47 completed, 26 unknown, 9 terminated, 6 recruiting. 27 Phase 4, 25 Not applicable, 23 Phase 2, 12 Phase 3, 9 Phase 1.
Follow esmolol: new trials by email Literature Review of esmolol trials Research Report on esmolol
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Predicting Early Circulatory Deterioration After Short-Acting Beta-Blocker Treatment in Intensive Care Patients Esmolol, Landiolol - Critical Illness | Completed | Shanghai Zhongshan Hospital | 2541 | 2026-08-01 | 2026-09-29 | |
| Esmolol Versus Dexmedetomidine for Opioid-sparing in Laparoscopic Gynecological Surgery Esmolol hydrochloride, Dexmedetomidine, Normal (0.9%) saline - Pain, Acute Post-Operative, Dexmedetomidine | Not applicable | Recruiting | Vasiliki Samartzi | 90 | 2026-07-15 | 2026-09-29 |
| Remifentanil vs Esmolol During Intubation for Cerebral Aneurysm Coil Embolization Remifentanil, Esmolol - Cerebral Aneurysm Unruptured, Intracranial Pressure | Not applicable | Not yet recruiting | Fatih Sultan Mehmet Training and Research Hospital | 84 | 2026-06-22 | 2026-06-22 |
| POCUS-Guided Esmolol in Septic Shock: A Pilot RCT Esmolol - Septic Shock | Phase 1 / Phase 2 | Not yet recruiting | John Basmaji | 100 | 2026-01-15 | 2026-01-06 |
| Esmolol Versus Sufentanil on the Quality of Post-cholecystectomy Recovery Laparoscopic Anaesthesia With Orotracheal Intubation on an Outpatient Basis Esmolol Hcl 10Mg/Ml Inj, Sufentanil 5 mcg - Laparoscopic Cholecystectomy Surgery | Phase 4 | Recruiting | University Hospital, Limoges | 120 | 2025-10-29 | 2026-04-13 |
| Effect of Opioid-free Anaesthesia on Postoperative Delirium in Elderly Patients Undergoing Gastrointestinal Surgery Dexmedetomidine, Esketamine, Esmolol - Delirium - Postoperative, Opioid-Free Anaesthesia | Phase 4 | Not yet recruiting | Qianfoshan Hospital | 406 | 2025-05-20 | 2025-05-06 |
| Efficacy and Safety Study of Urapidil Alone or With Esmolol in Treating Acute Hypertensive Intracerebral Hemorrhage Urapidil, Urapidil and Esmolol - Hypertensive Intracerebral Hemorrhage | Not yet recruiting | Qianfoshan Hospital | 600 | 2024-11-01 | 2024-10-10 | |
| Pre-operative Phentolamine Vs Intraoperative Esmolol Efficacy for Hypotensive Anesthesia in Functional Endoscopic Sinus Surgery Phentolamine, Esmolol - Preoperative, Phentolamine | Not applicable | Unknown | Ain Shams University | 60 | 2024-10-10 | 2024-10-01 |
| REMAP ECMO - Beta Receptor Modulation Trial Esmolol - Heart Failure, Cardiogenic Shock | Phase 2 | Unknown | Erasmus Medical Center | 20 | 2024-06-01 | 2024-07-26 |
| Impact of Administration of Esmolol on Nociception Level-guided Control of Nociception. Esmolol Hydrochloride, Saline - Opioid Use, Unspecified, Anesthesia | Phase 4 | Unknown | Ciusss de L'Est de l'Île de Montréal | 64 | 2024-04-16 | 2024-07-16 |
| Study of Microvascular Dysfunction, CFR and Cardioprotective Effect of Early Administration of Esmolol in MI Esmolol Hcl 10Mg/Ml Inj - Myocardial Infarction, Coronary Stenosis | Not applicable | Recruiting | National Medical Research Center for Cardiology, Ministry of Health of Russian Federation | 300 | 2024-01-29 | 2024-04-19 |
| Esmolol Versus Lidocaine on the Quality of Postoperative Recovery in Patients Undergoing Functional Endoscopic Sinus Surgery Esmolol Injection, Lidocaine IV - Chronic Rhinosinusitis, Enhanced Recovery After Surgery | Phase 1 / Phase 2 | Unknown | The Second People's Hospital of Huai'an | 60 | 2023-11-21 | 2024-06-13 |
| Efficacy of Esmolol in the Identification of Cardiovascular Disorders by Cirrhosis, Diabetes Mellitus and Cardiotoxic Treatments Esmolol Injection [Brevibloc] - Cirrhosis, Diabetes Mellitus | Phase 3 | Recruiting | Consorcio Centro de Investigación Biomédica en Red (CIBER) | 1000 | 2023-04-18 | 2024-10-01 |
| Effect of Esmolol on Oxygenation Index in Patients With Acute Respiratory Distress Syndrome Esmolol - Acute Respiratory Distress Syndrome | Phase 3 | Recruiting | Zhiming Jiang | 178 | 2023-02-20 | 2024-03-13 |
| Effects of Low-dose Esmolol on Myocardial Injury After Non-cardiac Surgery in Elderly Frail Patients Esmolol, Placebo Comparator: Placebo Comparator:normal saline(0.9%) - Frailty, Esmolol | Phase 4 | Recruiting | Yongtao Sun | 2000 | 2023-02-07 | 2023-03-29 |
| Effect of Esmolol on Perioperative Stress Reaction Esmolol, saline - Esmolol, Stress Reaction | Phase 4 | Unknown | Xiumei Song | 46 | 2023-02-01 | 2023-01-23 |
| The Effect of Esmolol Versus Dexmedetomidine on Postoperative Pain Control in Endoscopic Sinus Surgery: A Randomized Trial Esmolol Esterase, Dexmedetomidine - Patient's Satisfaction, Depth of Anesthesia | Not applicable | Unknown | Tanta University | 70 | 2022-12-30 | 2023-11-24 |
| Efficacy of Esmolol Versus Magnesium Sulphate on Quality of Recovery in Patients Undergoing Laparoscopic Cholecystectomy: Randomized Controlled Study Esmolol, Magnesium sulfate - Esmolol Adverse Reaction | Phase 2 / Phase 3 | Completed | Alexandria University | 60 | 2022-10-05 | 2023-05-09 |
| The Impact of Esmolol Administration on Postoperative Recovery Esmolol Hydrochloride, normal saline - Pain, Acute, Pain, Postoperative | Not applicable | Unknown | Aretaieion University Hospital | 70 | 2022-10-01 | 2022-10-27 |
| Comparison of Effects of Scalp Block and Intravenous Esmolol on Hemodynamic Response Following the Skull Pins Application for Elective Supratentorial Craniotomy Scalp block, Esmolol - Hemodynamic Instability | Not applicable | Completed | Khon Kaen University | 90 | 2022-09-19 | 2024-02-20 |
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Shock, Septic (12) · Pain, Postoperative (8) · Agnosia (7) · Pain (7) · Hypertension (6) · Tachycardia (5) · Hypotension (4) · Sepsis (4) · Atrial Fibrillation (3) · Myocardial Ischemia (3) · Nociceptive Pain (3) · Stroke (3) · Autonomic Nervous System Diseases (2) · Brain Neoplasms (2) · Cerebral Hemorrhage (2)
AOP Orphan Pharmaceuticals AG (3) · Cedars-Sinai Medical Center (3) · Hospital de Base (3) · The George Institute (3) · Ain Shams University (2) · Central Hospital, Nancy, France (2) · Diskapi Teaching and Research Hospital (2) · George Papanicolaou Hospital (2) · Northwestern University (2) · Novalead Pharma Private Limited (2) · Qianfoshan Hospital (2) · Shanghai Zhongshan Hospital (2) · Alexandria University (1) · Andrea Morelli (1) · Ankara Diskapi Training and Research Hospital (1)
United States (22) · China (12) · Egypt (8) · Turkey (Türkiye) (8) · Brazil (6) · France (6) · Canada (5) · Greece (4) · Italy (4) · Australia (3) · Czechia (3) · India (3) · Germany (2) · Russia (2) · South Korea (2)
Andrea Morelli, MD (2) · Craig Anderson, PhD (2) · Roya Yumul, MD, PhD (2) · Allan Walkey, MD (1) · Antoine Kimmoun, MD (1) · Armando Flor (1) · Ashu Rastogi, MD (1) · Asish Subedi, MD (1) · Bruce Neal, PhD (1) · Bruno Levy, MD PhD (1) · Christiaan L. Meuwese (1) · Craig S Anderson, MD (1) · Demet Altun (1)
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