Septic Shock: Clinical Trials

407 completed, 187 unknown, 85 recruiting, 63 not yet recruiting. 237 Not applicable, 119 Phase 2, 105 Phase 3, 70 Phase 4, 31 Phase 1.

By phase and status

Phase	Trials	Status
Not applicable	237	Completed 115, Unknown 54, Recruiting 30, Not yet recruiting 18, Terminated 14, Active not recruiting 2, Withdrawn 2, Enrolling by invitation 1, Suspended 1
Phase 2	119	Completed 67, Unknown 22, Terminated 12, Recruiting 7, Withdrawn 6, Not yet recruiting 3, Active not recruiting 1, Suspended 1
Phase 3	105	Completed 56, Unknown 16, Terminated 13, Recruiting 8, Not yet recruiting 4, Suspended 3, Withdrawn 3, Active not recruiting 2
Phase 4	70	Completed 33, Unknown 13, Terminated 10, Recruiting 9, Not yet recruiting 4, Withdrawn 1
Phase 1	31	Completed 20, Terminated 4, Unknown 4, Withdrawn 2, Not yet recruiting 1
Early Phase 1	2	Active not recruiting 1, Completed 1

Follow Septic Shock: new trials by email Literature Review of Septic Shock trials Research Report on Septic Shock

Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Extended vs. Intermittent Meropenem Infusion in Sepsis Patients in the ICU Extended beta-lactam antibiotics, Intermittent Beta-lactam antibiotics - Sepsis, Septic Shock		Not yet recruiting	Assiut University	90	2027-10-01	2026-09-01
Phase IIb Multicenter Randomized Controlled Trial Evaluating the Efficacy of Sivelestat in Patients With Septic Coagulopathy • Sivelestat intravenous infusion, NaCl intravenous infusion - Septic Shock, Coagulopathy	Phase 2	Not yet recruiting	University Hospital, Strasbourg, France	120	2027-08-01	2026-08-20
Immune Dysregulation During Sepsis: A Natural History Cohort Sepsis, Septic Shock		Not yet recruiting	National Heart, Lung, and Blood Institute (NHLBI)	500	2027-01-01	2026-10-09
Alveolar Dead Space as Predictor of Organ Failure in Severe Sepsis Sepsis, Severe Sepsis		Not yet recruiting	The University of Texas Health Science Center, Houston	30	2026-12-01	2025-06-11
Core-to-Big-Toe Temperature Gradient as a Marker of Peripheral Perfusion in Adult Patients With Septic Shock Septic Shock, Sepsis		Not yet recruiting	Assiut University	54	2026-11-01	2026-10-13
Clinical Performance Study of Microbio InfectID-BSI for Detection of Bacteria and Yeast With Patient Blood Samples InfectID-BSI (Bloodstream Infection) qPCR Assay - Bloodstream Infection, Sepsis		Not yet recruiting	Microbio Co Ltd	1500	2026-11-01	2026-10-08
Mechanistic Assessment of Norepinephrine Therapy vs. Angiotensin-II in Septic Shock Angiotensin II, Norepinephrine - Septic Shock	Phase 4	Not yet recruiting	Wake Forest University Health Sciences	78	2026-11-01	2026-09-24
Serum GDF-15 and LGALS3BP as Prognostic Biomarkers in Sepsis Serum GDF-15 and LGALS3BP Measurement - Sepsis, Septic Shock		Not yet recruiting	Inonu University	150	2026-11-01	2026-10-30
Neutrophil Activation and NETosis in Sepsis Sepsis, Septic Shock		Not yet recruiting	Assiut University	85	2026-10-20	2026-10-22
A Trial of Adjunctive Fludrocortisone (50mcg, 100mcg or Placebo) in Critically Ill Patients With Septic Shock Receiving Hydrocortisone, Evaluating Survival and Functional Recovery and the Influence of Transcriptomic Response Fludrocortisone 50 mcg daily, Fludrocortisone 100 mcg daily, Placebo - Septic Shock	Phase 3	Recruiting	The George Institute	2200	2026-10-16	2026-10-30
Sepsis ICU Gut Microbiome Analysis Naturally Occurring Exposures - Sepsis, Septic Shock		Not yet recruiting	Union Hospital, Tongji Medical College, Huazhong University of Science and Technology	180	2026-10-15	2026-10-08
Myeloid Bias in the Bone Marrow of Septic Patients and Its Correlation With Disease Severity and Prognosis: A Single-Center, Prospective Cohort Study Bone marrow aspirate collection - Sepsis, Septic Shock		Not yet recruiting	Union Hospital, Tongji Medical College, Huazhong University of Science and Technology	45	2026-10-15	2026-09-24
Comparison of Cardiac Index Measurement Using Right Ventricular Pressure Curve Analysis and Thermodilution Via a Swan-Ganz IQ™ Catheter. Swan-Ganz - Septic Shock		Recruiting	Assistance Publique - Hôpitaux de Paris	43	2026-10-15	2026-10-27
Early Optimization of Ceftazidime Regimen in Critical Care ceftazidime, plasma ceftazidime dosage - Infection in ICU, Sepsis	Not applicable	Not yet recruiting	Centre Hospitalier Universitaire de Saint Etienne	128	2026-10-01	2026-09-16
The Multicentre Prospective Observational Study on the Management of Septic Shock Septic Shock		Not yet recruiting	Bicetre Hospital	5000	2026-10-01	2026-03-06
Ionized Calcium as a Severity Marker in Septic Shock Patients Sepsis, Septic Shock		Not yet recruiting	Assiut University	160	2026-10-01	2026-09-10
Nucleosome Monitoring Relevance for Outcome Prediction in Critically Ill Patients Plasma H3.1 nucleosome measurement - Sepsis, Septic Shock		Not yet recruiting	Erasme University Hospital	1000	2026-10-01	2026-09-22
Microbiology Operations & Time Optimization in Sepsis laboratory infrastructure - Sepsis, Bloodstream Infection		Not yet recruiting	University Medicine Greifswald	1000	2026-10-01	2026-09-14
Dynamic POCUS of Diaphragm Function to Predict Respiratory Failure in Septic Shock Respiration Failure, Diaphragmatic Dysfunction		Not yet recruiting	Assiut University	120	2026-10-01	2026-09-15
PRIME Sepsis Trial: Early Sepsis Detection in the Emergency Department Using Presepsin and Immature Granulocytes Sepsis, Septic Shock		Not yet recruiting	Chang Gung Memorial Hospital	699	2026-10-01	2026-09-21

Showing 20 of 838. Sign in to see all of them.

Narrower conditions

Shock, Septic (838)  ·  Sepsis (404)  ·  Critical Illness (52)  ·  Acute Kidney Injury (47)  ·  Multiple Organ Failure (32)  ·  Shock (28)  ·  Infections (26)  ·  Systemic Inflammatory Response Syndrome (22)  ·  Respiratory Distress Syndrome (18)  ·  Diabetes Insipidus (16)  ·  Inflammation (11)  ·  Shock, Cardiogenic (11)  ·  Bacteremia (10)  ·  Emergencies (10)  ·  Heart Failure (9)

Broader conditions

Pathological Conditions, Signs and Symptoms (838)  ·  Pathologic Processes (835)  ·  Inflammation (827)  ·  Systemic Inflammatory Response Syndrome (816)  ·  Infections (812)  ·  Shock (810)  ·  Sepsis (434)  ·  Urogenital Diseases (69)  ·  Disease Attributes (68)  ·  Female Urogenital Diseases and Pregnancy Complications (67)  ·  Female Urogenital Diseases (66)  ·  Male Urogenital Diseases (66)  ·  Urologic Diseases (66)  ·  Cardiovascular Diseases (64)  ·  Kidney Diseases (64)

Interventions

Norepinephrine (30)  ·  Saline Solution (29)  ·  Ascorbic Acid (24)  ·  Hydrocortisone (23)  ·  Sodium Chloride (20)  ·  Blood Specimen Collection (18)  ·  Thiamine (16)  ·  Standard of Care (14)  ·  Dexmedetomidine (12)  ·  Terlipressin (12)  ·  Vasopressins (11)  ·  Angiotensin II (10)  ·  Methylene Blue (10)  ·  esmolol (10)  ·  Albumins (9)

Sponsors

Assistance Publique - Hôpitaux de Paris (22)  ·  Cairo University (16)  ·  Assiut University (14)  ·  Southeast University, China (14)  ·  Mahidol University (13)  ·  Centre Hospitalier Universitaire, Amiens (10)  ·  Ain Shams University (9)  ·  Hospices Civils de Lyon (9)  ·  Beth Israel Deaconess Medical Center (8)  ·  First Affiliated Hospital of Wannan Medical College (8)  ·  University of Roma La Sapienza (8)  ·  Dascena (7)  ·  University Hospital, Angers (7)  ·  University Hospital, Strasbourg, France (7)  ·  Assistance Publique Hopitaux De Marseille (6)

Countries

France (132)  ·  United States (122)  ·  China (69)  ·  Egypt (53)  ·  Italy (41)  ·  Germany (37)  ·  Canada (28)  ·  Denmark (25)  ·  Brazil (23)  ·  Sweden (21)  ·  Thailand (21)  ·  Turkey (Türkiye) (21)  ·  Spain (20)  ·  Netherlands (17)  ·  United Kingdom (17)

Top investigators

Andrea Morelli, MD (7)  ·  Anders Perner, MD, PhD (4)  ·  Ahmed Mukhtar, Professor (3)  ·  Alan E Jones, MD (3)  ·  Anand Kumar, MD (3)  ·  Eric Bellissant, MD, PhD (3)  ·  Lauralyn McIntyre, MD (3)  ·  Luciano Gattinoni, MD (3)  ·  Michael W Donnino, MD (3)  ·  Mohan Gurjar, MD, PDCC (3)  ·  Qingquan Lyu, Master (3)  ·  Ritankar Das, MSc (3)  ·  Surat Tongyoo, MD (3)  ·  Zhanguo Liu, M.D.PhD (3)

Results publications

PMID 26903338, PMID 28101605, PMID 11445675, PMID 11794169, PMID 21516036, PMID 23353941, PMID 29784057, PMID 34519356, PMID 34605781, PMID 12720570, PMID 16424713, PMID 17334251, PMID 18533029, PMID 19531784, PMID 19926252, PMID 20179283, PMID 21669950, PMID 22073193, PMID 23067578, PMID 23525934, PMID 23740148, PMID 23963131, PMID 23984731, PMID 24484547, PMID 24635770, PMID 24635772, PMID 24794878, PMID 25392034, PMID 25887027, PMID 26414292, PMID 26771781, PMID 26903335, PMID 26903336, PMID 27406647, PMID 27480413, PMID 27940189, PMID 28109962, PMID 28343448, PMID 28750598, PMID 29319721, PMID 29328496, PMID 30394918, PMID 30458880, PMID 30704260, PMID 30772908, PMID 31958982, PMID 32809003, PMID 33620405, PMID 36174744, PMID 36416787

NIH funding

2014 (4), 2018 (4), 2017 (3), 2016 (2), 2019 (2), 1RC3GM093717-01 (1), 2004 (1), 2005 (1), 2023 (1), 2025 (1), K23GM115690 (1), M01RR002558 (1), P01HL108801 (1), P30CA016672 (1), R01DK133142 (1)