48 completed, 11 terminated, 11 unknown, 7 recruiting. 90 Phase 1, 51 Phase 2.
Follow Shock: new trials by email Literature Review of Shock trials Research Report on Shock
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| CLL-1/CD70 Dual-Target CAR-T Cell Therapy for Acute Myeloid Leukemia CLL-1-CD70 CAR-T Cell Injection - Acute Myeloid Leukemia (AML), Relapsed/Refractory Acute Myeloid Leukemia | Phase 1 | Not yet recruiting | Liping Dou | 12 | 2026-11-30 | 2026-10-27 |
| Pre-emptive Anakinra for Cytokine Event Reduction Anakinra (Kineret®) - B-Acute Lymphoblastic Leukemia, CAR-T Cell Therapy | Phase 1 / Phase 2 | Withdrawn | Kevin McNerney | 2026-10-01 | 2026-08-13 | |
| CLL-1-Targeted In Vivo CAR-T Cell Immunotherapy for Relapsed/Refractory Acute Myeloid Leukemia SL1CC Injection - Relapsed/Refractory Acute Myeloid Leukemia (AML), Acute Myeloid Leukemia (AML) | Phase 1 | Not yet recruiting | Liping Dou | 12 | 2026-10-01 | 2026-10-02 |
| Bispecific CAR T Cells for B-cell Malignancies (BaseCAR-01 Trial) Experimental Intervention - B Cell Malignancies, B-cell Leukemia | Phase 1 | Not yet recruiting | University Hospital, Basel, Switzerland | 12 | 2026-06-01 | 2025-12-24 |
| Safety and Efficacy of FAP iCDC in Acute Myocardial Infarction With Cardiogenic Shock FAP allogeneic immunosuppressive CAR-DC - Cardiogenic Shock, Cardiogenic Shock Post Myocardial Infarction | Phase 1 | Not yet recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 18 | 2026-01-20 | 2026-02-02 |
| POCUS-Guided Esmolol in Septic Shock: A Pilot RCT Esmolol - Septic Shock | Phase 1 / Phase 2 | Not yet recruiting | John Basmaji | 100 | 2026-01-15 | 2026-01-06 |
| Point-of-Care AI Assistance and Critical Care Outcomes: A Randomized Trial Point-of-care large language model decision support (ChatGPT-5) - Critical Illness, Sepsis | Phase 1 / Phase 2 | Not yet recruiting | MetroWest Artificial Intelligence Research Workgroup | 1000 | 2026-01-01 | 2025-12-18 |
| A Comparative Study Between Dexmedetomidine Versus Methylprednisolone on Induced Inflammatory Response in Patients Undergoing On-pump CABG Normal saline, Dexmedetomidine, Methylprednisolone - Coronary Artery Disease, Systemic Inflammatory Response Syndrome | Phase 1 / Phase 2 | Unknown | Ain Shams University | 60 | 2025-09-01 | 2025-08-06 |
| A Phase 1b/2a Trial to Evaluate Invobenitug Also Known as Procizumab (PCZ; AK1967) in Critical Cardiovascular Care. AK1967 (Invobenitug also known as Procizumab), Placebo - Shock, Cardiogenic | Phase 1 / Phase 2 | Recruiting | 4TEEN4 Pharmaceuticals GmbH | 90 | 2025-07-13 | 2026-09-14 |
| Adjunctive Methylene Blue for Immunotherapy-related CRS and ICANS: Phase I Study Methylene Blue - Cytokine Release Syndrome, ICANS | Phase 1 | Recruiting | Institute of Hematology & Blood Diseases Hospital, China | 18 | 2025-06-28 | 2025-09-11 |
| Study of Cytokine Release Syndrome Prophylaxis and Treatment With Siltuximab Prior to Epcoritamab Siltuximab, Epcoritamab, Gemcitabine and oxaliplatin - Non-Hodgkin Lymphoma, Cytokine Release Syndrome | Phase 1 | Recruiting | Taylor Brooks | 20 | 2025-01-14 | 2026-06-25 |
| A Study in Healthy Subjects to Assess the Safety and Tolerability of a 120-hour Continuous Infusion of M6229 M6229, Placebo - Healthy Subjects | Phase 1 | Completed | Matisse Pharmaceuticals | 15 | 2024-11-21 | 2025-12-16 |
| Study on Safety and Efficacy of Two Doses of PRS CK STORM in the Modulation of the Cytokine Storm in Patients With Acute Respiratory Infection Caused by SARS-Cov-2, Influenza A, Influenza B and Respiratory Syncytial Virus (RSV) Placebo comparator, PRS CK STORM - SARS-CoV-2, Influenza, Human | Phase 1 / Phase 2 | Recruiting | PEACHES BIOTECH | 50 | 2024-10-02 | 2026-06-10 |
| Studying Topiramate for Re-Activating the HIV-1 Reservoir Topiramate - HIV-1-infection, Hiv | Phase 1 / Phase 2 | Unknown | Erasmus Medical Center | 12 | 2024-09-01 | 2024-02-28 |
| A Safety and Efficacy Trial of Istaroxime for Cardiogenic Shock Stage C Istaroxime, Placebo - Cardiogenic Shock | Phase 1 / Phase 2 | Active not recruiting | Windtree Therapeutics | 20 | 2024-06-01 | 2025-08-20 |
| Optimizing Reversal of HIV Latency With Combination Therapy Panobinostat 20 MG Oral Capsule, Pyrimethamine 200mg Oral Tablet, Lenalidomide 25 MG Oral Capsule - Hiv | Phase 1 / Phase 2 | Unknown | Erasmus Medical Center | 49 | 2024-04-01 | 2024-02-05 |
| Study of CTO1681 for the Prevention and Treatment of CRS in Patients Receiving CAR T-Cell Therapy CTO1681 10 µg, CTO1681 20 μg, CTO1681 30 μg - Cytokine Release Syndrome | Phase 1 / Phase 2 | Recruiting | CytoAgents, Inc. | 54 | 2023-12-28 | 2026-08-31 |
| Individualized or Conventional Transfusion Strategies During Peripheral VA-ECMO Packed Red Blood Cells (PRBCs) - Cardiogenic Shock, Extracorporeal Membrane Oxygenation | Phase 1 | Recruiting | University Hospital, Lille | 236 | 2023-09-18 | 2026-09-17 |
| Improvement of Organ Function by Apigenin in Elderly Patients With Sepsis apigenin, sterilized water - Sepsis, Septic Shock | Phase 1 / Phase 2 | Completed | Zhujiang Hospital | 20 | 2023-09-01 | 2024-03-13 |
| Phase 1b MMV367 PK/PD and Safety in Healthy Adult Volunteers Experimentally Infected With Blood Stage P. Falciparum MMV367 3mg, P. falciparum IBSM infection, MMV367 5mg - Infections, Vector Borne Diseases | Phase 1 | Completed | Medicines for Malaria Venture | 12 | 2023-08-01 | 2025-12-10 |
Showing 20 of 90. Sign in to see all of them.
Shock, Septic (41) · Sepsis (31) · Cytokine Release Syndrome (20) · COVID-19 (9) · Systemic Inflammatory Response Syndrome (9) · Critical Illness (5) · Inflammation (5) · Multiple Organ Failure (5) · Respiratory Distress Syndrome (5) · Pneumonia (4) · Recurrence (4) · Shock, Cardiogenic (4) · Wounds and Injuries (4) · Acute Lung Injury (3)
Pathological Conditions, Signs and Symptoms (90) · Pathologic Processes (89) · Inflammation (66) · Systemic Inflammatory Response Syndrome (62) · Infections (57) · Respiratory Tract Diseases (16) · Sepsis (16) · Virus Diseases (13) · Hemic and Lymphatic Diseases (11) · Lung Diseases (11) · RNA Virus Infections (11) · Respiratory Tract Infections (10) · Cardiovascular Diseases (9) · Coronaviridae Infections (9)
Saline Solution (5) · Meropenem (4) · Ascorbic Acid (3) · Bronchoscopy (3) · Cyclophosphamide (3) · Valproic Acid (3) · Ventilators, Mechanical (3) · fludarabine (3) · AP 1903 reagent (2) · Albumins (2) · Propofol (2) · Thiamine (2) · fludarabine phosphate (2) · 2-(phenylmethyl)-1-naphthol (1) · AB103 (1)
Beth Israel Deaconess Medical Center (3) · King Abdul Aziz Specialist Hospital (3) · Biomedizinische Forschungs gmbH (2) · Dr. Hasan Alam (2) · Erasmus Medical Center (2) · Jinhua Central Hospital (2) · Liping Dou (2) · Southeast University, China (2) · UNC Lineberger Comprehensive Cancer Center (2) · Wake Forest University Health Sciences (2) · 4TEEN4 Pharmaceuticals GmbH (1) · A.P.J. Vlaar (1) · Ain Shams University (1) · Alberta Health Services, Calgary (1) · Alexander Flannery, 859-323-4011 (1)
United States (32) · China (12) · Canada (5) · Netherlands (5) · Australia (4) · Saudi Arabia (4) · Spain (4) · Egypt (3) · Germany (3) · Mexico (3) · Austria (2) · Belgium (2) · France (2) · Poland (2) · Turkey (Türkiye) (2)
Alan E Jones, MD (2) · Hasan Alam, MD (2) · Martha M Eibl, MD (2) · Michael W Donnino, MD (2) · Adelina Pellicer, MD PhD (1) · Alan Cross, MD (1) · Alexander H. Flannery, Pharm.D. (1) · Alexander P Vlaar, MD, PhD, MBA (1) · Alexandre Mebazaa, Professor (1) · Ali Dehghan-Manshadi, MD (1) · Alpha Fowler, MD (1) · Anastasia Kotanidou, MD, PhD (1) · Andreas Holbro, Prof. Dr. (1) · Anthony F Suffredini, M.D. (1) · Benoit Bestgen, PhD (1)
PMID 10415784, PMID 12563677, PMID 14719037, PMID 15663512, PMID 16553654, PMID 17181919, PMID 18097874, PMID 18805742, PMID 19280394, PMID 19397687, PMID 19453649, PMID 19998041, PMID 20236457, PMID 20809942, PMID 20955600, PMID 21131395, PMID 21190486, PMID 21325598, PMID 21371308, PMID 22028728, PMID 22071998, PMID 22545014, PMID 22731679, PMID 23374652, PMID 23594433, PMID 23857856, PMID 24088271, PMID 24300013, PMID 24484547, PMID 24691607, PMID 25286986, PMID 25456364, PMID 25805204, PMID 26049730, PMID 26443879, PMID 26605292, PMID 26825368, PMID 26836806, PMID 26867177, PMID 27038920, PMID 27296693, PMID 27318038, PMID 27707765, PMID 28131429, PMID 28203424, PMID 28497259, PMID 28584818, PMID 28960096, PMID 29351985, PMID 30074491
2018 (1), 2023 (1), 2025 (1), K12CA120780 (1), K12TR005104 (1), M01RR002558 (1), R44CA295189 (1)