200 completed, 64 unknown, 42 recruiting, 36 terminated. 111 Not applicable, 79 Phase 2, 35 Phase 1, 34 Phase 3, 12 Phase 4.
Follow Acute Lung Injury: new trials by email Literature Review of Acute Lung Injury trials Research Report on Acute Lung Injury
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The Variable Ventilation Trial (Part A) Variable Ventilation, Conventional Ventilation - ARDS (Acute Respiratory Distress Syndrome) | Not applicable | Not yet recruiting | Brigham and Women's Hospital | 20 | 2027-02-01 | 2026-08-27 |
| Self-directed Mobile Mindfulness to Address ICU Survivors' Psychological Distress Lift mobile mindfulness, Enlighten Recovery education program - Critical Illness, Heart Failure | Not applicable | Not yet recruiting | Duke University | 450 | 2027-01-01 | 2026-07-08 |
| SWedish Intensive Care Biobank Any Condition Underlying Critical Illness | Not yet recruiting | Uppsala University | 25000 | 2027-01-01 | 2026-05-13 | |
| Continuous vs Bolus Neuromuscular Blockade Regimens in Moderate to Severe Hypoxemic Respiratory Failure and ARDS (COBRA) Neuromuscular Blocking Agent - Bolus Dosing, Neuromuscular Blocking Agent - Continuous Infusion - ARDS (Acute Respiratory Distress Syndrome) | Phase 2 | Not yet recruiting | University of Calgary | 100 | 2027-01-01 | 2026-05-14 |
| The Effect of Catheter Size on the Efficacy of Ultralow-flow Extracorporeal Carbon Dioxide Removal System in Acute Respiratory Distress Syndrome 12F Catheter, 13F Catheter, 15F Catheter - ARDS (Acute Respiratory Distress Syndrome) | Not applicable | Not yet recruiting | Chulalongkorn University | 30 | 2026-12-01 | 2026-10-08 |
| Safety and Efficacy Study of GKL-006RTU in Moderate to Severe Acute Respiratory Distress Syndrome (ARDS) GKL-006RTU injection, Placebo - ARDS (Acute Respiratory Distress Syndrome) | Phase 1 / Phase 2 | Not yet recruiting | Beijing Gene Key Life Technology Co., Ltd | 52 | 2026-11-10 | 2026-09-30 |
| EARLY-SARDS: Early AlveolaR Lung biologY Underling Sepsis-Associated ARDS Serial bronchoalveolar lavage and biological-physiological assessment - Acute Hypoxemic Respiratory Failure, Sepsis | Not yet recruiting | Hospital Universitari Vall d'Hebron Research Institute | 145 | 2026-10-15 | 2026-08-28 | |
| Assessment of Blood Viscosity in ARDS (Acute Respiratory Distress Syndrome) Blood draws (peripheral venous puncture), Blood draws (arterial catheter, central venous line, or Swan-Ganz catheter) - ARDS | Not yet recruiting | Hospices Civils de Lyon | 46 | 2026-10-01 | 2026-09-16 | |
| Ondansetron for the Prevention of Patient Self-Inflicted Lung Injury in Patients With ARDS - Pilot RCT Ondansetron hydrochloride 8 mg IV Q8H, 0.9 % Normal Saline 10 ml - ARDS (Acute Respiratory Distress Syndrome), Invasive Mechanical Ventilation | Phase 2 / Phase 3 | Not yet recruiting | Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal | 76 | 2026-10-01 | 2026-05-14 |
| Time-controlled Adaptive Ventilation (TCAV) Compared With Conventional Ventilation in Patients With Moderate-to-severe Acute Respiratory Distress Syndrome (ARDS) Secondary to Community-acquired Pneumonia Invasive ventilation with the Time-controlled Adaptative Ventilation settings applied to the Airway Pressure Release Ventilation mode, Volume Control - ARDS (Acute Respiratory Distress Syndrome) | Not applicable | Not yet recruiting | Central Hospital, Nancy, France | 56 | 2026-10-01 | 2026-07-01 |
| Fibrotic Disease Activity in Cardiopulmonary Disorders Using 18F-Fibroblast Activation Protein Inhibitor (18F-FAPI-74) PET/CT Imaging [18F]FAPI-74, 18F-FAPI-74 PET/CT Imaging - Allogeneic Stem Cell Transplantation, Lung Allograft Transplantation | Phase 3 | Recruiting | National Heart, Lung, and Blood Institute (NHLBI) | 210 | 2026-09-18 | 2026-10-06 |
| Observational, Non-interventional Biomarker and Endotyping Study ARDS (Acute Respiratory Distress Syndrome) | Recruiting | Prenosis, Inc. | 1200 | 2026-09-14 | 2026-09-28 | |
| Precision Medicine Adaptive Network Platform Trial in Hypoxemic Acute Respiratory Failure Simvastatin, Baricitinib - ARDS (Acute Respiratory Distress Syndrome), Acute Hypoxic Respiratory Failure | Phase 2 | Not yet recruiting | University of Colorado, Denver | 300 | 2026-09-01 | 2026-10-08 |
| Trial of Total Lung Protective Ventilation in Adult VV-ECMO Patients With Severe ARDS Mechanical Power Targeted Ventilation - ARDS (Acute Respiratory Distress Syndrome), VV ECMO | Not applicable | Not yet recruiting | University of Virginia | 24 | 2026-09-01 | 2026-09-01 |
| The Impact of Low Versus High Positive End-expiratory Pressure on Diaphragm Function, Ventilation Efficiency, and Lung Mechanics Low positive end-expiratory pressure, Medium positive end-expiratory pressure, High positive end-expiratory pressure - Respiratory Failure, ARDS (Acute Respiratory Distress Syndrome) | Not applicable | Recruiting | Vastra Gotaland Region | 25 | 2026-08-31 | 2026-09-02 |
| Assessment of Acute Respiratory Distress in Children Presenting to the Emergency Department: Clinical, Epidemiological, and Etiological Insights Acute Respiratory Distress Syndrome | Not yet recruiting | Assiut University | 70 | 2026-08-30 | 2025-09-02 | |
| Outer Membrane Vesicle and Ferroptosis-Related Signatures in Sepsis-Associated Acute Lung Injury Caused by Extra-Pulmonary Hypervirulent Klebsiella Pneumoniae Sepsis, Acute Lung Injury(ALI) | Not yet recruiting | Southeast University, China | 120 | 2026-07-06 | 2026-07-13 | |
| BALance: ARDS Deconvolution by Bronchoalveolar Lavage Multiomics and Radiomics sampling blood, Lavage with physiologic saline solution - ARDS (Acute Respiratory Distress Syndrome) | Recruiting | Medical University of Vienna | 130 | 2026-07-01 | 2026-07-10 | |
| EIT Evaluation of the Impact of Inhaled Nitric Oxide on Ventilation/Perfusion Mismatch in ARDS Patients Receiving Noninvasive Respiratory Support Inhale different doses of nitric oxide - ARDS (Acute Respiratory Distress Syndrome) | Not yet recruiting | Ming Zhong | 40 | 2026-06-30 | 2026-06-01 | |
| Anti-CD14 Treatment With IC14 in Hospitalized ARDS Patients Atibuclimab, Placebo - Acute Respiratory Distress Syndrome, Adult Respiratory Distress Syndrome | Phase 2 | Recruiting | Implicit Bioscience | 56 | 2026-06-17 | 2026-07-29 |
Showing 20 of 390. Sign in to see all of them.
Respiratory Distress Syndrome (154) · COVID-19 (45) · Respiratory Insufficiency (30) · Sepsis (29) · Pneumonia (26) · Acute Kidney Injury (13) · Lung Injury (13) · Transfusion-Related Acute Lung Injury (12) · Hypoxia (11) · Ventilator-Induced Lung Injury (11) · Lung Diseases (10) · Critical Illness (9) · Severe Acute Respiratory Syndrome (9) · Coronavirus Infections (8)
Respiratory Tract Diseases (387) · Lung Diseases (380) · Lung Injury (377) · Respiration Disorders (176) · Pathological Conditions, Signs and Symptoms (94) · Infections (93) · Pathologic Processes (78) · Respiratory Tract Infections (66) · RNA Virus Infections (50) · Virus Diseases (49) · Nidovirales Infections (46) · Coronaviridae Infections (45) · Pneumonia, Viral (42) · Coronavirus Infections (39) · Pneumonia (39)
Sodium Chloride (12) · Saline Solution (11) · Ascorbic Acid (7) · Respiration, Artificial (7) · Continuous Positive Airway Pressure (6) · Prone Position (5) · Dexmedetomidine (4) · Oxygen (4) · Positive-Pressure Respiration (4) · Standard of Care (4) · Bronchoscopy (3) · Heparin (3) · Nitric Oxide (3) · Ultrasonography (3) · aviptadil (3)
Assistance Publique - Hôpitaux de Paris (7) · Peking Union Medical College Hospital (7) · Policlinico Hospital (6) · Southeast University, China (6) · GlaxoSmithKline (5) · Mayo Clinic (5) · Medical University of Vienna (5) · National Heart, Lung, and Blood Institute (NHLBI) (5) · University Hospital, Ghent (5) · Ain Shams University (4) · Changhai Hospital (4) · Johns Hopkins University (4) · National Taiwan University Hospital (4) · PPD Development, LP (4) · University Hospital, Clermont-Ferrand (4)
United States (118) · China (57) · France (39) · Italy (22) · Canada (18) · Spain (18) · United Kingdom (18) · Germany (17) · Turkey (Türkiye) (11) · Austria (10) · Belgium (9) · Egypt (9) · Taiwan (9) · Brazil (7) · Sweden (6)
Davide Chiumello, MD (4) · Jonathan C Javitt, MD, MPH (3) · Kuang Cheng Chan, M.D. (3) · Lai Jiang, chief doctor (3) · Dale M. Needham, MD, PhD (2) · Daryl Kor, MD (2) · George O'Connor, MD (2) · Huaiwu He, MD (2) · Idit Matot, MD (2) · Jesus Villar, MD, PhD (2) · Ognjen Gajic, M.D. (2) · Paolo Pelosi, MD (2)
PMID 27440140, PMID 22307571, PMID 22340260, PMID 25818272, PMID 26832963, PMID 26936876, PMID 29420341, PMID 30624279, PMID 34473343, PMID 35244208, PMID 37487152, PMID 10835058, PMID 10945393, PMID 11719313, PMID 15753733, PMID 15812622, PMID 16014597, PMID 16044083, PMID 16556697, PMID 16690982, PMID 16763218, PMID 17426195, PMID 17585106, PMID 17925413, PMID 17989152, PMID 18270353, PMID 18451319, PMID 19001507, PMID 19272543, PMID 19357507, PMID 19364558, PMID 19384204, PMID 19713451, PMID 19887665, PMID 19995347, PMID 20154071, PMID 20160606, PMID 20405117, PMID 20424554, PMID 20426859, PMID 20562130, PMID 20633284, PMID 20802164, PMID 21220996, PMID 21297069, PMID 21435708, PMID 21562125, PMID 21809107, PMID 21811626, PMID 21976613
N01HR056179 (4), P50HL073994 (2), 1UG3AT013109-01 (1), 1UM1HL116885-01 (1), 2004 (1), 2016 (1), 2017 (1), 2019 (1), 2025 (1), K23HL085526 (1), K23HL112855 (1), KL2RR024151 (1), R01HL052586 (1), R01HL067939 (1), R01HL086667 (1)