1018 completed, 328 unknown, 314 recruiting, 130 terminated. 667 Not applicable, 179 Phase 2, 132 Phase 3, 98 Phase 1, 78 Phase 4.
Follow Heart Defects, Congenital: new trials by email Literature Review of Heart Defects, Congenital trials Research Report on Heart Defects, Congenital
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Clinical Trial of a MEK Inhibitor for RASopathy-Associated Severe Infantile Hypertrophic Cardiomyopathy: Baby MERIT Trametinib - HCM, Noonan Syndrome and Other Rasopathy | Phase 3 | Not yet recruiting | Carelon Research | 25 | 2027-08-01 | 2026-09-14 |
| TORCH-LATAM-003: Regional Advanced-Therapy Pathways for Congenital Heart Disease TORCH Congenital Advanced Therapies Pathway (TORCH-CATP) - Congenital Heart Disease, Advanced Heart Failure | Not applicable | Not yet recruiting | CardioVision International Tech, S.A.S. de C.V. | 360 | 2027-03-30 | 2026-10-13 |
| WSO BEAT STROKE Initiative Educational and implementation Neurocardiology tool, No educational or implementation tool will be provided - Stroke, PFO - Patent Foramen Ovale | Not applicable | Not yet recruiting | Luciano A. Sposato | 2400 | 2027-03-01 | 2026-09-18 |
| TORCH-LATAM: A Regional Pathway to Improve Transplant Evaluation for Congenital Heart Disease TORCH Integrated Transplant Access Pathway (TORCH-ITAP) - Congenital Heart Disease | Not applicable | Not yet recruiting | CardioVision International Tech, S.A.S. de C.V. | 600 | 2027-03-01 | 2026-10-13 |
| Fetal Aortic Valvuloplasty for Evolving Hypoplastic Left Heart Syndrome Fetal Aortic Valvuloplasty Procedure, Emerge Monorail and Over-The-Wire PTCA Dilatation Catheter, Trek RX and Mini Trek RX Coronary Dilatation Catheter - Hypoplastic Left Heart Syndrome | Not applicable | Enrolling by invitation | Mauro H. Schenone | 80 | 2027-01-01 | 2026-05-01 |
| Radiological Markers for PDA Management in Preterm Infants Organ doppler, Echocardiography - Patent Ductus Arteriosus in Preterm Infants | Not applicable | Not yet recruiting | Assiut University | 88 | 2027-01-01 | 2026-09-10 |
| Influence of Lung Volume Optimization Maneuver on Cardiac Output and Lung Compliance in Ventilated Children With Congenital Heart Disease Undergoing Surgical Repair End-expiratory lung volume optimization maneuver with PEEP titration, Standard Care (in control arm) - Congenital Heart Disease, Cardiopulmonary Bypass | Phase 1 / Phase 2 | Not yet recruiting | Charite University, Berlin, Germany | 80 | 2027-01-01 | 2026-10-15 |
| Adaptive Digital Exercise Rehabilitation for Children After CHD Surgery JITAI-Based Digital Exercise Rehabilitation Program, Standard Exercise Rehabilitation Program - Congenital Heart Disease (CHD), Congenital Heart Disease in Children | Not applicable | Not yet recruiting | The Children's Hospital of Zhejiang University School of Medicine | 130 | 2026-12-30 | 2026-05-08 |
| Physical Activity and Functional Capacity in Patients With Congenital Long QT Syndrome Questionnaires, Cardiopulmonary exercise testing, 24-hour Holter monitoring - Long QT Syndrome, Channelopathies | Not yet recruiting | University of Sao Paulo | 120 | 2026-11-01 | 2026-10-07 | |
| Comparison of the Best Method for Measuring Anti-Xa Activity in Children Receiving Unfractionated Heparin in Cardiac Intensive Care (COMPAXE-HNF) blood sampling for measuring anti-Xa activity, measurement of anti-XA activity - Congenital Heart Disease, Unfractionated Heparin | Not applicable | Not yet recruiting | Centre Hospitalier Universitaire de la Réunion | 22 | 2026-11-01 | 2026-09-21 |
| Dapagliflozin and Right Heart Recovery After ASD Device Closure trans catheter device closure - ASD2(Secundum Atrial Septal Defect) | Not applicable | Not yet recruiting | Assiut University | 70 | 2026-11-01 | 2026-09-17 |
| UltraTrac for Cardiac Output Monitoring in Congenital Heart Disease UltraTrac - Congenital Heart Disease, Cardiac Output | Not applicable | Not yet recruiting | University of Minnesota | 70 | 2026-11-01 | 2026-10-08 |
| MAGiC - Congenital Heart DIsease Cardiac ablation using the MAGiC Ablation Catheter - Supraventricular Tachycardia (SVT), Congenital Heart Disease (CHD) | Not yet recruiting | Stereotaxis | 40 | 2026-10-31 | 2026-09-10 | |
| Migraine Headaches Elimination With Patent Foramen Ovale-Directed Therapy Prasugrel 5mg, Transcatheter Closure of Patent Foramen Ovale - Migraine Disease, Patent Foramen Ovale | Phase 3 | Recruiting | Columbia University | 32 | 2026-10-15 | 2026-10-08 |
| RVOT Stenting Versus Surgical RV-PA Conduit in Cyanotic Adults Cyanotic Congenital Heart Disease, Right Ventricular Outflow Tract Obstruction | Not yet recruiting | Assiut University | 30 | 2026-10-10 | 2026-10-08 | |
| Echocardiographic Assessment of Valvular Dysfunction in Children With CHD Congenital Heart Disease, Valvular Heart Disease | Not yet recruiting | Assiut University | 100 | 2026-10-10 | 2026-10-08 | |
| Starry-Sky Projection and Maternal Voice for Sleep After Pediatric Cardiac Surgery Starry-Sky Projection, Conventional Lighting, Maternal Voice - Congenital Heart Disease (CHD), Postoperative Sleep | Not applicable | Not yet recruiting | Shanghai Jiao Tong University School of Medicine | 172 | 2026-10-08 | 2026-10-02 |
| First-in-human Clinical Trial to Assess Safety and Efficacy of the CardiaZn Bioresorbable Stent in Children With Pulmonary Artery Stenosis and Aortic Coarctation CardiaZn Bioresorbable Stent - Aortic Coarctation, Pulmonary Artery Stenosis | Not applicable | Not yet recruiting | PediaStent LLC | 45 | 2026-10-01 | 2026-06-04 |
| The Effect of Telerehabilitation Exercises in Children With Congenital Heart Disease Inspiratory Muscle Training, Functional Inspiratory Muscle Training - Congenital Heart Disease, Telerehabilitation | Not applicable | Not yet recruiting | Izmir Democracy University | 32 | 2026-10-01 | 2026-10-02 |
| International Multicenter Outcomes of Transcatheter Pulmonary Flow Restrictors in Congenital and Acquired Heart Disease Transcatheter pulmonary flow restriction - Congenital Heart Disease | Enrolling by invitation | Fondation Hôpital Saint-Joseph | 150 | 2026-10-01 | 2026-09-15 |
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Ductus Arteriosus, Patent (137) · Foramen Ovale, Patent (135) · Turner Syndrome (124) · Long QT Syndrome (101) · Tetralogy of Fallot (90) · Univentricular Heart (85) · Heart Septal Defects, Atrial (81) · Hypoplastic Left Heart Syndrome (67) · Heart Failure (64) · Bicuspid Aortic Valve Disease (62) · Marfan Syndrome (61) · Heart Diseases (54) · Heart Septal Defects, Ventricular (52) · Cardiovascular Diseases (51)
Cardiovascular Abnormalities (2074) · Congenital Abnormalities (2068) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (2067) · Cardiovascular Diseases (2034) · Heart Diseases (2001) · Pathological Conditions, Signs and Symptoms (407) · Genetic Diseases, Inborn (346) · Pathologic Processes (325) · Heart Septal Defects (247) · Vascular Diseases (223) · Urogenital Diseases (222) · Abnormalities, Multiple (220) · Female Urogenital Diseases and Pregnancy Complications (220) · Nervous System Diseases (207)
Ibuprofen (34) · Acetaminophen (30) · Human Growth Hormone (30) · Blood Specimen Collection (26) · Saline Solution (20) · Echocardiography (18) · Sodium Chloride (18) · Exercise (16) · Exercise Test (16) · Dexmedetomidine (15) · Indomethacin (13) · Surgical Procedures, Operative (13) · Losartan (11) · Surveys and Questionnaires (11) · Clopidogrel (10)
Boston Children's Hospital (47) · Assiut University (40) · Emory University (36) · The Hospital for Sick Children (26) · University of Aarhus (25) · University Hospital, Montpellier (23) · National Heart, Lung, and Blood Institute (NHLBI) (22) · Assistance Publique - Hôpitaux de Paris (21) · Stanford University (20) · University of Alberta (19) · Abbott Medical Devices (18) · Children's Healthcare of Atlanta (17) · Children's Hospital Medical Center, Cincinnati (17) · China National Center for Cardiovascular Diseases (17) · Novo Nordisk A/S (17)
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Cathy Hammerman, MD (6) · M. Louise Markert, MD, PhD (5) · William Mahle, MD (5) · William T Mahle, MD (5) · Alexander Egbe, MBBS, MPH (4) · Andrew S Mackie, MD, SM (4) · Brian Kogon, MD (4) · Brian McCrindle, MD (4) · Muhammad Y Qureshi, MBBS (4) · Shoujun Li, MD (4)
PMID 18035553, PMID 18424759, PMID 18557726, PMID 19066739, PMID 20236866, PMID 33112424, PMID 17284531, PMID 37979797, PMID 12084585, PMID 22065264, PMID 36519620, PMID 42002216, PMID 15100156, PMID 17307535, PMID 17911499, PMID 18155964, PMID 19127223, PMID 20978268, PMID 21600541, PMID 22939929, PMID 23228403, PMID 23258386, PMID 23477994, PMID 23607606, PMID 23735475, PMID 23972966, PMID 26283668, PMID 27444506, PMID 27609682, PMID 29222139, PMID 29367212, PMID 31419019, PMID 31487545, PMID 31722151, PMID 32381162, PMID 33045104, PMID 33748192, PMID 33826508, PMID 34032839, PMID 34039015, PMID 36713022, PMID 36858690, PMID 36891906, PMID 36978128, PMID 37435053, PMID 37844519, PMID 38072392, PMID 38768982, PMID 39526355, PMID 40665900
2023 (7), K12HD043494 (7), R01AI047040 (7), U01HL068270 (7), R01AI054843 (6), 2016 (5), U54HL096458 (5), 2019 (4), R56AI047040 (4), 2008 (3), 2014 (3), 2015 (3), 2025 (3), R01HL160761 (3), U01HL068269 (3)