65 completed, 12 recruiting, 5 terminated, 4 unknown. 92 Phase 2, 12 Phase 1, 8 Phase 3.
Follow Tobacco Use: new trials by email Literature Review of Tobacco Use trials Research Report on Tobacco Use
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| THCV Treatment for Smokers Δ9-Tetrahydrocannabivarin (oral gummy), Matched Placebo (oral gummy) - Tobacco Use Disorder, Smoking Cessation | Phase 2 | Not yet recruiting | University of California, Los Angeles | 32 | 2026-10-01 | 2026-08-04 |
| GLP-1 Receptor Agonists to Decrease Ethanol and CVD Risk in HIV Semaglutide (Rybelsus®), Placebo - HIV, Alcohol | Phase 2 | Recruiting | Vanderbilt University Medical Center | 200 | 2026-04-17 | 2026-05-26 |
| Understanding the Clinical Pharmacology of Marijuana-Tobacco Co-administration Cannabis, Nicotine, Pax Loose Leaf Vaporizer - THC, Cannabis | Phase 2 | Recruiting | University of California, San Francisco | 48 | 2025-07-01 | 2026-01-07 |
| Neural Mechanisms Connecting Deficient Sleep and Smoking Relapse Experimental health intervention, Varenicline - Tobacco Use, Tobacco Cessation | Phase 2 | Recruiting | Yale University | 114 | 2025-04-21 | 2026-06-05 |
| Examining the Effects of Cytisinicline on Neural Substrates of Cigarette Cue-reactivity Cytisinicline, Placebo Oral Capsule - Smoking Cessation, Tobacco Use Disorder | Phase 2 | Recruiting | University of California, Los Angeles | 64 | 2024-12-05 | 2025-12-03 |
| Cannabidiol for Reducing Cigarette Use Cannabidiol (CBD) 800 mg, Placebo - Tobacco Use Disorder, Tobacco Smoking | Phase 2 | Recruiting | University of California, Los Angeles | 120 | 2024-10-31 | 2026-04-13 |
| E-Cigarettes for Harm Reduction in Smokers With Opioid Use Disorder Telehealth Motivational Counseling, Nicotine Replacement Product, National Institute on Drug Abuse (NIDA) Standardized Research Electronic Cigarette (SREC). - Opioid Use Disorder, Cigarette Smoking | Phase 2 | Recruiting | NYU Langone Health | 302 | 2024-08-08 | 2026-11-09 |
| Semaglutide for Post-Smoking Cessation Weight Management semaglutide 2.4mg, Placebo, Nicotine Replacement Therapy (NRT, nicotine patch) - Obesity, Overweight | Phase 2 | Recruiting | The University of Texas Health Science Center, Houston | 197 | 2024-04-23 | 2026-09-21 |
| Breathe Easier With Tadalafil Therapy for Dyspnea in COPD-PH Tadalafil, Placebo - Chronic Obstructive Pulmonary Disease, Pulmonary Hypertension | Phase 2 | Recruiting | VA Office of Research and Development | 126 | 2024-04-01 | 2026-05-15 |
| Dyadic Financial Incentive Treatments for Dual Smoker Couples Financial Incentive Treatment (FIT) - Smoking, Cigarette | Phase 2 | Recruiting | University of Oklahoma | 900 | 2024-01-18 | 2026-04-29 |
| CAN-DOSE Study: Cessation With Augmented Nicotine for Dual Use Of Smoking and E-cigarettes Regular Nicotine patch and lozenge dose, Augmented Nicotine patch and lozenge dose - Smoking Cessation, Electronic Cigarette Use | Phase 2 | Completed | Medical University of South Carolina | 46 | 2023-12-05 | 2025-11-26 |
| 5-HT2A Agonist Psilocybin in the Treatment of Tobacco Use Disorder Psilocybin, Niacin - Tobacco Use Disorder | Phase 2 | Recruiting | Johns Hopkins University | 66 | 2023-11-01 | 2026-06-29 |
| Free Samples for Health Ask-Advise-Refer, Nicotine Patch, 14 Mg/24 Hr Transdermal Film, Extended Release, Nicotine lozenge - Cigarette Smoking | Phase 2 | Completed | Sandra Japuntich | 1239 | 2023-06-12 | 2026-07-24 |
| Overcoming Nicotine Dependence to Enable Quitting Nicotine Replacement Therapy (NRT) Sampling, Practice Quitting (PQ) Counseling, Motivational Interviewing (MI) Counseling - Tobacco Use, Smoking Cessation | Phase 1 / Phase 2 | Recruiting | Rush University Medical Center | 780 | 2023-03-24 | 2026-09-09 |
| Exenatide for Smoking Cessation and Prevention of Weight Gain Exenatide 2 milligram (mg) Injection, Placebo, Nicotine patch - Smoking Cessation, Weight Gain | Phase 2 | Completed | The University of Texas Health Science Center, Houston | 140 | 2022-12-07 | 2026-03-23 |
| Semaglutide for Alcohol Use Disorder Semaglutide, Sham/placebo - Alcohol Use Disorder, Cigarette Smoking | Phase 2 | Completed | University of North Carolina, Chapel Hill | 48 | 2022-09-02 | 2025-04-02 |
| Mobile Health Technology for Personalized Tobacco Cessation Support in Laos Nicotine patch, Self-help materials (to support smoking cessation), Smartphone-based automated treatment for smoking cessation - Cigarette Smoking | Phase 2 | Recruiting | University of Oklahoma | 500 | 2022-04-27 | 2025-08-15 |
| Mobile Health Technology for Personalized Tobacco Cessation Support Among Cancer Survivors in Laos Nicotine patch, Self-help materials (to support smoking cessation), Smartphone-based automated treatment for smoking cessation - Cigarette Smoking | Phase 2 | Completed | University of Oklahoma | 80 | 2022-04-20 | 2024-08-28 |
| Incentives for Oklahoma Tobacco Helpline Engagement in Persistent Poverty Counties Coaching calls, Nicotine replacement therapy, Financial Incentives - Cigarette Smoking, Nicotine Dependence | Phase 2 | Completed | University of Oklahoma | 165 | 2022-03-09 | 2024-12-30 |
| Heart Rate Variability Biofeedback for Smoking Cessation Treatment Cognitive-Behavioral Smoking Cessation, Heart Rate Variability Biofeedback, Nicotine patch - Tobacco Smoking | Phase 2 | Completed | Rutgers, The State University of New Jersey | 28 | 2021-11-29 | 2024-05-01 |
Showing 20 of 92. Sign in to see all of them.
Cigarette Smoking (59) · Smoking Cessation (33) · Tobacco Use Disorder (31) · Smoking (21) · Tobacco Smoking (13) · Vaping (7) · Tobacco Use Cessation (6) · Alcoholism (4) · Behavior, Addictive (4) · Schizophrenia (4) · Alcohol Drinking (3) · Depression (3) · Marijuana Abuse (3) · Obesity (3)
Behavior (92) · Tobacco Smoking (56) · Smoking (54) · Mental Disorders (43) · Health Behavior (39) · Chemically-Induced Disorders (36) · Substance-Related Disorders (34) · Pathological Conditions, Signs and Symptoms (12) · Signs and Symptoms (7) · Pathologic Processes (6) · Alcohol-Related Disorders (4) · Body Weight (4) · Compulsive Behavior (4) · Impulsive Behavior (4)
Tobacco Use Cessation Devices (23) · Nicotine Replacement Therapy (11) · Nicotine (9) · Varenicline (9) · Bupropion (5) · Electronic Nicotine Delivery Systems (5) · Cognitive Behavioral Therapy (4) · Sugars (4) · Behavior Therapy (3) · Counseling (3) · semaglutide (3) · Biofeedback, Psychology (2) · Crisis Intervention (2) · Mecamylamine (2) · S-Adenosylmethionine (2)
Duke University (8) · Mayo Clinic (5) · Oregon Research Institute (4) · University of California, Los Angeles (4) · University of Oklahoma (4) · Medical University of South Carolina (3) · Yale University (3) · Boston Children's Hospital (2) · Brown University (2) · Johns Hopkins University (2) · NYU Langone Health (2) · National Institute on Drug Abuse (NIDA) (2) · New York State Psychiatric Institute (2) · RAND (2) · Rutgers, The State University of New Jersey (2)
United States (83) · Denmark (2) · Laos (2) · Russia (1)
Jed E Rose, Ph.D. (5) · Christian Hendershot, Ph.D. (2) · Christian Meyer, Dr. (2) · Herbert H. Severson, PhD (2) · James M Davis, M.D. (2) · Jed E. Rose, Ph.D. (2) · John R. Knight, MD (2) · Jon O Ebbert, MD (2) · Judith S. Gordon, Ph.D (2) · Laura MacPherson, PhD (2) · Luba Yammine, PhD (2) · Ulrich John, Prof. Dr. (2) · Adam M Leventhal, PhD (1) · Amanda Mathew, PhD (1)
PMID 33605440, PMID 37142273, PMID 17652247, PMID 18480694, PMID 18686184, PMID 19050988, PMID 19786427, PMID 20081039, PMID 20093899, PMID 20211945, PMID 20466951, PMID 20675426, PMID 21565525, PMID 21656058, PMID 21785892, PMID 22007015, PMID 22157229, PMID 23454876, PMID 23873976, PMID 25886752, PMID 25914872, PMID 27094910, PMID 27349898, PMID 27449226, PMID 27535024, PMID 29054128, PMID 31589323, PMID 32075695, PMID 32608505, PMID 33593332, PMID 33792551, PMID 33852730, PMID 34375409, PMID 34611902, PMID 35930287, PMID 37230961, PMID 37316311, PMID 37682573, PMID 38663460, PMID 39198824, PMID 39477130, PMID 39868569, PMID 39937469, PMID 40409566, PMID 40554081, PMID 40736921, PMID 42101840, PMID 42166710
P50DA027840 (5), R34DA043751 (2), 2005 (1), I01CX002543 (1), K01MD015295 (1), K23DA022471 (1), P30CA068485 (1), P30CA225520 (1), P60AA032176 (1), R01CA084225 (1), R01CA107442 (1), R01DA017947 (1), R01DA017972 (1), R01DA018730 (1), R01DA023507 (1)