55 completed, 9 terminated, 8 recruiting, 8 unknown. 26 Not applicable, 24 Phase 2, 16 Phase 3, 15 Phase 4, 6 Phase 1.
Follow Thiamine: new trials by email Literature Review of Thiamine trials Research Report on Thiamine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study on Thiamine Supplementation to REduce braiN Injury Associated With Chronic Alcohol Use in Outpatients With Alcohol Use Disorder Thiamine - Alcohol Use Disorder | Phase 2 | Not yet recruiting | Institut National de la Santé Et de la Recherche Médicale, France | 60 | 2026-10-23 | 2026-09-28 |
| Oral Thiamine (Vitamin B1) for Depression in Children and Adolescents thiamine hydrochloride 100 mg - Major Depressive Disorder (MDD), Thiamine | Phase 2 | Not yet recruiting | Massachusetts General Hospital | 40 | 2026-10-01 | 2026-08-28 |
| Clinical Trial On The Effect Of Artisterol On Risk Factors In Individuals With Suboptimal Cholesterol Levels investigational product containing phytosterol, artichoke extract and thiamin, Placebo - Hyperlipoproteinemia | Not applicable | Recruiting | Zentiva, k.s. | 106 | 2026-04-24 | 2026-05-12 |
| Synbiotic Supplement With Botanical Extracts for Gut Microbiota Balance in Irritable Bowel Syndrome Synbiotic supplement containing probiotic strains, botanical extracts, magnesium, vitamin B1, and L-theanine designed to support gut microbiota balance. - Irritable Bowel Syndrome (IBS) | Not applicable | Not yet recruiting | Iuliu Hatieganu University of Medicine and Pharmacy | 8 | 2026-04-01 | 2026-03-16 |
| Effectiveness of Neuroplasticity-Targeted Supplements on Neuroinflammatory Markers, ADHD Symptom Severity, and Clinical Scores in Children Inulin, Probiotic, Omega-3 Fatty Acids - Attention Deficit Hyperactivity Disorder | Not applicable | Recruiting | Khyber Medical University Peshawar | 68 | 2026-03-01 | 2026-06-24 |
| Affect of Melatonin on Sleep and Cognition in Cirrhosis Melatonin tablet 3 mg once daily, Thiamine - Hepatic Encephalopathy, Covert Hepatic Encephalopathy | Not applicable | Recruiting | Weill Medical College of Cornell University | 18 | 2025-08-05 | 2026-07-29 |
| Comparative Study of Combination Treatment of Bionerv E+ Versus Vitamin B Complex in Treatment of Diabetic Polyneuropathy in Type 2 Diabetic Patients and Its Effect on Wound Healing Alpha-Lipoic Acid, Vitamin B1, Vitamin B6, Vitamin B12, Vitamin E, Vitamin B1, Vitamin B6, Vitamin B12 - Diabetic Foot Ulcer (DFU), Diabetic Symmetrical Polyneuropathy | Not applicable | Recruiting | BREGO Life Sciences | 100 | 2025-07-22 | 2026-10-16 |
| Thiamine Intervention and Coronary Artery Bypass Grafting Thiamine, Placebo - Coronary Heart Disease, Coronary Artery Bypass Grafting | Early Phase 1 | Recruiting | University of California, Los Angeles | 52 | 2024-10-10 | 2026-08-03 |
| Type 2 Diabetes and Blood Brain Barrier Improvement Thiamine, Placebo - Type2diabetes | Early Phase 1 | Recruiting | University of California, Los Angeles | 52 | 2024-08-01 | 2026-03-13 |
| The Role of Thiamine After Transcatheter Closure in Children With Left-to-Right Shunt Congenital Heart Disease Thiamine - Congenital Heart Disease, Thiamine Deficiency | Early Phase 1 | Completed | Universitas Sumatera Utara | 86 | 2024-05-01 | 2026-03-24 |
| COLchicine and Thiamine in Heart Failure Due to Ischemic Heart Disease Colchicine 0.5 MG, Colchicine placebo, Thiamine Mononitrate 300 mg - Heart Failure | Phase 3 | Recruiting | Hamilton Health Sciences Corporation | 2500 | 2024-01-29 | 2026-10-02 |
| Efficacy of Vitamin B1 in Familial Adenomatous Polyposis Patients. Vitamin B1 - Familial Adenomatous Polyposis (FAP) | Not applicable | Enrolling by invitation | Shanghai Zhongshan Hospital | 10 | 2024-01-08 | 2026-04-24 |
| Efficacy of Early Intravenous High-dose Vitamin C in Post-cardiac Arrest Shock. Vitamin C (Laroscorbine) + Vitamin B1 (Bevitine), standard treatment - Cardiac Arrest | Phase 2 | Recruiting | Centre Hospitalier de Bethune | 234 | 2023-12-27 | 2026-05-08 |
| Supplemental Thiamine in Septic Shock: A Before-after Study Thiamin - Septic Shock | Completed | Hospital Sao Domingos | 73 | 2023-09-01 | 2024-04-18 | |
| the Effect of Vitamin B 1 on Menstrual Pattern After Insertion of the IUD. VITAMIN B1 500mg, intra-uterine contraceptive device - Intra-uterine Device Complication | Phase 3 | Unknown | Beni-Suef University | 200 | 2023-07-30 | 2023-08-02 |
| Effect of Thiamine on Serum Glucagon And Reactive Oxygen Species (ROS) Vitamin B, Placebo - Sepsis, Thiamine Deficiency | Not applicable | Completed | Universitas Sumatera Utara | 30 | 2022-10-01 | 2022-12-23 |
| Steroid, Thiamine and Ascorbic Acid for Comatose Out-of-hospital Cardiac Arrest Survivors The combined supplement of Ascorbic acid, Thiamine, and Cortisol, Placebo - Out-Of-Hospital Cardiac Arrest, Postcardiac Arrest Syndrome | Phase 2 | Completed | Asan Medical Center | 160 | 2021-12-31 | 2025-06-11 |
| Evaluation of Aminobutyric Acid, Glutamic Acid, Calcium, Thiamine, Pyridoxine and Cyanocobalamin as Therapy for Vertigo Gamma-aminobutyric acid tartarate, glutamic acid, dibasic calcium phosphate, thiamine nitrate, pyridoxine chloride and cyanocobalamin, Ginger - Vertigo | Phase 4 | Completed | Fundação Educacional Serra dos Órgãos | 334 | 2021-11-22 | 2023-05-17 |
| B1 and Magnesium Supplements on Glucose Metabolism in Low-carb Dieters vitamin B1 and magnesium supplements - Diet, Carbohydrate-restricted | Not applicable | Suspended | University of Glasgow | 18 | 2021-10-01 | 2021-04-30 |
| HAT for the Treatment of Sepsis Associated With NASTI HAT, Placebo - Necrotizing Soft Tissue Infection, Sepsis | Phase 1 / Phase 2 | Terminated | Ascension Health | 10 | 2021-09-10 | 2024-07-24 |
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Shock, Septic (20) · Sepsis (19) · Thiamine Deficiency (12) · Heart Failure (8) · Critical Illness (5) · Acidosis, Lactic (4) · Beriberi (4) · Heart Arrest (4) · Diabetes Mellitus (3) · Fatigue (3) · Acquired Immunodeficiency Syndrome (2) · Hyperlactatemia (2) · Post-Cardiac Arrest Syndrome (2) · Abortion, Habitual (1) · Acidosis (1)
Beth Israel Deaconess Medical Center (8) · Universitas Sumatera Utara (3) · Baystate Medical Center (2) · Daewoong Pharmaceutical Co. LTD. (2) · Hamilton Health Sciences Corporation (2) · Mahidol University (2) · University of California, Los Angeles (2) · Amsterdam UMC, location VUmc (1) · Asan Medical Center (1) · Ascension Health (1) · Australian and New Zealand Intensive Care Research Centre (1) · BREGO Life Sciences (1) · Beijing Tongren Hospital (1) · Beni-Suef University (1) · Catholic University of the Sacred Heart (1)
United States (27) · Canada (6) · China (6) · Brazil (4) · Indonesia (4) · South Korea (4) · Egypt (3) · Thailand (3) · Australia (2) · Denmark (2) · France (2) · Malaysia (2) · Mexico (2) · Switzerland (2) · Austria (1)
Michael W Donnino, MD (4) · Howard Smithline, MD (2) · Katherine M Berg, MD (2) · Narumon Densupsoontorn, MD (2) · Adam Buckholz, MD MS (1) · Adham Mohamed, PharmD (1) · Adhrie Sugiarto (1) · Andrew S Greenberg (1) · Angelique ME Spoelstra-de Man, Dr. (1) · Ari Moskowitz, MD (1) · Bastian Lubis, Dr (1) · Chaitong Churuangsuk, MD (1) · Cheah SK DR, M. D. (1) · Chutintorn Sriphrapradang, M.D. (1) · Cornelia DeRiese, MD (1)
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2025 (1), K23HL128814 (1), R01DK108722 (1), R01DK112886 (1), R01HL136705 (1), R21AG081720 (1), R21AG085268 (1)