pharmaceuticals Incorporated | 2027-07-31 | 2026-03-25 | |
| A Study to Investigate the Efficacy and Safety of Roxadustat (FG-4592) for Treating Anemia in Participants With Myelodysplastic Syndromes (MDS) Roxadustat, Placebo - Myelodysplastic Syndromes | Phase 3 | Not yet recruiting | Kyntra Bio | 201 | 2027-04-01 | 2026-07-23 |
| MBI for Pain and Sleep in Adolescents and Young Adults With Sickle Cell Disease Mindfulness-based intervention - Chronic Pain, Sickle Cell Disease | Not applicable | Not yet recruiting | University of Illinois at Chicago | 48 | 2027-02-01 | 2026-09-21 |
| Heterologous Cord Blood-Derived Red Blood Cell for Transfusion in Extremely Preterm Infants Cord Blood Red Blood Cells, Standard Adult Donor Red Blood Cells - Extremely Premature Infant, Anemia Neonatal | Not applicable | Not yet recruiting | Hospital Clinic of Barcelona | 176 | 2027-01-01 | 2026-03-31 |
| Study of NM8074 in Adult PNH Patients With Inadequate Response to Soliris NM8074, Soliris - Paroxysmal Nocturnal Hemoglobinuria | Phase 2 | Not yet recruiting | NovelMed Therapeutics | 12 | 2027-01-01 | 2026-04-13 |
| Gene Therapy of Beta Thalassemia Using a Self-inactivating Lentiviral Vector Gene-modified autologous hematopoeitic stem cells - Beta-Thalassemia | Not applicable | Not yet recruiting | Shenzhen Geno-Immune Medical Institute | 20 | 2026-12-31 | 2026-08-27 |
| A Study of the Efficacy and Safety of FXS6837 Capsules Compared to Eculizumab for 24 Weeks in Patients With PNH. FXS6837 Capsule, Eculizumab infusion - Paroxysmal Nocturnal Hemoglobinuria | Phase 3 | Not yet recruiting | Shanghai Fosun Pharmaceutical Industrial Development Co. Ltd. | 90 | 2026-12-10 | 2026-08-05 |
| CK0801 for Treatment of Aplastic Anemia CK0801 - Aplastic Anemia | Phase 2 | Not yet recruiting | Cellenkos, Inc. | 12 | 2026-12-03 | 2026-10-20 |
| Study to Characterize Mismatched to Fully HLA-Matched Ossium HPC, Marrow and Living Donor Transplantation in Patients With Hematologic Malignancies Ossium HPC, Marrow, Standard of care living donor - Haplo Related, Standard of care living donor - Mismatched Unrelated - Hematologic Malignancy, Acute Leukemia | Not applicable | Not yet recruiting | Ossium Health, Inc. | 300 | 2026-12-01 | 2026-09-10 |
| Efficacy and Safety of Spironolactone in Pediatric Hemodialysis Patients With Anemia. Spironolactone (drug), Iron Supplement, Erythropoietin stimulating agent - Anemia | Phase 2 | Not yet recruiting | Ain Shams University | 40 | 2026-12-01 | 2026-07-20 |
| Phenotyping Acute Non-Severe Anemia in the Emergency Department Total hemoglobin mass measurement, Focused transthoracic echocardiography, Near-infrared spectroscopy - Anemia | Not applicable | Not yet recruiting | Hospices Civils de Lyon | 59 | 2026-12-01 | 2026-08-12 |
| A Study to Test the Non-Inferiority of Ferric Bepectate IV Against Ferric Carboxymaltose in Patients With Iron Deficiency Anemia Ferric Bepectate IV Injection, Ferric Carboxymaltose Injection [Ferinject], Ferric Carboxymaltose Injection [Injectafer®] - Iron Deficiency Anemia (IDA) | Phase 3 | Not yet recruiting | AFT Pharmaceuticals, Ltd. | 1366 | 2026-12-01 | 2026-08-20 |
| Daily Iron vs Every-other-day Iron for Pediatric Patients With IDA iron sulfate - Iron Deficiency Anemia | Phase 4 | Not yet recruiting | Loma Linda University | 100 | 2026-12-01 | 2026-07-10 |
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Anemia, Sickle Cell (1118) · Anemia, Iron-Deficiency (581) · Anemia, Aplastic (355) · Myelodysplastic Syndromes (344) · Anemia, Refractory, with Excess of Blasts (318) · beta-Thalassemia (264) · Leukemia, Myeloid, Acute (250) · Renal Insufficiency, Chronic (221) · Leukemia (220) · Thalassemia (220) · Hemoglobinuria, Paroxysmal (189) · Iron Deficiencies (187) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (178) · Leukemia, Myelomonocytic, Chronic (150)
Hemic and Lymphatic Diseases (4671) · Hematologic Diseases (4538) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (1843) · Anemia, Hemolytic (1835) · Genetic Diseases, Inborn (1641) · Anemia, Hemolytic, Congenital (1524) · Hemoglobinopathies (1413) · Pathological Conditions, Signs and Symptoms (1178) · Nutritional and Metabolic Diseases (1051) · Bone Marrow Diseases (1029) · Metabolic Diseases (980) · Pathologic Processes (960) · Iron Metabolism Disorders (729) · Disease Attributes (663)
Cyclophosphamide (178) · Epoetin Alfa (166) · fludarabine phosphate (130) · Darbepoetin alfa (117) · ferric carboxymaltose (116) · Cyclosporine (115) · fludarabine (112) · Antilymphocyte Serum (101) · ferrous sulfate (100) · Whole-Body Irradiation (97) · Busulfan (94) · Hydroxyurea (90) · Mycophenolic Acid (90) · Iron (88) · continuous erythropoietin receptor activator (68)
National Heart, Lung, and Blood Institute (NHLBI) (124) · Hoffmann-La Roche (105) · Novartis Pharmaceuticals (83) · Assistance Publique - Hôpitaux de Paris (78) · Amgen (65) · Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (60) · St. Jude Children's Research Hospital (55) · Assiut University (49) · Alexion Pharmaceuticals, Inc. (48) · Institute of Hematology & Blood Diseases Hospital, China (48) · Fred Hutchinson Cancer Center (42) · Children's Hospital Medical Center, Cincinnati (41) · National Cancer Institute (NCI) (41) · Swiss Federal Institute of Technology (41) · GlaxoSmithKline (37)
United States (1916) · France (387) · China (348) · United Kingdom (331) · Italy (304) · Germany (267) · Canada (243) · Spain (195) · Egypt (137) · Netherlands (125) · Turkey (Türkiye) (124) · Belgium (122) · Australia (116) · Brazil (111) · South Korea (111)
John F Tisdale, M.D. (16) · Ariel Koren, MD (13) · Swee Lay Thein, M.D. (12)
PMID 36005278, PMID 36791280, PMID 41114449, PMID 34932836, PMID 26965694, PMID 37975597, PMID 33783815, PMID 36240296, PMID 38780066, PMID 34724566, PMID 37254256, PMID 29958797, PMID 38775255, PMID 29674506, PMID 40277027, PMID 40569673, PMID 41026975, PMID 42133908, PMID 23343061, PMID 23343062, PMID 23738544, PMID 26589907, PMID 29419434, PMID 31413088, PMID 34175041, PMID 34219224, PMID 36749544, PMID 38363466, PMID 40359056, PMID 40576086, PMID 18328118, PMID 19208097, PMID 20175775, PMID 21982521, PMID 24916507, PMID 26504182, PMID 30504345, PMID 30957581, PMID 31203241, PMID 31974203, PMID 32499241, PMID 32678434, PMID 33661274, PMID 34362786, PMID 34710946, PMID 34922648, PMID 36594181, PMID 36860093, PMID 36975201, PMID 37651553
2017 (24), 2023 (24), 2019 (23), 2016 (21), P30CA015704 (21), 2014 (17), 2015 (12), P30CA006973 (12), 2018 (11), 2005 (9), 2008 (9), 2009 (8), P30CA043703 (8), U01HL065238 (8), U54HL070587 (8)