36 completed, 6 recruiting, 3 terminated, 3 unknown. 54 Phase 1, 12 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 54 | Completed 36, Recruiting 6, Terminated 3, Unknown 3, Withdrawn 3, Active not recruiting 2, Not yet recruiting 1 |
| Phase 2 | 12 | Completed 9, Recruiting 1, Terminated 1, Withdrawn 1 |
Follow Tobacco Use: new trials by email Literature Review of Tobacco Use trials Research Report on Tobacco Use
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Impact of Sweeteners on the Addictive Threshold of Nicotine Nicotine 0.05 mg/pulse and 0.1 mg/pulse, Saline Placebo (0.5mL injection), sucralose - Smoking ( Cigarette) | Phase 1 | Not yet recruiting | Yale University | 36 | 2026-09-01 | 2026-08-31 |
| Effects of Cannabidiol on Stress and Nicotine Withdrawal Epidiolex - CBD, Stress | Phase 1 | Recruiting | Johns Hopkins University | 90 | 2025-08-25 | 2026-08-10 |
| E-cigarette Harm Reduction Among PLWHA in South Africa Nicotine Replacement Therapy (NRT), E-Cigarette (EC), Counseling - Tobacco Smoking | Phase 1 | Completed | NYU Langone Health | 106 | 2025-04-15 | 2026-06-09 |
| Effect of Cannabis on E-Cigarette Use Behavior THC High Dose, THC Low Dose, THC 0mg - Cannabis Use, Tobacco Use | Phase 1 | Recruiting | Johns Hopkins University | 100 | 2025-03-19 | 2026-04-09 |
| Effect of Cannabis on Cigarette Use Behavior THC 30mg, THC 5mg, THC 0mg - Cannabis Use, Tobacco Use | Phase 1 | Recruiting | Johns Hopkins University | 100 | 2025-01-22 | 2026-01-16 |
| Concurrent vs. Sequential Cessation of Dual Cigarette and E-cigarette Use Varenicline, Counseling, Guided Self-Change Booklets - Cigarette Smoking, E-Cigarette Use | Phase 1 | Completed | Yale University | 19 | 2024-04-01 | 2026-11-05 |
| Overcoming Nicotine Dependence to Enable Quitting Nicotine Replacement Therapy (NRT) Sampling, Practice Quitting (PQ) Counseling, Motivational Interviewing (MI) Counseling - Tobacco Use, Smoking Cessation | Phase 1 / Phase 2 | Recruiting | Rush University Medical Center | 780 | 2023-03-24 | 2026-09-09 |
| Oral Cannabidiol for Tobacco Cessation 300 mg Cannabidiol, 600 mg Cannabidiol, Placebo - Tobacco Use, Tobacco Smoking | Phase 1 | Recruiting | Johns Hopkins University | 50 | 2022-11-01 | 2026-01-07 |
| Biomarkers of Exposure and Effect in Standardized Research E-cigarette (SREC) Users Standardized Research E-cigarette (SREC) - Smoking, Cigarette | Phase 1 | Completed | Masonic Cancer Center, University of Minnesota | 47 | 2022-05-11 | 2026-10-15 |
| Nornicotine in Smokeless Tobacco as a Precursor for Carcinogen Exposure Herbal Snuff (Smokeless Tobacco) - Smokeless Tobacco | Phase 1 | Active not recruiting | Masonic Cancer Center, University of Minnesota | 55 | 2021-10-19 | 2025-11-26 |
| Study of EMB-001 as a Potential Smoking Cessation Treatment EMB-001 - Tobacco Use Disorder | Phase 1 / Phase 2 | Terminated | Embera NeuroTherapeutics, Inc. | 13 | 2021-06-10 | 2026-11-05 |
| The Role of Nicotine and Non-Nicotine Alkaloids in E-Cigarette Use and Dependence E-cigarettes - Nicotine Dependence | Phase 1 / Phase 2 | Completed | Duke University | 20 | 2021-05-21 | 2024-02-21 |
| STARS (Smoking Treatment And Remote Sampling) Study Varenicline 0.5 MG, Nicotine Replacement Therapy (NRT) - Smoking, Smoking Cessation | Phase 1 / Phase 2 | Completed | Medical University of South Carolina | 652 | 2021-02-08 | 2026-02-17 |
| Brain Imaging in Tobacco Smokers During a Quit Attempt [F18]-ASEM (3-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-6-[18F]fluorodibenzo[b,d]thiophene 5,5-dioxide), Contingency Management - Tobacco Use Disorder, Tobacco Smoking | Phase 1 | Completed | Johns Hopkins University | 15 | 2019-12-16 | 2024-08-06 |
| Text Messaging-Based Smoking Cessation Program for Homeless Youth Group counseling and nicotine replacement, Group counseling, nicotine replacement, and text messaging support - Cigarette Smoking | Phase 1 / Phase 2 | Completed | RAND | 77 | 2019-05-30 | 2020-07-22 |
| Effects of Random Nicotine Delivery on Smoking Cessation Nicotine Film - Smoking Cessation, Cigarette Smoking | Phase 1 / Phase 2 | Completed | Milton S. Hershey Medical Center | 45 | 2019-03-12 | 2021-01-22 |
| Effects of Nicotine in Tobacco Smokers Cigarette 1, Cigarette 2, Patch 1 - Smoking, Tobacco, Smoking (Tobacco) Addiction | Phase 1 | Completed | University of Southern California | 221 | 2019-02-04 | 2023-07-13 |
| Imaging Sex Differences in Smoking-Induced Pulmonary Inflammation [18F]NOS - Smoking, Cigarette, Smoking E-cigarette | Phase 1 | Recruiting | University of Pennsylvania | 100 | 2018-10-23 | 2026-09-24 |
| Nicotinic Hepatic Metabolism on Neuroreceptor Substrates of Nicotine Addiction 2-[18F]-FA PET/CT, I.V. Nicotine - Smoking, Tobacco | Phase 1 | Active not recruiting | University of Pennsylvania | 13 | 2018-06-28 | 2026-02-03 |
| A Laboratory Model of Increasing Delta-9-tetrahydrocannabinol (THC) Potency on Cigarette Smoking THC - Tobacco Use | Phase 1 | Completed | Battelle Memorial Institute | 9 | 2018-05-07 | 2019-10-02 |
Showing 20 of 54. Sign in to see all of them.
Cigarette Smoking (26) · Tobacco Use Disorder (16) · Smoking (12) · Smoking Cessation (12) · Tobacco Smoking (10) · Marijuana Abuse (4) · Alcoholism (3) · Harm Reduction (3) · Tobacco Use Cessation (3) · Vaping (3) · Behavior, Addictive (2) · Sedentary Behavior (2) · Substance-Related Disorders (2) · Alcohol Drinking (1)
Behavior (54) · Smoking (26) · Tobacco Smoking (24) · Mental Disorders (21) · Chemically-Induced Disorders (19) · Substance-Related Disorders (17) · Health Behavior (15) · Pathological Conditions, Signs and Symptoms (4) · Alcohol-Related Disorders (3) · Compulsive Behavior (2) · Disease Attributes (2) · Impulsive Behavior (2) · Pathologic Processes (2) · Signs and Symptoms (2)
Varenicline (5) · Counseling (4) · Nicotine Replacement Therapy (4) · Tobacco, Smokeless (4) · Dronabinol (3) · Nicotine (3) · Tobacco Use Cessation Devices (3) · Behavior Therapy (2) · Bupropion (2) · Cannabidiol (2) · Cotinine (2) · Electronic Nicotine Delivery Systems (2) · Memantine (2) · Nicotine Chewing Gum (2) · 3-(1,4-diazabicyclo(3.2.2)nonan-4-yl)-6-fluorodibenzo(b,d)thiophene 5,5-dioxide (1)
Johns Hopkins University (5) · Contract Research Organization el AB (3) · Duke University (3) · University of California, Los Angeles (3) · Yale University (3) · 22nd Century Group, Inc. (2) · Boston Children's Hospital (2) · Masonic Cancer Center, University of Minnesota (2) · National Institute on Drug Abuse (NIDA) (2) · New York State Psychiatric Institute (2) · University of California, San Francisco (2) · University of North Carolina, Chapel Hill (2) · University of Pennsylvania (2) · Alexza Pharmaceuticals, Inc. (1) · Battelle Memorial Institute (1)
United States (46) · Sweden (3) · South Africa (1) · South Korea (1) · United Kingdom (1)
Erik Lunell, MD, PhD (3) · Adam Bisaga, M.D. (2) · Debra Kelsh, MD (2) · Dustin Lee, PhD (2) · Irina Stepanov, PhD (2) · John R. Knight, MD (2) · Lisa Fucito, PhD (2) · Neal L Benowitz, MD (2) · Adam M Leventhal, PhD (1) · Amanda Mathew, PhD (1) · Bruce McCarthy, MD (1) · Christi A Patten, P (1) · Christopher Sciamanna, MD (1) · David Peden (1) · Dustin C Lee, PhD (1)
PMID 33605440, PMID 19050988, PMID 27896797, PMID 28725452, PMID 29139311, PMID 32075695, PMID 33792551, PMID 33852730, PMID 34375409, PMID 42101840
R01DA017572 (2), R01DA058624 (2), 271201400069C-0-0-1 (1), 271201500019C-0-0-1 (1), F31DA040369 (1), K23AA020000 (1), K24DA023464 (1), P50CA196530 (1), R01DA025156 (1), R01DA027232 (1), R01DA038554 (1), R01MH078596 (1), R21DA038775 (1), R21DA045744 (1), R21DA047795 (1)