33 completed, 13 unknown, 10 terminated, 9 recruiting. 71 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 71 | Completed 33, Unknown 13, Terminated 10, Recruiting 9, Not yet recruiting 4, Active not recruiting 1, Withdrawn 1 |
Follow Septic Shock: new trials by email Literature Review of Septic Shock trials Research Report on Septic Shock
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Mechanistic Assessment of Norepinephrine Therapy vs. Angiotensin-II in Septic Shock Angiotensin II, Norepinephrine - Septic Shock | Phase 4 | Not yet recruiting | Wake Forest University Health Sciences | 78 | 2026-11-01 | 2026-09-24 |
| Hydrocortisone and Fludrocortisone for the Treatment of Septic Shock Hydrocortisone plus Fludrocortisone, Standard care - Septic Shock | Phase 4 | Recruiting | Northern Jiangsu People's Hospital | 336 | 2026-03-02 | 2026-03-04 |
| Early Dexmedetomidine and Sympathetic Regulation in Sepsis Dexmedetomidine (DEX), Placebo - Sepsis, Septic Shock | Phase 4 | Not yet recruiting | Sichuan Academy of Medical Sciences | 168 | 2026-03-01 | 2026-03-13 |
| Thymosin Alpha 1 and IgM Levels in Sepsis Thymalfasin - Sepsis, Septic Shock | Phase 4 | Active not recruiting | Southeast University, China | 36 | 2026-02-20 | 2026-11-06 |
| Continuous Infusion Versus Intermittent Bolus Hydrocortisone in Septic Shock Hydrocortisone Continuous Infusion, Hydrocortisone Intermittent Bolus - Septic Shock | Phase 4 | Completed | Benha University | 110 | 2026-01-01 | 2026-07-10 |
| Randomized Control Study in REsuscitation of SEpsis Trial Pharmaceutical fresh frozen plasma, Normal Saline, Ringer lactate (RL) - Septic Shock, Pediatric Critical Illness | Phase 4 | Not yet recruiting | Fundación Cardioinfantil Instituto de Cardiología | 150 | 2025-07-01 | 2025-06-25 |
| Empirical Meropenem Versus Piperacillin/Tazobactam for Adult Patients With Sepsis Meropenem, Piperacillin/Tazobactam - Sepsis, Septic Shock | Phase 4 | Recruiting | Scandinavian Critical Care Trials Group | 5800 | 2025-06-26 | 2025-07-03 |
| Early Versus Late Adjunctive Vasopressin in Septic Shock vasopressin - early initiation, vasopressin - standard initiation - Sepsis, Septic Shock | Phase 4 | Recruiting | The Cleveland Clinic | 300 | 2025-04-29 | 2026-08-31 |
| Shenfu Injection Modulates Carotid Elasticity in Septic Shock Shenfu Injection - Septic Shock, Vascular Dysfunction | Phase 4 | Not yet recruiting | First Affiliated Hospital of Wannan Medical College | 48 | 2025-04-15 | 2025-04-08 |
| Early Angiotensin II in the Emergency Department Angiotensin II Infusion - Septic Shock | Phase 4 | Recruiting | Brett A Faine | 20 | 2025-04-01 | 2026-09-02 |
| Oral Bedtime Melatonin in Critically Ill Patients Oral Bedtime Melatonin, Placebo suspension or capsule - Septic Shock, Stroke Hemorrhagic | Phase 4 | Unknown | Hospital San Carlos, Madrid | 160 | 2025-02-01 | 2024-03-01 |
| Beta-Lactam Antibiotics InitiaL ExpoSure OptimisEd in CriticallY Ill Patients with SEpsis Double dosing of beta-lactam antibiotic - Sepsis - to Reduce Mortality in the Intensive Care Unit, Sepsis | Phase 4 | Recruiting | Erasmus Medical Center | 980 | 2025-01-03 | 2025-01-09 |
| Use of Epoetin Alfa and Iron Derisomaltose in Treatment of Anemia in Patients With Sepsis or Septic Shock: a Randomized Controlled Trial Iron, EPO, 0.9 % NaCl - Anemia, Sepsis | Phase 4 | Recruiting | Piotr Czempik | 200 | 2024-11-10 | 2024-12-27 |
| The Effect of Dexmedetomidine on the Renal Functions in Septic Critically Ill Patients Dexmedetomidine, Propofol - Sepsis, Septic Shock | Phase 4 | Recruiting | Cairo University | 128 | 2024-10-01 | 2024-10-09 |
| The Preventive Effect of Shenfu Injection on Myocardial Dysfunction in Sepsis Shenfu Injection - Septic Cardiomyopathy, Septic Shock | Phase 4 | Recruiting | First Affiliated Hospital of Wannan Medical College | 440 | 2024-10-01 | 2025-03-27 |
| Renal Outcomes in the Early Use of Vasopressin in the Treatment of Septic Shock vasopressin infusion when the norepinephrine dosage is equal to or greater than 0.25 mcg/kg/min, vasopressin infusion when the norepinephrine dosage is equal to or greater than 0.5 mcg/kg/min - Septic Shock, Renal Function Replacement | Phase 4 | Unknown | Azienda Usl di Bologna | 264 | 2024-05-15 | 2024-06-24 |
| Vasopressin for Septic Shock Pragmatic Trial Vasopressin, Recommendation to use a lower initiation threshold for vasopressin, Recommendation to use a higher initiation threshold for vasopressin - Septic Shock | Phase 4 | Completed | Intermountain Health Care, Inc. | 3959 | 2024-02-01 | 2026-08-03 |
| Hemodynamic Response to Angiotensin-II When Used as the Second Vasopressor Agent for Septic Shock Angiotensin II and hydrocortisone sodium succinate - Septic Shock, Shock | Phase 4 | Unknown | Kingman Regional Medical Center | 50 | 2023-12-04 | 2024-05-23 |
| The Construction and Application of Therapeutic System of Intelligent Decision-Oriented Hemodynamic Organized Therapy for Shock Patients norepinephrine+vasopressin, Norepinephrine - Septic Shock | Phase 4 | Unknown | Peking Union Medical College Hospital | 60 | 2023-05-01 | 2023-06-02 |
| Role of Ulinastatin in Preventing Severe Sepsis and Consequent Morbidities and Mortality Ulinastatin - Severe Sepsis, Septic Shock | Phase 4 | Unknown | Jinnah Postgraduate Medical Centre | 175 | 2023-05-01 | 2023-06-08 |
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Shock, Septic (71) · Sepsis (34) · Diabetes Insipidus (6) · Acute Kidney Injury (4) · Shock (4) · Critical Illness (2) · Systemic Inflammatory Response Syndrome (2) · Anemia (1) · Arrhythmias, Cardiac (1) · Cardiomyopathies (1) · Edema (1) · Emergencies (1) · Fibrosis (1) · Gram-Negative Bacterial Infections (1) · Heart Arrest (1)
Infections (71) · Inflammation (71) · Pathologic Processes (71) · Pathological Conditions, Signs and Symptoms (71) · Systemic Inflammatory Response Syndrome (69) · Shock (67) · Sepsis (37) · Female Urogenital Diseases (11) · Female Urogenital Diseases and Pregnancy Complications (11) · Male Urogenital Diseases (11) · Urogenital Diseases (11) · Urologic Diseases (11) · Kidney Diseases (10) · Cardiovascular Diseases (6) · Endocrine System Diseases (6)
Norepinephrine (7) · Hydrocortisone (6) · Sodium Chloride (6) · Angiotensin II (5) · Dexmedetomidine (5) · Saline Solution (5) · Vasopressins (4) · Ascorbic Acid (3) · Crystalloid Solutions (3) · Giapreza (3) · Midazolam (3) · Adrenal Cortex Hormones (2) · Albumins (2) · Fentanyl (2) · Fludrocortisone (2)
Southeast University, China (6) · Cairo University (3) · Ain Shams University (2) · Asan Medical Center (2) · First Affiliated Hospital of Wannan Medical College (2) · Peking Union Medical College Hospital (2) · The Cleveland Clinic (2) · University of New Mexico (2) · Alexander Flannery (1) · Anders Perner (1) · Anders Perner, MD, PhD (1) · Assistance Publique Hopitaux De Marseille (1) · Association Niçoise de Réanimation Médicale (1) · Association Pour La Promotion A Tours De La Reanimation Medicale (1) · Association pour le Développement de la Recherche et de l'Enseignement en Médecine d'Urgence (1)
United States (14) · China (10) · Egypt (7) · France (7) · Denmark (5) · Brazil (4) · Italy (3) · Sweden (3) · Australia (2) · Czechia (2) · South Korea (2) · Switzerland (2) · United Kingdom (2) · Austria (1) · Belgium (1)
Joao P Teixeira, MD (2) · Nathan D Nielsen, MD MSc (2) · Ahmed Mukhtar (1) · Alessandro Pontes-Arruda, MD, PhD (1) · Alexander H Flannery, Pharm.D. (1) · Amany M Mohamed, Ph.D (1) · Anders Perner, MD PhD (1) · Ashish Khanna, MD (1) · Balasubramanian Venkatesh (1) · Bethany A Kalich (1) · Bin Du, MD (1) · Cassio Mallmann, MD (1)
PMID 23963131, PMID 30394918, PMID 34605781, PMID 11529214, PMID 11588440, PMID 12500513, PMID 12519925, PMID 15187514, PMID 15343008, PMID 16134766, PMID 16879732, PMID 18305265, PMID 18698227, PMID 19068113, PMID 19531784, PMID 19703817, PMID 19926252, PMID 20109575, PMID 20725823, PMID 21545483, PMID 22477787, PMID 22518026, PMID 23796235, PMID 24151551, PMID 24370612, PMID 24794878, PMID 25313879, PMID 25457118, PMID 25887027, PMID 26903338, PMID 27111533, PMID 27398737, PMID 27480413, PMID 27483065, PMID 27686349, PMID 28409297, PMID 28618919, PMID 28659186, PMID 28750598, PMID 28785470, PMID 28866112, PMID 28903154, PMID 28973220, PMID 29290746, PMID 29319721, PMID 29328496, PMID 29347874, PMID 29467017, PMID 29784057, PMID 29859008
2014 (1), 2016 (1), 2017 (1), 2023 (1), R01HL177834 (1), UL1RR024975-01 (1), UL1TR000445-06 (1), UL1TR001449 (1)