43 completed, 11 unknown, 4 terminated, 3 enrolling by invitation. 27 Phase 4, 22 Not applicable, 8 Phase 3, 6 Phase 2, 5 Phase 1.
Follow Mepivacaine: new trials by email Literature Review of Mepivacaine trials Research Report on Mepivacaine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Immersive VR to Reduce Stress, Anxiety, and Pain During PICC/Midline Placement Immersive Virtual Reality, Peripherally Inserted Central Catheter (PICC), Mepivacaine 2% Injection - Vasoconstriction, Biomarkers | Not applicable | Not yet recruiting | diana garcia | 202 | 2027-01-15 | 2026-07-10 |
| Comparing Spinal Anesthesia With 1% Chloroprocaine Versus 1% Mepivacaine in Patients Undergoing Outpatient Primary Total Knee Arthroplasty Mepivacaine Injection, Chloroprocaine Injection - Recovery Period, Anesthesia | Phase 4 | Not yet recruiting | Nova Scotia Health Authority | 170 | 2026-03-31 | 2026-02-06 |
| Hysteroscopy Anesthesia for Relief of Pain Local paracervical Anesthesia, Placebo - Pain Management, Outpatient Hysteroscopy | Not applicable | Not yet recruiting | Maimónides Biomedical Research Institute of Córdoba | 70 | 2025-09-06 | 2025-09-17 |
| Comparison of Lidocaine, Mepivacaine, and Dry Needling in Myofascial Pain Syndrome Dry Needling, Lidocaine Hydrochloride, Mepivacaine Hydrochloride - Myofascial Pain Syndrome, Temporomandibular Joint Disorders | Not applicable | Completed | Sümer Münevveroğlu | 75 | 2025-05-01 | 2025-08-08 |
| Assessment of Anesthetic Efficacy and Hemodynamic Stability of Two LA Drugs for Hypertensive Patients 4% Articaine HCL With 1:100,000 Epinephrine, 3% plain mepivacaine HCL - Hypertension | Not applicable | Enrolling by invitation | Tanta University | 60 | 2025-01-10 | 2025-11-18 |
| Local Anesthetic Clinical Trial Lidocaine, Bupivacaine Hydrochloride, Mepivacaine Hydrochloride - Mohs Micrographic Surgery, Anesthesia, Local | Phase 4 | Enrolling by invitation | Baylor Research Institute | 400 | 2025-01-07 | 2026-05-22 |
| Avoid With Locoregional Analgesia Persistant Postoperative Pain In Children Carbocaine, Profofol and/or Suxaméthonium and/or Sévoflurane - Persistent Postoperative Pain | Phase 3 | Unknown | Nantes University Hospital | 208 | 2024-06-06 | 2024-06-12 |
| Mepivacaine Versus Bupivacaine Onset Time in Ultrasound-guided Ankle Blocks Mepivacaine, Bupivacaine - Ankle Block, Foot Surgery | Phase 4 | Enrolling by invitation | Mayo Clinic | 50 | 2024-03-11 | 2026-09-18 |
| Mepivacaine vs Bupivacaine Spinal Anesthesia for TKA Mepivacaine, Bupivacaine - Anesthesia, Spinal, Arthroplasty, Replacement, Knee | Phase 4 | Completed | Prisma Health-Upstate | 138 | 2024-02-16 | 2025-08-28 |
| Hemodynamic Effects of Different Vasoconstrictors in Mandibular Exodontia 2% Mepivacaine with 1:100,000 epinephrine, 2% Mepivacaine with 1:55,000 Epinephrine Bitartrate - Hemodynamics, Pain | Phase 4 | Completed | King Abdulaziz University | 52 | 2024-02-10 | 2025-06-12 |
| Wide Awake Open Carpal Tunnel Release With or Without a Tourniquet Mepivacaine, Combinations - Carpal Tunnel Syndrome | Not applicable | Unknown | Region Skane | 120 | 2024-01-09 | 2023-12-26 |
| Combination of Buffered Anesthetic to Treat Mandibular Molars Sodium bicarbonate, Lidocaine w/ epi, Articaine w/ epi - Symptomatic Irreversible Pulpitis | Phase 4 | Terminated | Indiana University | 40 | 2023-12-05 | 2025-05-13 |
| Stellate Ganglion Block for COVID-induced Parosmia Stellate Ganglion Block, Placebo Sham Injection - COVID-19-Induced Parosmia | Phase 2 | Completed | Washington University School of Medicine | 48 | 2023-10-25 | 2025-11-10 |
| Understanding Rebound Pain After Regional Anesthesia Resolution in Healthy Volunteers Mepivacaine - Regional Anesthesia Morbidity, Pain, Acute | Phase 1 | Completed | Brigham and Women's Hospital | 40 | 2023-09-28 | 2025-11-05 |
| Articaine Efficacy and Safety for 3 Years Old Children Mepivacaine 2% with epinephrine 1:100,000, Articaine (4%) with epinephrine 1:100,000 - Dental Caries in Children, Dental Diseases | Phase 3 | Active not recruiting | Qassim Health Cluster | 200 | 2023-07-01 | 2024-12-27 |
| Impact of Tramadol Addiction On Dental Anesthesia Success articaine@ (4% 1:100000 epinephrine) dental anesthesia - Dental Pain and Sensation Disorder, Anesthesia, Local | Phase 4 | Unknown | University of Algiers | 300 | 2023-06-10 | 2023-06-18 |
| Spinal Hypobaric Local Anesthetic Study Spinal hypobaric Mepivacaine Local Anesthetic Injection, Spinal hypobaric Bupivacaine Local Anesthetic Injection - Anesthesia, Local | Completed | University Health Network, Toronto | 60 | 2023-06-09 | 2025-03-28 | |
| Genicular and Anterior Femoral Cutaneous Nerve Blocks for Total Knee Arthroplasty Bupivacaine Injection, Dexamethasone injection, Fentanyl - Total Knee Replacement, Genicular Nerve Block | Phase 4 | Completed | Hospital for Special Surgery, New York | 244 | 2023-06-07 | 2025-10-08 |
| Healing Process and Blood Sugar Level Following Local Anesthetic Infiltration With and Without Vasoconstrictor Local anaesthesia with vasocontrictor (Mepivacaine hydrochloride 20 mg (2%) + Levonordefrin hydrochloride 0.06 mg) - Diabetes, Anesthesia, Local | Not applicable | Completed | Minia University | 40 | 2023-05-20 | 2024-12-31 |
| Photobiomodulation for Controlling Pre-Local Anesthetic Injection Pain Photobiomodulation, Mepivacaine hydrochloride in combination with epinephrine, Photobiomodulation simulation - Fear Needles | Not applicable | Completed | University of Nove de Julho | 50 | 2023-02-15 | 2024-07-18 |
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Pain (9) · Agnosia (4) · Pain, Postoperative (3) · Anosmia (2) · Bites and Stings (2) · COVID-19 (2) · Dental Pulp Diseases (2) · Olfaction Disorders (2) · Osteoarthritis, Hip (2) · Osteoarthritis, Knee (2) · Sensation Disorders (2) · Acute Kidney Injury (1) · Acute Pain (1) · Anterior Cruciate Ligament Injuries (1) · Anxiety Disorders (1)
Cairo University (6) · Hospital for Special Surgery, New York (5) · Brigham and Women's Hospital (3) · Duke University (2) · Mayo Clinic (2) · University Health Network, Toronto (2) · Vanderbilt University Medical Center (2) · Washington University School of Medicine (2) · ASST Gaetano Pini-CTO (1) · Afshan Amjad Ali (1) · Azienda Sanitaria-Universitaria Integrata di Udine (1) · Baylor Research Institute (1) · Birmingham Women's and Children's NHS Foundation Trust (1) · Centre Hospitalier Annecy Genevois (1) · Centre Hospitalier Universitaire, Amiens (1)
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