33 completed, 5 terminated. 11 Phase 2, 9 Phase 1, 7 Not applicable, 6 Phase 3, 5 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 11 | Completed 10, Terminated 1 |
| Phase 1 | 9 | Completed 9 |
| Not applicable | 7 | Completed 4, Terminated 3 |
| Phase 3 | 6 | Completed 6 |
| Phase 4 | 5 | Completed 4, Terminated 1 |
Follow Desipramine: new trials by email Literature Review of Desipramine trials Research Report on Desipramine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Desipramine in Infantile Neuroaxonal Dystrophy (INAD). Desipramine - Infantile Neuroaxonal Dystrophy | Phase 4 | Terminated | Duke University | 4 | 2019-01-14 | 2020-10-14 |
| Comparing Effectiveness of Duloxetine and Desipramine in Patients With Chronic Pain: A Pragmatic Trial Using Point of Care Randomization Duloxetine, Desipramine - Chronic Pain | Phase 4 | Completed | Stanford University | 86 | 2018-09-20 | 2025-11-06 |
| Effect of Desipramine on Upper Airway Collapsibility and Genioglossus Muscle Activity in Patients With Obstructive Sleep Apnea - Study B Desipramine, Placebo - Sleep Apnea, Obstructive | Phase 2 | Completed | Brigham and Women's Hospital | 16 | 2015-04-01 | 2017-03-30 |
| Effect of Desipramine on Genioglossus Muscle Activity in Healthy Adults Study A Desipramine, Placebo - Sleep Apnea, Obstructive | Phase 2 | Completed | Brigham and Women's Hospital | 17 | 2015-03-01 | 2017-03-30 |
| Desipramine Hydrochloride and Filgrastim For Stem Cell Mobilization in Patients With Multiple Myeloma Undergoing Stem Cell Transplant Desipramine Hydrochloride, Filgrastim, Laboratory Biomarker Analysis - DS (Durie/Salmon) Stage I Plasma Cell Myeloma, DS Stage II Plasma Cell Myeloma | Not applicable | Terminated | Albert Einstein College of Medicine | 10 | 2013-09-01 | 2023-03-28 |
| Phase 2a Desipramine in Small Cell Lung Cancer and Other High-Grade Neuroendocrine Tumors Desipramine HCL - Small Cell Lung Cancer (SCLC), Neuroendocrine Tumors | Phase 2 | Terminated | Joel Neal | 6 | 2012-10-01 | 2017-04-17 |
| A Randomized Trial of Medical and Surgical Treatments for Patients With GERD Symptoms That Are Refractory to Proton Pump Inhibitors Nissen fundoplication, baclofen, Desipramine - GERD | Phase 3 | Completed | VA Office of Research and Development | 366 | 2012-08-13 | 2020-01-22 |
| Risperidone and Desipramine in Alcohol Use and Schizophrenia Risperidone + Desipramine - Schizophrenia, Alcoholism | Phase 2 | Completed | Dartmouth-Hitchcock Medical Center | 12 | 2011-12-01 | 2018-03-23 |
| A Drug Interaction Study to Assess the Effect of LY2603618 on the Metabolic Pathway of Desipramine LY2603618, Desipramine, Pemetrexed - Cancer | Phase 1 | Completed | Eli Lilly and Company | 20 | 2011-06-01 | 2018-10-25 |
| Compare the Pharmacokinetics of Omeprazole, Rosiglitazone, and Desipramine When Administered With Avanafil in Healthy Male Subjects Omeprazole, Rosiglitazone, Desipramine - Erectile Dysfunction | Phase 1 | Completed | VIVUS LLC | 60 | 2010-04-01 | 2011-08-11 |
| Efficacy of Antidepressants in Chronic Back Pain cognitive behavioral therapy, desipramine hydrochloride, benztropine mesylate 0.125 mg daily - Back Pain | Phase 2 | Completed | VA Office of Research and Development | 142 | 2010-01-01 | 2016-11-29 |
| Pilot Study of the Effects of the Desipramine on the Neurovegetative Parameters of the Child With Rett Syndrome Administration of a high dose of desipramine, Administration of a low dose of desipramine, Administration of a placebo - Rett Syndrome | Phase 2 | Completed | Assistance Publique Hopitaux De Marseille | 36 | 2009-02-17 | 2018-07-26 |
| Irritable Bowel Syndrome (IBS) Functional Magnetic Resonance Imaging (fMRI) With Desipramine Desipramine - Irritable Bowel Syndrome | Not applicable | Terminated | Washington University School of Medicine | 18 | 2009-02-01 | 2026-01-22 |
| To Evaluate the Effect of Mirabegron (YM178) on Blood Levels of Desipramine When They Are Taken Together mirabegron, desipramine - Pharmacokinetics of Mirabegron, Healthy Subjects | Phase 1 | Completed | Astellas Pharma Inc | 28 | 2008-10-01 | 2014-04-10 |
| Study Evaluating the Pharmacokinetics of the Potential Drug Interaction Between HCV-796 and Desipramine HCV-796, Desipramine - Healthy | Phase 1 | Completed | Wyeth is now a wholly owned subsidiary of Pfizer | 22 | 2007-06-01 | 2008-04-14 |
| Study Evaluating the Effects of DVS SR and Duloxetine on the Pharmacokinetics of Desipramine in Healthy Subjects desvenlafaxine SR, desipramine, duloxetine - Depression, Depressive Disorder | Phase 3 | Completed | Wyeth is now a wholly owned subsidiary of Pfizer | 20 | 2006-09-01 | 2007-05-28 |
| Pre-Treatment Positron Emission Topography Scanning for Increasing Success in Antidepressant Treatment Escitalopram, Desipramine - Depression | Not applicable | Completed | New York State Psychiatric Institute | 37 | 2006-09-01 | 2019-03-19 |
| Study Evaluating the Effects of DVS SR and Paroxetine on the Pharmacokinetics of Desipramine in Healthy Subjects desvenlafaxine SR, desipramine, paroxetine - Depression | Phase 3 | Completed | Wyeth is now a wholly owned subsidiary of Pfizer | 20 | 2006-05-01 | 2007-12-07 |
| Tricyclic Antidepressants (TCAs) on Gastric Emptying Desipramine, Amitriptyline - Dyspepsia | Not applicable | Terminated | Temple University | 10 | 2005-09-01 | 2021-03-05 |
| Vulvar Vestibulitis Clinical Trial: Desipramine-Lidocaine topical lidocaine + oral desipramine, and/or placebo - Vulvar Disease | Not applicable | Completed | University of Rochester | 128 | 2002-08-01 | 2007-11-14 |
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Depression (14) · Depressive Disorder, Major (6) · Cocaine-Related Disorders (3) · Substance-Related Disorders (3) · Alcoholism (2) · Back Pain (2) · Chronic Pain (2) · Depressive Disorder (2) · Irritable Bowel Syndrome (2) · Sleep Apnea, Obstructive (2) · Abdominal Pain (1) · Agnosia (1) · Anxiety Disorders (1) · Chickenpox (1) · Colonic Diseases, Functional (1)
Sandoz (4) · New York State Psychiatric Institute (3) · Wyeth is now a wholly owned subsidiary of Pfizer (3) · Brigham and Women's Hospital (2) · National Institute on Drug Abuse (NIDA) (2) · US Department of Veterans Affairs (2) · VA Office of Research and Development (2) · Albert Einstein College of Medicine (1) · Assistance Publique Hopitaux De Marseille (1) · Astellas Pharma Inc (1) · Boehringer Ingelheim (1) · Dartmouth-Hitchcock Medical Center (1) · Duke University (1) · Eli Lilly and Company (1) · Emory University (1)
United States (28) · France (2) · Canada (1)
Frank Gawin, M.D. (2) · Jules Kann, M.D. (2) · Jules Kann, Ph.D. (2) · Alan I Green, MD (1) · Andrew Wellman, MD PhD (1) · Andrew Wellman, MD, PhD (1) · Brenda Toner, PhD (1) · Cheryl Gonzalez, M.D. (1) · David C Foster, MD, MPH (1) · Dominique L Musselman, MD,MS (1) · Douglas A. Drossman, M.D. (1) · Gregory S. Sayuk, MD (1)
PMID 15365580, PMID 15913920, PMID 17414235, PMID 17727882, PMID 18378867, PMID 19305326, PMID 19414708, PMID 20733439, PMID 22089316, PMID 23664414, PMID 25220861, PMID 26967681, PMID 29468173, PMID 31618539, PMID 32068667, PMID 33128939
2008 (1), P30CA013330 (1), P50DA009236 (1), R01DA006234 (1), R01DK049334 (1), R01HD040123 (1), R01HL065523 (1), R01MH015413 (1), R01MH074813 (1), R21MH052737 (1)