87 completed, 33 unknown, 20 recruiting, 11 not yet recruiting. 114 Not applicable, 20 Phase 2, 15 Phase 1, 8 Phase 3, 7 Phase 4.
Follow Phototherapy: new trials by email Literature Review of Phototherapy trials Research Report on Phototherapy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Circadian-Optimized Light Therapy for the Treatment of Patients With Advanced Melanoma Receiving Tumor-Infiltrating Lymphocyte Therapy Biospecimen Collection, Internet-Based Intervention, Medical Device Usage and Evaluation - Advanced Cutaneous Melanoma, Clinical Stage III Cutaneous Melanoma AJCC v8 | Phase 1 | Not yet recruiting | City of Hope Medical Center | 8 | 2026-12-23 | 2026-06-05 |
| A Clinical Trial of the Administration of Light Therapy to Prevent Mouth Sores in Children With Cancer Photobiomodulation for prevention arm, Photobiomodulation for exploratory arm - Mucositis Oral | Not applicable | Not yet recruiting | Medical College of Wisconsin | 50 | 2026-11-01 | 2026-10-06 |
| Comparison Of Fenofibrate Vs Phenobarbitone As Adjunct To Phototherapy In Reducing Total Serum Bilirubin In Indirect Hyperbilirubinemia In Neonates Fenofibrate + Phototherapy, Phenobarbitone + Phototherapy - Jaundice, Neonatal | Phase 4 | Not yet recruiting | Rubab Fatima | 70 | 2026-10-01 | 2026-08-19 |
| Effects of Photobiomodulation on Inflammation and Chronic Pain in Knee Osteoarthritis (EPIC-KO) Photobiomodulation therapy (PBM) device, Sham PBM device - Chronic Knee Pain | Not applicable | Not yet recruiting | University of Florida | 30 | 2026-09-01 | 2026-08-20 |
| A Study Of Phototherapy In Patients With Dementia To Improve BPSD Phototherapy - Dementia | Not applicable | Not yet recruiting | Mayo Clinic | 70 | 2026-08-15 | 2026-07-16 |
| Bilirubin Thresholds in Preterm Infants on Neonatal Intensive CarE Units: The B-NICE Trial Phototherapy, Exchange Transfusion - Neonatal Hyperbilirubinemia, Treatment Decisions | Not applicable | Not yet recruiting | University Medical Center Groningen | 680 | 2026-08-01 | 2026-06-29 |
| Informing Implementation of a Circadian-Focused Intervention for Postpartum Depression Light therapy - Postpartum Depression (PPD) | Not applicable | Recruiting | University of Michigan | 30 | 2026-07-29 | 2026-08-14 |
| Signature Response to Light Therapy in Unipolar and Bipolar Major Depressive Episode (MDE) Light therapy - Major Depressive Episode | Not applicable | Recruiting | Assistance Publique - Hôpitaux de Paris | 173 | 2026-06-17 | 2026-08-12 |
| Light and Sleep Fragmentation Light therapy - Sleep, Mild Cognitive Impairment | Phase 4 | Not yet recruiting | Stanford University | 120 | 2026-06-01 | 2023-08-25 |
| Study of Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes in Vitiligo Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes (hUC-MSC-Exos) Intravenous Infusion, Oral Prednisone, Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes (hUC-MSC-Exos) Local Injection - Vitiligo, Mesenchymal Stem Cells | Phase 1 / Phase 2 | Not yet recruiting | Xijing Hospital | 96 | 2026-04-01 | 2026-04-09 |
| Feasibility of Light Therapy in the Pediatric Intensive Care Unit (ICU) Light Therapy - Circadian Dysregulation, Light Exposure | Not applicable | Recruiting | Laura Beth Kalvas | 30 | 2026-03-26 | 2026-05-22 |
| Melanotan II (MT-II) as an Adjunct to NB-UVB Phototherapy for Repigmentation in Stable Nonsegmental Vitiligo Melanotan II (MT-II), Placebo, Narrowband UV-B (NB-UVB) phototherapy - NonSegmental Vitiligo, Nonsegmental Vitiligo (Stable) | Phase 2 | Recruiting | Hudson Biotech | 60 | 2026-02-02 | 2026-02-27 |
| Effect of Ursodeoxycholic Acid on Indirect Hyperbilirubinemia in Neonates Treated With Phototherapy Phototherapy with placebo, Phototherapy with ursodeoxycholic acid - Hyperbilirubinemia Indirect | Not applicable | Completed | Muhammad Aamir Latif | 220 | 2026-02-01 | 2026-10-09 |
| Bright Light Therapy for Depressed Geriatric Inpatients Bright light therapy, dim red light - Unipolar Depression | Phase 2 | Enrolling by invitation | Medical University of South Carolina | 20 | 2025-11-14 | 2026-04-16 |
| See the Impact Beem's Blue Light Therapy Has on Your Skin Health! Blue Light Therapy - Skin | Not applicable | Recruiting | Efforia, Inc | 100 | 2025-10-06 | 2025-12-23 |
| Predictive and Diagnostic Value of BIND Score in Assessment of Severe Neonatal Jaundice Cases in Neonatal Intensive Care Unit Phototherapy - Neonatal Hyperbilirubinemia | Not yet recruiting | Assiut University | 80 | 2025-10-01 | 2025-09-30 | |
| Low-level Light Therapy Versus Intense Pulsed Light to Prevent Iatrogenic Dry Eye Disease After Cataract Surgery LLLT, IPL - Cataract Surgery, Eye Dryness | Not applicable | Not yet recruiting | Clinique Trenel | 60 | 2025-09-30 | 2025-07-08 |
| Light Therapy on Pain and Synovitis 810 nm Light Therapy, Sham Light Therapy - Knee Pain Chronic, Synovitis of Knee | Not applicable | Recruiting | The Hong Kong Polytechnic University | 80 | 2025-07-13 | 2025-11-26 |
| The Efficacy of Ursodeoxycholic Acid (UDCA) as Adjuvant Therapy to Phototherapy in the Management of Neonatal Indirect Hyperbilirubinemia Phototherapy, ursodeoxycholic acid (UDCA) - Hyperbilirubinemia, Neonatal Indirect | Not applicable | Recruiting | Tishreen University Hospital | 70 | 2025-06-26 | 2026-04-21 |
| Improving Sleep in Veterans With the Polytrauma Clinical Triad Morning Bright Light Therapy, Negative Ion Generator - Traumatic Brain Injury, Post-traumatic Stress Disorder | Not applicable | Recruiting | VA Office of Research and Development | 96 | 2025-05-01 | 2026-06-29 |
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Hyperbilirubinemia, Neonatal (16) · Vitiligo (12) · Depression (11) · Hyperbilirubinemia (11) · Depressive Disorder, Major (9) · Jaundice, Neonatal (8) · Jaundice (7) · Parasomnias (6) · Psoriasis (6) · Mycosis Fungoides (5) · Seasonal Affective Disorder (5) · Sleep Initiation and Maintenance Disorders (5) · Depressive Disorder (4) · Sleep Disorders, Circadian Rhythm (4) · Sleep Wake Disorders (4)
University of Nove de Julho (7) · Mayo Clinic (5) · Roswell Park Cancer Institute (5) · University of Aarhus (5) · Assistance Publique - Hôpitaux de Paris (3) · Assiut University (3) · Henry Ford Health System (3) · InfaCare Pharmaceuticals Corporation, a Mallinckrodt Company (3) · Northwestern University (3) · Russian Academy of Medical Sciences (3) · University of British Columbia (3) · University of Michigan (3) · Amgen (2) · Cairo University (2) · Hospital de Clinicas de Porto Alegre (2)
United States (72) · Brazil (14) · France (11) · Canada (8) · China (8) · Denmark (6) · Taiwan (6) · Egypt (4) · Netherlands (4) · Germany (3) · Pakistan (3) · South Korea (3) · Austria (2) · Belgium (2) · Poland (2)
Jonathan E Elliott, PhD (2) · Kelly J Rohan, Ph.D. (2) · Konstantin V. Danilenko, MD (2) · Murad Alam, MD (2) · Raymond W Lam, MD (2) · Aaron Mangold (1) · Adnan H Dayoub, Prof.Neonat (1) · Afton Hassett (1) · Agneta Markstroem, Ass. Prof. (1) · Alan Robbins, M.D. (1) · Ammar Ahmed, MD (1) · Anna Wirz-Justice, PhD (1) · Anne Cortey, Doctor (1)
PMID 11072777, PMID 12413768, PMID 17053058, PMID 18380206, PMID 19067714, PMID 19651954, PMID 20555351, PMID 21172691, PMID 21182447, PMID 21254315, PMID 21421326, PMID 21535997, PMID 22167295, PMID 22658437, PMID 22802603, PMID 22846406, PMID 23059149, PMID 23172325, PMID 23429094, PMID 23514124, PMID 23520221, PMID 23840645, PMID 24748460, PMID 24919587, PMID 24942380, PMID 24957189, PMID 25187583, PMID 25234100, PMID 25514875, PMID 25859764, PMID 26040789, PMID 26178890, PMID 26539881, PMID 27541148, PMID 27769202, PMID 27869623, PMID 28602137, PMID 28900751, PMID 29603017, PMID 29734184, PMID 29870447, PMID 30054245, PMID 30458636, PMID 30770426, PMID 31526286, PMID 31534356, PMID 31924662, PMID 32089783, PMID 32338720, PMID 32377287
P01CA084203 (2), P30CA016056 (2), 2005 (1), 2009 (1), 2015 (1), 2023 (1), I01RX004822 (1), IK2RX002947 (1), M01RR000051 (1), P30CA033572 (1), R01HL081761 (1), R01MH078982 (1), R01NR021025 (1), R03HD101056 (1), R03MH065946 (1)