72 completed, 26 recruiting, 25 unknown, 15 terminated. 155 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 155 | Completed 72, Recruiting 26, Unknown 25, Terminated 15, Not yet recruiting 8, Withdrawn 8, Active not recruiting 1 |
Follow Shock: new trials by email Literature Review of Shock trials Research Report on Shock
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Capital Offload-Shock Immediate renal replacement therapy - Hypervolemia, Cardiogenic Shock | Phase 4 | Not yet recruiting | Ottawa Heart Institute Research Corporation | 456 | 2026-12-01 | 2026-10-30 |
| Mechanistic Assessment of Norepinephrine Therapy vs. Angiotensin-II in Septic Shock Angiotensin II, Norepinephrine - Septic Shock | Phase 4 | Not yet recruiting | Wake Forest University Health Sciences | 78 | 2026-11-01 | 2026-09-24 |
| Dopamine vs. Norepinephrine for Hypotension in Neonates With Pulmonary Hypertension (DONE) Dopamine administration, Norepinephrine - Hypotension and Shock, Pulmonary Hypertension of the Newborn (PPHN) | Phase 4 | Recruiting | University of California, Davis | 30 | 2026-10-30 | 2026-08-18 |
| Eduction in ImmunoSuppressive Regimen Among Kidney Transplant Recipients Patients Admitted to the Intensive Care Unit for Septic Shock and/or Acute Respiratory Failure Hydrocortisone Hemisuccinate: 200 mg per day., reduction of the level of immunosuppression - Sepsis and Septic Shock, Acute Respiratory Failure | Phase 4 | Recruiting | University Hospital, Strasbourg, France | 212 | 2026-08-11 | 2026-08-20 |
| Adult Outpatient Linvoseltamab With Tocilizumab Prophylaxis to Mitigate the Risk of Cytokine Release Syndrome (CRS) Linvoseltamab, Tocilizumab - Relapsed/Refractory Multiple Myeloma (RRMM) | Phase 4 | Recruiting | Regeneron Pharmaceuticals | 30 | 2026-07-15 | 2026-10-27 |
| Prolonged Nasogastric Administration of Ketones in Decompensated Heart Failure Ketone Monoester (KE) - Acute Heart Failure (AHF), Cardiogenic Shock | Phase 4 | Recruiting | Institute for Clinical and Experimental Medicine | 12 | 2026-04-04 | 2026-04-14 |
| Hydrocortisone and Fludrocortisone for the Treatment of Septic Shock Hydrocortisone plus Fludrocortisone, Standard care - Septic Shock | Phase 4 | Recruiting | Northern Jiangsu People's Hospital | 336 | 2026-03-02 | 2026-03-04 |
| Early Dexmedetomidine and Sympathetic Regulation in Sepsis Dexmedetomidine (DEX), Placebo - Sepsis, Septic Shock | Phase 4 | Not yet recruiting | Sichuan Academy of Medical Sciences | 168 | 2026-03-01 | 2026-03-13 |
| Continuous Infusion Versus Intermittent Bolus Hydrocortisone in Septic Shock Hydrocortisone Continuous Infusion, Hydrocortisone Intermittent Bolus - Septic Shock | Phase 4 | Completed | Benha University | 110 | 2026-01-01 | 2026-07-10 |
| Sivelestat Treatment for Postoperative Organ Protection in Type A Aortic Dissection Conventional treatment, Sivelestat sodium, Placebo - Type A Aortic Dissection, Organ Failure, Multiple | Phase 4 | Not yet recruiting | Shanghai Zhongshan Hospital | 236 | 2025-09-01 | 2025-09-05 |
| Randomized Control Study in REsuscitation of SEpsis Trial Pharmaceutical fresh frozen plasma, Normal Saline, Ringer lactate (RL) - Septic Shock, Pediatric Critical Illness | Phase 4 | Not yet recruiting | Fundación Cardioinfantil Instituto de Cardiología | 150 | 2025-07-01 | 2025-06-25 |
| Empirical Meropenem Versus Piperacillin/Tazobactam for Adult Patients With Sepsis Meropenem, Piperacillin/Tazobactam - Sepsis, Septic Shock | Phase 4 | Recruiting | Scandinavian Critical Care Trials Group | 5800 | 2025-06-26 | 2025-07-03 |
| Ciprofol's Impact on Oxygenator Function in Extracorporeal Membrane Oxygenation (ECMO) Patients Ciprofol, Midazolam - ECMO Treatment, ARDS (Acute Respiratory Distress Syndrome) | Phase 4 | Not yet recruiting | First Affiliated Hospital of Wannan Medical College | 30 | 2025-05-01 | 2025-04-18 |
| Early Versus Late Adjunctive Vasopressin in Septic Shock vasopressin - early initiation, vasopressin - standard initiation - Sepsis, Septic Shock | Phase 4 | Recruiting | The Cleveland Clinic | 300 | 2025-04-29 | 2026-08-31 |
| Shenfu Injection Modulates Carotid Elasticity in Septic Shock Shenfu Injection - Septic Shock, Vascular Dysfunction | Phase 4 | Not yet recruiting | First Affiliated Hospital of Wannan Medical College | 48 | 2025-04-15 | 2025-04-08 |
| Early Angiotensin II in the Emergency Department Angiotensin II Infusion - Septic Shock | Phase 4 | Recruiting | Brett A Faine | 20 | 2025-04-01 | 2026-09-02 |
| Oral Bedtime Melatonin in Critically Ill Patients Oral Bedtime Melatonin, Placebo suspension or capsule - Septic Shock, Stroke Hemorrhagic | Phase 4 | Unknown | Hospital San Carlos, Madrid | 160 | 2025-02-01 | 2024-03-01 |
| Early Hydrocortisone Versus Regular Treatment in Shock in Extremely Preterm Neonates - an Open Randomized Controlled Trial Intravascular Hydrocortisone (stress dosage): 1 mg/k/dose each 8 hours for 5 days, Vasoactive drug therapies - Shock, Preterm Birth Complication | Phase 4 | Active not recruiting | Coordinación de Investigación en Salud, Mexico | 76 | 2025-02-01 | 2025-11-25 |
| Beta-Lactam Antibiotics InitiaL ExpoSure OptimisEd in CriticallY Ill Patients with SEpsis Double dosing of beta-lactam antibiotic - Sepsis - to Reduce Mortality in the Intensive Care Unit, Sepsis | Phase 4 | Recruiting | Erasmus Medical Center | 980 | 2025-01-03 | 2025-01-09 |
| Accelerated vs. Standard Continuous Renal Replacement Therapy for Patients With Cardiogenic Shock Undergoing Veno-arterial ExtraCorporeal Membrane Oxygenator Early initiation of continuous renal replacement therapy, Standard initiation of continuous renal replacement therapy - Cardiogenic Shock, Acute Kidney Injury | Phase 4 | Recruiting | Samsung Medical Center | 408 | 2024-12-31 | 2026-01-05 |
Showing 20 of 155. Sign in to see all of them.
Shock, Septic (80) · Sepsis (44) · Shock, Cardiogenic (23) · Systemic Inflammatory Response Syndrome (18) · Multiple Organ Failure (13) · Diabetes Insipidus (10) · Acute Kidney Injury (7) · Myocardial Infarction (7) · Critical Illness (6) · Cytokine Release Syndrome (5) · Tachycardia (4) · COVID-19 (3) · Heart Arrest (3) · Heart Failure (3)
Pathologic Processes (155) · Pathological Conditions, Signs and Symptoms (155) · Inflammation (103) · Infections (90) · Systemic Inflammatory Response Syndrome (86) · Cardiovascular Diseases (42) · Sepsis (42) · Vascular Diseases (35) · Heart Diseases (31) · Ischemia (24) · Myocardial Ischemia (24) · Necrosis (24) · Infarction (23) · Female Urogenital Diseases (19)
Norepinephrine (14) · Hydrocortisone (9) · Saline Solution (7) · Sodium Chloride (7) · Vasopressins (7) · Angiotensin II (6) · Albumins (5) · Dexmedetomidine (5) · Adrenal Cortex Hormones (4) · Ascorbic Acid (4) · Dexamethasone (4) · Midazolam (4) · Midodrine (4) · Standard of Care (4) · hydrocortisone hemisuccinate (4)
Southeast University, China (5) · Peking Union Medical College Hospital (4) · Ain Shams University (3) · Cairo University (3) · First Affiliated Hospital of Wannan Medical College (3) · Medical University of Vienna (3) · Ottawa Heart Institute Research Corporation (3) · The Cleveland Clinic (3) · Amsterdam UMC, location VUmc (2) · Asan Medical Center (2) · Central Hospital, Nancy, France (2) · Charles University, Czech Republic (2) · Copenhagen University Hospital, Rigshospitalet (2) · Karolinska Institutet (2) · Oslo University Hospital (2)
United States (26) · France (16) · China (14) · Canada (11) · Egypt (8) · Germany (8) · Denmark (7) · Brazil (6) · Netherlands (6) · Czechia (5) · Italy (5) · Spain (5) · Sweden (5) · Norway (4) · South Korea (4)
Holger Thiele, MD (2) · Joao P Teixeira, MD (2) · Nathan D Nielsen, MD MSc (2) · Ahlem Trifi (1) · Ahmed Mukhtar (1) · Alaa F Fathy, researcher (1) · Alessandro Pontes-Arruda, MD, PhD (1) · Alexander H Flannery, Pharm.D. (1) · Amany M Mohamed, Ph.D (1) · Amir Herman, MD, PhD (1) · Anders Hartmann, MD, Ph.D. (1) · Anders Perner, MD PhD (1)
PMID 34605781, PMID 18305265, PMID 23963131, PMID 27483065, PMID 29600824, PMID 30394918, PMID 33647946, PMID 36416787, PMID 10321661, PMID 10697064, PMID 10923728, PMID 11529214, PMID 11588440, PMID 12186604, PMID 12500513, PMID 12519925, PMID 12794416, PMID 15187514, PMID 15343008, PMID 16134766, PMID 16879732, PMID 18698227, PMID 19007597, PMID 19068113, PMID 19175450, PMID 19318651, PMID 19531784, PMID 19703817, PMID 19926252, PMID 19958532, PMID 20109575, PMID 20725823, PMID 21526919, PMID 21545483, PMID 21705897, PMID 21926570, PMID 21960699, PMID 22477787, PMID 22488003, PMID 22518026, PMID 22920912, PMID 23006898, PMID 23073953, PMID 23288914, PMID 23652522, PMID 23796235, PMID 24011548, PMID 24127770, PMID 24151551, PMID 24370612
2014 (3), 2017 (2), 2008 (1), 2009 (1), 2016 (1), 2018 (1), 2023 (1), R01HL177834 (1), UL1RR024975-01 (1), UL1TR000445-06 (1), UL1TR001449 (1)