Fibrosis: Clinical Trials

1653 completed, 790 unknown, 456 recruiting, 227 terminated. 1089 Not applicable, 617 Phase 2, 347 Phase 3, 292 Phase 1, 276 Phase 4.

By phase and status

Phase	Trials	Status
Not applicable	1089	Completed 493, Unknown 246, Recruiting 134, Not yet recruiting 67, Terminated 55, Withdrawn 45, Active not recruiting 31, Enrolling by invitation 14, Suspended 4
Phase 2	617	Completed 310, Unknown 90, Terminated 78, Recruiting 69, Active not recruiting 25, Withdrawn 23, Not yet recruiting 16, Enrolling by invitation 3, Suspended 3
Phase 3	347	Completed 174, Unknown 57, Recruiting 38, Terminated 33, Active not recruiting 15, Withdrawn 14, Not yet recruiting 10, Enrolling by invitation 3, Suspended 3
Phase 1	292	Completed 175, Unknown 50, Recruiting 26, Terminated 19, Withdrawn 9, Not yet recruiting 8, Active not recruiting 3, Enrolling by invitation 1, Suspended 1
Phase 4	276	Completed 131, Unknown 84, Recruiting 18, Terminated 18, Not yet recruiting 10, Active not recruiting 7, Withdrawn 6, Enrolling by invitation 1, Suspended 1
Early Phase 1	39	Completed 16, Unknown 12, Active not recruiting 4, Terminated 3, Recruiting 2, Not yet recruiting 1, Withdrawn 1

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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Screening Cardiometabolic Opportunities Using Transformative Echocardiography Artificial Intelligence (SCOUT Echo-AI) AI-Enabled Identification (EchoNet-Liver) - MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease, Cirrhosis	Not applicable	Not yet recruiting	Kaiser Permanente	2000	2028-01-01	2026-08-13
A Phase IV, Two-part, Open-label Study Assessing the Pharmacokinetics, Safety and Pharmacodynamics of Spironolactone Oral Suspension in Pediatric Patients Spironolactone Oral Suspension - Edema Due to Heart Failure or Cirrhosis	Phase 4	Not yet recruiting	CMP Development, LLC	96	2027-06-01	2026-10-22
Post-Operative Use of FS2 to Mitigate Scarring in Burn Patients IP1 control cream (Vehicle base), IP2 - 0.5% w/w FS2 - Burn Scar, Burn Wound	Phase 2 / Phase 3	Recruiting	Birch BioMed Inc	70	2027-03-01	2026-09-30
Phase II Clinical Study on Preliminary Efficacy and Safety of ETD-001 Gel for Hypertrophic Scars ETD-001 gel, Placebo - Hypertrophic Scars	Phase 2	Not yet recruiting	Etern Therapeutics Wuxi Limited	90	2027-02-28	2026-10-23
Within-Session Repeatability of EUS-Guided Portal Pressure Gradient Measurement Repeated EUS-Guided Portal Pressure Gradient Measurement - Portal Hypertension, Chronic Liver Disease		Not yet recruiting	University Hospital Muenster	150	2027-01-01	2026-10-26
Dermabrasion for Free Flap Aesthetic Enhancement Dermabrasion - Scar Conditions and Fibrosis of Skin	Not applicable	Not yet recruiting	Milton S. Hershey Medical Center	40	2027-01-01	2026-08-24
The Application of Lifestyle Enhancing Validated Integrative Therapies for Everyday Pain in Cirrhosis High-touch self-management program, Low-touch self-management program - Cirrhoses, Liver	Not applicable	Not yet recruiting	University of Pennsylvania	625	2027-01-01	2026-10-02
Fiber-Optic Navigation During TIPS Creation: A Prospective Pilot Study Fiber-Optic Navigation System - Liver Cirrhosis, Refractory Ascites	Not applicable	Not yet recruiting	Medical University Innsbruck	30	2027-01-01	2026-03-13
Pomegranate Dietary Supplements in AUD and ALD Pomegranate Dietary Ssupplement - Alcohol Use Disorder, Alcohol-associated Liver Disease		Not yet recruiting	University of Louisville	144	2027-01-01	2026-07-24
"Anticipant"-TIPS After a First Portal-hypertension-related Complication in Cirrhosis TIPS, Standard of Care (SOC) - Cirrhosis	Not applicable	Not yet recruiting	University Hospital, Toulouse	266	2027-01-01	2026-10-22
Inflammatory and Neuroimmune Guided Investigation of Underlying Fatigue in Patients With Cirrhosis Cirrhosis Alcoholic, Fatigue Symptom		Not yet recruiting	King's College London	50	2027-01-01	2026-10-27
Long-term Extension Study to Evaluate Safety and Tolerability of Admilparant in Participants With Pulmonary Fibrosis BMS-986278 - Pulmonary Fibrosis	Phase 3	Not yet recruiting	Bristol-Myers Squibb	2380	2026-12-16	2026-10-30
Prickly Pear Pulp Powder Along With an Anti-inflammatory Diet in Patients Having Liver Fibrosis Experimental, Placebo - Lipid Profile, Blood Glucose	Not applicable	Not yet recruiting	University of Lahore	120	2026-12-15	2026-10-29
PET/MRI of Primary Sclerosing Cholangitis Radiotracer Injection, Contrast Media, Magnetic Resonance, Imaging - PSC		Not yet recruiting	Massachusetts General Hospital	10	2026-12-10	2026-10-14
The Effects of Timolol On Healing and Cosmesis of Mohs Scalp Wounds: An Open Label Trial Topical Timolol, Normal Saline - Surgical Wounds, Mohs Surgery	Phase 2	Not yet recruiting	Geisinger Clinic	45	2026-12-01	2026-10-14
Erlotinib for Hepatocellular Carcinoma Chemoprevention erlotinib hydrochloride, Placebo - Cirrhosis, Liver, Advanced Liver Fibrosis	Phase 2	Not yet recruiting	University of Texas Southwestern Medical Center	60	2026-12-01	2026-06-24
Isocaloric Navy-Bean Substitution in Adults With MASLD Dietary Supplement/Behavioral: Navy Bean-Rich Diet, Habitual Diet (Control) - Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), Liver Fibrosis	Not applicable	Not yet recruiting	Icahn School of Medicine at Mount Sinai	40	2026-11-25	2026-11-10
Effect of an Intraoperative Polynucleotide Injection on Scar Quality After Thyroidectomy Polynucleotide (PN-HPT), Sterile 0.9% Sodium Chloride - Postoperative Surgical Scar, Scar	Not applicable	Not yet recruiting	Dr. Lutfi Kirdar Kartal Training and Research Hospital	80	2026-11-20	2026-09-23
Prospective AI-SC Trial Artificial Intelligence Selection Committee (AI-SC) - Liver Cirrhosis		Not yet recruiting	University Health Network, Toronto	200	2026-11-13	2026-11-10
A Study of Fatigue, Itching and Daily Activities in People With Primary Biliary Cholangitis Starting Elafibranor Elafibranor - Primary Biliary Cholangitis (PBC)		Not yet recruiting	Ipsen	50	2026-11-02	2026-10-30

Showing 20 of 3631. Sign in to see all of them.

Narrower conditions

Liver Cirrhosis (1269)  ·  Cicatrix (407)  ·  Pulmonary Fibrosis (333)  ·  Hypertension, Portal (225)  ·  Liver Cirrhosis, Biliary (214)  ·  Non-alcoholic Fatty Liver Disease (205)  ·  Carcinoma, Hepatocellular (182)  ·  Liver Diseases (161)  ·  Keloid (136)  ·  Hepatitis C (131)  ·  Cicatrix, Hypertrophic (128)  ·  Tissue Adhesions (121)  ·  Ascites (115)  ·  Fatty Liver (113)

Broader conditions

Pathological Conditions, Signs and Symptoms (3631)  ·  Pathologic Processes (3616)  ·  Digestive System Diseases (2071)  ·  Liver Diseases (1854)  ·  Respiratory Tract Diseases (409)  ·  Infections (379)  ·  Lung Diseases (372)  ·  Neoplasms (318)  ·  Virus Diseases (311)  ·  Skin and Connective Tissue Diseases (308)  ·  Nutritional and Metabolic Diseases (306)  ·  Hepatitis (293)  ·  Neoplasms by Site (289)  ·  Cicatrix (285)

Interventions

Blood Specimen Collection (43)  ·  Albumins (35)  ·  Ribavirin (35)  ·  Rifaximin (34)  ·  Carvedilol (30)  ·  Ursodeoxycholic Acid (30)  ·  pirfenidone (29)  ·  Standard of Care (28)  ·  Portasystemic Shunt, Transjugular Intrahepatic (26)  ·  Propranolol (26)  ·  Sodium Chloride (26)  ·  Exercise (25)  ·  Saline Solution (24)  ·  Terlipressin (23)  ·  TGFB3 protein, human (20)

Sponsors

Institute of Liver and Biliary Sciences, India (73)  ·  Assistance Publique - Hôpitaux de Paris (61)  ·  Assiut University (44)  ·  Massachusetts General Hospital (32)  ·  Gilead Sciences (30)  ·  National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (30)  ·  Post Graduate Institute of Medical Education and Research, Chandigarh (28)  ·  Mayo Clinic (27)  ·  Seoul National University Hospital (26)  ·  Hospices Civils de Lyon (25)  ·  Renovo (25)  ·  Cairo University (22)  ·  Northern Jiangsu People's Hospital (21)  ·  Beijing Friendship Hospital (20)  ·  Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran (20)

Countries

United States (1032)  ·  China (449)  ·  France (333)  ·  United Kingdom (241)  ·  Italy (212)  ·  Spain (206)  ·  Germany (203)  ·  Canada (201)  ·  India (149)  ·  South Korea (140)  ·  Belgium (126)  ·  Egypt (118)  ·  Netherlands (111)  ·  Denmark (95)  ·  Australia (90)

Top investigators

Guo-Qing Jiang, MD (14)  ·  Jasmohan S Bajaj, MD (8)  ·  Elliot Tapper, MD (7)  ·  Jeong Min Lee, MD (7)  ·  Michael H Tirgan, MD (7)  ·  Shiyao Chen, Professor (7)

Results publications

PMID 37467180, PMID 28388260, PMID 35688625, PMID 25543678, PMID 27847279, PMID 33460002, PMID 39115183, PMID 19362676, PMID 21836029, PMID 26835133, PMID 30739368, PMID 31047956, PMID 33434107, PMID 33902584, PMID 35120736, PMID 36740893, PMID 37391667, PMID 37786277, PMID 38235907, PMID 10924629, PMID 12028528, PMID 12834941, PMID 15105384, PMID 15113289, PMID 15253184, PMID 16020491, PMID 16079683, PMID 16306522, PMID 16799972, PMID 17105757, PMID 18054553, PMID 19208350, PMID 19570764, PMID 20130466, PMID 20199501, PMID 20558165, PMID 20927486, PMID 21145834, PMID 21571362, PMID 21688284, PMID 22027579, PMID 22335782, PMID 22732511, PMID 22821361, PMID 22994906, PMID 23239552, PMID 23872605, PMID 24480619, PMID 24834811, PMID 24836310

NIH funding

2016 (17), 2014 (13), 2023 (10), 2019 (8), 2009 (7), 2008 (6), 2025 (6), 2015 (5), 2018 (5), 2017 (4), 2004 (3), P30CA060553 (3), R01DK058763 (3), 2005 (2), N01CN00035 (2)