228 completed, 39 unknown, 34 recruiting, 33 terminated. 124 Phase 2, 88 Phase 3, 66 Phase 4, 52 Not applicable, 46 Phase 1.
Follow Hydrocortisone: new trials by email Literature Review of Hydrocortisone trials Research Report on Hydrocortisone
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Osilodrostat for Glycemic Control in Mild Autonomous Cortisol Secretion (MACS) With Difficult-To-Control Type 2 Diabetes - A Randomized, Double-Blind, Placebo-Controlled Phase 2 Study Osilodrostat (Isturisa), Placebo, hydrocortisone 10mg - Mild Autonomous Cortisol Secretion (MACS), Diabetes Mellitus (Type 2) | Phase 2 | Not yet recruiting | Beckey Trinh | 44 | 2026-11-01 | 2026-11-06 |
| Effects of Pharmacological Stress and rTMS on Executive Function in Opioid Use Disorder Yohimbine + Hydrocortisone, Active rTMS, Placebo - Opioid Use Disorder | Phase 2 | Not yet recruiting | Wayne State University | 20 | 2026-10-01 | 2025-12-30 |
| Intrathecal Cytarabine and Hydrocortisone for the Early Treatment of ICANS in Patients Undergoing CAR T Therapy for Non Hodgkin Lymphoma Therapeutic Hydrocortisone, Cytarabine, Dexamethasone - Non-hodgkin Lymphoma, Recurrent Diffuse Large B-Cell Lymphoma | Phase 2 | Recruiting | Vanderbilt-Ingram Cancer Center | 59 | 2026-09-25 | 2026-10-02 |
| A Study to Find the Highest Dose of SNDX-5613 (Revumenib) as a Treatment Option After Hematopoietic Stem Cell Transplant in Children With Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, and Mixed Phenotype Acute Leukemia Biospecimen Collection, Bone Marrow Aspiration, Bone Marrow Biopsy - Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia | Phase 1 | Withdrawn | Children's Oncology Group | 2026-09-10 | 2026-05-05 | |
| GI-06: The Impact of Perioperative Hydrocortisone on Patients Undergoing Partial Pancreatectomy Hydrocortisone, Pancreatic resection - Pancreatic Cancer, Pancreatic Adenocarcinoma | Phase 1 | Not yet recruiting | University of Illinois at Chicago | 20 | 2026-09-01 | 2026-09-01 |
| Trial of Revumenib Plus FLA Chemotherapy for Children With Relapsed or Refractory NUP98-rearranged AML." Revumenib, Fludarabine, Cytarabine (Ara-C) - Leukemia, Myeloid, Acute | Phase 2 | Not yet recruiting | Therapeutic Advances in Childhood Leukemia Consortium | 24 | 2026-08-31 | 2026-07-22 |
| Testing the Addition of Daratumumab to Chemotherapy for Treating Patients With Newly-Diagnosed T-Cell Lymphoblastic Leukemia (T-ALL) and T-Cell Lymphoblastic Lymphoma (T-LL) Biopsy Procedure, Biospecimen Collection, Bone Marrow Aspiration - Stage II T Lymphoblastic Leukemia/Lymphoma, Stage III T Lymphoblastic Leukemia/Lymphoma | Phase 2 / Phase 3 | Not yet recruiting | Children's Oncology Group | 1708 | 2026-08-28 | 2026-07-30 |
| Sleep Loss and Circadian Misalignment - Mechanisms of Insulin Resistance Metyrapone And Hydrocortisone, Dextrose, insulin - Shift Work Schedule, Circadian Rhythm | Phase 4 | Recruiting | Washington State University | 48 | 2026-07-16 | 2026-09-18 |
| Adaptive Platform Trial for Personnalisation of Sepsis Treatment in Children and Adults: a Multi-national, Treatable Traits-guided, Adaptive, Exploratory, Bayesian Basket Trial Tocilizumab, Baricitinib, Anakinra - Sepsis | Phase 2 | Recruiting | Assistance Publique - Hôpitaux de Paris | 2000 | 2026-07-09 | 2026-10-20 |
| Safety and Efficacy of Asciminib in Pediatrics and Young Adults With Relapse/Refractory (r/r) Philadelphia Positive (Ph+) or ABL-class Ph-like Acute Lymphoblastic Leukemia (ALL) Asciminib Adult formulation, Asciminib Pediatric formulation, Dexamethasone - Acute Lymphoblastic Leukemia, Leukemia, Lymphoblastic, Acute, Philadelphia-Positive | Phase 1 / Phase 2 | Recruiting | Novartis Pharmaceuticals | 50 | 2026-07-05 | 2026-10-15 |
| Intraperitoneal Hydrocortisone for Postoperative Pain and CRP Following Caesarean Section hydrocortisone, Nornal Saline - Postoperative Pain, Caesarean Section | Phase 4 | Completed | Raditsya Mada Gautama, MD | 50 | 2026-06-25 | 2026-10-23 |
| Imaging CRF X NOP Interactions in Alcohol Use Disorder Baseline [C-11]NOP-1A PET scan, Hydrocortisone, Post-hydrocortisone [C-11]NOP-1A PET scan - Alcohol Use Disorder | Early Phase 1 | Recruiting | Rajesh Narendran | 90 | 2026-06-01 | 2026-06-03 |
| Comparing Hydrocortisone and Prednisolone for Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD) Methylprednisolone (drug), Hydrocortisone - Chronic Obstructive Pulmonary Disease (COPD) | Phase 4 | Recruiting | Copenhagen Respiratory Research | 2000 | 2026-03-10 | 2026-03-18 |
| Comparing Hydrocortisone and Prednisolone for Community Acquired Pneumonia (CAP) Methylprednisolone (drug), hydrocortisone - Community Acquired Pneumonia (CAP) | Phase 4 | Recruiting | Copenhagen Respiratory Research | 1600 | 2026-03-10 | 2026-03-18 |
| Hydrocortisone and Fludrocortisone for the Treatment of Septic Shock Hydrocortisone plus Fludrocortisone, Standard care - Septic Shock | Phase 4 | Recruiting | Northern Jiangsu People's Hospital | 336 | 2026-03-02 | 2026-03-04 |
| Pilot Study of IT Topotecan and Maintenance Chemotherapy for HR-EBTs in Children < 6 Years, Post Consolidation Cytarabine IT, hydrocortisone, Cisplatin - CNS Embryonal Tumor, CNS, Medulloblastoma | Early Phase 1 | Recruiting | C17 Council | 15 | 2025-09-23 | 2026-11-02 |
| Preventing Postoperative Complications in Patients Undergoing High-risk Pancreatoduodenectomy With a Bundle Approach Including Hydrocortisone, Octreotide, and the Teres Ligament Patch (PANENCA) HOP bundle - Pancreas Head Cancer, Pancreas Adenocarcinoma | Phase 4 | Recruiting | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 400 | 2025-09-01 | 2025-12-22 |
| Topical Terbinafine Versus Hydrocortisone Combined With Oral Itraconazole for Seborrheic Dermatitis Itraconazole, Terbinafine 1% cream, Hydrocortisone 1% cream - Seborrheic Dermatitis | Phase 4 | Completed | Can Tho University of Medicine and Pharmacy | 76 | 2025-07-07 | 2026-10-30 |
| Testing the Addition of the Anti-cancer Drug Venetoclax and/or the Anti-cancer Immunotherapy Blinatumomab to the Usual Chemotherapy Treatment for Infants With Newly Diagnosed KMT2A-rearranged or KMT2A-non-rearranged Leukemia Asparaginase Erwinia chrysanthemi, Biospecimen Collection, Blinatumomab - Acute Leukemia of Ambiguous Lineage, B Acute Lymphoblastic Leukemia | Phase 2 | Recruiting | National Cancer Institute (NCI) | 153 | 2025-06-05 | 2026-10-27 |
| Intrathecal Cytarabine, Methotrexate, and Hydrocortisone for the Prevention of High-Grade Chimeric Antigen Receptor T-Cell-Associated Neurotoxicity Syndrome Biospecimen Collection, Cytarabine, Lumbar Puncture - Hematopoietic and Lymphatic System Neoplasm | Phase 2 | Recruiting | OHSU Knight Cancer Institute | 26 | 2025-06-04 | 2026-06-26 |
Showing 20 of 378. Sign in to see all of them.
Precursor Cell Lymphoblastic Leukemia-Lymphoma (47) · Shock, Septic (29) · Leukemia (28) · Sepsis (26) · Adrenal Insufficiency (25) · Prostatic Neoplasms (21) · Burkitt Lymphoma (17) · Leukemia, Biphenotypic, Acute (15) · Adrenal Hyperplasia, Congenital (13) · Lymphoma (13) · Stress Disorders, Post-Traumatic (12) · Addison Disease (11) · Leukemia, Myeloid, Acute (8) · Lymphoma, Large B-Cell, Diffuse (7) · Recurrence (7)
Children's Oncology Group (20) · National Cancer Institute (NCI) (16) · Neurocrine UK Limited (11) · St. Jude Children's Research Hospital (8) · Dana-Farber Cancer Institute (7) · Stanford University (7) · Ain Shams University (6) · Charite University, Berlin, Germany (5) · Haukeland University Hospital (5) · Therapeutic Advances in Childhood Leukemia Consortium (5) · Beth Israel Deaconess Medical Center (4) · Hospital for Special Surgery, New York (4) · Insel Gruppe AG, University Hospital Bern (4) · Merck Sharp & Dohme LLC (4) · PETHEMA Foundation (4)
United States (176) · Canada (38) · France (32) · Australia (30) · United Kingdom (25) · Germany (23) · Switzerland (19) · China (17) · Italy (15) · Israel (14) · Puerto Rico (14) · Brazil (13) · Egypt (13) · Netherlands (13) · New Zealand (13)
Abhik Das, PhD (3) · Elizabeth Raetz, MD (3) · Seetha Shankaran, MD (3) · A Koch (2) · Abbot R Laptook, MD (2) · Carl T D'Angio, MD (2) · Christian Brun Buisson, MD (2) · Deborah P Merke, M.D. (2) · Didier Keh, MD (2) · Djillali Annane, MD (2) · Edward F Bell, MD (2) · Julio C. Barredo, MD (2)
PMID 38767196, PMID 35141873, PMID 41671463, PMID 23525934, PMID 27695824, PMID 33045104, PMID 33527139, PMID 35087332, PMID 35622074, PMID 41732008, PMID 10321661, PMID 10499612, PMID 10697064, PMID 10722036, PMID 10820362, PMID 10923728, PMID 11162047, PMID 1138591, PMID 11426549, PMID 11502226, PMID 11512567, PMID 11600602, PMID 12011123, PMID 12186604, PMID 12239143, PMID 12454520, PMID 12545007, PMID 12560440, PMID 12630816, PMID 12700374, PMID 12933380, PMID 14747052, PMID 15020604, PMID 15042678, PMID 15273558, PMID 15353542, PMID 15368546, PMID 15637138, PMID 15767942, PMID 1607900, PMID 16556894, PMID 16570523, PMID 16609069, PMID 16809737, PMID 16888080, PMID 17039234, PMID 17132719, PMID 17136402, PMID 17138821, PMID 17404083
U10CA180886 (13), U10CA098543 (12), 2009 (3), 2023 (3), U10HD021364 (3), U10HD021373 (3), U10HD021385 (3), U10HD027851 (3), U10HD027853 (3), U10HD027856 (3), U10HD027880 (3), U10HD027904 (3), U10HD034216 (3), U10HD036790 (3), U10HD040492 (3)