58 completed, 18 unknown, 5 not yet recruiting, 5 recruiting. 30 Phase 2, 29 Not applicable, 13 Phase 3, 10 Phase 1, 8 Phase 4.
Follow Methylene Blue: new trials by email Literature Review of Methylene Blue trials Research Report on Methylene Blue
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Phase 2 Study of Methylene Blue Photodynamic Therapy for Treatment of Breast Abscesses Standard of care breast abscess drainage, Methylene Blue, Lipid Emulsion - Breast Abscess | Phase 2 | Not yet recruiting | University of Rochester | 50 | 2027-07-01 | 2026-08-19 |
| Efficacy of Methylene Blue Photodynamic Therapy for Treatment of Deep Tissue Abscesses Methylene Blue, Lipid Emulsion, Insertion of optical fiber - Abscess | Phase 2 | Not yet recruiting | University of Rochester | 120 | 2026-07-15 | 2026-02-10 |
| Topical Methylene Blue-Photodynamic Therapy (MB-PDT) for Burn Wound Infection Methylene Blue, Blue Light Illumination - Burns, Wound Infection | Early Phase 1 | Not yet recruiting | University of Oklahoma | 50 | 2026-06-01 | 2026-05-19 |
| Methylene Blue in Total Knee Arthroplasty (TKA) Methylene Blue 10 MG/ML (intra-articular application), Revision Arthroplasty for PJI (DAIR), Primary Total Knee Arthroplasty - Total Knee Arthroplasty, Prosthetic-joint Infection | Phase 1 | Recruiting | University of Miami | 20 | 2026-02-04 | 2026-04-14 |
| Early Methylene Blue in the Microhemodynamics of Septic Patients Methylene blue infusion - Septic Shock, Hypoperfusion | Phase 2 / Phase 3 | Recruiting | Centro de Estudos e Pesquisa em Emergencias Medicas e Terapia Intensiva | 50 | 2026-01-09 | 2026-03-27 |
| Local Methylene Blue Injection for Prevention of Anastomotic Leakage and Permanent Stoma After Low Anterior Resection for Rectal Cancer methylene blue injection - Rectal Cancers | Phase 2 | Recruiting | Peking University Cancer Hospital & Institute | 26 | 2025-11-25 | 2026-09-22 |
| Methylene Blue Treatment of Chronic Hepatitis B Virus Infection Methylene Blue - Chronic HBV Infection | Phase 2 | Recruiting | Fondazione Epatocentro Ticino | 10 | 2025-09-01 | 2026-08-21 |
| Efficacy of Methylene Blue Plus Ropivacaine for Post-Hemorrhoidectomy Pain. Methylene Blue (0.3%) with Ropivacaine Hydrochloride (0.75%), Methylene Blue (0.1%) with Ropivacaine Hydrochloride (0.75%) - Mixed Hemorrhoids, Milligan-Morgan Hemorrhoidectomy | Phase 4 | Not yet recruiting | The Affiliated Hospital of Putian University | 177 | 2025-08-30 | 2025-09-10 |
| Local Injection Methylene Blue Combined With Radiation in HNSCC Patients Methylene Blue (50 mg/10ml) - Head and Neck Cancer, Local Recurrent Tumor | Early Phase 1 | Active not recruiting | China Medical University Hospital | 10 | 2025-08-01 | 2026-02-27 |
| Hemodynamic Effects of Intradermal Methylene Blue During Breast Surgery Under General Anesthesia Methylene Blue, Standard Surgical Care Without Dye - Breast Cancer, Breast Surgery | Completed | Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital | 220 | 2025-07-01 | 2026-04-30 | |
| Adjunctive Methylene Blue for Immunotherapy-related CRS and ICANS: Phase I Study Methylene Blue - Cytokine Release Syndrome, ICANS | Phase 1 | Recruiting | Institute of Hematology & Blood Diseases Hospital, China | 18 | 2025-06-28 | 2025-09-11 |
| Adjunctive Methylene Blue in Septic Shock Methylene Blue, Usual Care - Septic Shock | Phase 3 | Completed | Dr. Shannon M. Fernando | 50 | 2025-06-02 | 2026-03-19 |
| The Effect of Methylene Blue Infiltrating Injection on Anal Pain After Milligan-Morgan Surgery: A Randomized Controlled Clinical Study Methylene Blue - Mixed Hemorrhoids | Phase 3 | Enrolling by invitation | The Second Affiliated Hospital of Anhui University of Traditional Chinese Medicine | 60 | 2024-10-25 | 2024-10-28 |
| Methylene Blue for the Treatment of Septic Shock Methylene Blue, Placebo - Septic Shock | Phase 3 | Completed | Northern Jiangsu People's Hospital | 88 | 2024-08-05 | 2026-02-04 |
| Clinical and Microbiological Evaluation of Laser Therapy in the Treatment of Periodontal Disease in Stages III and IV Antimicrobial photodynamic therapy and 0.005% methylene blue (PDT), Photobiomodulation with a red laser (PBM-RL), Saline solution - Periodontitis, Periodontitis, Adult | Not applicable | Completed | Universidade Federal Fluminense | 20 | 2024-05-06 | 2026-02-27 |
| Intravenous Methylene Blue for Treating Refractory Neonatal Septic Shock Methylene Blue, Placebo - Neonatal Sepsis, Shock, Septic | Phase 2 / Phase 3 | Not yet recruiting | Post Graduate Institute of Medical Education and Research, Chandigarh | 130 | 2024-03-15 | 2024-03-12 |
| A Study of Ropivacaine Combined With Different Concentrations of Methylene Blue Fascia Iliaca Block in Postoperative Analgesia, Cognition, and Hip Function Recovery in Patients Undergoing Hip Arthroplasty Ropivacaine combined with methylene blue for iliac fascia block - Femoral Neck Disease | Not applicable | Unknown | Wang wanxia | 75 | 2024-03-15 | 2024-07-25 |
| Low Dose Versus High Dose Methylene Blue in Septic Patients Normal saline, Methylene Blue low dose, Methylene Blue high dose - Septic Shock | Phase 2 / Phase 3 | Completed | National Cancer Institute, Egypt | 90 | 2023-08-01 | 2024-07-05 |
| A Study of Ropivacaine Complex Methylene Blue Fascia Iliaca Compartment Block on Analgesia in Patients Undergoing Hip Arthroplasty Ropivacaine combined with methylene blue for iliac fascia block - Femoral Neck Disease | Not applicable | Completed | Wang wanxia | 90 | 2023-06-20 | 2025-02-04 |
| A French Observational Study of Indocyanine Green for Patients With Breast Cancer Having a Sentinel Lymph Node Biopsy. Sentinel lymph node identification, indocyanine green, methylene blue - Breast Cancer | Completed | BTG International Inc. | 101 | 2023-06-06 | 2024-05-10 |
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Shock, Septic (12) · Breast Neoplasms (7) · Shock (5) · COVID-19 (4) · Periodontal Diseases (3) · Sepsis (3) · Vasoplegia (3) · Abscess (2) · Chronic Periodontitis (2) · Emergence Delirium (2) · Malaria (2) · Methemoglobinemia (2) · Neonatal Sepsis (2) · Neoplasms (2) · Periodontal Pocket (2)
Heidelberg University (3) · University of Rochester (3) · Ain Shams University (2) · Chinese Academy of Sciences (2) · Chulalongkorn University (2) · Fondazione Epatocentro Ticino (2) · Fudan University (2) · Mashhad University of Medical Sciences (2) · The University of Texas Health Science Center at San Antonio (2) · University of Nove de Julho (2) · University of Oxford (2) · Wang wanxia (2) · Affiliated Hospital to Academy of Military Medical Sciences (1) · Alexandria University (1) · American Regent, Inc. (1)
United States (22) · China (17) · Brazil (7) · Egypt (5) · France (4) · Iran (4) · Thailand (4) · Burkina Faso (3) · Canada (3) · Russia (3) · Switzerland (3) · United Kingdom (3) · India (2) · Turkey (Türkiye) (2) · Hungary (1)
Ashwani K Sharma, MD (2) · Daryoush Hamidi Alamdari, Ph.D (2) · Jun Zhang, PhD (2) · Laurie Christensen, BS (2) · Timothy M Baran, PhD (2) · Adriana Miclescu (1) · Ahmed Mukhtar, Professor (1) · Alassane Dicko, MD (1) · Alfonso Fiorelli, MD, PhD (1) · Artem A. Shiryaev, Ph.D. (1) · Ayman I Tharwat, MD (1) · Balazs Banky, PhD (1) · Boris Mraovic, MD (1) · Bruno Megarbane (1)
PMID 11588440, PMID 12500513, PMID 16134766, PMID 24358319, PMID 27497181, PMID 36915146, PMID 12519925, PMID 14759425, PMID 15267226, PMID 17698886, PMID 18286187, PMID 18477932, PMID 19415120, PMID 19846959, PMID 20093545, PMID 20109575, PMID 21246318, PMID 24151551, PMID 24316434, PMID 24350844, PMID 24814697, PMID 25267980, PMID 25410983, PMID 26683506, PMID 27284082, PMID 27673307, PMID 28576285, PMID 28593326, PMID 28686823, PMID 28723883, PMID 28840449, PMID 29151412, PMID 29290809, PMID 29422384, PMID 29508706, PMID 29936590, PMID 30231909, PMID 30859424, PMID 31027098, PMID 31600221, PMID 32270211, PMID 32453920, PMID 32520577, PMID 32828741, PMID 34019535, PMID 34719443, PMID 36237547, PMID 36324139, PMID 36505110, PMID 36705345
2017 (1), R34MH087375 (1), U10CA027469 (1)