118 completed, 37 unknown, 26 terminated, 19 recruiting. 232 Phase 3, 53 Phase 2.
Follow Shock: new trials by email Literature Review of Shock trials Research Report on Shock
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study to Assess Safety and Efficacy of Centhaquine as a Resuscitative Agent Normal Saline, Centhaquine - Hypovolemic Shock | Phase 3 | Not yet recruiting | Pharmazz, Inc. | 430 | 2027-02-01 | 2026-09-17 |
| A Trial of Adjunctive Fludrocortisone (50mcg, 100mcg or Placebo) in Critically Ill Patients With Septic Shock Receiving Hydrocortisone, Evaluating Survival and Functional Recovery and the Influence of Transcriptomic Response Fludrocortisone 50 mcg daily, Fludrocortisone 100 mcg daily, Placebo - Septic Shock | Phase 3 | Recruiting | The George Institute | 2200 | 2026-10-16 | 2026-10-30 |
| Randomized Evaluation of Istaroxime for Stabilization in Acute Heart Failure-Cardiogenic Shock istaroxime, placebo - Cardiogenic Shock | Phase 2 / Phase 3 | Recruiting | Seismic Pharmaceuticals Operations LLC | 600 | 2026-09-09 | 2026-09-23 |
| Efficacy of the Alpha 2 Agonist Dexmedetomidine for Sympathetic Deactivation in REfractory Septic Shock Dexmedetomidine 100 µg/mL, intravenous solution, Stardard care - Septic Shock, Vasopressor Resistance | Phase 3 | Not yet recruiting | Hospices Civils de Lyon | 360 | 2026-09-01 | 2026-05-06 |
| Assessing the Efficacy of Dapagliflozin as a Vasculoprotective Treatment in Septic Shock Patients With Microcirculatory Dysfunction Dapaglifozin, Placebo - Septic Shock | Phase 3 | Not yet recruiting | University Hospital, Strasbourg, France | 568 | 2026-07-01 | 2026-03-27 |
| Comparative Efficacy and Safety of Propofol-Ketamine Combination Versus Propofol Monotherapy in Geriatric Patients Under Invasive Ventilation Ketofol, propofol (drug) - The Critically Ill Patient is Requiring Intubation, Septic Shock | Phase 3 | Active not recruiting | Helwan University | 70 | 2026-05-13 | 2026-10-15 |
| Ivabradine in the Acute Management of Cardiogenic Shock Ivabradine 5mg Tab, Placebo Oral Tablet - Cardiogenic Shock Post Myocardial Infarction | Phase 3 | Recruiting | National Institute of Cardiovascular Diseases, Pakistan | 200 | 2026-04-20 | 2026-07-20 |
| Comparison of Two Etoposide Initiation Strategies for Severe Hemophagocytic Lymphohistiocytosis Etoposide (Early strategy), Etoposide (Delayed strategy) - Hemophagocytic Lymphohistiocytosis | Phase 3 | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 176 | 2026-04-01 | 2026-04-23 |
| Systematic Adjunction of Vasopressine in Septic Shock Vasopressin administration, Sodium chloride administration - Septic Shock | Phase 3 | Recruiting | Assistance Publique Hopitaux De Marseille | 120 | 2026-03-24 | 2026-10-26 |
| Early Methylene Blue in the Microhemodynamics of Septic Patients Methylene blue infusion - Septic Shock, Hypoperfusion | Phase 2 / Phase 3 | Recruiting | Centro de Estudos e Pesquisa em Emergencias Medicas e Terapia Intensiva | 50 | 2026-01-09 | 2026-03-27 |
| Human Albumin for Resuscitation in Surgical Septic Shock: A Randomized Controlled Trial (ALBUS Study) Human Albumin 20% Solution, Standard Care (in control arm) - Critical Illness, Septic Shock | Phase 3 | Not yet recruiting | Mahidol University | 304 | 2025-12-01 | 2025-11-19 |
| REMIMID-ICU: Remimazolam vs Midazolam for Deep Sedation in Hemodynamically Unstable, Mechanically Ventilated Adults Remimazolam Besylate, Midazolam - Critical Illness; Mechanical Ventilation; Shock | Phase 3 | Not yet recruiting | Yancheng First People's Hospital | 180 | 2025-10-01 | 2025-09-04 |
| Weaning Approaches for Vasopressin in Sepsis Titrated weaning of vasopressin., Abrupt weaning of vasopressin. - Septic Shock | Phase 3 | Recruiting | Hospital Nossa Senhora da Conceicao | 82 | 2025-10-01 | 2026-01-02 |
| Inhaled Isoflurane for Sedation of Invasively Ventilated Patients With Cardiogenic Shock on Extracorporeal Membrane Oxygenation Inahled Isoflurane, Propofol, midazolam - Cardiogenic Shock, ECMO | Phase 3 | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 300 | 2025-09-15 | 2025-08-01 |
| NexCAR19 (Talikabtagene Autoleucel) in Relapsed/Refractory B-Cell Malignancies (NexCAR19) Talikabtagene Autoleucel - Relapsed/Refractory B-cell Acute Lymphoblastic Leukemia (B-ALL), Relapsed/Refractory Non-Hodgkin Lymphoma | Phase 2 / Phase 3 | Recruiting | Health Institutes of Turkey | 40 | 2025-09-11 | 2026-03-30 |
| Optimization Strategies for Blood Transfusion Protocols in the Emergency Treatment of Hemorrhagic Shock low-titer O-group whole blood, 1:1:1 component transfusion, ABO- and Rh-compatible whole blood - Hemorrhage, Hemorrhagic Shock | Phase 3 | Not yet recruiting | Xijing Hospital | 180 | 2025-09-01 | 2025-08-19 |
| A Combination Therapy With Ceftazidime and Fosfomycin Will be Compared to Ceftazidime Alone in Hospitalized Adult Patients With Suspected Severe Gram-negative Bacterial Infections Ceftazidime± avibactam with fosfomycin, Ceftazidime± avibactam with placebo - Gram Negative Infections, Sepsis and Septic Shock | Phase 3 | Recruiting | Angela HUTTNER | 100 | 2025-08-25 | 2025-09-26 |
| Adjunctive Methylene Blue in Septic Shock Methylene Blue, Usual Care - Septic Shock | Phase 3 | Completed | Dr. Shannon M. Fernando | 50 | 2025-06-02 | 2026-03-19 |
| Dalargin for Prevention of Organ Disfunction in High-Risk Abdominal Surgery Dalargin, 0.9 % NaCl - Postoperative Complications, Multiple Organ Failure | Phase 3 | Completed | Botkin Hospital | 200 | 2025-05-13 | 2026-09-23 |
| Evaluation of Early Administration of Levetiracetam in the Prevention and Treatment Encephalopathy in Septic Shock: Randomized, Double-blind, Placebo-controlled Trial Levetiracetam IV, Placebo control - Septic Shock | Phase 3 | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 280 | 2025-03-15 | 2025-03-12 |
Showing 20 of 232. Sign in to see all of them.
Shock, Septic (132) · Sepsis (79) · Cytokine Release Syndrome (24) · COVID-19 (22) · Shock, Hemorrhagic (18) · Shock, Cardiogenic (15) · Critical Illness (11) · Multiple Organ Failure (11) · Pneumonia (11) · Wounds and Injuries (11) · Systemic Inflammatory Response Syndrome (10) · Acute Kidney Injury (8) · Diabetes Insipidus (8) · Inflammation (8)
Pathological Conditions, Signs and Symptoms (232) · Pathologic Processes (229) · Inflammation (166) · Infections (164) · Systemic Inflammatory Response Syndrome (162) · Sepsis (66) · Respiratory Tract Diseases (36) · Cardiovascular Diseases (32) · Lung Diseases (32) · Vascular Diseases (30) · Respiratory Tract Infections (28) · Coronaviridae Infections (22) · Nidovirales Infections (22) · Pneumonia, Viral (22)
Saline Solution (24) · Hydrocortisone (16) · Norepinephrine (16) · Sodium Chloride (15) · Ascorbic Acid (11) · Standard of Care (9) · Methylene Blue (8) · Ringer's Lactate (8) · Albumins (6) · Vasopressins (6) · Fludrocortisone (5) · Thiamine (5) · Dexmedetomidine (4) · Dobutamine (4) · Ketamine (4)
Assistance Publique - Hôpitaux de Paris (12) · Cairo University (6) · Australian and New Zealand Intensive Care Research Centre (4) · University of Sao Paulo (4) · University of Versailles (4) · Hospices Civils de Lyon (3) · Jason Sperry (3) · Alexandria University (2) · Beth Israel Deaconess Medical Center (2) · Central Hospital, Nancy, France (2) · Centre Hospitalier Universitaire Dijon (2) · Centre Hospitalier Universitaire de Besancon (2) · Centre Hospitalier Universitaire de Nīmes (2) · Centre Hospitalier Universitaire, Amiens (2) · Cristina Martinez (2)
France (55) · United States (47) · Canada (18) · Brazil (17) · Germany (16) · Italy (15) · Spain (14) · Australia (12) · Belgium (12) · Egypt (12) · Netherlands (12) · United Kingdom (11) · Denmark (8) · Mexico (8) · China (7)
Ahmed Mukhtar, Professor (3) · Konrad Reinhart, MD (3) · Anders Perner, MD, PhD (2) · Andrea Morelli, MD (2) · Didier Keh, MD (2) · Djillali Annane, MD (2) · Djillali Annane, MD, PhD (2) · Jason Sperry, MD (2) · Joaquin Espinosa, PhD (2) · Luciano Gattinoni, MD (2) · Michael W Donnino, MD (2) · Pietro Caironi, MD (2) · Qingquan Lyu, Master (2)
PMID 21615299, PMID 23525934, PMID 23984731, PMID 24635772, PMID 25647203, PMID 25947955, PMID 27695824, PMID 33438477, PMID 36915146, PMID 38531812, PMID 40271704, PMID 10371570, PMID 10722036, PMID 10933646, PMID 1138591, PMID 11502226, PMID 11588440, PMID 12454520, PMID 12500513, PMID 12519925, PMID 12545007, PMID 12700374, PMID 14759425, PMID 1607900, PMID 16134766, PMID 1632474, PMID 16570523, PMID 16616623, PMID 16757723, PMID 16978417, PMID 17109736, PMID 17387132, PMID 17698886, PMID 17720019, PMID 18090009, PMID 18184957, PMID 18184958, PMID 18353115, PMID 18444850, PMID 18477932, PMID 18552688, PMID 19114908, PMID 19228496, PMID 19534818, PMID 19593244, PMID 19730258, PMID 19851126, PMID 19926252, PMID 20103758, PMID 20200382
2018 (4), 2005 (3), 2017 (3), 2014 (2), 2019 (2), 2023 (2), 2025 (2), U01HL077863 (2), 1UG3HL157401-01A1 (1), 2009 (1), 2015 (1), K08HD052885 (1), K23GM083211 (1), P30CA138292 (1), R01HD096901 (1)