82 completed, 40 recruiting, 24 unknown, 17 terminated. 86 Not applicable, 68 Phase 2, 34 Phase 1, 14 Phase 3, 8 Phase 4.
Follow Cryosurgery: new trials by email Literature Review of Cryosurgery trials Research Report on Cryosurgery
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Cryoablation Combined With Anlotinib Plus TQB2868 in Patients With Advanced Intrahepatic Cholangiocarcinoma Anlotinib, TQB2868 Injection, cryoablation - Intrahepatic Cholangiocarcinoma | Phase 2 | Not yet recruiting | Fudan University | 56 | 2026-10-01 | 2026-09-29 |
| CRYO-TOUCH: Cryoablation of the Primary Breast Tumor in Metastatic Breast Cancer Cryoablation, Patient-Reported Outcome Assessment - Metastatic Breast Cancer | Not applicable | Not yet recruiting | Hospices Civils de Lyon | 42 | 2026-10-01 | 2026-06-30 |
| Study on Sequential Cryoablation, Relaforp Alpha, and Chemotherapy for Bile Duct Tumors PD-1 and chemotherapy, cryoablation - Biliary Tract Cancer (BTC) | Phase 2 | Recruiting | Tianjin Medical University Cancer Institute and Hospital | 30 | 2026-10-01 | 2026-07-24 |
| Cryoablation Combined With Hepatic Arterial Infusion of Iparomlimab and Tuvonralimab (QL1706), Intravenous Dacarbazine, and Oral Lenvatinib in Patients With Liver Metastases From Malignant Melanoma: a Single-arm, Phase II, Prospective Trial Cryoablation, Iparomlimab and Tuvonralimab, Dacarbazine - Melanoma (Skin) Stage IV | Phase 2 | Recruiting | Sun Yat-sen University | 28 | 2026-10-01 | 2026-09-29 |
| Cryoablation Combined With QL1706 (Iparomlimab/Tuvonralimab) Plus Lenvatinib in Patients With Advanced Biliary Tract Cancer. QL1706 (Iparomlimab/Tuvonralimab), Lenvatinib, Cryoablation - Biliary Tract Cancer (BTC) | Phase 2 | Not yet recruiting | Fudan University | 180 | 2026-09-20 | 2026-09-21 |
| Post-Marketing Study for Early-Stage Low-Risk Breast Cancer Treatment Using ProSense® Cryoablation (ChoICE Trial) Cryoablation - Low-Risk, Early Stage Breast Cancer | Not applicable | Recruiting | IceCure Medical Ltd. | 400 | 2026-07-17 | 2026-10-20 |
| Correlation Between Diagnostic Nerve Block Response and Cryoneurolysis Outcome in Chronic Musculoskeletal Disorders cryoablation - Chronic Musculoskeletal Pain, Cryo Analgesia | Not applicable | Not yet recruiting | Universitair Ziekenhuis Brussel | 50 | 2026-07-01 | 2026-04-27 |
| Improving Cryoablation Efficacy With BARRigel Rectal Spacing (ICE-BARR) Barrigel Injectable Gel, Cryoablation - Prostate Cancer (Diagnosis), Transperineal Cryoablation | Not applicable | Recruiting | NYU Langone Health | 20 | 2026-06-17 | 2026-07-09 |
| Percutaneous Thermo-ablation for the Treatment of Prostate Cancer Oligometastatasis (TA-P-OLIM) Thermal ablation - Oligometastatic Prostate Cancer (OMPC), Prostate Cancer (Adenocarcinoma) | Withdrawn | University Hospital, Ghent | 2026-05-10 | 2026-05-13 | ||
| Luminal Breast Cancer Cryoablation Cryoablation with liquid nitrogen (Prosense® system) - Breast Cancer, Breast Cancer (Early Breast Cancer) | Not applicable | Recruiting | Lucía Graña López | 140 | 2026-04-08 | 2026-04-16 |
| CRYO-1: Cryoablation in Elderly Patients With Early-Stage Breast Cancer. Cryoablation / Cryotherapy - Breast Cancer Stage I, Breast Cancer Early Stage Breast Cancer (Stage 1-3) | Not applicable | Not yet recruiting | St. Antonius Hospital | 61 | 2026-04-01 | 2026-03-23 |
| Grouping Immune-modulation With Cryoablation (LOGIC) for Breast Cancers Cryoablation, Cryoablation combined with PD1 Inhibitor - Triple Negative Breast Cancer | Phase 1 / Phase 2 | Not yet recruiting | Texas Tech University Health Sciences Center | 36 | 2026-03-01 | 2025-09-09 |
| Neuroma-Associated Pain Management After Combat-Related Trauma in Ukraine cryoablation, Radiofrequency ablation alone - Pain Management, Quality of Life | Not applicable | Completed | Ukrainian Society of Regional Anesthesia and Pain Therapy | 100 | 2026-02-05 | 2026-10-19 |
| SEED-CRYO: Sequential 125I Seed Implantation Followed by Cryoablation vs Single-Modality Local Therapy in Unresectable Solid Tumors Iodine-125 (125I) Seed Implantation, cryoablation, Sequential 125I Seed Implantation Followed by Cryoablation - Unresectable Solid Tumors | Phase 2 | Not yet recruiting | Li Min | 150 | 2026-02-01 | 2026-03-04 |
| Lesion-Allocated Therapy for Multiple Metastases and Tumor-Zoned Treatment for Bulky Tumors: A Phase II Study of Iodine-125 Seed Implantation Combined With Cryoablation in High-Burden Metastatic Disease Iodine-125 (125I) Seed Implantation (Low-Dose-Rate Brachytherapy), cryoablation, Lesion Allocation and Tumor Zoning Strategy - High-Burden Metastatic Solid Tumors | Phase 2 | Not yet recruiting | Li Min | 90 | 2026-02-01 | 2026-02-27 |
| Comprehensive Multicenter Study on the Management of Acute Pain Following Thoracic Combat-Related Trauma in Ukraine Cryoablation, Radiofrequency ablation alone - Pain Management, Thoracic Trauma | Not applicable | Recruiting | Lviv National Medical University | 50 | 2026-01-01 | 2026-02-02 |
| Cryoablation Combined With the Dual-Function Antibody PD-1/CTLA-4 for the Treatment of LAPC Following Failure of First-Line AG Therapy Cryoablation, Dual-Function Antibody PD-1/CTLA-4 - Pancreatic Adenocarcinoma Locally Advanced | Phase 2 | Recruiting | Ruijin Hospital | 20 | 2025-12-15 | 2025-12-29 |
| Assessment of Pulmonary Vein Isolation Using a Balloon Catheter With Pulsed Field Energy in Atrial Fibrillation Pulsed Field Ablation (PFA) with VOLT Catheter, Thermal Ablation (Radiofrequency or Cryoablation) - Atrial Fibrillation (AF) | Not applicable | Recruiting | Sebastien Knecht | 136 | 2025-12-05 | 2026-05-12 |
| Safety and Efficacy Evaluation of Cryoablation in the Treatment of Ground-Glass Nodules Cryoablation - Lung Cancer | Not applicable | Recruiting | Ruijin Hospital | 90 | 2025-11-21 | 2026-01-22 |
| Stereotactic Guided Biopsy and Cryoablation Stereotactic Guided Biopsy and Cryoablation - Breast Cancer | Not applicable | Withdrawn | Montefiore Medical Center | 2025-10-01 | 2026-02-27 |
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Breast Neoplasms (25) · Neoplasm Metastasis (18) · Atrial Fibrillation (16) · Prostatic Neoplasms (12) · Carcinoma, Hepatocellular (10) · Carcinoma, Renal Cell (10) · Lung Neoplasms (10) · Melanoma (10) · Carcinoma, Non-Small-Cell Lung (9) · Kidney Neoplasms (8) · Liver Neoplasms (8) · Pain (8) · Sarcoma (8) · Colorectal Neoplasms (6) · Biliary Tract Neoplasms (4)
Fuda Cancer Hospital, Guangzhou (22) · Fudan University (13) · Boston Scientific Corporation (8) · Mayo Clinic (6) · M.D. Anderson Cancer Center (5) · Shanghai Chest Hospital (4) · Emory University (3) · Massachusetts General Hospital (3) · Memorial Sloan Kettering Cancer Center (3) · Mirror Biologics, Inc. (3) · Ruijin Hospital (3) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (3) · Sun Yat-sen University (3) · University of California, San Diego (3) · Alliance for Clinical Trials in Oncology (2)
United States (80) · China (53) · France (9) · Brazil (5) · Italy (5) · Netherlands (5) · Canada (4) · Denmark (4) · Germany (3) · Austria (2) · Belgium (2) · Poland (2) · Russia (2) · Singapore (2) · Spain (2)
Jibing Chen, MD, PhD (7) · Peng Wang, MD (5) · Guifeng Liu, PhD (3) · Jibing Chen, PhD (3) · Brian Ilfeld, MD, MS (2) · Carsten Kock-Jensen, MD (2) · Jerry Matteo, MD (2) · Matthew R. Callstrom, MD, PhD (2) · Meghan J Mooradian, MD (2) · Min Li (2) · Peng Wang (2) · Peter J. Littrup, MD (2) · Ricardo MC Freitas, PhD (2) · Tim F Greten, M.D. (2) · AeRang Kim, MD, PhD (1)
PMID 11877663, PMID 11966728, PMID 12533168, PMID 15168956, PMID 15770533, PMID 16019852, PMID 16264158, PMID 17110769, PMID 18054441, PMID 18067627, PMID 18470620, PMID 18565579, PMID 18582827, PMID 18834631, PMID 18946063, PMID 19219697, PMID 19892345, PMID 20231500, PMID 20706107, PMID 20725550, PMID 20974443, PMID 21123824, PMID 22075702, PMID 24672213, PMID 24682079, PMID 24732979, PMID 25431023, PMID 25534572, PMID 25607709, PMID 25920033, PMID 26217925, PMID 26902298, PMID 26969219, PMID 27042964, PMID 27162549, PMID 27221361, PMID 27381589, PMID 27566765, PMID 27738068, PMID 27816492, PMID 28050693, PMID 28508945, PMID 28654336, PMID 28679643, PMID 28720474, PMID 28923358, PMID 29070025, PMID 29487221, PMID 29626424, PMID 29672193
P30CA006973 (2), P30CA022453 (2), U10CA098543 (2), 2025 (1), P30CA012197 (1), P30CA015083 (1), P30CA068485 (1), P30CA093373 (1), P50CA097274 (1), R01CA219960 (1)