697 completed, 291 unknown, 155 recruiting, 141 terminated. 514 Not applicable, 227 Phase 2, 135 Phase 3, 102 Phase 1, 56 Phase 4.
Follow Respiratory Distress Syndrome: new trials by email Literature Review of Respiratory Distress Syndrome trials Research Report on Respiratory Distress Syndrome
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Multicentric, Randomized Study to Assess Safety and Efficacy of Centhaquine in Patients With ARDS Normal Saline, Centhaquine - Acute Respiratory Distress Syndrome (ARDS) | Phase 2 | Not yet recruiting | Pharmazz, Inc. | 80 | 2027-05-01 | 2026-09-17 |
| To Evaluate the Safety and Potential Therapeutic Activity of JadiCell™, an Investigational Umbilical Cord-Derived Mesenchymal Stem Cell Therapy, in Patients Diagnosed With Acute Respiratory Distress Syndrome (ARDS). Subjects in the UC-MSC treatment group will receive two intravenous infusions (at day 0 and 3) of 100 million UC-MSC., Controls will receive two infusions of vehicle solution. - Acute Respiratory Distress Syndrome | Phase 3 | Not yet recruiting | Breathe Biologics, Inc. | 128 | 2027-03-01 | 2026-10-01 |
| Speed of Lung Inflation During Ventilation of Extremely Preterm Infants Long PRT, Short PRT - Respiratory Distress Syndrome, Newborn, Respiratory Distress Syndrome in Premature Infant | Not applicable | Not yet recruiting | Murdoch Childrens Research Institute | 68 | 2027-02-01 | 2026-06-24 |
| The NEU - CAP Trial Local standard care of monitoring non-invasive ventilation, CO₂-guided Non-Invasive Ventilation - Infant, Premature, Diseases, Birth, Preterm | Not applicable | Not yet recruiting | Leiden University Medical Center | 1860 | 2027-01-01 | 2026-08-10 |
| Tracing Of Real-time glu13Cose Metabolism in Human Immune Cells - Intensive Care Unit 13C6-Glucose - Glucose, Metabolism | Not applicable | Not yet recruiting | Vanderbilt University Medical Center | 25 | 2026-11-01 | 2026-09-09 |
| Right Heart Injury Monitoring on ECMO Transthoracic echocardiogram, High sensitivity troponin, N-terminal pro-B-type natriuretic peptide - Acute Respiratory Distress Syndrome (ARDS), Acute Respiratory Failure (ARF) | Not yet recruiting | Papworth Hospital NHS Foundation Trust | 30 | 2026-11-01 | 2026-10-19 | |
| A Study of the Determinants of Neurological Outcomes in Patients With Acute Respiratory Distress Syndrome Blood test scores calculations - Acute Respiratory Distress Syndrome (ARDS), s100b | Not applicable | Not yet recruiting | University Hospital, Angers | 150 | 2026-10-17 | 2026-07-27 |
| Effect of Automated Oxygen Control on Early-childhood Lung Mechanics Forced oscillometry technique - Prematurity, Respiratory Distress Neonatal | Not yet recruiting | King's College Hospital NHS Trust | 60 | 2026-10-12 | 2026-10-14 | |
| Effect of Albumin Therapy in Mechanically Ventilated Patients With Sepsis-Associated ARDS Acute Respiratory Distress Syndrome, Sepsis | Not yet recruiting | The Second Affiliated Hospital of Hainan Medical University | 260 | 2026-10-10 | 2026-10-13 | |
| nCPAP Versus High-Flow Nasal Cannula in Preterm Infants With RDS Non-invasive respiratory support - Respiratory Distress Syndrome, Premature Birth | Not applicable | Not yet recruiting | Assiut University | 94 | 2026-10-10 | 2026-10-09 |
| Effect of Spontaneous Breathing in APRV Mode on Respiratory Physiology of ARDS Patients APRV ventilation with low-level spontaneous breathing, APRV ventilation with high-level spontaneous breathing, APRV ventilation with fully suppressed spontaneous breathing - Acute Respiratory Distress Syndrome | Not applicable | Not yet recruiting | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 15 | 2026-10-01 | 2026-09-01 |
| Little Lungs Study Calfactant, Budesonide - Invasive Mechanical Ventilation, Severe Respiratory Distress Syndrome | Phase 1 / Phase 2 | Not yet recruiting | University of Wisconsin, Madison | 24 | 2026-10-01 | 2026-09-29 |
| Noninvasive High Frequency Oscillatory Ventilation Versus Nasal Intermittent Mandatory Ventilation for Respiratory Distress Syndrome in Preterm Neonates Noninvasive High Frequency Oscillatory Ventilation, Nasal Intermittent Mandatory Ventilation - Respiratory Distress Syndrome (RDS), Newborn | Not applicable | Not yet recruiting | Aga Khan University | 158 | 2026-10-01 | 2026-09-23 |
| Serum sRAGE, CC16, and Syndecan-1 as Predictors of ARDS and Mortality After Severe Chest Trauma No intervention - observational study - Acute Respiratory Distress Syndrome, Chest Trauma | Not yet recruiting | Assiut University | 85 | 2026-10-01 | 2026-08-19 | |
| Chest Ultrasound as Diagnostic and Prognostic Tool in Neonatal RDS Respiratory Distress Syndrome, Newborn, Neonatal Respiratory Distress | Not yet recruiting | Assiut University | 82 | 2026-09-28 | 2026-10-15 | |
| Chest X-Ray Versus Lung Ultrasound in Neonatal Pneumonia Neonatal Pneumonia, Respiratory Distress Syndrome | Not yet recruiting | Assiut University | 100 | 2026-09-02 | 2026-09-08 | |
| Multimodal Physiologic State Intelligence Study OMNIPHYS Multimodal Ultrasound Imaging System - Heart Failure, Cardiomyopathies | Enrolling by invitation | Truway Health, Inc. | 25000 | 2026-09-02 | 2026-09-10 | |
| AI-Guided Mechanical Ventilation in Children: A Randomized Controlled Trial AI-generated recommendations for ventilator parameters. - Acute Respiratory Distress Syndrome, Pneumonia in Children | Not applicable | Not yet recruiting | Wu Rongzhou | 200 | 2026-09-01 | 2026-07-27 |
| Comparison of Different PEEP Strategies in Moderate-to-Severe ARDS Based on Various Bedside Assessment Tools Ventilation at different levels of PEP including a test involving a gradual decrease in PEP. - Acute Respiratory Distress Syndrome | Not applicable | Not yet recruiting | Centre Hospitalier Universitaire de Nice | 45 | 2026-09-01 | 2026-08-03 |
| Spontaneous vs Controlled Mechanical Ventilation in Acute Hypoxemic Respiratory Failure Spontaneous Ventilation Strategy, Controlled Ventilation Strategy - Acute Respiratory Distress Syndrome (ARDS), Acute Hypoxemic Respiratory Failure | Not applicable | Recruiting | Oslo University Hospital | 80 | 2026-09-01 | 2026-10-15 |
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COVID-19 (200) · Acute Lung Injury (152) · Premature Birth (134) · Respiratory Distress Syndrome, Newborn (122) · Respiratory Insufficiency (117) · Pneumonia (67) · Sepsis (65) · Coronavirus Infections (57) · Bronchopulmonary Dysplasia (50) · Respiratory Aspiration (45) · Lung Diseases (43) · Critical Illness (40) · Pulmonary Atelectasis (37) · Transient Tachypnea of the Newborn (36)
Respiration Disorders (1467) · Respiratory Tract Diseases (1463) · Lung Diseases (1434) · Pathological Conditions, Signs and Symptoms (356) · Infections (351) · Respiratory Tract Infections (265) · Pathologic Processes (254) · RNA Virus Infections (234) · Virus Diseases (233) · Lung Injury (231) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (230) · Nidovirales Infections (226) · Coronaviridae Infections (225) · Infant, Newborn, Diseases (213) · Infant, Premature, Diseases (204)
Prone Position (31) · Continuous Positive Airway Pressure (26) · Sodium Chloride (23) · Dexamethasone (18) · Saline Solution (17) · poractant alfa (17) · Standard of Care (16) · Blood Specimen Collection (12) · Positive-Pressure Respiration (12) · Respiration, Artificial (12) · Surface-Active Agents (11) · Budesonide (10) · beractant (9) · Betamethasone (8) · Methylprednisolone (8)
Assistance Publique - Hôpitaux de Paris (35) · Southeast University, China (24) · University Hospital, Clermont-Ferrand (16) · Hospices Civils de Lyon (15) · Ain Shams University (14) · Daping Hospital and the Research Institute of Surgery of the Third Military Medical University (14) · Massachusetts General Hospital (11) · NICHD Neonatal Research Network (11) · National Heart, Lung, and Blood Institute (NHLBI) (11) · Policlinico Hospital (11) · University of Minnesota (11) · Bicetre Hospital (9) · National Taiwan University Hospital (9) · University Hospital, Angers (9) · University Hospital, Toulouse (9)
United States (353) · France (218) · China (147) · Italy (93) · Canada (72) · Spain (64) · Turkey (Türkiye) (59) · Germany (54) · United Kingdom (52) · Brazil (39) · Egypt (38) · Taiwan (29) · Belgium (28) · Argentina (21) · Sweden (21)
Edward F. Donovan, MD (8) · Seetha Shankaran, MD (8) · Davide Chiumello, MD (7) · Richard A. Ehrenkranz, MD (7) · Sheldon B. Korones, MD (7) · Avroy A. Fanaroff, MD (6) · Barbara J. Stoll, MD (6) · Charles R. Bauer, MD (6) · David K. Stevenson, MD (6) · James A. Lemons, MD (6) · Jon E. Tyson, MD MPH (6) · Laurent Brochard, MD (5) · Lu-Ann Papile, MD (5) · Shi Yuan, PhD,MD (5) · Waldemar A. Carlo, MD (5)
PMID 26903337, PMID 25693014, PMID 10793162, PMID 22797452, PMID 23688302, PMID 30624279, PMID 11401896, PMID 19255741, PMID 20843245, PMID 25647235, PMID 27440140, PMID 27620287, PMID 33177145, PMID 34425070, PMID 34473343, PMID 38341938, PMID 1388792, PMID 16009843, PMID 20197533, PMID 27757516, PMID 28422025, PMID 29420341, PMID 30291378, PMID 305471, PMID 3230208, PMID 34259448, PMID 413500, PMID 10793167, PMID 16641394, PMID 16714767, PMID 16763218, PMID 18270352, PMID 18272893, PMID 18317237, PMID 18383112, PMID 18841536, PMID 19647838, PMID 20180736, PMID 20439601, PMID 20539253, PMID 21885390, PMID 22025591, PMID 22222548, PMID 22307571, PMID 22337229, PMID 22340260, PMID 22526637, PMID 23050520, PMID 23166334, PMID 23339639
U10HD021385 (10), U10HD027880 (10), U10HD021397 (8), U10HD027853 (8), U10HD027871 (8), U10HD027904 (8), U10HD034216 (8), 2019 (7), M01RR000070 (7), M01RR000750 (7), M01RR006022 (7), M01RR008084 (7), U10HD021364 (7), U10HD021373 (7), U10HD021415 (7)