11 completed, 5 terminated, 2 recruiting, 2 withdrawn. 24 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 24 | Completed 11, Terminated 5, Recruiting 2, Withdrawn 2, Active not recruiting 1, Enrolling by invitation 1, Not yet recruiting 1, Unknown 1 |
Follow Thoracic Injuries: new trials by email Literature Review of Thoracic Injuries trials Research Report on Thoracic Injuries
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Perioperative Lidocaine for Lung Protection in Infants Undergoing Cardiac Surgery Lidocaine %2 ampoule, Normal Saline (0.9% NaCl) - Congenital Heart Disease, Postoperative Pulmonary Complications | Phase 4 | Not yet recruiting | The Children's Hospital of Zhejiang University School of Medicine | 320 | 2026-04-01 | 2026-03-30 |
| Suzetrigine for Acute Pain Control in Patients With Multiple Rib Fractures Suzetrigine (SUZ), Placebo - Rib Fractures | Phase 4 | Enrolling by invitation | University of California, Irvine | 80 | 2025-11-13 | 2025-12-08 |
| INTERCOSTAL NERVE BLOCK: Efficacy of CINB for Patients With Multiple Rib Fractures Ropivacaine, Non steroidal anti-inflammatory drug and opioids - Rib Fractures | Phase 4 | Recruiting | Zachary Warriner | 180 | 2025-09-23 | 2026-10-29 |
| Cryo Rib Fracture Study Cryoablation, ESP Catheter - Rib Fractures | Phase 4 | Recruiting | University of Minnesota | 48 | 2025-01-10 | 2026-02-17 |
| Analgesic Techniques for Rib Fractures ESP block with catheter using ropivacaine (bolus followed by continuous infusion), Lidocaine bolus (1 mg/kg) and infusion starting at 1 mg/kg/h - Rib Fractures | Phase 4 | Active not recruiting | Thomas Jefferson University | 24 | 2024-09-23 | 2025-09-09 |
| Ibuprofen Versus Dexketoprofen in Rib Fractures Ibuprofen 800 mg, Dexketoprofen 50 mg - Rib Fracture | Phase 4 | Completed | Ankara City Hospital Bilkent | 128 | 2024-01-01 | 2026-10-06 |
| Lidocaine Patches in Elderly Patients With Traumatic Rib Fractures Placebo Patch, 4% Lidocaine Patch - Rib Fractures | Phase 4 | Terminated | Medical College of Wisconsin | 5 | 2023-10-01 | 2026-07-08 |
| Pragmatic Research on Diuretic Management in Early BPD Pilot Furosemide (plus potassium chloride), Placebo (plus placebo electrolyte solution) - Bronchopulmonary Dysplasia | Phase 4 | Completed | Children's Hospital Medical Center, Cincinnati | 19 | 2023-08-17 | 2026-07-14 |
| Dexmedotomidine for Acute Pain Control in Patients With Multiple Rib FracturesRandomized Controlled Trial Dexmedetomidine, Placebo - Rib Fractures, Pain, Acute | Phase 4 | Completed | University of California, Irvine | 41 | 2021-11-12 | 2026-03-25 |
| Lidocaine Spray for Pain Control in Rib Fractures Lidocaine topical - Rib Fractures, Analgesia | Phase 4 | Completed | Ankara City Hospital Bilkent | 48 | 2021-06-01 | 2022-08-17 |
| Continuous Erector Spinae Plane Blocks for Rib Fractures Active ropivacaine 0.3% erector spinae plane perineural administration, Placebo erector spinae plane perineural administration - Rib Fractures, Trauma | Phase 4 | Terminated | University of California, San Diego | 4 | 2021-05-23 | 2023-06-12 |
| Ketamine vs Lidocaine in Traumatic Rib Fractures Ketamine, Lidocaine - Rib Fractures, Rib Fracture Multiple | Phase 4 | Completed | Brittany Hoyte | 61 | 2021-04-01 | 2026-11-04 |
| Continuous Intravenous Lidocaine Infusion Versus Placebo for Rib Fracture Analgesia Saline infusion, Lidocaine infusion - Rib Fractures | Phase 4 | Terminated | Stanford University | 1 | 2020-02-10 | 2023-11-30 |
| Effect of Coolant Spray on Traumatic Rib Pain of Geriatric Patients Coolant spray (Cryos ®Spray, Phyto Performance, Italy), Saline solution - Thorax; Fracture, Pain; Thorax, Thoracic, Spine, With Radicular and Visceral Pain | Phase 4 | Completed | Ataturk University | 101 | 2019-10-01 | 2021-06-24 |
| US-guided SAPB for Rib Fractures in the ED Bupivacaine, Fentanyl, morphine, hydromorphone, hydrocodone, acetaminophen, ketorolac, gabapentin, ketamine, ibuprofen - Rib Fractures, Rib Fracture Multiple | Phase 4 | Unknown | Andrew A Herring | 70 | 2018-11-06 | 2018-12-19 |
| Lidocaine Infusions for Rib Fractures Lidocaine infusion, Saline infusion - Rib Fracture Multiple, Trauma Chest | Phase 4 | Withdrawn | Stanford University | 2018-06-15 | 2021-06-28 | |
| Trial of Injected Liposomal Bupivacaine vs Bupivacaine Infusion After Surgical Stabilization of Rib Fractures Liposomal bupivacaine injection, Bupivacaine indwelling catheter - Drug Effect, Rib Fractures | Phase 4 | Completed | Denver Health and Hospital Authority | 36 | 2017-10-05 | 2021-09-29 |
| Ketamine Infusion Therapy for the Management of Acute Pain in Adult Rib Fracture Patients Ketamine, Placebo, Intercostal Nerve Block - Wounds and Injuries, Rib Fractures | Phase 4 | Completed | Medical College of Wisconsin | 153 | 2015-09-01 | 2020-02-05 |
| Dexmedetomidine for Non-invasive Ventilation After Chest Trauma Dexmedetomidine, Placebo - Thoracic Injuries | Phase 4 | Completed | University Hospital, Grenoble | 20 | 2015-09-01 | 2017-03-09 |
| Exparel for Pain Control During Care of Rib Fractures EXPAREL - Pain | Phase 4 | Withdrawn | Michael Moncure, MD | 2015-04-01 | 2017-01-19 |
Showing 20 of 24. Sign in to see all of them.
Rib Fractures (19) · Pain (5) · Agnosia (4) · Lung Injury (3) · Acute Pain (2) · Emergencies (2) · Wounds and Injuries (2) · Acute Lung Injury (1) · Bronchopulmonary Dysplasia (1) · Disease (1) · Flail Chest (1) · Fractures, Bone (1) · Heart Defects, Congenital (1) · Inflammation (1)
Wounds and Injuries (22) · Fractures, Bone (18) · Pathological Conditions, Signs and Symptoms (12) · Neurologic Manifestations (9) · Signs and Symptoms (9) · Nervous System Diseases (5) · Neurobehavioral Manifestations (4) · Pathologic Processes (4) · Perceptual Disorders (4) · Lung Diseases (3) · Respiratory Tract Diseases (3) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (2) · Disease Attributes (2) · Cardiovascular Abnormalities (1)
Ibuprofen (3) · Ketamine (3) · Acetaminophen (2) · Analgesics, Opioid (2) · Dexmedetomidine (2) · Fentanyl (2) · Lidocaine (2) · Morphine (2) · Saline Solution (2) · Anti-Inflammatory Agents, Non-Steroidal (1) · Bupivacaine (1) · Cryosurgery (1) · Furosemide (1) · Gabapentin (1) · Hydrocodone (1)
Ankara City Hospital Bilkent (2) · Medical College of Wisconsin (2) · Stanford University (2) · University of California, Irvine (2) · Andrew A Herring (1) · Ataturk University (1) · Brittany Hoyte (1) · Children's Hospital Medical Center, Cincinnati (1) · Denver Health and Hospital Authority (1) · Michael Moncure, MD (1) · Oregon Health and Science University (1) · The Children's Hospital of Zhejiang University School of Medicine (1) · The Cooper Health System (1) · Thomas Jefferson University (1) · University Hospital, Clermont-Ferrand (1)
United States (17) · Turkey (Türkiye) (3) · France (2) · Canada (1) · China (1)
Ahmet Burak Erdem, M.D. (1) · Andrew Herring, MD (1) · Anna Maria Hibbs, MD, MSCE (1) · Arun Nagdev, MD (1) · Brian M Ilfeld, MD, MS (1) · Cynthia R Fusco, DO (1) · Daniel Mantuani, MD, MPH (1) · Eben Clattenburg, MD (1) · Eric Schwenk, MD (1) · Fredric Pieracci, MD MPH (1) · Heather Kaplan, MD, MSCE (1) · Jeff Choi, MD (1) · Jeffry Nahmias, MD (1) · John C Mayberry, MD, FACS (1) · John J Finneran IV, MD (1)
PMID 19934395, PMID 23706726, PMID 27611637, PMID 27812971, PMID 29149140, PMID 30376537, PMID 33951024, PMID 40900569
R34HL158586 (1)