56 completed, 16 unknown, 13 terminated, 8 recruiting. 105 Phase 3, 26 Phase 2.
Follow Septic Shock: new trials by email Literature Review of Septic Shock trials Research Report on Septic Shock
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Trial of Adjunctive Fludrocortisone (50mcg, 100mcg or Placebo) in Critically Ill Patients With Septic Shock Receiving Hydrocortisone, Evaluating Survival and Functional Recovery and the Influence of Transcriptomic Response Fludrocortisone 50 mcg daily, Fludrocortisone 100 mcg daily, Placebo - Septic Shock | Phase 3 | Recruiting | The George Institute | 2200 | 2026-10-16 | 2026-10-30 |
| Assessing the Efficacy of Dapagliflozin as a Vasculoprotective Treatment in Septic Shock Patients With Microcirculatory Dysfunction Dapaglifozin, Placebo - Septic Shock | Phase 3 | Not yet recruiting | University Hospital, Strasbourg, France | 568 | 2026-07-01 | 2026-03-27 |
| Comparative Efficacy and Safety of Propofol-Ketamine Combination Versus Propofol Monotherapy in Geriatric Patients Under Invasive Ventilation Ketofol, propofol (drug) - The Critically Ill Patient is Requiring Intubation, Septic Shock | Phase 3 | Active not recruiting | Helwan University | 70 | 2026-05-13 | 2026-10-15 |
| Systematic Adjunction of Vasopressine in Septic Shock Vasopressin administration, Sodium chloride administration - Septic Shock | Phase 3 | Recruiting | Assistance Publique Hopitaux De Marseille | 120 | 2026-03-24 | 2026-10-26 |
| Early Methylene Blue in the Microhemodynamics of Septic Patients Methylene blue infusion - Septic Shock, Hypoperfusion | Phase 2 / Phase 3 | Recruiting | Centro de Estudos e Pesquisa em Emergencias Medicas e Terapia Intensiva | 50 | 2026-01-09 | 2026-03-27 |
| Human Albumin for Resuscitation in Surgical Septic Shock: A Randomized Controlled Trial (ALBUS Study) Human Albumin 20% Solution, Standard Care (in control arm) - Critical Illness, Septic Shock | Phase 3 | Not yet recruiting | Mahidol University | 304 | 2025-12-01 | 2025-11-19 |
| Weaning Approaches for Vasopressin in Sepsis Titrated weaning of vasopressin., Abrupt weaning of vasopressin. - Septic Shock | Phase 3 | Recruiting | Hospital Nossa Senhora da Conceicao | 82 | 2025-10-01 | 2026-01-02 |
| Adjunctive Methylene Blue in Septic Shock Methylene Blue, Usual Care - Septic Shock | Phase 3 | Completed | Dr. Shannon M. Fernando | 50 | 2025-06-02 | 2026-03-19 |
| Evaluation of Early Administration of Levetiracetam in the Prevention and Treatment Encephalopathy in Septic Shock: Randomized, Double-blind, Placebo-controlled Trial Levetiracetam IV, Placebo control - Septic Shock | Phase 3 | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 280 | 2025-03-15 | 2025-03-12 |
| Venous Excess Ultrasound for Personalized Resuscitation in Septic Shock Venous Excess Ultrasound (VEXUS)-Guided Management - Septic Shock, Sepsis | Phase 3 | Not yet recruiting | Western University, Canada | 80 | 2024-12-01 | 2024-11-20 |
| Norepinephrine and Vasopressin for Rescue Versus Early Vasopressin for Vasopressor Dependent Sepsis Early Vasopressin, Norepinephrine and Vasopressin for Rescue - Septic Shock | Phase 3 | Recruiting | Hospital do Coracao | 2800 | 2024-11-21 | 2026-01-30 |
| A Phase III, Open Label, Randomized, Controlled Study of VBI-S in the Treatment of Hypovolemia in Patients With Septic Shock (VBI-S-02) VBI-S - Septic Shock, Sepsis | Phase 3 | Completed | Vivacelle Bio | 39 | 2024-08-06 | 2026-10-26 |
| Methylene Blue for the Treatment of Septic Shock Methylene Blue, Placebo - Septic Shock | Phase 3 | Completed | Northern Jiangsu People's Hospital | 88 | 2024-08-05 | 2026-02-04 |
| The Effect of Early Norepinephrine on Stroke Volume Index, Cardiac Index, Lactate, and Arterial Elastance in Pediatric Septic Shock Norepinephrine, Ringer's Lactate - Septic Shock, Sepsis | Phase 2 / Phase 3 | Completed | Universitas Indonesia | 42 | 2024-03-25 | 2024-06-20 |
| Extracorporal Cytokin Removal in Septic Shock: a Prospective, Randomized, Multicenter Clinical Trial Standard medical therapy, Standard medical therapy plus cytokine removal treatment using Cytosorb, with the adsorber changed in every 12 hours, Standard medical therapy plus cytokine removal treatment using Cytosorb, with the adsorber changed in every 24 hours - Septic Shock | Phase 3 | Suspended | University of Pecs | 135 | 2024-01-01 | 2023-04-20 |
| Strong Albumin Solutions in Patients With Septic Shock hyperoncotic human albumin solution, Buffered crystalloid solutions - Sepsis, Septic Shock | Phase 2 / Phase 3 | Completed | Manchester University NHS Foundation Trust | 47 | 2023-11-10 | 2026-02-09 |
| Low Dose Versus High Dose Methylene Blue in Septic Patients Normal saline, Methylene Blue low dose, Methylene Blue high dose - Septic Shock | Phase 2 / Phase 3 | Completed | National Cancer Institute, Egypt | 90 | 2023-08-01 | 2024-07-05 |
| The Effect Of Resuscitation Guided By Two Different Dynamic Parameters On Time To Normalization Of The Capillary Refill Time In Adult Patients With Septic Shock Group VTI, Group IVC - Septic Shock, Resuscitation | Phase 3 | Completed | Kasr El Aini Hospital | 90 | 2023-07-21 | 2025-04-29 |
| Adjunctive Esketamine for Analgesia in Mechanically Ventilated Septic Shock Patients Esketamine, Saline, Remifentanil + propofol - Septic Shock, Mechanical Ventilation Complication | Phase 3 | Unknown | Nanfang Hospital, Southern Medical University | 124 | 2023-05-31 | 2023-11-22 |
| Piperacillin-tazobactam and Temocillin as Carbapenem-alternatives for the Treatment of Severe Infections Due to Extended-spectrum Beta-lactamase-Producing Gram-negative Enterobacteriaceae in the Intensive Care Unit Piperacillin/tazobactam or temocillin, Meropenem - Sepsis, Septic Shock | Phase 3 | Unknown | Assistance Publique - Hôpitaux de Paris | 600 | 2023-03-11 | 2023-04-18 |
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Shock, Septic (105) · Sepsis (50) · Critical Illness (5) · Acute Kidney Injury (4) · Shock (4) · Diabetes Insipidus (3) · Infections (3) · Neoplasms (2) · Pneumonia (2) · Adrenal Insufficiency (1) · Agnosia (1) · Anemia (1) · Atrial Fibrillation (1) · Bacteremia (1) · Fibrosis (1)
Inflammation (105) · Pathologic Processes (105) · Pathological Conditions, Signs and Symptoms (105) · Systemic Inflammatory Response Syndrome (105) · Infections (102) · Shock (101) · Sepsis (55) · Female Urogenital Diseases (7) · Female Urogenital Diseases and Pregnancy Complications (7) · Kidney Diseases (7) · Male Urogenital Diseases (7) · Urogenital Diseases (7) · Urologic Diseases (7) · Cardiovascular Diseases (6) · Disease Attributes (5)
Saline Solution (14) · Norepinephrine (10) · Ascorbic Acid (9) · Hydrocortisone (9) · Methylene Blue (7) · Fludrocortisone (5) · Sodium Chloride (5) · Thiamine (5) · Albumins (4) · Ringer's Lactate (4) · Terlipressin (4) · Dexmedetomidine (3) · Ketamine (3) · Meropenem (3) · Dobutamine (2)
Assistance Publique - Hôpitaux de Paris (6) · Cairo University (6) · University of Versailles (3) · Beth Israel Deaconess Medical Center (2) · Centre Hospitalier Universitaire Dijon (2) · Centre Hospitalier Universitaire, Amiens (2) · Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico (2) · Frisius Medisch Centrum (2) · Kompetenznetz Sepsis (2) · Northern Jiangsu People's Hospital (2) · Rennes University Hospital (2) · The George Institute (2) · University of Roma La Sapienza (2) · University of Virginia (2) · Air Force Specialized Hospital, Cairo, Egypt (1)
France (23) · United States (12) · Egypt (10) · Brazil (8) · Canada (6) · Italy (6) · Denmark (5) · Netherlands (5) · Spain (5) · Germany (4) · Mexico (4) · Australia (3) · China (3) · Thailand (3) · Belgium (2)
Ahmed Mukhtar, Professor (3) · Anders Perner, MD, PhD (2) · Andrea Morelli, MD (2) · Konrad Reinhart, MD (2) · Luciano Gattinoni, MD (2) · Michael W Donnino, MD (2) · Pietro Caironi, MD (2) · Qingquan Lyu, Master (2) · Thomas Deufel, MD (2) · Abdelrhman Hussein (1) · Adham Mohamed, PharmD (1) · Ahmed Hasanin, Professor (1) · Alain Cariou, MD (1) · Alexandra Kadl, MD (1)
PMID 23525934, PMID 23984731, PMID 24635772, PMID 10722036, PMID 1138591, PMID 11502226, PMID 12454520, PMID 12545007, PMID 12700374, PMID 1607900, PMID 16570523, PMID 16978417, PMID 17720019, PMID 18184958, PMID 18353115, PMID 19114908, PMID 19730258, PMID 19851126, PMID 19926252, PMID 20103758, PMID 20332511, PMID 20594297, PMID 20646908, PMID 20924555, PMID 21129208, PMID 21516036, PMID 21615299, PMID 21827677, PMID 21929764, PMID 22692171, PMID 227054, PMID 22738085, PMID 23352693, PMID 23353941, PMID 24037226, PMID 24207137, PMID 24484547, PMID 24794878, PMID 24807084, PMID 24838355, PMID 25099709, PMID 25270275, PMID 25407570, PMID 25466837, PMID 25855898, PMID 25862039, PMID 25907781, PMID 26771781, PMID 26847922, PMID 26903338
2018 (3), 2014 (2), 2005 (1), 2017 (1), 2019 (1), 2025 (1), R01HD096901 (1)