51 completed, 6 withdrawn, 5 terminated, 5 unknown. 19 Phase 3, 15 Phase 2, 13 Phase 1, 13 Phase 4, 8 Not applicable.
Follow Hydrocodone: new trials by email Literature Review of Hydrocodone trials Research Report on Hydrocodone
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Clinical Trial of MK-6916 in Participants With Pain After Bunion Removal Surgery (MK-6916-007) MK-6916, Hydrocodone/acetaminophen (HB/APAP), MK-6916 Placebo - Pain Management | Phase 2 | Not yet recruiting | Merck Sharp & Dohme LLC | 380 | 2026-11-23 | 2026-10-07 |
| An Artificial Intelligence Driven Approach to Optimize Patient Selection for a Transitional Pain Service TPS-Select, Pharmacologic Pain Management, Interventional Pain Procedures - Postsurgical Pain Management, Postsurgical Pain, Chronic | Phase 3 | Not yet recruiting | University of California, San Francisco | 474 | 2026-10-01 | 2026-10-09 |
| A Clinical Trial of GRT7040 in Adults With Acute Pain Following Bunionectomy GRT7040, Hydrocodone bitartrate/ acetaminophen (HB/APAP), Placebo (matched to HB/APAP) - Acute Pain, Bunionectomy | Phase 2 | Not yet recruiting | Grünenthal GmbH | 400 | 2026-09-01 | 2026-09-15 |
| Efficacy of Methylprednisolone for Pain Control After ACL Repair Meloxicam 15 mg, Medrol 4 MG Oral Tablet Includes Medrol Dosepak, Gabapentin 300 mg - ACL Surgery, Pain Management | Phase 4 | Recruiting | St. Louis University | 90 | 2025-10-21 | 2025-10-24 |
| Study to Investigate the Safety, Tolerability and Pharmacokinetics of QEV-817 Oral Suspension Hydrocodone Bitartrate, Hydrocodone Bitartrate + Doxapram Hydrochloride - Healthy, PK Drug-drug Interaction Study | Phase 1 | Completed | Quivive Pharma, Inc. | 8 | 2025-08-18 | 2026-08-05 |
| Assessment of Medrol Dosepak to Reduce Opioid Consumption in Foot and Ankle Surgical Patients medrol dosepak, HYDROcodone Oral Tablet - Foot Injuries and Disorders, Ankle Injuries and Disorders | Phase 2 | Recruiting | Emory University | 180 | 2025-01-27 | 2026-03-09 |
| 5x-Multiplier vs 3-Tier Model for Discharge Opioid Prescriptions After Intra-abdominal Cancer Surgery: A Randomized Clinical Trial Hydrocodone, Tramadol, Oxycodone - Intra-abdominal Cancer | Phase 2 | Completed | M.D. Anderson Cancer Center | 165 | 2024-03-27 | 2026-09-09 |
| Hydrocodone Compared to Acetaminophen and Ibuprofen for Post-nail Procedure Analgesia Hydrocodone 5Mg/Acetaminophen 325Mg Tab, Acetaminophen 1000mg, Ibuprofen 400 mg - Nail Diseases, Nail Abnormality | Phase 4 | Completed | Weill Medical College of Cornell University | 20 | 2022-11-10 | 2023-09-28 |
| Multimodal Analgesia Effect on Post Surgical Patient Neurontin, Dilaudid Injectable Product, Marcaine Injectable Product - Obesity, Morbid, Surgery | Phase 4 | Completed | University of California, Davis | 60 | 2021-01-20 | 2026-09-14 |
| Postoperative Pain Control in Septum and Sinus Surgery Acetaminophen 325 mg Oral Tablet, Acetaminophen 650 mg Oral Tablet, OxyCODONE 5 mg Oral Tablet - Post-operative Pain, Sinus Surgery | Phase 4 | Completed | Corewell Health East | 65 | 2019-11-27 | 2023-08-31 |
| Narcotic Versus Non-narcotic Medication for Pain Management After Wrist/Hand Fractures Hydrocodone 5Mg/Acetaminophen 500Mg Tab, Acetaminophen 500Mg Tab, Ibuprofen 600 mg tab - Distal Radius Fracture, Pain Management | Phase 4 | Unknown | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 250 | 2019-08-01 | 2021-03-01 |
| Naproxen Sodium/Acetaminophen Proof of Concept Dosing Study 440 mg naproxen sodium with 1000 mg acetaminophen, 220 mg naproxen sodium with 650 mg acetaminophen, 10 mg hydrocodone + 650 mg acetaminophen - Pain | Phase 2 | Completed | Johnson & Johnson Consumer Inc., McNeil Consumer Healthcare Division | 290 | 2019-05-28 | 2022-12-05 |
| Nonopioid Analgesia After Arthroscopic Meniscus Surgery Celecoxib, Hydrocodon/Acetaminophen, Ketorolac - Meniscus Disorder, Narcotic Use | Early Phase 1 | Completed | Henry Ford Health System | 61 | 2019-01-22 | 2023-12-05 |
| Levorphanol as a Second Line Opioid in Reducing Pain in Patients With Cancer Hydrocodone, Hydromorphone, Levorphanol - Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm | Early Phase 1 | Terminated | M.D. Anderson Cancer Center | 43 | 2018-11-29 | 2025-08-03 |
| Pain Medications Following Thyroidectomy and Parathyroidectomy Non-narcotic group regimen, Narcotic group regimen - Thyroid Disease, Parathyroid Diseases | Phase 1 | Completed | MetroHealth Medical Center | 126 | 2018-11-15 | 2019-12-26 |
| US-guided SAPB for Rib Fractures in the ED Bupivacaine, Fentanyl, morphine, hydromorphone, hydrocodone, acetaminophen, ketorolac, gabapentin, ketamine, ibuprofen - Rib Fractures, Rib Fracture Multiple | Phase 4 | Unknown | Andrew A Herring | 70 | 2018-11-06 | 2018-12-19 |
| Pharmacokinetics and Safety of Commonly Used Drugs in Lactating Women and Breastfed Infants Tranexamic acid (TXA), labetalol, metformin - Lactating Women on Select DOI, Breastfed Infants of Mothers on Select DOI | Recruiting | Duke University | 1600 | 2018-10-04 | 2026-07-29 | |
| Multimodal Analgesia in Shoulder Arthroplasty Acetaminophen, Celecoxib 200mg, Celecoxib 400 mg - Shoulder Pain, Opioid Use | Phase 3 | Withdrawn | Rush University Medical Center | 2018-06-01 | 2021-09-28 | |
| Controlled Trial to Determine Most Effective Post-Operative Analgesia After Third Molar Extraction Ketorolac, Oxycodone, Acetaminophen - Pain, Post-operative, Third Molar | Early Phase 1 | Completed | United States Naval Medical Center, San Diego | 80 | 2018-02-14 | 2024-07-10 |
| A Comparison of Plasma Concentrations of Hydrocodone and Acetaminophen After Administration of Different Amounts of Tablets of a New and a Marketed Tablet Formulation in Healthy Adults GRT7014 - Abuse Deterrend Tablet, Norco 5Mg-325Mg Tablet - Opioid-Related Disorders, Pain, Acute | Phase 1 | Withdrawn | Grünenthal GmbH | 2017-09-01 | 2017-07-21 |
Showing 20 of 73. Sign in to see all of them.
Pain (23) · Pain, Postoperative (11) · Agnosia (7) · Acute Pain (5) · Chronic Pain (4) · Nausea (4) · Vomiting (3) · Ankle Injuries (2) · Back Pain (2) · Opioid-Related Disorders (2) · Osteoarthritis (2) · Postoperative Nausea and Vomiting (2) · Toothache (2) · Body Weight Changes (1) · Carpal Tunnel Syndrome (1)
Zogenix, Inc. (8) · Abbott (7) · AbbVie (prior sponsor, Abbott) (6) · Grünenthal GmbH (3) · Charleston Laboratories, Inc (2) · M.D. Anderson Cancer Center (2) · Mallinckrodt (2) · Merck Sharp & Dohme LLC (2) · Purdue Pharma LP (2) · University of California, Davis (2) · University of California, San Francisco (2) · Albany Medical College (1) · Andrew A Herring (1) · Cephalon (1) · Corewell Health East (1)
United States (53) · Canada (4)
Pedro Quintana Diez, MD (6) · Rita Jain, MD (5) · Herbert Neuman, MD (2) · Kenneth Lasseter, MD (2) · Rita Jain, M.D. (2) · A. Johnston Stewart, MB, MRCGP (1) · Akhila S Reddy (1) · Andrew A Monte, MD (1) · Andrew Bishara, MD (1) · Andrew Chang, MD (1) · Andrew Herring, MD (1) · Arun Nagdev, MD (1) · Barbara Jachniewicz, MSN, CRNFA, (1) · Barth L Wilsey, MD (1)
PMID 28072811, PMID 17113683, PMID 19135997, PMID 19209273, PMID 19535182, PMID 19660492, PMID 26111544, PMID 26312961, PMID 26681111, PMID 26749219, PMID 31961377, PMID 32416981, PMID 35076931, PMID 37619705, PMID 40583965
R01DE005215 (1)