Systemic Inflammatory Response Syndrome: Clinical Trials

1846 completed, 745 unknown, 354 recruiting, 225 terminated. 937 Not applicable, 424 Phase 2, 362 Phase 3, 263 Phase 4, 167 Phase 1.

By phase and status

Phase	Trials	Status
Not applicable	937	Completed 499, Unknown 178, Recruiting 97, Not yet recruiting 65, Terminated 49, Withdrawn 27, Active not recruiting 12, Suspended 6, Enrolling by invitation 4
Phase 2	424	Completed 207, Unknown 75, Terminated 56, Recruiting 29, Withdrawn 29, Not yet recruiting 15, Active not recruiting 9, Suspended 3, Enrolling by invitation 1
Phase 3	362	Completed 185, Unknown 59, Terminated 51, Recruiting 28, Not yet recruiting 14, Withdrawn 13, Active not recruiting 7, Suspended 5
Phase 4	263	Completed 134, Unknown 47, Recruiting 28, Terminated 27, Not yet recruiting 10, Withdrawn 9, Active not recruiting 7, Enrolling by invitation 1
Phase 1	167	Completed 108, Terminated 13, Unknown 12, Recruiting 11, Not yet recruiting 9, Withdrawn 9, Active not recruiting 4, Enrolling by invitation 1
Early Phase 1	12	Completed 5, Recruiting 3, Not yet recruiting 2, Active not recruiting 1, Unknown 1

Follow Systemic Inflammatory Response Syndrome: new trials by email Literature Review of Systemic Inflammatory Response Syndrome trials Research Report on Systemic Inflammatory Response Syndrome

Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Restricted or Liberal Fluid for Haemodynamic Resuscitation in Sepsis Vasopressors, Fluids - Septic Shock, Fluid Resuscitation		Not yet recruiting	Australian and New Zealand Intensive Care Research Centre	7838	2027-11-01	2026-11-09
Extended vs. Intermittent Meropenem Infusion in Sepsis Patients in the ICU Extended beta-lactam antibiotics, Intermittent Beta-lactam antibiotics - Sepsis, Septic Shock		Not yet recruiting	Assiut University	90	2027-10-01	2026-09-01
Phase IIb Multicenter Randomized Controlled Trial Evaluating the Efficacy of Sivelestat in Patients With Septic Coagulopathy • Sivelestat intravenous infusion, NaCl intravenous infusion - Septic Shock, Coagulopathy	Phase 2	Not yet recruiting	University Hospital, Strasbourg, France	120	2027-08-01	2026-08-20
Comparison of Sepsis Prediction Algorithms Epic Sepsis Model Version - 1, Epic Sepsis Model Version - 2, Emory Sepsis Model - Sepsis		Not yet recruiting	Emory University	1200	2027-03-01	2026-10-26
G-CSF In Neonatal Sepsis With Neutropenia Granulocyte-colony stimulating factor (G-CSF), Standard Sepsis Management - Neonatal Sepsis, Neutropenia	Not applicable	Not yet recruiting	University of Health Sciences Lahore	52	2027-02-15	2026-10-22
The Extended Study of Prevalence of Infection in Intensive Care IV Sepsis, Infection		Not yet recruiting	Universidad de la Sabana	10000	2027-02-01	2026-06-29
Biological Effects of Hemoadsorption in Septic Shock Hemoadsorption cartridge - Septic Shock, Vasopressor Resistance, Multiple Organ Dysfunction	Not applicable	Not yet recruiting	Miguel Sanchez Garcia	16	2027-01-07	2026-07-20
Self-directed Mobile Mindfulness to Address ICU Survivors' Psychological Distress Lift mobile mindfulness, Enlighten Recovery education program - Critical Illness, Heart Failure	Not applicable	Not yet recruiting	Duke University	450	2027-01-01	2026-07-08
Remote Ischemic Postconditioning in Septic Shock Remote ischemic conditioning, No intervention - Adult Patients With Septic Shock Admitted in Intensive Care Unit	Not applicable	Not yet recruiting	Hospices Civils de Lyon	720	2027-01-01	2026-10-09
SWedish Intensive Care Biobank Any Condition Underlying Critical Illness		Not yet recruiting	Uppsala University	25000	2027-01-01	2026-05-13
Immune Dysregulation During Sepsis: A Natural History Cohort Sepsis, Septic Shock		Not yet recruiting	National Heart, Lung, and Blood Institute (NHLBI)	500	2027-01-01	2026-10-09
Efficacy of Para-Tyrosine Supplementation on the Survival and Clinical Outcome in Patients With Sepsis Para-Tyrosine supplementation, Placebo solution - Sepsis	Phase 2	Suspended	University of Pecs	296	2027-01-01	2025-03-30
Prediction and Prevention of Bloodstream Infections After Kidney Transplantation Pivmecillinam, Placebo - Kidney Transplant Infection, Bloodstream Infection	Phase 3	Not yet recruiting	Susanne Dam Nielsen, MD, DMSc	180	2027-01-01	2026-10-16
Longitudinal Trajectories of Myocardial Work in Patients With Sepsis Sepsis, Septic Shock Hyperdynamic		Not yet recruiting	Shanghai Zhongshan Hospital	215	2027-01-01	2026-11-04
Blood Purification in Septic Children blood purification(CVVH), blood purification(TPE+CVVH), blood purification(HP+CVVH) - Sepsis, Blood Purification	Not applicable	Not yet recruiting	Children's Hospital of Fudan University	120	2027-01-01	2026-10-27
Double Plasma Separation and Adsorption in Acute-on-Chronic Liver Failure (DPMAS-ACLF Trial) Standard medical therapy (SMT), Double Plasma Molecular Adsorption System (DPMAS) - Acute-on-Chronic Liver Failure (ACLF)	Not applicable	Not yet recruiting	Institute of Liver and Biliary Sciences, India	56	2026-12-15	2026-11-06
Vitamin C for Acute Kidney Injury in ACLF With Septic Shock: A Randomized Controlled Trial Vitamin C, Standard of Care (SOC) - Acute-on-Chronic Liver Failure (ACLF)	Not applicable	Not yet recruiting	Institute of Liver and Biliary Sciences, India	110	2026-12-15	2026-11-06
Vancomycin Exposure and Biomarker Tracking Using Real-time Monitoring of Interstitial Fluid Biomarkers, Acute Kidney Injury		Not yet recruiting	Nutromics	200	2026-12-01	2026-10-23
Alveolar Dead Space as Predictor of Organ Failure in Severe Sepsis Sepsis, Severe Sepsis		Not yet recruiting	The University of Texas Health Science Center, Houston	30	2026-12-01	2025-06-11
Cahnge in Management of Suspected Early Onset Neonetal Sepsis After Assimilation of Early Onset Sepsis Calculator No intervention - Neonatal Early-onset Sepsis		Not yet recruiting	Hillel Yaffe Medical Center	6300	2026-12-01	2026-04-07

Showing 20 of 3611. Sign in to see all of them.

Narrower conditions

Sepsis (2310)  ·  Shock, Septic (1064)  ·  Bacteremia (265)  ·  Critical Illness (197)  ·  Neonatal Sepsis (190)  ·  Infections (188)  ·  Cytokine Release Syndrome (163)  ·  Acute Kidney Injury (144)  ·  COVID-19 (116)  ·  Pneumonia (110)  ·  Inflammation (109)  ·  Shock (102)  ·  Respiratory Distress Syndrome (101)  ·  Endotoxemia (80)

Broader conditions

Pathological Conditions, Signs and Symptoms (3610)  ·  Pathologic Processes (3596)  ·  Inflammation (3502)  ·  Infections (3264)  ·  Shock (1358)  ·  Sepsis (1044)  ·  Bacterial Infections and Mycoses (435)  ·  Respiratory Tract Diseases (424)  ·  Urogenital Diseases (363)  ·  Disease Attributes (358)  ·  Lung Diseases (353)  ·  Female Urogenital Diseases and Pregnancy Complications (338)  ·  Bacterial Infections (300)  ·  Cardiovascular Diseases (265)

Interventions

Blood Specimen Collection (76)  ·  Saline Solution (68)  ·  Sodium Chloride (54)  ·  Standard of Care (51)  ·  Norepinephrine (44)  ·  Ascorbic Acid (43)  ·  Hydrocortisone (41)  ·  Meropenem (35)  ·  Vancomycin (28)  ·  Thiamine (27)  ·  Daptomycin (25)  ·  Dexmedetomidine (23)  ·  Piperacillin, Tazobactam Drug Combination (23)  ·  Gentamicins (18)  ·  Anti-Bacterial Agents (17)

Sponsors

Assistance Publique - Hôpitaux de Paris (62)  ·  Assiut University (49)  ·  Ain Shams University (46)  ·  Radboud University Medical Center (33)  ·  Southeast University, China (32)  ·  National Institute of Allergy and Infectious Diseases (NIAID) (27)  ·  National Taiwan University Hospital (26)  ·  Hospices Civils de Lyon (25)  ·  Cairo University (24)  ·  Copenhagen University Hospital, Rigshospitalet (23)  ·  Tanta University (23)  ·  Chinese PLA General Hospital (21)  ·  Pfizer (21)  ·  Central Hospital, Nancy, France (17)  ·  Hellenic Institute for the Study of Sepsis (17)

Countries

United States (732)  ·  France (386)  ·  China (361)  ·  Germany (189)  ·  Egypt (166)  ·  Italy (150)  ·  Spain (130)  ·  Canada (129)  ·  Netherlands (120)  ·  United Kingdom (119)  ·  Turkey (Türkiye) (97)  ·  Belgium (93)  ·  Denmark (89)  ·  Brazil (81)  ·  Switzerland (72)

Top investigators

Peter Pickkers, MD, PhD (9)  ·  Andrea Morelli, MD (7)  ·  Bernd Jilma, MD (5)  ·  Claudia Spies, MD, Prof. (5)  ·  Evangelos Giamarellos-Bourboulis, MD, PhD (5)  ·  Evangelos J Giamarellos-Bourboulis, MD, PhD (5)  ·  Lixin Xie, MD (5)  ·  Niels Moeller, Professor (5)  ·  Philip Efron, MD (5)  ·  Anders Perner, MD, PhD (4)  ·  Ayman A Yousef, MD (4)

Results publications

PMID 26903338, PMID 11445675, PMID 28459966, PMID 28597967, PMID 33891293, PMID 28101605, PMID 31280481, PMID 34605781, PMID 21516036, PMID 26903335, PMID 28343448, PMID 34519356, PMID 36416787, PMID 11794169, PMID 16424713, PMID 18158437, PMID 19531784, PMID 20179283, PMID 23353941, PMID 23899564, PMID 24171518, PMID 24794878, PMID 25392034, PMID 26903336, PMID 27940189, PMID 28871441, PMID 29084247, PMID 29784057, PMID 32192578, PMID 32520577, PMID 33620405, PMID 39716214, PMID 10470572, PMID 11395904, PMID 11588440, PMID 12500513, PMID 12519925, PMID 12720570, PMID 15276536, PMID 15636651, PMID 16134766, PMID 16497588, PMID 16855261, PMID 17334251, PMID 17638928, PMID 18090355, PMID 18434884, PMID 18457586, PMID 18533029, PMID 18702960

NIH funding

2014 (11), 2019 (10), 2025 (10), 2023 (9), 2015 (7), 2017 (7), 2018 (6), 2005 (5), 2016 (5), U10HD021373 (5), U10HD021385 (5), M01RR000070 (4), M01RR000750 (4), M01RR006022 (4), M01RR008084 (4)