110 completed, 39 unknown, 30 recruiting, 13 terminated. 46 Not applicable, 30 Phase 2, 29 Phase 4, 23 Phase 3, 17 Phase 1.
Follow Adrenal Insufficiency: new trials by email Literature Review of Adrenal Insufficiency trials Research Report on Adrenal Insufficiency
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| IT and IV Lentiviral Gene Therapy for X-ALD Intrathecal and intravenous LV gene therapy - X-linked Adrenoleukodystrophy | Not applicable | Not yet recruiting | Shenzhen Geno-Immune Medical Institute | 30 | 2027-06-01 | 2026-09-01 |
| Hydrocortisone Versus Methylprednisolone for the Treatment of Glucocorticoid-Induced Adrenal Insufficiency Patients will receive 3 mg of methylprednisolone once daily. The dose is administered in the morning (1 ½ tablets of 2 mg Medrol after breakfast)., Patients will receive 15 mg of hydrocortisone daily. The dose is split into 10 mg in the morning after breakfast and 5 mg after 6-7 hours. - Adrenal Insufficiency | Phase 4 | Not yet recruiting | University Medical Centre Ljubljana | 66 | 2026-09-01 | 2026-07-14 |
| Evaluation of Circadian Hormonal Balance: LC-MS/MS Measurement of Salivary and Serum Steroids in Patients With Congenital Adrenal Hyperplasia Congenital Adrenal Hyperplasia, Adrenal Insufficiency | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 50 | 2026-09-01 | 2026-07-21 | |
| Prevalence of Adrenal Insufficiency and Associated Factors in Rheumatoid Arthritis Patients Using Low-dose Corticosteroids. ACTH stimulation test, Cortisol - Reumatoid Arthritis, Corticosteroids Adverse Reaction | Recruiting | Bursa Yuksek Ihtisas Training and Research Hospital | 120 | 2026-07-31 | 2026-10-08 | |
| Telehealth Music Therapy for Adults With Endocrine Disorder and Depression Telehealth Resource Oriented Music Therapy - Type 1 Diabetes, Hashimoto Disease | Not applicable | Recruiting | Appalachian State University | 10 | 2026-07-16 | 2026-07-30 |
| Combination Osilodrostat and Cabergoline in Cushing's Disease osilodrostat, osilodrostat and cabergoline - Cushing Disease Due to Increased ACTH Secretion | Phase 4 | Enrolling by invitation | University of Basrah | 50 | 2026-05-11 | 2026-05-22 |
| A Study to Investigate OCS Tapering in Adult Participants With Generalized Myasthenia Gravis Treated With Ravulizumab Oral Corticosteroid Tapering Schedule, Ravulizumab, Prednisone/Prednisolone - Generalized Myasthenia Gravis, gMG | Phase 4 | Recruiting | Alexion Pharmaceuticals, Inc. | 75 | 2026-03-04 | 2026-04-09 |
| Risks of Ramadan Fasting in Patients With Primary Adrenal Insufficiency Treated With Prednisolone. Ramadan fasting - Primary Adrenal Insufficiency, Ramadan Fasting | Not applicable | Not yet recruiting | Hopital La Rabta | 35 | 2026-01-22 | 2026-01-26 |
| Comparison of Glucocorticoid Tapering Schedules in Rheumatoid Arthritis Prednisolone - Rheumatoid Arthritis (RA) | Phase 4 | Not yet recruiting | Seoul National University Hospital | 206 | 2025-12-01 | 2025-11-25 |
| Establishment and Clinical Application of Reference Intervals of Salivary Cortisol Healthy Adult, Cushing Syndrome | Recruiting | Shanghai 6th People's Hospital | 220 | 2025-09-01 | 2025-09-11 | |
| Continuous Steroid Monitoring in Interstitial Fluid With Wearable and Nanoparticle-enhanced Biosensors for Improved Management of Adrenal Disorders Participants will use the biossensor for 48 h - Cushing Syndrome, Primary Aldosteronism | Not applicable | Not yet recruiting | University of Sao Paulo General Hospital | 246 | 2025-06-01 | 2025-05-20 |
| SPL Insufficiency Syndrome (SPLIS)/NPHS14: a SPLIS Observational Study and Patient Registry (International) no intervention - Sphingolipidoses, Enzyme Deficiency | Recruiting | University of California, San Francisco | 120 | 2025-04-22 | 2025-10-24 | |
| Natural History of Sphingosine Phosphate Lyase Insufficiency Syndrome (SPLIS) no intervention - Sphingosine Phosphate Lyase Insufficiency Syndrome (SPLIS) | Recruiting | University of California, San Francisco | 28 | 2025-04-22 | 2026-08-04 | |
| Epidural Spinal Cord Stimulation for Lower-limb Impairment in Adrenomyeloneuropathy Spinal cord stimulation - Adrenomyeloneuropathy Without Cerebral Involvement | Not applicable | Recruiting | Third Military Medical University | 10 | 2025-02-10 | 2025-01-28 |
| Glucagon-like Peptide-1 Receptor Agnoists for the Assessment of Adrenal Function semaglutide, Placebo - Healthy Volunteer Study, HPA | Not applicable | Completed | University Hospital, Basel, Switzerland | 22 | 2025-01-16 | 2026-02-11 |
| Study on the Incidence of Adrenal Insufficiency After Surgery in Primary Aldosteronism Patients Concurrent With or Without Autonomous Cortisol Secretion complete ACTH stimulation test the day after surgery and complete ACTH stimulation test 1 or 4 week for patients with Adrenal Insufficiency - Primary Aldosteronism, Autonomous Cortisol Secretion | Recruiting | Qifu Li | 521 | 2025-01-02 | 2026-05-01 | |
| Treatment Study in Patients Treated With Both Insulin & Hydrocortisone OD dual-release Hydrocortisone, TID Hydrocortisone - Diabetes Mellitus, Adrenal Insufficiency | Not applicable | Withdrawn | Vastra Gotaland Region | 2025-01-01 | 2026-07-07 | |
| Growing up With the Young Endocrine Support System (YESS!) YESS! game, Snake '97, Transition-toolkit - Congenital Adrenal Hyperplasia, Hypogonadotropic Hypogonadism | Not applicable | Not yet recruiting | dr. Laura C. G. de Graaff-Herder | 160 | 2024-12-01 | 2023-09-07 |
| Tolerability and Acceptance of Two Oral Hydrocortisone Compounding Formulation for Pediatrics 3D printed chewable formulation of hydrocortisone, Oral suspension of hydrocortisone - Adrenal Insufficiency | Phase 4 | Unknown | Hospital Universitari Vall d'Hebron Research Institute | 35 | 2024-09-01 | 2024-05-30 |
| A Swiss Assessment of Hypothalamic-pituitary-adrenal Axis Suppression After Glucocorticoid Therapy for Leukemia and Lymphoblastic Lymphoma in Children Adrenal Insufficiency, Leukemia, Lymphoblastic, Acute, Pediatric | Recruiting | University Children's Hospital Basel | 40 | 2024-08-13 | 2026-05-08 |
Showing 20 of 219. Sign in to see all of them.
Adrenoleukodystrophy (62) · Addison Disease (35) · Leukodystrophy, Metachromatic (18) · Leukodystrophy, Globoid Cell (14) · Adrenal Hyperplasia, Congenital (13) · Cushing Syndrome (10) · Peroxisomal Disorders (10) · Metabolism, Inborn Errors (9) · Mucopolysaccharidosis I (9) · Rare Diseases (8) · Sphingolipidoses (8) · Diabetes Mellitus, Type 1 (6) · Gaucher Disease (6) · Hyperaldosteronism (6)
Adrenal Gland Diseases (219) · Endocrine System Diseases (214) · Nutritional and Metabolic Diseases (99) · Metabolic Diseases (89) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (82) · Nervous System Diseases (82) · Brain Diseases (79) · Genetic Diseases, Inborn (77) · Central Nervous System Diseases (76) · Metabolism, Inborn Errors (69) · Neurologic Manifestations (66) · Intellectual Disability (65) · Neurobehavioral Manifestations (65) · Brain Diseases, Metabolic (63)
Hydrocortisone (34) · Cosyntropin (7) · Prednisolone (5) · hydrocortisone hemisuccinate (5) · Alemtuzumab (4) · Blood Specimen Collection (3) · Dehydroepiandrosterone (3) · Dexamethasone (3) · Etomidate (3) · Hematologic Tests (3) · Lorenzo's oil (3) · Melphalan (3) · Prednisone (3) · Stem Cell Transplantation (3) · trierucate (3)
Neurocrine UK Limited (10) · Wuerzburg University Hospital (8) · Haukeland University Hospital (7) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (6) · Masonic Cancer Center, University of Minnesota (6) · Genetix Biotherapeutics Inc. (5) · Assistance Publique - Hôpitaux de Paris (4) · Copenhagen University Hospital, Rigshospitalet (4) · University of Wuerzburg (4) · Hopital La Rabta (3) · Hugo W. Moser Research Institute at Kennedy Krieger, Inc. (3) · Imperial College London (3) · Pujol, Aurora, M.D. (3) · Shire (3) · University of Roma La Sapienza (3)
United States (67) · Germany (27) · United Kingdom (25) · France (20) · Italy (15) · Netherlands (15) · China (10) · Norway (8) · Spain (8) · Denmark (7) · Sweden (7) · Canada (6) · Switzerland (6) · Argentina (4) · Australia (4)
Paul Orchard, MD (5) · Bruno Allolio, MD (4) · Stefanie Hahner, MD, Prof. (4) · Joanne Kurtzberg, MD (3) · Karim Meeran, MBBS BSc MD (3) · Ulla Feldt-Rasmussen, Professor (3) · A Koch (2) · Adeline Vanderver, MD (2) · Andrea M Isidori, MD, PhD (2) · Deborah P Merke, M.D. (2) · Gerald V Raymond, M.D. (2) · Girish Sharma (2) · Jens S Christiansen, Professor (2) · John Henderson, MD (2)
PMID 39383458, PMID 21586746, PMID 39383459, PMID 10321661, PMID 10697064, PMID 10923728, PMID 11231629, PMID 11399225, PMID 12186604, PMID 1478121, PMID 17684047, PMID 18184957, PMID 18509277, PMID 18784570, PMID 19383806, PMID 19833552, PMID 19892975, PMID 20103758, PMID 21593113, PMID 22073145, PMID 22112807, PMID 2268888, PMID 22855336, PMID 22904181, PMID 22911730, PMID 22990093, PMID 23385627, PMID 23672956, PMID 23761380, PMID 23845948, PMID 23966770, PMID 24170102, PMID 24884782, PMID 24944332, PMID 25066331, PMID 25419882, PMID 25494662, PMID 25619170, PMID 25620457, PMID 25705800, PMID 26067718, PMID 26075496, PMID 26646751, PMID 26914224, PMID 27153945, PMID 27490921, PMID 27680873, PMID 27801983, PMID 28472487, PMID 28521880
2009 (3), 2018 (2), 2014 (1), 2015 (1), 2016 (1), K23NS087151 (1), R01HD113778 (1), U01NS106845 (1), U54NS115052 (1)