67 completed, 22 unknown, 12 terminated, 7 recruiting. 119 Phase 2, 26 Phase 3, 19 Phase 1.
Follow Septic Shock: new trials by email Literature Review of Septic Shock trials Research Report on Septic Shock
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Phase IIb Multicenter Randomized Controlled Trial Evaluating the Efficacy of Sivelestat in Patients With Septic Coagulopathy • Sivelestat intravenous infusion, NaCl intravenous infusion - Septic Shock, Coagulopathy | Phase 2 | Not yet recruiting | University Hospital, Strasbourg, France | 120 | 2027-08-01 | 2026-08-20 |
| NAI for Sepsis With Persistent Lymphopenia Nogapendekin alfa inbakicept (NAI), Standard of Care (SOC) - Sepsis, Septic Shock | Phase 2 | Not yet recruiting | ImmunityBio, Inc. | 50 | 2026-07-06 | 2026-05-11 |
| Adjunctive Fludrocortisone in Septic Shock Fludrocortisone 100 mcg daily, Placebo - Sepsis, Septic Shock | Phase 2 | Recruiting | Chinese University of Hong Kong | 32 | 2026-04-01 | 2026-06-02 |
| POCUS-Guided Esmolol in Septic Shock: A Pilot RCT Esmolol - Septic Shock | Phase 1 / Phase 2 | Not yet recruiting | John Basmaji | 100 | 2026-01-15 | 2026-01-06 |
| Early Methylene Blue in the Microhemodynamics of Septic Patients Methylene blue infusion - Septic Shock, Hypoperfusion | Phase 2 / Phase 3 | Recruiting | Centro de Estudos e Pesquisa em Emergencias Medicas e Terapia Intensiva | 50 | 2026-01-09 | 2026-03-27 |
| Study SOLACE SEPSIS Sodium Lactate, 3% NaCl - Septic Shock, Intracranial Hypertension | Phase 2 | Recruiting | University Hospital Pilsen | 40 | 2024-11-24 | 2026-04-14 |
| Dexmedetomidine and Vasopressin in Septic Shock DEX-PRESSIN, Standard of Care - Sepsis, Septic Shock | Phase 2 | Unknown | Mansoura University | 260 | 2024-06-01 | 2024-03-12 |
| The Effect of Early Norepinephrine on Stroke Volume Index, Cardiac Index, Lactate, and Arterial Elastance in Pediatric Septic Shock Norepinephrine, Ringer's Lactate - Septic Shock, Sepsis | Phase 2 / Phase 3 | Completed | Universitas Indonesia | 42 | 2024-03-25 | 2024-06-20 |
| Umbilical Mesenchymal Stromal Cells as Cellular Immunotherapy for Septic Shock Allogeneic umbilical cord-derived human mesenchymal stromal cells, Placebo - Septic Shock, Sepsis | Phase 2 | Recruiting | Ottawa Hospital Research Institute | 296 | 2024-02-14 | 2024-12-05 |
| Human Albumin Treatment in Adult Septic Shock. A Study Evaluating Immune Response and Organ Failure. Human albumin, Saline solution - Septic Shock | Phase 2 | Withdrawn | Albimmune SL | 2024-02-01 | 2024-07-31 | |
| Strong Albumin Solutions in Patients With Septic Shock hyperoncotic human albumin solution, Buffered crystalloid solutions - Sepsis, Septic Shock | Phase 2 / Phase 3 | Completed | Manchester University NHS Foundation Trust | 47 | 2023-11-10 | 2026-02-09 |
| Safety and Feasibility of Metformin for Sepsis Induced AKI Metformin low dose, Metformin high dose, Placebo - Sepsis, Septic Shock | Phase 2 | Completed | Hernando Gomez | 80 | 2023-11-08 | 2026-06-09 |
| Improvement of Organ Function by Apigenin in Elderly Patients With Sepsis apigenin, sterilized water - Sepsis, Septic Shock | Phase 1 / Phase 2 | Completed | Zhujiang Hospital | 20 | 2023-09-01 | 2024-03-13 |
| Low Dose Versus High Dose Methylene Blue in Septic Patients Normal saline, Methylene Blue low dose, Methylene Blue high dose - Septic Shock | Phase 2 / Phase 3 | Completed | National Cancer Institute, Egypt | 90 | 2023-08-01 | 2024-07-05 |
| Early Versus Conventional Cessation of Hydrocortisone in Septic Shock normal saline solution, Hydrocortisone and normal saline solution - Septic Shock, Adverse Event | Phase 2 | Unknown | Mahidol University | 160 | 2023-07-05 | 2024-04-05 |
| Effects of Paroxetine on Cardiovascular Function in Septic Patients Paroxetine - Septic Shock, Sepsis | Phase 2 | Completed | Universidade do Extremo Sul Catarinense - Unidade Academica de Ciecias da Saude | 130 | 2023-06-10 | 2026-08-24 |
| Therapeutic Plasma Exchange in Septic Shock: A Pilot Study Therapeutic Plasma Exchange - Septic Shock | Phase 2 | Recruiting | University of Manitoba | 80 | 2023-06-01 | 2025-08-17 |
| Xanthohumol as an Adjuvant in the Treatment of Septic Shock Xanthohumol - Septic Shock, Pneumonia | Phase 2 | Recruiting | Medical University of Lublin | 50 | 2023-01-09 | 2025-07-04 |
| Midodrine Effect on the Mortality Rates in Septic Shock Patients Midodrine Oral Tablet - Septic Shock | Phase 2 | Completed | Noha Mansour | 100 | 2022-11-07 | 2025-03-03 |
| Gram Type Infection-Specific Sepsis Identification Using Machine Learning InSight - Sepsis, Severe Sepsis | Phase 2 | Withdrawn | Dascena | 2022-05-01 | 2021-09-23 |
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Shock, Septic (119) · Sepsis (62) · Infections (5) · Shock (5) · Disease (4) · Inflammation (4) · Systemic Inflammatory Response Syndrome (4) · Acute Kidney Injury (3) · Critical Illness (3) · Diabetes Insipidus (2) · Hyperglycemia (2) · Hypotension (2) · Multiple Organ Failure (2) · Pathologic Processes (2) · Tachycardia (2)
Pathological Conditions, Signs and Symptoms (119) · Pathologic Processes (117) · Inflammation (115) · Systemic Inflammatory Response Syndrome (115) · Infections (114) · Shock (114) · Sepsis (57) · Urogenital Diseases (6) · Cardiovascular Diseases (5) · Female Urogenital Diseases (5) · Female Urogenital Diseases and Pregnancy Complications (5) · Kidney Diseases (5) · Lung Diseases (5) · Male Urogenital Diseases (5) · Respiratory Tract Diseases (5)
Ascorbic Acid (10) · Saline Solution (10) · Thiamine (7) · esmolol (7) · Sodium Chloride (6) · Hydrocortisone (5) · Norepinephrine (5) · Standard of Care (5) · Methylene Blue (4) · Terlipressin (4) · Bronchoscopy (3) · Dobutamine (3) · Glucose (3) · Meropenem (3) · Phenylephrine (3)
University of Roma La Sapienza (6) · Dascena (5) · Beth Israel Deaconess Medical Center (4) · Ferring Pharmaceuticals (3) · King Abdul Aziz Specialist Hospital (3) · Mahidol University (3) · Ottawa Hospital Research Institute (3) · University of Manitoba (3) · AstraZeneca (2) · Jinhua Central Hospital (2) · M.D. Anderson Cancer Center (2) · Mansoura University (2) · Noha Mansour (2) · Rennes University Hospital (2) · Zhujiang Hospital (2)
United States (28) · France (14) · Italy (11) · Canada (9) · Denmark (7) · Egypt (7) · Belgium (6) · China (5) · Australia (4) · Germany (4) · Brazil (3) · Netherlands (3) · Saudi Arabia (3) · Thailand (3) · Czechia (2)
Andrea Morelli, MD (5) · Eric Bellissant, MD, PhD (3) · Michael W Donnino, MD (3) · Ritankar Das, MSc (3) · Andrea Morelli, M.D. (2) · Justin Lindemann, MD (2) · Lauralyn McIntyre, MD (2) · Ryan Zarychanski, MD MSc (2) · Warren Botnick, MD (2) · Wayne Dankner, MD (2) · Zhanguo Liu, M.D.PhD (2) · Abele Donati, MD (1) · Adham Mohamed, PharmD (1) · Ahmed Mohamed Mukhtar, M,D (1)
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