Thoracic Injuries: Clinical Trials

119 completed, 54 unknown, 36 recruiting, 28 terminated. 125 Not applicable, 24 Phase 4, 19 Phase 2, 13 Phase 1, 11 Phase 3.

By phase and status

Phase	Trials	Status
Not applicable	125	Completed 52, Unknown 26, Recruiting 15, Terminated 12, Not yet recruiting 8, Withdrawn 4, Active not recruiting 3, Suspended 3, Enrolling by invitation 2
Phase 4	24	Completed 11, Terminated 5, Recruiting 2, Withdrawn 2, Active not recruiting 1, Enrolling by invitation 1, Not yet recruiting 1, Unknown 1
Phase 2	19	Completed 6, Unknown 6, Terminated 3, Withdrawn 2, Not yet recruiting 1, Recruiting 1
Phase 1	13	Unknown 5, Completed 3, Withdrawn 3, Terminated 2
Phase 3	11	Unknown 4, Completed 3, Terminated 2, Not yet recruiting 1, Recruiting 1
Early Phase 1	5	Completed 2, Unknown 2, Terminated 1

Follow Thoracic Injuries: new trials by email Literature Review of Thoracic Injuries trials Research Report on Thoracic Injuries

Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Real-time Ultrasound Guidance for Thoracic Epidural Blocks Real-time ultrasound guidance for thoracic epidural catheter placement. - Analgesia, Thoracic Tumors		Withdrawn	University of Chile		2027-07-01	2026-05-19
Effect on Bronchodilation Response and Ventilation Heterogeneity of Different Inhalation Volumes in COPD Inhalation of bronchodilation therapy at FRC, Inhalation of bronchodilation therapy at RV - COPD, Lung Injury		Not yet recruiting	University of Milan	30	2026-12-01	2026-05-04
Medical,Nursing Record,PE, Blood Test and Radiological Examination ,Morality and Mobility of Multiple Trauma Patient Collect results of trauma patients - Trauma Centers/Statistics & Numerical Data, Trauma Blunt		Not yet recruiting	St. Martin De Porress Hospital	700	2026-12-01	2026-11-04
SPSIP vs ESP Block for Analgesia After Rib Fracture Surgery Erector Spinae Plane Block (ESP), Serratus Posterior Superior Intercostal Plane (SPSIP) - Rib Fracture, Postoperative Pain	Not applicable	Not yet recruiting	Antalya City Hospital	60	2026-11-15	2026-05-11
Predictive Value of Chest Trauma Score , Revised Trauma Score , and Glasgow Coma Scale in Patients Presenting With Chest Trauma at Assiut University Emergency Unit. Chest Trauma		Not yet recruiting	Assiut University	100	2026-10-01	2026-09-10
Combined Lung and Diaphragmatic Ultrasound to Predict Respiratory Failure in Blunt Chest Trauma Blunt Chest Trauma, Respiratory Failure		Not yet recruiting	Assiut University	130	2026-10-01	2026-09-08
Serum sRAGE, CC16, and Syndecan-1 as Predictors of ARDS and Mortality After Severe Chest Trauma No intervention - observational study - Acute Respiratory Distress Syndrome, Chest Trauma		Not yet recruiting	Assiut University	85	2026-10-01	2026-08-19
Comparison of Dexmedetomidine Versus Dexamethasone as Adjuvants to Bupivacaine in Ultrasound-Guided Erector Spinae Plane Block for Acute Pain Management in Patients With Traumatic Rib Fractures Dexmedetomidine with Bupivacaine in ESPB, Dexamethasone with Bupivacaine in ESPB - Rib Fractures, Acute Pain	Phase 2 / Phase 3	Not yet recruiting	Assiut University	100	2026-10-01	2026-09-18
High-Sensitivity Troponin T Kinetics and 30-Day Outcomes After Major Abdominal Surgery (TROP-MAS) High-sensitivity cardiac troponin T (hs-cTnT) surveillance - Myocardial Infarction (MI), Perioperative Myocardial Injury		Not yet recruiting	Bach Mai Hospital	650	2026-10-01	2026-09-30
Erector Spinae Plane vs Serratus Anterior Plane Catheter Infusions for Acute Pain Management in Patients With Traumatic Rib Fractures Erector spinae plane catheter, Serratus plane catheter - Traumatic Rib Fracture(s), Traumatic Rib Fracture	Not applicable	Recruiting	Sunnybrook Health Sciences Centre	66	2026-09-09	2026-10-23
Personalized Ventilator Settings for Patients on ECMO Personalized Positive End-Expiratory Pressure (PEEP) - Acute Respiratory Distress Syndrome (ARDS), Extracorporeal Membrane Oxygenation	Not applicable	Enrolling by invitation	University of California, San Diego	62	2026-09-01	2026-09-02
Percutaneous Cryoablation of Intercostal Nerves for the Treatment of Rib Fractures Percutaneous Cryoablation of Intercostal Nerves, Multi-modal pain regimen - Trauma, Rib Fractures	Not applicable	Not yet recruiting	Loma Linda University	30	2026-09-01	2026-02-09
Inhalational Versus Intravenous Anesthesia on Postoperative Lung Injury in Septic Patients Undergoing Surgery Inhalation Anesthesia, intravenous anesthesia - Sepsis, Lung Injury	Not applicable	Not yet recruiting	Sixth Affiliated Hospital, Sun Yat-sen University	480	2026-08-15	2026-05-22
Functional Residual Capacity and Alveolar Recruitment in Single-lung Ventilation: a Randomized Study VPFE monitoring with intraoperative alveolar recruitment maneuvers. - Lung Injury	Not applicable	Not yet recruiting	University Hospital, Rouen	44	2026-07-01	2026-06-09
Monoamine Oxidase A PET/CT in Various MAO-A-Related Disease Diagnostic Test: 18F-AIPFA-1026 - Depression, Anxiety		Recruiting	Tianjin Medical University	200	2026-06-25	2026-09-08
Evaluation of Serratus Plane Block on the Respiratory Pattern in Patients With Multiple Rib Fractures Serratus plane block (continuous or single-shot) - Rib Fractures, Spirometry	Not applicable	Not yet recruiting	Niguarda Hospital	72	2026-06-01	2026-04-16
Point of Care Ultrasound (POCUS) for Diagnosis and Treatment of Fractures in the Costal Cartilage Rib Fracture, Cartilage Damage		Not yet recruiting	Sahlgrenska University Hospital	100	2026-06-01	2026-04-28
Surgery for Unstable Chest Wall Injuries - How Many Fractures Should be Fixed? Surgical stabilization of two fractures per rib, Surgical stabilization of one fracture per rib. - Rib Fracture Multiple, Flail Chest	Not applicable	Not yet recruiting	Sahlgrenska University Hospital	100	2026-05-05	2026-04-28
Perioperative Lidocaine for Lung Protection in Infants Undergoing Cardiac Surgery Lidocaine %2 ampoule, Normal Saline (0.9% NaCl) - Congenital Heart Disease, Postoperative Pulmonary Complications	Phase 4	Not yet recruiting	The Children's Hospital of Zhejiang University School of Medicine	320	2026-04-01	2026-03-30
Zimmer Biomet-RibFix Titan The RibFix Titan™ device should be used within this arm of the study. - Rib Fracture, Rib Fracture Multiple		Recruiting	Zimmer Biomet	54	2026-03-31	2026-04-21

Showing 20 of 282. Sign in to see all of them.

Narrower conditions

Rib Fractures (109)  ·  Lung Injury (103)  ·  Wounds and Injuries (24)  ·  Respiratory Distress Syndrome (20)  ·  Respiratory Insufficiency (20)  ·  Agnosia (16)  ·  Acute Pain (15)  ·  Acute Lung Injury (13)  ·  Flail Chest (13)  ·  Heart Injuries (13)  ·  Pain (12)  ·  Pneumonia (11)  ·  COVID-19 (9)  ·  Ventilator-Induced Lung Injury (9)

Broader conditions

Wounds and Injuries (258)  ·  Respiratory Tract Diseases (117)  ·  Fractures, Bone (104)  ·  Lung Diseases (101)  ·  Pathological Conditions, Signs and Symptoms (83)  ·  Signs and Symptoms (44)  ·  Pathologic Processes (42)  ·  Neurologic Manifestations (39)  ·  Respiration Disorders (36)  ·  Infections (25)  ·  Nervous System Diseases (24)  ·  Respiratory Tract Infections (19)  ·  Pain (18)  ·  Cardiovascular Diseases (17)

Interventions

Dexmedetomidine (8)  ·  Saline Solution (7)  ·  Bupivacaine (6)  ·  Lidocaine (6)  ·  Morphine (6)  ·  Acetaminophen (5)  ·  Analgesics, Opioid (5)  ·  Sodium Chloride (5)  ·  Anti-Inflammatory Agents, Non-Steroidal (4)  ·  Ibuprofen (4)  ·  Ketamine (4)  ·  Ropivacaine (4)  ·  Fentanyl (3)  ·  Naproxen (3)  ·  Standard of Care (3)

Sponsors

Assiut University (14)  ·  National Taiwan University Hospital (5)  ·  Sahlgrenska University Hospital (5)  ·  Stanford University (5)  ·  University of California, San Diego (5)  ·  Chang Gung Memorial Hospital (4)  ·  University Health Network, Toronto (4)  ·  Ain Shams University (3)  ·  Al-Nahrain University (3)  ·  Ankara City Hospital Bilkent (3)  ·  Caner İşevi, MD (3)  ·  Ege University (3)  ·  GlaxoSmithKline (3)  ·  University Hospital, Grenoble (3)  ·  Zimmer Biomet (3)

Countries

United States (83)  ·  China (23)  ·  Turkey (Türkiye) (19)  ·  Canada (17)  ·  Egypt (12)  ·  France (12)  ·  Italy (12)  ·  United Kingdom (11)  ·  Taiwan (9)  ·  Spain (7)  ·  Netherlands (5)  ·  Australia (4)  ·  Germany (4)  ·  Sweden (4)  ·  Switzerland (4)

Top investigators

Ewan Goligher, MD, PhD (4)  ·  Hsien-Chi Liao, MD (3)  ·  Eva-Corina Caragounis, MD (2)  ·  Hans Granhed, MD PhD (2)  ·  Joseph D Forrester, MD (2)  ·  Steffen Rosslenbroich, PD Dr. med. (2)  ·  A.B. van Vugt, MD, PhD (1)  ·  Adi Osman, MD (1)  ·  Adrian Hernandez, MD (1)  ·  Ahmet Burak Erdem, M.D. (1)  ·  Ajai K Malhotra, MD (1)  ·  Ajai Malhotra, MD (1)

Results publications

PMID 10834680, PMID 10963540, PMID 11003329, PMID 11090541, PMID 11193758, PMID 11265032, PMID 11837920, PMID 12355007, PMID 12460865, PMID 12734158, PMID 14407094, PMID 15082295, PMID 15345974, PMID 15454805, PMID 15519191, PMID 1566999, PMID 15795288, PMID 15862493, PMID 15965583, PMID 16302942, PMID 16307931, PMID 16508485, PMID 16750696, PMID 16818489, PMID 17050868, PMID 17161082, PMID 17414339, PMID 17650692, PMID 17707752, PMID 17925411, PMID 18053373, PMID 18456674, PMID 18492911, PMID 18936319, PMID 19283744, PMID 19306978, PMID 19359920, PMID 19359922, PMID 19539280, PMID 19760233, PMID 19787388, PMID 19837806, PMID 19865549, PMID 19889411, PMID 19934395, PMID 19962042, PMID 20032030, PMID 20078434, PMID 20228291, PMID 20583979

NIH funding

2014 (1), 2016 (1), 2019 (1), 2023 (1), K23HL181397 (1), KL2TR003168 (1), R01HL098087 (1), R01HL140963 (1), R24AA019661 (1), R34HL158586 (1), T32GM075770 (1), U54GM104940 (1)