119 completed, 24 unknown, 17 recruiting, 7 terminated. 115 Not applicable, 18 Phase 2, 11 Phase 3, 10 Phase 1, 3 Phase 4.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Sota-ES - Sotatercept in Patients With Congenital Heart Disease and Eisenmenger´s Syndrome Sotatercept - Congenital Heart Disease (CHD), Eisenmenger Syndrome | Phase 2 | Not yet recruiting | Philipps University Marburg | 40 | 2026-09-01 | 2026-03-27 |
| SIRIUS - Initial Combination Therapy With an Endothelin Receptor Antagonist, a Phosphodiesterase-5 Inhibitor and Sotatercept in Patients With Newly Diagnosed Pulmonary Arterial Hypertension Sotatercept 0.3 mg/kg escalating to 0.7 mg/kg, Sotatercept - Pulmonary Arterial Hypertension (PAH) | Phase 2 | Not yet recruiting | Philipps University Marburg | 25 | 2026-07-01 | 2025-12-05 |
| FEEL-GOOD: A Multicenter Trial of a Mindfulness-Based Group Therapy in Young Adults With Early Psychosis FEEL GOOD, Treatment as Usual (TAU) - Delusional Disorder, Brief Psychotic Disorder | Not applicable | Recruiting | Stephanie Mehl | 252 | 2026-05-27 | 2026-09-22 |
| Large Language Models to Aid Gynecological Oncology Treatment Local language model, Guideline pdf - Breast Cancer | Not applicable | Completed | Philipps University Marburg | 70 | 2026-05-22 | 2026-08-19 |
| Prevention-in-PD-Study Multidomain lifestyle intervention - Parkinson's Disease (PD) | Not applicable | Recruiting | University Hospital Schleswig-Holstein | 99 | 2026-04-01 | 2026-10-15 |
| Improved Management of Patients With Recent-Onset Stable Chest Pain IMPRO - Cross-Sectoral Care Model for Coronary Diagnostics - Coronary Artery Disease (CAD) | Not applicable | Recruiting | Philipps University Marburg | 3369 | 2026-04-01 | 2026-04-07 |
| Dynamic Networks in Depression Treatment: Mechanisms of Change in Pharmacological, Psychological and Combined Treatment of Depression Psychopharmacological treatment, Cognitive-behavioral group treatment (CBGT-D) - Depression - Major Depressive Disorder | Phase 4 | Not yet recruiting | Goethe University | 90 | 2026-02-01 | 2026-03-23 |
| Development of the PTSD-iMPACT to Measure PTSD-Related Functional Impairment in Children and Adolescents - A Validation Study in Switzerland and Germany PTSD - Post Traumatic Stress Disorder, PTSD-Related Functional Impairment in Children and Adolescents | Recruiting | University Children's Hospital, Zurich | 1200 | 2025-12-15 | 2026-01-26 | |
| Enhancing Generalization of Virtual Reality Exposure for Public Speaking Anxiety VR Exposure, Standard Mental Rehearsal, Mental Rehearsal With Extinction Memory Updating - Public Speaking Anxiety, Public Speaking Fear | Not applicable | Recruiting | Philipps University Marburg | 48 | 2025-11-26 | 2026-01-09 |
| Dynamic Network Response to TMS Treatment MDD | Recruiting | Goethe University | 100 | 2025-11-24 | 2026-02-20 | |
| Group Therapy for Major Depression: Comparing Expectation-Focused and Reward-Focused Psychotherapy Approaches Expectation-Focused Psychotherapeutic Intervention, Reward Enhancement and Activation Therapy - Major Depressive Disorder (MDD) | Not applicable | Recruiting | Philipps University Marburg | 150 | 2025-10-13 | 2026-02-10 |
| Evaluation of a Retrieval Augmented Large Language Model as a Diagnostic Copilot in Rheumatology Prof. Valmed - Diagnosis | Not applicable | Completed | Philipps University Marburg | 82 | 2025-10-12 | 2026-04-08 |
| Ecological Momentary Intervention for Reward in Anhedonia Training of reward processing/sensitivity, Relaxation Training (PMR), Psychoeducation - Anhedonia, Anxiety | Not applicable | Recruiting | Philipps University Marburg | 60 | 2025-06-18 | 2026-01-09 |
| Neurological Development In Toddlers After Maternal SARS-CoV-2 Infection During Pregnancy SARS CoV-2, Developmental Disorder | Enrolling by invitation | Philipps University Marburg | 250 | 2025-04-01 | 2025-05-13 | |
| Cross-Cultural Differences in the Network Structure of Social Anxiety and Body Dysmorphic Symptoms Cross sectional study - Depression, Anxiety | Completed | Philipps University Marburg | 1523 | 2025-03-31 | 2025-05-08 | |
| The Efficacy of Prospective Mental Imagery in Enhancing Approach Motivation Among Socially Anxious Individuals Psychoeducation, Prospective Mental Imagery, Verbal Reasoning - Social Anxiety, Social Phobia | Not applicable | Completed | Philipps University Marburg | 129 | 2025-03-04 | 2026-07-07 |
| Al to Improve the Diagnosis of Rare Rheumatic Diseases ChatGPT - Rheumatic Diseases | Not applicable | Completed | Philipps University Marburg | 68 | 2025-01-07 | 2025-05-29 |
| Pediatric Intensive Care Transport Registry Critical Care Medicine, Transportation of Patients | Recruiting | Philipps University Marburg | 1000 | 2024-11-25 | 2025-07-20 | |
| Evaluating a Digital Intervention for Alleviating Diabetes-specific Emotional Distress in Adults Living With T2DM covivio - Glucose Metabolism Disorders (Including Diabetes Mellitus), Metabolic Disease | Not applicable | Active not recruiting | Gaia AG | 250 | 2024-10-09 | 2026-06-15 |
| Multisite Virtual Reality Intervention for Speech Anxiety Single-session VR exposure intervention - Public Speaking, Speech Anxiety | Not applicable | Completed | Boston University Charles River Campus | 1542 | 2024-10-08 | 2025-12-18 |
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Depression (18) · Anxiety Disorders (7) · Parkinson Disease (7) · COVID-19 (6) · Pulmonary Disease, Chronic Obstructive (6) · Breast Neoplasms (5) · Emotional Regulation (5) · Psychotic Disorders (5) · Phobia, Social (4) · Schizophrenia (4) · Depressive Disorder, Major (3) · Diabetes Mellitus, Type 2 (3) · Epilepsy (3) · Glossophobia (3) · Mental Disorders (3)
Cognitive Behavioral Therapy (8) · Palliative Care (4) · Therapeutics (3) · ACE-011 (2) · Antidepressive Agents (2) · Autogenic Training (2) · Mindfulness (2) · Observation (2) · Waiting Lists (2) · Amisulpride (1) · Amitriptyline (1) · Atropine (1) · BNT162 Vaccine (1) · Bone Wires (1) · CD56 Antigen (1)
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PMID 25830326, PMID 26659569, PMID 28647166, PMID 29627147, PMID 38801091, PMID 39749328, PMID 16968582, PMID 18193350, PMID 18600443, PMID 19045972, PMID 20682676, PMID 22377563, PMID 22455972, PMID 22595362, PMID 22980538, PMID 23446073, PMID 23760766, PMID 23837551, PMID 24435778, PMID 25273302, PMID 25280500, PMID 25467540, PMID 25505396, PMID 25618900, PMID 26094644, PMID 26248510, PMID 26629721, PMID 26655432, PMID 26725462, PMID 26913587, PMID 27109808, PMID 27113231, PMID 27160582, PMID 27405652, PMID 27532739, PMID 27551051, PMID 27741200, PMID 27792735, PMID 27869485, PMID 28069021, PMID 28086884, PMID 28416015, PMID 28434944, PMID 28505167, PMID 28606503, PMID 28806216, PMID 28846584, PMID 28867416, PMID 28915894, PMID 29169740
2015 (1), 2016 (1), 2019 (1), 2025 (1)