15 completed, 5 recruiting, 4 unknown, 3 active not recruiting. 12 Phase 4, 7 Phase 3, 6 Phase 2, 5 Not applicable, 3 Phase 1.
Follow Angiotensin II: new trials by email Literature Review of Angiotensin II trials Research Report on Angiotensin II
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Mechanistic Assessment of Norepinephrine Therapy vs. Angiotensin-II in Septic Shock Angiotensin II, Norepinephrine - Septic Shock | Phase 4 | Not yet recruiting | Wake Forest University Health Sciences | 78 | 2026-11-01 | 2026-09-24 |
| Angiotensin II for Post Cardiac Surgery Vasoplegia (ANGII_V) Angiotensin II (Giapreza®) - Vasoplegic Shock, Cardiopulmonary Bypass | Phase 4 | Not yet recruiting | Methodist Healthcare System of San Antonio | 329 | 2026-07-01 | 2026-06-26 |
| Radioembolization With Intra-arterial Angiotensin II to Improve Tumor-absorbed Dose (RADIANT) Angiotensin II (Giapreza®), Yttrium-90 radioembolization - Liver Cancer (Locally Advanced or Metastatic), Liver Cancer Adult | Phase 2 | Recruiting | Niek Wijnen | 15 | 2026-01-01 | 2026-03-30 |
| ANG-First Trial (Angiotensin II as First-Line Vasopressor Therapy in Cardiac Surgery) Angiotensin II - Vasodilatory Hypotension During or After Cardiac Surgery | Phase 4 | Recruiting | University of Maryland St. Joseph Medical Center | 100 | 2025-05-06 | 2025-12-22 |
| Reducing Cardiac-surgery Associated Acute Kidney Injury Occurence by Administering Angiotensin II Angiotensin II, Noradrenalin - Cardiac Surgery, Vasoplegia | Phase 3 | Recruiting | Universität Münster | 1022 | 2025-03-31 | 2025-07-18 |
| Efficacy and Safety of Angiotensin II Injection Versus Placebo in Patients With Refractory Distributed Shock Angiotensin II Injection, 0.9% sodium chloride injection - Vasodilatory Shock | Phase 3 | Recruiting | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | 214 | 2024-07-23 | 2025-01-23 |
| The Effect of Vasopressor Therapy on Renal Perfusion in Septic Shock Angiotensin II, Vasopressin, Norepinephrine - Septic Shock, Acute Kidney Injury | Not applicable | Recruiting | King's College Hospital NHS Trust | 45 | 2024-01-05 | 2025-04-04 |
| Balance of Angiotensin II Receptors in Vessel Function After Preeclampsia Compound 21, Angiotensin II - Preeclampsia | Early Phase 1 | Completed | Anna Stanhewicz, PhD | 24 | 2023-12-08 | 2024-12-24 |
| Hemodynamic Response to Angiotensin-II When Used as the Second Vasopressor Agent for Septic Shock Angiotensin II and hydrocortisone sodium succinate - Septic Shock, Shock | Phase 4 | Unknown | Kingman Regional Medical Center | 50 | 2023-12-04 | 2024-05-23 |
| Serum Biomarkers to Predict Response to Angiotensin II in Septic Shock Angiotensin II - Septic Shock, Vasodilatory Shock | Phase 4 | Completed | University of New Mexico | 42 | 2023-04-17 | 2026-07-02 |
| Angiotensin II in Liver Transplantation Angiotensin II, Saline - Liver Transplant; Complications, Vasoplegia | Phase 2 / Phase 3 | Active not recruiting | University of California, San Francisco | 50 | 2022-06-28 | 2026-03-20 |
| Angiotensin II for Distributive Shock Angiotensin II, Placebo - Distributive Shock | Phase 4 | Terminated | Northwestern University | 2 | 2022-06-01 | 2026-04-13 |
| Angiotensin 2 for AKI After OLT Angiotensin II, Norepinephrine - Cirrhosis, Liver, End Stage Liver DIsease | Phase 4 | Active not recruiting | University of California, Los Angeles | 30 | 2022-04-08 | 2026-06-12 |
| Angiotensin II vs. Vasopressin in Septic Shock Angiotensin II, Vasopressin - Septic Shock | Phase 4 | Withdrawn | University of New Mexico | 2022-01-03 | 2024-03-15 | |
| Reducing Acute Kidney Injury Occurence by Administering Angiotensin II Angiotensin II, Control - Cardiac Surgery, Vasoplegia | Phase 3 | Completed | Universität Münster | 64 | 2021-12-27 | 2023-03-24 |
| Angiotensin 2 for Hepatorenal Syndrome Angiotensin II, Midodrine, Octreotide - Hepatorenal Syndrome, Cirrhosis | Phase 2 | Withdrawn | University of California, Los Angeles | 2021-07-01 | 2024-03-06 | |
| Renin and Renal Biomarker Response to Angiotensin II Standard of Care, Angiotensin II - Septic Shock, Acute Kidney Injury | Phase 4 | Completed | Alexander Flannery | 30 | 2020-10-19 | 2024-09-04 |
| Angiotensin II in the Perioperative Management of Hypotension in Kidney Transplant Recipients Angiotensin II - Shock, Surgical, Shock | Phase 4 | Completed | University of Illinois at Chicago | 20 | 2020-08-13 | 2022-12-21 |
| Efficacy and Safety of Angiotensin II Use in Coronavirus Disease(COVID)-19 Patients With Acute Respiratory Distress Syndrome Angiotensin II, Interleukin-1 receptor antagonist - COVID, Acute Respiratory Distress Syndrome | Unknown | Guy's and St Thomas' NHS Foundation Trust | 50 | 2020-06-01 | 2021-08-04 | |
| Angiotensin II in General Anesthesia Angiotensin II - Hypertension | Phase 4 | Completed | Wake Forest University Health Sciences | 32 | 2019-10-03 | 2025-08-24 |
Showing 20 of 36. Sign in to see all of them.
Shock, Septic (10) · Acute Kidney Injury (8) · Sepsis (6) · Hypertension (5) · Vasoplegia (5) · Hypotension (3) · Aneurysm (2) · Fibrosis (2) · Insulin Resistance (2) · Shock (2) · Carcinoma, Hepatocellular (1) · Diabetes Insipidus (1) · Diabetes Mellitus (1) · End Stage Liver Disease (1) · Glomerulonephritis, Membranous (1)
Brigham and Women's Hospital (4) · La Jolla Pharmaceutical Company (3) · University of California, Los Angeles (2) · University of Edinburgh (2) · University of New Mexico (2) · Universität Münster (2) · Wake Forest University Health Sciences (2) · Alexander Flannery (1) · Anna Stanhewicz, PhD (1) · Assistance Publique - Hôpitaux de Paris (1) · Austin Health (1) · Cairo University (1) · Chia Tai Tianqing Pharmaceutical Group Co., Ltd. (1) · George Washington University (1) · Guy's and St Thomas' NHS Foundation Trust (1)
United States (21) · United Kingdom (5) · Germany (3) · Australia (2) · Belgium (2) · France (2) · Netherlands (2) · Canada (1) · China (1) · Egypt (1) · Finland (1) · Lithuania (1) · New Zealand (1) · Switzerland (1)
Alexander Zarbock, MD (2) · Gordon H Williams, MD (2) · Joao P Teixeira, MD (2) · Nathan D Nielsen, MD MSc (2) · Ahmed Mukhtar, Professor (1) · Alexander H Flannery, Pharm.D. (1) · Ashish Khanna, MD (1) · Bindu Chamarthi, MD (1) · Choy Lewis, MD (1) · Forbes McGain, MBBS FJFICM (1) · Gareth D Barnes, MBChB (1) · George F Tidmarsh, MD, PhD (1) · Karine Dahan, MD (1) · Lakhmir Chawla, MD (1)
PMID 22247480, PMID 23519586, PMID 23547240, PMID 24191286, PMID 24466071, PMID 25286986, PMID 26931475, PMID 27352623, PMID 28528561, PMID 30144016, PMID 31340979, PMID 32028998, PMID 32609011, PMID 34778952, PMID 37147690, PMID 37984940, PMID 38103056, PMID 38637829, PMID 38870103, PMID 39972379
2025 (1), R01HL104032 (1), R01HL177834 (1), UL1TR001449 (1)