495 completed, 205 unknown, 124 recruiting, 79 terminated. 333 Not applicable, 178 Phase 2, 92 Phase 1, 92 Phase 3, 33 Phase 4.
Follow Lung Injury: new trials by email Literature Review of Lung Injury trials Research Report on Lung Injury
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The Variable Ventilation Trial (Part A) Variable Ventilation, Conventional Ventilation - ARDS (Acute Respiratory Distress Syndrome) | Not applicable | Not yet recruiting | Brigham and Women's Hospital | 20 | 2027-02-01 | 2026-08-27 |
| Strap To Reduce Apnea in Preterm Infants: A Randomized Crossover Trial Chinstrap - Apnea of Prematurity, Intermittent Hypoxemia | Not applicable | Not yet recruiting | University of Alabama at Birmingham | 20 | 2027-01-15 | 2026-10-27 |
| Self-directed Mobile Mindfulness to Address ICU Survivors' Psychological Distress Lift mobile mindfulness, Enlighten Recovery education program - Critical Illness, Heart Failure | Not applicable | Not yet recruiting | Duke University | 450 | 2027-01-01 | 2026-07-08 |
| SWedish Intensive Care Biobank Any Condition Underlying Critical Illness | Not yet recruiting | Uppsala University | 25000 | 2027-01-01 | 2026-05-13 | |
| Continuous vs Bolus Neuromuscular Blockade Regimens in Moderate to Severe Hypoxemic Respiratory Failure and ARDS (COBRA) Neuromuscular Blocking Agent - Bolus Dosing, Neuromuscular Blocking Agent - Continuous Infusion - ARDS (Acute Respiratory Distress Syndrome) | Phase 2 | Not yet recruiting | University of Calgary | 100 | 2027-01-01 | 2026-05-14 |
| Heterologous Cord Blood-Derived Red Blood Cell for Transfusion in Extremely Preterm Infants Cord Blood Red Blood Cells, Standard Adult Donor Red Blood Cells - Extremely Premature Infant, Anemia Neonatal | Not applicable | Not yet recruiting | Hospital Clinic of Barcelona | 176 | 2027-01-01 | 2026-03-31 |
| The Effect of Catheter Size on the Efficacy of Ultralow-flow Extracorporeal Carbon Dioxide Removal System in Acute Respiratory Distress Syndrome 12F Catheter, 13F Catheter, 15F Catheter - ARDS (Acute Respiratory Distress Syndrome) | Not applicable | Not yet recruiting | Chulalongkorn University | 30 | 2026-12-01 | 2026-10-08 |
| Effect on Bronchodilation Response and Ventilation Heterogeneity of Different Inhalation Volumes in COPD Inhalation of bronchodilation therapy at FRC, Inhalation of bronchodilation therapy at RV - COPD, Lung Injury | Not yet recruiting | University of Milan | 30 | 2026-12-01 | 2026-05-04 | |
| CAffeine Use in Prolonged Oxygen Use in meConium aspIration Syndrome in Neonatal Outcomes (CAPUCINO) Caffeine citrate, Saline (NaCl 0,9 %) (placebo) - Meconium Aspiration Syndrome | Phase 2 | Not yet recruiting | University of Alberta | 20 | 2026-11-12 | 2026-10-26 |
| Safety and Efficacy Study of GKL-006RTU in Moderate to Severe Acute Respiratory Distress Syndrome (ARDS) GKL-006RTU injection, Placebo - ARDS (Acute Respiratory Distress Syndrome) | Phase 1 / Phase 2 | Not yet recruiting | Beijing Gene Key Life Technology Co., Ltd | 52 | 2026-11-10 | 2026-09-30 |
| Continued Pressure for Alveolar Protection (CPAP Trial) CPAP, Nasal Cannula - Bronchopulmonary Dysplasia (BPD) | Not applicable | Recruiting | NICHD Neonatal Research Network | 860 | 2026-11-05 | 2026-07-14 |
| Development and Prospective Validation of the AutoEIT Foundation Model for ARDS AutoEIT Model Training, AutoEIT Blinded Validation - ARDS (Acute Respiratory Distress Syndrome), Respiratory Failure | Not yet recruiting | Ruijin Hospital | 1200 | 2026-11-01 | 2026-10-27 | |
| A Study of the Determinants of Neurological Outcomes in Patients With Acute Respiratory Distress Syndrome Blood test scores calculations - Acute Respiratory Distress Syndrome (ARDS), s100b | Not applicable | Not yet recruiting | University Hospital, Angers | 150 | 2026-10-17 | 2026-07-27 |
| EARLY-SARDS: Early AlveolaR Lung biologY Underling Sepsis-Associated ARDS Serial bronchoalveolar lavage and biological-physiological assessment - Acute Hypoxemic Respiratory Failure, Sepsis | Not yet recruiting | Hospital Universitari Vall d'Hebron Research Institute | 145 | 2026-10-15 | 2026-08-28 | |
| National Surveillance and Prevention of Neonatal VAP Ventilator-Associated Pneumonia (VAP), Neonatal, Bronchopulmonary Dysplasia (BPD) | Not yet recruiting | University of Alberta | 1500 | 2026-10-01 | 2026-06-25 | |
| Preliminary Study on Microplastics Deposition in Ventilator Circuit and the Risk of Bronchopulmonary Dysplasia in Premature Infants Bronchopulmonary Dysplasia | Not yet recruiting | Huiyi Li | 100 | 2026-10-01 | 2026-09-30 | |
| Early Prediction of Bronchopulmonary Dysplasia in Preterm Infants Using Clinical Data Artificial Intelligence-Based Risk Prediction - Bronchopulmonary Dysplasia | Not yet recruiting | Konya City Hospital | 108 | 2026-10-01 | 2026-07-09 | |
| Parent Perceptions of OptiPAP Junior Nasal CPAP interface: OptiPAP Junior, Nasal CPAP interface: FlexiTrunk - Bronchopulmonary Dysplasia (BPD), Preterm Birth Complication | Not applicable | Not yet recruiting | Sharp HealthCare | 60 | 2026-10-01 | 2026-09-23 |
| Assessment of Blood Viscosity in ARDS (Acute Respiratory Distress Syndrome) Blood draws (peripheral venous puncture), Blood draws (arterial catheter, central venous line, or Swan-Ganz catheter) - ARDS | Not yet recruiting | Hospices Civils de Lyon | 46 | 2026-10-01 | 2026-09-16 | |
| Ondansetron for the Prevention of Patient Self-Inflicted Lung Injury in Patients With ARDS - Pilot RCT Ondansetron hydrochloride 8 mg IV Q8H, 0.9 % Normal Saline 10 ml - ARDS (Acute Respiratory Distress Syndrome), Invasive Mechanical Ventilation | Phase 2 / Phase 3 | Not yet recruiting | Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal | 76 | 2026-10-01 | 2026-05-14 |
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Acute Lung Injury (381) · Bronchopulmonary Dysplasia (360) · Respiratory Distress Syndrome (230) · Premature Birth (155) · Ventilator-Induced Lung Injury (120) · Respiratory Insufficiency (68) · COVID-19 (55) · Pneumonia (42) · Lung Diseases (40) · Radiation Pneumonitis (39) · Sepsis (38) · Meconium Aspiration Syndrome (25) · Respiratory Aspiration (24) · Hypertension, Pulmonary (21)
Respiratory Tract Diseases (1024) · Lung Diseases (996) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (396) · Infant, Newborn, Diseases (377) · Infant, Premature, Diseases (355) · Ventilator-Induced Lung Injury (353) · Respiration Disorders (330) · Pathological Conditions, Signs and Symptoms (228) · Urogenital Diseases (201) · Female Urogenital Diseases and Pregnancy Complications (200) · Pregnancy Complications (182) · Pathologic Processes (179) · Wounds and Injuries (158) · Obstetric Labor Complications (155)
Saline Solution (23) · Sodium Chloride (23) · Continuous Positive Airway Pressure (15) · Budesonide (12) · Respiration, Artificial (10) · Ascorbic Acid (8) · Azithromycin (7) · Blood Specimen Collection (7) · Dexmedetomidine (7) · Hydrocortisone (7) · Positive-Pressure Respiration (7) · Prone Position (7) · Standard of Care (7) · Surface-Active Agents (7) · Control Groups (6)
NICHD Neonatal Research Network (17) · Assistance Publique - Hôpitaux de Paris (13) · Children's Hospital of Philadelphia (12) · National Heart, Lung, and Blood Institute (NHLBI) (12) · University of Alabama at Birmingham (9) · GlaxoSmithKline (8) · Peking Union Medical College Hospital (8) · Boston Children's Hospital (7) · Medical University of Vienna (7) · Policlinico Hospital (7) · Southeast University, China (7) · University of Colorado, Denver (7) · Ain Shams University (6) · Assiut University (6) · Centre Hospitalier Intercommunal Creteil (6)
United States (319) · China (139) · France (76) · Canada (74) · Italy (51) · Turkey (Türkiye) (38) · United Kingdom (38) · Spain (36) · Germany (29) · Belgium (19) · Egypt (19) · Taiwan (18) · Austria (17) · Australia (16) · Brazil (16)
Seetha Shankaran, MD (12) · Barbara J. Stoll, MD (10) · Richard A. Ehrenkranz, MD (10) · Waldemar A. Carlo, MD (9) · Edward F. Donovan, MD (8) · Charles R. Bauer, MD (7) · Abbot R. Laptook, MD (6) · Abhik Das, PhD (6) · Avroy A. Fanaroff, MD (6) · David K. Stevenson, MD (6) · Krisa P. Van Meurs, MD (6) · Ronald N. Goldberg, MD (6) · Sheldon B. Korones, MD (6) · James A. Lemons, MD (5)
PMID 22797452, PMID 27440140, PMID 16763218, PMID 22307571, PMID 22340260, PMID 23339639, PMID 24508444, PMID 25818272, PMID 26192398, PMID 26351971, PMID 26832963, PMID 26872367, PMID 26903337, PMID 26936876, PMID 27620287, PMID 29420341, PMID 29872859, PMID 30624279, PMID 31773328, PMID 31931417, PMID 33876883, PMID 34473343, PMID 35244208, PMID 37487152, PMID 38365446, PMID 10065750, PMID 10379020, PMID 10400143, PMID 10545589, PMID 10632246, PMID 10793162, PMID 10794783, PMID 10802492, PMID 10829971, PMID 10835058, PMID 10945393, PMID 11090541, PMID 11150359, PMID 11193758, PMID 11401896, PMID 11416871, PMID 11549557, PMID 11719313, PMID 12219057, PMID 12371452, PMID 12460865, PMID 12538782, PMID 12734158, PMID 1388792, PMID 14407094
U10HD021364 (13), U10HD021385 (13), U10HD027853 (13), U10HD027880 (13), U10HD021373 (12), U10HD034216 (12), U10HD027851 (11), U10HD027856 (11), U10HD027871 (11), U10HD027904 (11), M01RR008084 (10), U10HD021397 (10), M01RR000750 (8), M01RR000070 (7), M01RR000997 (7)