1310 completed, 433 unknown, 388 recruiting, 166 terminated. 887 Not applicable, 257 Phase 2, 165 Phase 3, 129 Phase 1, 97 Phase 4.
Follow Cardiovascular Abnormalities: new trials by email Literature Review of Cardiovascular Abnormalities trials Research Report on Cardiovascular Abnormalities
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Clinical Trial of a MEK Inhibitor for RASopathy-Associated Severe Infantile Hypertrophic Cardiomyopathy: Baby MERIT Trametinib - HCM, Noonan Syndrome and Other Rasopathy | Phase 3 | Not yet recruiting | Carelon Research | 25 | 2027-08-01 | 2026-09-14 |
| TORCH-LATAM-003: Regional Advanced-Therapy Pathways for Congenital Heart Disease TORCH Congenital Advanced Therapies Pathway (TORCH-CATP) - Congenital Heart Disease, Advanced Heart Failure | Not applicable | Not yet recruiting | CardioVision International Tech, S.A.S. de C.V. | 360 | 2027-03-30 | 2026-10-13 |
| WSO BEAT STROKE Initiative Educational and implementation Neurocardiology tool, No educational or implementation tool will be provided - Stroke, PFO - Patent Foramen Ovale | Not applicable | Not yet recruiting | Luciano A. Sposato | 2400 | 2027-03-01 | 2026-09-18 |
| TORCH-LATAM: A Regional Pathway to Improve Transplant Evaluation for Congenital Heart Disease TORCH Integrated Transplant Access Pathway (TORCH-ITAP) - Congenital Heart Disease | Not applicable | Not yet recruiting | CardioVision International Tech, S.A.S. de C.V. | 600 | 2027-03-01 | 2026-10-13 |
| Fetal Aortic Valvuloplasty for Evolving Hypoplastic Left Heart Syndrome Fetal Aortic Valvuloplasty Procedure, Emerge Monorail and Over-The-Wire PTCA Dilatation Catheter, Trek RX and Mini Trek RX Coronary Dilatation Catheter - Hypoplastic Left Heart Syndrome | Not applicable | Enrolling by invitation | Mauro H. Schenone | 80 | 2027-01-01 | 2026-05-01 |
| Radiological Markers for PDA Management in Preterm Infants Organ doppler, Echocardiography - Patent Ductus Arteriosus in Preterm Infants | Not applicable | Not yet recruiting | Assiut University | 88 | 2027-01-01 | 2026-09-10 |
| Influence of Lung Volume Optimization Maneuver on Cardiac Output and Lung Compliance in Ventilated Children With Congenital Heart Disease Undergoing Surgical Repair End-expiratory lung volume optimization maneuver with PEEP titration, Standard Care (in control arm) - Congenital Heart Disease, Cardiopulmonary Bypass | Phase 1 / Phase 2 | Not yet recruiting | Charite University, Berlin, Germany | 80 | 2027-01-01 | 2026-10-15 |
| A First-In-Man Study to Assess Safety and Efficacy of Ultra High Pressure PTA Balloon ULTRAVIOLET in Treating A-V Fistula Stenosis PTA balloon - Arterio-venous Fistula, Stenosis of Arteriovenous Dialysis Fistula | Not applicable | Not yet recruiting | Cardionovum GmbH | 35 | 2027-01-01 | 2026-10-20 |
| Phase 1b Study of TX002100 in Participants With Hematologic Support-Dependent Hereditary Hemorrhagic Telangiectasia (HHT) TX002100 - Hereditary Hemorrhagic Telangiectasia (HHT) | Phase 1 | Not yet recruiting | Tectonic Operating Company, Inc. | 20 | 2026-12-31 | 2026-10-15 |
| Adaptive Digital Exercise Rehabilitation for Children After CHD Surgery JITAI-Based Digital Exercise Rehabilitation Program, Standard Exercise Rehabilitation Program - Congenital Heart Disease (CHD), Congenital Heart Disease in Children | Not applicable | Not yet recruiting | The Children's Hospital of Zhejiang University School of Medicine | 130 | 2026-12-30 | 2026-05-08 |
| Single-Needle Distal Return for Long-Term Arteriovenous Fistula Care Single-Needle Distal Return (SNDR) Cannulation, Standard Two-Needle AVF Cannulation - Hemodialysis Access, Arteriovenous Fistula | Not applicable | Recruiting | Suzhou Municipal Hospital of Anhui Province | 100 | 2026-12-15 | 2026-01-28 |
| Twenty-five Years of Advanced RadioTherapy at San Raffaele Hospital Advanced radiotherapy techniques - Malignant Tumor, Benign Neoplasm | Not yet recruiting | IRCCS San Raffaele | 10000 | 2026-11-15 | 2026-10-26 | |
| Physical Activity and Functional Capacity in Patients With Congenital Long QT Syndrome Questionnaires, Cardiopulmonary exercise testing, 24-hour Holter monitoring - Long QT Syndrome, Channelopathies | Not yet recruiting | University of Sao Paulo | 120 | 2026-11-01 | 2026-10-07 | |
| Comparison of the Best Method for Measuring Anti-Xa Activity in Children Receiving Unfractionated Heparin in Cardiac Intensive Care (COMPAXE-HNF) blood sampling for measuring anti-Xa activity, measurement of anti-XA activity - Congenital Heart Disease, Unfractionated Heparin | Not applicable | Not yet recruiting | Centre Hospitalier Universitaire de la Réunion | 22 | 2026-11-01 | 2026-09-21 |
| Dapagliflozin and Right Heart Recovery After ASD Device Closure trans catheter device closure - ASD2(Secundum Atrial Septal Defect) | Not applicable | Not yet recruiting | Assiut University | 70 | 2026-11-01 | 2026-09-17 |
| UltraTrac for Cardiac Output Monitoring in Congenital Heart Disease UltraTrac - Congenital Heart Disease, Cardiac Output | Not applicable | Not yet recruiting | University of Minnesota | 70 | 2026-11-01 | 2026-10-08 |
| MAGiC - Congenital Heart DIsease Cardiac ablation using the MAGiC Ablation Catheter - Supraventricular Tachycardia (SVT), Congenital Heart Disease (CHD) | Not yet recruiting | Stereotaxis | 40 | 2026-10-31 | 2026-09-10 | |
| Migraine Headaches Elimination With Patent Foramen Ovale-Directed Therapy Prasugrel 5mg, Transcatheter Closure of Patent Foramen Ovale - Migraine Disease, Patent Foramen Ovale | Phase 3 | Recruiting | Columbia University | 32 | 2026-10-15 | 2026-10-08 |
| RVOT Stenting Versus Surgical RV-PA Conduit in Cyanotic Adults Cyanotic Congenital Heart Disease, Right Ventricular Outflow Tract Obstruction | Not yet recruiting | Assiut University | 30 | 2026-10-10 | 2026-10-08 | |
| Echocardiographic Assessment of Valvular Dysfunction in Children With CHD Congenital Heart Disease, Valvular Heart Disease | Not yet recruiting | Assiut University | 100 | 2026-10-10 | 2026-10-08 |
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Heart Defects, Congenital (989) · Arteriovenous Fistula (223) · Ductus Arteriosus, Patent (137) · Foramen Ovale, Patent (135) · Turner Syndrome (124) · Telangiectasia, Hereditary Hemorrhagic (106) · Long QT Syndrome (101) · Tetralogy of Fallot (91) · Univentricular Heart (85) · Heart Septal Defects, Atrial (81) · Arteriovenous Malformations (79) · Vascular Malformations (75) · Heart Failure (68) · Hypoplastic Left Heart Syndrome (67)
Congenital, Hereditary, and Neonatal Diseases and Abnormalities (2662) · Congenital Abnormalities (2657) · Cardiovascular Diseases (2618) · Heart Diseases (2022) · Heart Defects, Congenital (1098) · Pathological Conditions, Signs and Symptoms (733) · Vascular Diseases (707) · Pathologic Processes (494) · Vascular Malformations (482) · Genetic Diseases, Inborn (354) · Nervous System Diseases (334) · Urogenital Diseases (319) · Female Urogenital Diseases and Pregnancy Complications (314) · Pathological Conditions, Anatomical (259)
Ibuprofen (34) · Blood Specimen Collection (32) · Acetaminophen (30) · Human Growth Hormone (30) · Saline Solution (22) · Sodium Chloride (22) · Echocardiography (20) · Exercise Test (19) · Exercise (18) · Dexmedetomidine (16) · Surveys and Questionnaires (16) · Surgical Procedures, Operative (15) · Bevacizumab (14) · Indomethacin (13) · Sirolimus (13)
Assiut University (50) · Boston Children's Hospital (50) · Emory University (38) · Hospices Civils de Lyon (31) · The Hospital for Sick Children (27) · Assistance Publique - Hôpitaux de Paris (25) · University of Aarhus (25) · Stanford University (24) · University Hospital, Montpellier (24) · National Heart, Lung, and Blood Institute (NHLBI) (23) · Mayo Clinic (21) · University of Alberta (19) · Abbott Medical Devices (18) · Children's Healthcare of Atlanta (18) · Children's Hospital Medical Center, Cincinnati (18)
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PMID 18035553, PMID 18424759, PMID 18557726, PMID 19066739, PMID 20236866, PMID 33112424, PMID 17284531, PMID 36184076, PMID 37979797, PMID 12084585, PMID 18000608, PMID 22065264, PMID 24586400, PMID 36519620, PMID 42002216, PMID 15100156, PMID 17307535, PMID 17911499, PMID 18155964, PMID 19127223, PMID 20978268, PMID 21600541, PMID 22169361, PMID 22939929, PMID 23228403, PMID 23258386, PMID 23477994, PMID 23607606, PMID 23735475, PMID 23972966, PMID 24146883, PMID 24252784, PMID 24676541, PMID 26283668, PMID 27107394, PMID 27444506, PMID 27609682, PMID 29222139, PMID 29367212, PMID 30657990, PMID 31379715, PMID 31419019, PMID 31487545, PMID 31722151, PMID 32381162, PMID 32573726, PMID 33045104, PMID 33748192, PMID 33826508, PMID 34032839
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