201 completed, 44 unknown, 20 recruiting, 12 terminated. 144 Not applicable, 68 Phase 2, 41 Phase 1, 12 Phase 3, 11 Phase 4.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Episodic Future Thinking, Loss Aversion and Cigarette Smoking Episodic Future Thinking, Control Episodic Thinking - Tobacco Smoking | Not applicable | Withdrawn | University of Vermont | 2050-01-01 | 2026-05-04 | |
| PDAC Regression and Intraoperative Surgical Margin With Neoadjuvant TAMP (PRISM-TAMP) Gemcitabine Delivered by Transarterial Microperfusion - Pancreatic Ductal Adenocarcinoma (PDAC), Borderline Resectable Pancreatic Cancer | Phase 1 / Phase 2 | Not yet recruiting | University of Vermont | 10 | 2026-12-01 | 2026-03-17 |
| Smartphone-based Incentives Intervention to Increase Smoking Cessation During Pregnancy Best Practices, Financial Incentives - Smoking During Pregnancy and Postpartum, Perinatal Cigarette Smoking | Not applicable | Not yet recruiting | University of Vermont | 137 | 2026-09-01 | 2026-09-24 |
| Phase 1B Trial of Intratumoral Cisplatin for Stage IV Lung Cancer cisplatin (cis-diamminedichloroplatinum(II) (CDDP)) - Lung Cancer Metastatic, Lung Cancer (NSCLC) | Phase 1 | Not yet recruiting | University of Vermont | 12 | 2026-07-01 | 2026-03-27 |
| Esketamine Versus Crisis Response Planning Versus Enhanced Treatment as Usual for Suicide Prevention: A Pragmatic Randomized Trial in a Brazilian Municipality (SAVE) Intravenous Esketamine, Crisis Response Planning (CRP), Enhanced Treatment as Usual (eTAU) - Suicide Prevention, Ketamine | Phase 4 | Recruiting | University of Sao Paulo | 478 | 2026-06-01 | 2026-09-16 |
| RE-FIT (Remote Exercise for Physical Function in WTC Responders With Prostate Cancer) Remote Supervised Exercise Program - Prostate Cancer | Not applicable | Not yet recruiting | University of Vermont | 40 | 2026-06-01 | 2026-02-27 |
| A Multi-Site Hybrid Type I Effectiveness-Implementation Randomized Trial of an Emergency Care Action Plan for Infants With Medical Complexity Emergency Care Action Plan - Chronic Disease Management, Infants Health | Not applicable | Not yet recruiting | University of Vermont | 500 | 2026-04-01 | 2025-06-06 |
| Prolonged Exposure Therapy to Treat Posttraumatic Stress Disorder in Pregnant Patients Prolonged exposure therapy + incentives for therapy session attendance - Posttraumatic Stress Disorder, Pregnancy | Not applicable | Recruiting | University of Vermont | 30 | 2026-02-05 | 2026-05-13 |
| Readiness to Change and the Implementation of Home Modifications for Adults Over 60 Face-to-face educational session, On-line educational session - Older Adults (60 - 85 Years Old) | Not applicable | Not yet recruiting | University of Vermont | 40 | 2026-01-28 | 2026-02-03 |
| Fezolinetant for Treating Hot Flashes in Men With Prostate Cancer Fezolinetant - Prostate CA, Androgen Deprivation Therapy | Phase 2 | Recruiting | University of Vermont | 32 | 2025-12-18 | 2026-02-05 |
| Food Insecurity and Eating Behavior Among Adults Receiving Buprenorphine or Methadone Maintenance Treatment: Pilot Study 2 NE + Meal Delivery (NE+MD) intervention - Food Security | Not applicable | Recruiting | University of Vermont | 40 | 2025-11-07 | 2025-11-26 |
| DOAC - Dosing Options in AntiCoagulation Prophylaxis Apixaban 2.5 mg twice daily, Apixaban 5 mg once daily, No anticoagulation - Cancer, VTE (Venous Thromboembolism) | Phase 3 | Recruiting | University of Vermont | 996 | 2025-10-17 | 2026-02-05 |
| Groceries for Residents of Southeastern USA to Stop Hypertension Dietitian-Assisted DASH groceries, Self-directed shopping - Hypertension, Elevated Blood Pressure | Not applicable | Recruiting | Beth Israel Deaconess Medical Center | 150 | 2025-10-14 | 2026-08-19 |
| Implementing VTE Prevention in Ambulatory Cancer Care Clinical program - Venous Thromboembolism, Neoplasms | Not applicable | Enrolling by invitation | University of Vermont | 25 | 2025-10-01 | 2025-12-18 |
| Contingency Management to Improve Medication for Opioid Use Disorder Continuation After the Emergency Department Contingency Management, Usual care as prescribed by the ED physicians - Opioid Use Disorder | Not applicable | Completed | University of Vermont | 12 | 2025-09-02 | 2026-10-20 |
| A Phase 1B Investigator Initiated Study of Safety and Tolerability of Dexamethasone (D) in Combination With Venetoclax-based Low-Intensity Therapy (LIT) in Treatment-Naïve Acute Myeloid Leukemia (AML): DLIT-AML Dexamethasone plus Venetoclax-based Low-Intensity Therapy - AML - Acute Myeloid Leukemia | Phase 1 | Enrolling by invitation | University of Vermont | 20 | 2025-09-01 | 2025-10-06 |
| Clinical Screening and Peer Interventions to Prevent Substance Use in At-Risk Adolescents Peer to peer video to raise awareness about substance use - Initation of Substance Use Disorder | Not applicable | Not yet recruiting | University of Vermont | 50 | 2025-09-01 | 2025-07-20 |
| Preventing Perinatal Anxiety: Testing an Internet-delivered Intervention Preventing Postpartum Onset Distress (P-POD), Anxiety Education (ANX-ED) - Postpartum Disorder | Not applicable | Not yet recruiting | West Virginia University | 100 | 2025-08-01 | 2025-07-17 |
| Improving Neurodevelopmental ouTcomes After Prenatal Cannabinoid in uTero Exposure Play and Learn Strategies (PALS) Program - Developmental Delay | Not applicable | Recruiting | IDeA States Pediatric Clinical Trials Network | 20 | 2025-02-06 | 2025-06-24 |
| Comparing the Effectiveness of the 'Think in Nerve Length and Layers' (TINLL) Approach to Traditional Treatment for Patients With Lateral Elbow Pain. TINLL techniques for relieving radial nerve tension, Traditional techniques to stretch and strengthen muscles - Lateral Elbow Tendinopathy (Tennis Elbow) | Not applicable | Recruiting | University of Vermont | 68 | 2024-11-26 | 2026-02-04 |
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Opioid-Related Disorders (32) · Obesity (22) · Tobacco Use Disorder (20) · Motor Activity (15) · Breast Neoplasms (13) · Asthma (12) · Smoking Cessation (12) · Weight Loss (11) · Neoplasms (10) · Vaping (10) · Overweight (8) · Smoking (8) · Recurrence (7) · Substance-Related Disorders (7) · Infertility (6)
Buprenorphine (22) · Exercise (6) · Practice Guidelines as Topic (5) · Cisplatin (4) · Dexamethasone (4) · Electronic Nicotine Delivery Systems (4) · Fertility (3) · Pioglitazone (3) · Tobacco Use Cessation Devices (3) · Amino Acids (2) · Aminosalicylic Acid (2) · Aspirin (2) · Behavior Therapy (2) · Clomiphene (2) · Cognitive Behavioral Therapy (2)
United States (274) · Bangladesh (3) · Brazil (1) · Czechia (1) · Hong Kong (1) · India (1) · Uganda (1)
Warren Bickel, Ph.D. (22) · John R Hughes, MD (6) · Christos Coutifaris, MD (5) · Esther Eisenberg, MD, MPH (5) · Heping Zhang, PhD (5) · Michael Diamond, MD (5) · Nanette Santoro, MD (5) · Peter Casson, MD (5) · Richard Legro, MD (5) · Robert Brzyski, MD, PhD (5) · Benjamin Littenberg, MD (4) · Stephen T Higgins, PhD (4) · Andrea C Villanti, PhD, MPH (3) · Beth Kirkpatrick, M.D. (3) · Chris E Holmes, MD, PhD (3)
PMID 42560883, PMID 32628945, PMID 33079196, PMID 34242666, PMID 34255068, PMID 36208817, PMID 38236223, PMID 39240566, PMID 24662210, PMID 26354094, PMID 26413816, PMID 27402910, PMID 29102040, PMID 29778387, PMID 30085176, PMID 32150314, PMID 33190149, PMID 34180998, PMID 35125179, PMID 39672366, PMID 10661603, PMID 10731544, PMID 11129360, PMID 11250852, PMID 11403816, PMID 15115421, PMID 15385274, PMID 16720082, PMID 16756420, PMID 16776793, PMID 16950371, PMID 17356959, PMID 18238963, PMID 18430748, PMID 19386937, PMID 19433757, PMID 19727256, PMID 19875989, PMID 19929029, PMID 20008695, PMID 20537810, PMID 20678891, PMID 21200063, PMID 21262782, PMID 21330650, PMID 21496800, PMID 21601986, PMID 21645894, PMID 21778256, PMID 21882997
R01DA006969 (6), U54DA036114 (6), P20GM103644 (5), P50DA036114 (3), U10HD055925 (3), R01DK056746 (2), U01AR071158 (2), U10HL084904 (2), U24AR071113 (2), U24DK112326 (2), U24DK112331 (2), U24DK112340 (2), U24DK112341 (2), U24DK112342 (2), U24DK112348 (2)