76 completed, 54 unknown, 17 not yet recruiting, 14 recruiting. 56 Not applicable, 15 Phase 2, 13 Phase 4, 11 Phase 3, 5 Phase 1.
Follow Multiple Organ Failure: new trials by email Literature Review of Multiple Organ Failure trials Research Report on Multiple Organ Failure
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Alveolar Dead Space as Predictor of Organ Failure in Severe Sepsis Sepsis, Severe Sepsis | Not yet recruiting | The University of Texas Health Science Center, Houston | 30 | 2026-12-01 | 2025-06-11 | |
| FOUR-Based Modification of ICU Severity Scores ICU Mortality (Survival Rate) | Not yet recruiting | Al-Nahrain University | 2000 | 2026-11-01 | 2026-09-22 | |
| Prognostic Value of Stress Hyperglycemia Ratio in Critically Ill Patients Critical Illness, Hyperglycemia | Not yet recruiting | Assiut University | 230 | 2026-10-01 | 2026-10-02 | |
| pSOFA Score in Predicting Mortality in Pediatric Intensive Care Critical Illness, Multiple Organ Dysfunction Syndrome | Not yet recruiting | Assiut University | 121 | 2026-09-30 | 2026-10-05 | |
| AI-Based Precision Transfusion Prediction Model in Critically Ill Patients Red Blood Cell Transfusion Exposure - Critical Illness, Multiple Organ Dysfunction Syndrome | Not yet recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 2598 | 2026-09-01 | 2026-08-13 | |
| Adding a Gastrointestinal Subscore to SOFA2 for Mortality Risk Assessment in the ICU: The SOFA2-GIS Study Critical Illness, Multiple Organ Failure | Not yet recruiting | Ozkul Yilmaz Colak | 800 | 2026-07-01 | 2026-05-26 | |
| Hemoadsorpion in Patients With Septic Shock: Efficacy and Safety Evaluation Efferon LPS, Toramyxin PMX 20R, Jafron HA 330 - Septic Shock | Not applicable | Not yet recruiting | Moscow Multidisciplinary Clinical Center "Kommunarka" | 76 | 2026-06-25 | 2026-07-02 |
| Metabolic and Functional Study of γδ T Cells in Critically Ill Patients Sepsis, Critical Illness | Recruiting | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 105 | 2026-06-21 | 2026-10-27 | |
| TDAP in Burn Patients (Group 2) Observational Cohort (No Intervention) - Sepsis, Burn Injury | Not yet recruiting | Henry M. Jackson Foundation for the Advancement of Military Medicine | 80 | 2026-05-15 | 2026-02-04 | |
| Surgical Critical Care Initiative (SC2i) Tissue and Data Acquisition Protocol (TDAP) in Burn Patients Improving the Robustness and Generalizability of Post-burn Sepsis Prediction With the Post-Burn Sepsis Digital Twin. Group 1 Observational Cohort (No Intervention) - Sepsis, Burn Injury | Not yet recruiting | Henry M. Jackson Foundation for the Advancement of Military Medicine | 40 | 2026-05-15 | 2026-02-04 | |
| Efferon LPS Hemoadsorption in Cardiac Surgery Patients Efferon LPS - Cardiac Disease, Multiple Organ Dysfunction Syndrome | Not applicable | Recruiting | Efferon JSC | 60 | 2026-04-22 | 2026-08-26 |
| Extracorporeal Blood Purification Using Oxiris for Septic Shock (EXPLORE Study) Oxiris Filter (Blood Purification Device) - Septic Shock, Multi Organ Failure | Not applicable | Not yet recruiting | Pusan National University Yangsan Hospital | 62 | 2026-02-01 | 2026-01-14 |
| ICU Admission Diagnoses and ICU Mortality Critical Illness, Sepsis | Completed | Ataturk University | 1248 | 2026-01-30 | 2026-02-04 | |
| Effect of oXiris Hemofilter Use in Septic Shock: A Multicenter Retrospective Cohort Study Septic Shock, Multiorgan Failure | Recruiting | Seoul National University Bundang Hospital | 360 | 2026-01-22 | 2026-04-20 | |
| Mechanisms of Prognostic Regulation andPrecision Phenotype Ldentification in Severe Infections Driven by SpecializedPro-Resolving Mediators Sepsis, Severe Infection | Not yet recruiting | Second Affiliated Hospital of Wenzhou Medical University | 300 | 2026-01-15 | 2026-01-21 | |
| Point-of-Care AI Assistance and Critical Care Outcomes: A Randomized Trial Point-of-care large language model decision support (ChatGPT-5) - Critical Illness, Sepsis | Phase 1 / Phase 2 | Not yet recruiting | MetroWest Artificial Intelligence Research Workgroup | 1000 | 2026-01-01 | 2025-12-18 |
| Safety, Tolerability and Performance of the NucleoCapture Extracorporeal Therapeutic Apheresis Device in the Reduction of Circulating cfDNA/NETs in Subjects With Pancreatitis NucleoCapture device - Acute Pancreatitis, Organ Failure, Multiple | Not applicable | Not yet recruiting | Liverpool University Hospitals NHS Foundation Trust | 20 | 2025-12-01 | 2025-03-20 |
| ICU Background Early Awareness for Critical deterioratiON ICU Beacon - Respiratory Failure, Circulatory Failure | Recruiting | ETH Zurich | 1962 | 2025-12-01 | 2026-06-15 | |
| Sivelestat Treatment for Postoperative Organ Protection in Type A Aortic Dissection Conventional treatment, Sivelestat sodium, Placebo - Type A Aortic Dissection, Organ Failure, Multiple | Phase 4 | Not yet recruiting | Shanghai Zhongshan Hospital | 236 | 2025-09-01 | 2025-09-05 |
| Study on the Establishment of a System for Early Warning and Prognostic Evaluation of Patients With Heat Stroke Peripheral blood test - Heat Stroke, Early Waking | Not yet recruiting | Xijing Hospital | 150 | 2025-08-31 | 2025-08-14 |
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Sepsis (57) · Shock, Septic (35) · Critical Illness (33) · Acute Kidney Injury (19) · Respiratory Distress Syndrome (13) · Systemic Inflammatory Response Syndrome (13) · Inflammation (12) · Shock (12) · Wounds and Injuries (11) · COVID-19 (10) · Infections (10) · Respiratory Insufficiency (10) · Pancreatitis (8) · Burns (6)
Pathological Conditions, Signs and Symptoms (190) · Pathologic Processes (189) · Shock (178) · Infections (82) · Inflammation (72) · Systemic Inflammatory Response Syndrome (66) · Disease Attributes (39) · Respiratory Tract Diseases (32) · Urogenital Diseases (29) · Female Urogenital Diseases (28) · Female Urogenital Diseases and Pregnancy Complications (28) · Kidney Diseases (28) · Male Urogenital Diseases (28) · Urologic Diseases (28) · Digestive System Diseases (25)
Blood Specimen Collection (4) · Glutamine (4) · Sodium Chloride (4) · Standard of Care (4) · Hemoperfusion (3) · Continuous Renal Replacement Therapy (2) · Observation (2) · Plasma Exchange (2) · Saline Solution (2) · Watchful Waiting (2) · alanylglutamine (2) · maltodextrin (2) · urinastatin (2) · 2-(3',4'-dihydroxyphenyl-1-azo)benzimidazole (1) · Alanine (1)
University of Ulm (4) · Chang Gung Memorial Hospital (3) · Hospices Civils de Lyon (3) · Massachusetts General Hospital (3) · University of Leicester (3) · University of Rostock (3) · Amsterdam UMC, location VUmc (2) · Assiut University (2) · Croatian Society for Organ Support (2) · Efferon JSC (2) · Fujian Medical University (2) · Hai Li (2) · Henry M. Jackson Foundation for the Advancement of Military Medicine (2) · IRCCS Azienda Ospedaliero-Universitaria di Bologna (2) · Karolinska Institutet (2)
United States (30) · China (24) · Germany (16) · France (15) · Netherlands (8) · Sweden (7) · Taiwan (7) · Belgium (5) · Canada (5) · Italy (5) · Russia (5) · Spain (5) · United Kingdom (5) · Croatia (4) · Turkey (Türkiye) (4)
Manfred Weiss, MD, MBA (3) · Hai Li (2) · Alan Jones, MD (1) · Aleksandr Eremenko, MD (1) · Alma R Marroquin-Escamilla, MD (1) · Anders Hartmann, MD, Ph.D. (1) · Apostolos Armaganidis, MD, PhD (1) · Baofeng Zhu, MD (1) · Bart Wuurman, M.Sc. (1) · Belaid Bouhemad, MD, PhD (1) · Bernard Allaouchiche, Prof. (1) · Bernard Cholley, MD, PhD (1) · Camille Jeanne-Leroyer, PharmD (1)
PMID 12720570, PMID 17334251, PMID 18375483, PMID 20802500, PMID 21669950, PMID 22073193, PMID 22110166, PMID 23401516, PMID 24137663, PMID 32109631, PMID 34412498, PMID 35037228, PMID 36052222, PMID 37517452, PMID 40633959, PMID 42649506, PMID 8700363, PMID 10470572, PMID 10890632, PMID 10933646, PMID 11395904, PMID 12682500, PMID 12794416, PMID 15276536, PMID 16305874, PMID 16374442, PMID 16497588, PMID 16676075, PMID 16819346, PMID 16855261, PMID 17015742, PMID 17167117, PMID 17414612, PMID 17464154, PMID 17592301, PMID 17638928, PMID 17646526, PMID 18090355, PMID 18305265, PMID 18429658, PMID 18434884, PMID 18444850, PMID 18501759, PMID 18548133, PMID 18552695, PMID 18594226, PMID 18620598, PMID 18702960, PMID 18954696, PMID 19048243
2014 (2), U54GM062119 (2), 2009 (1), 2018 (1), 2019 (1), 2023 (1), P30CA016672 (1), R01GM104481 (1), UH3HL125119 (1)