20 completed, 4 terminated, 4 unknown, 2 withdrawn. 31 Phase 1, 19 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 31 | Completed 20, Terminated 4, Unknown 4, Withdrawn 2, Not yet recruiting 1 |
| Phase 2 | 19 | Completed 14, Unknown 2, Not yet recruiting 1, Terminated 1, Withdrawn 1 |
Follow Septic Shock: new trials by email Literature Review of Septic Shock trials Research Report on Septic Shock
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| POCUS-Guided Esmolol in Septic Shock: A Pilot RCT Esmolol - Septic Shock | Phase 1 / Phase 2 | Not yet recruiting | John Basmaji | 100 | 2026-01-15 | 2026-01-06 |
| Improvement of Organ Function by Apigenin in Elderly Patients With Sepsis apigenin, sterilized water - Sepsis, Septic Shock | Phase 1 / Phase 2 | Completed | Zhujiang Hospital | 20 | 2023-09-01 | 2024-03-13 |
| The Efficacy of Adjunctive Use of Ondansetron in Patients With Sepsis and Septic Shock Ondansetron, Placebo - Sepsis, Septic Shock | Phase 1 / Phase 2 | Unknown | Noha Mansour | 40 | 2022-04-24 | 2023-03-15 |
| Intravenously Administered M6229 in Critically Ill Sepsis Patients M6229 - Sepsis, Septic Shock | Phase 1 | Completed | A.P.J. Vlaar | 10 | 2022-04-05 | 2025-02-11 |
| Microcirculation Recruitment Using Albumin 20% and Terlipressin in Septic Patients Albumin 20% and terlipressin - Septic Shock | Phase 1 | Unknown | Amany Mousa Salama Muhammed | 36 | 2021-10-01 | 2021-10-15 |
| High-dose Intravenous Vitamin C in Patients With Septic Shock Sodium Ascorbate - Sepsis, Severe, Septic Shock | Phase 1 | Unknown | Melbourne Health | 30 | 2021-09-27 | 2022-11-04 |
| Advanced Mesenchymal Enhanced Cell THerapY for SepTic Patients GEM00220 - Septic Shock | Phase 1 | Terminated | Northern Therapeutics | 11 | 2021-08-11 | 2024-04-16 |
| Therapeutic Plasma Exchange in Adult Patients With Severe Sepsis Therapeutic plasma exchange - Septic Shock | Phase 1 | Completed | Alberta Health Services, Calgary | 17 | 2020-10-21 | 2025-10-03 |
| Effect of Bronchoscopy on the Outcome of Patients With Severe Sepsis With ARDS and Complicated by VAP From Prolonged Ventilation Meropenem, bronchoscopy, ventilator - ARDS, Septic Shock | Phase 1 / Phase 2 | Completed | King Abdul Aziz Specialist Hospital | 200 | 2020-07-02 | 2023-10-10 |
| Effect of Bronchoscopy on the Outcome of Patients With Severe Sepsis With ARDS and Complicated by VAP From Prolonged Ventilation Meropenem, bronchoscopy, ventilator - ARDS, Septic Shock | Phase 1 / Phase 2 | Completed | King Abdul Aziz Specialist Hospital | 200 | 2020-07-02 | 2022-07-06 |
| Effect of Bronchoscopy on the Outcome of Patients With Severe Sepsis With ARDS and Complicated by VAP From Prolonged Ventilation Meropenem, bronchoscopy, ventilator - ARDS, Septic Shock | Phase 1 / Phase 2 | Completed | King Abdul Aziz Specialist Hospital | 200 | 2020-07-02 | 2023-10-10 |
| Vitamin C, Steroids, and Thiamine, and Cerebral Autoregulation and Functional Outcome in Septic Shock Stress-dose Hydrocortisone plus Vitamin C, isotonic sodium chloride solution placebo plus isotonic sodium chloride solution placebo - Septic Shock | Phase 1 / Phase 2 | Terminated | University of Athens | 26 | 2018-09-06 | 2024-12-19 |
| LIPIDS-P Trial Phase I/II Trial Smoflipid - Sepsis, Severe, Septic Shock | Phase 1 / Phase 2 | Completed | University of Florida | 59 | 2018-08-17 | 2025-08-11 |
| Effect of Mesenchymal Stromal Cells on Sepsis and Septic Shock Mesenchymal stem cells - Sepsis, Septic Shock | Phase 1 / Phase 2 | Completed | TC Erciyes University | 30 | 2018-03-11 | 2022-03-16 |
| The Effect of Remote Ischemic Conditioning on the Microcirculation in Sepsis Remote ischemic conditioning - Septic Shock, Sepsis | Phase 1 / Phase 2 | Completed | Lithuanian University of Health Sciences | 26 | 2018-02-01 | 2021-03-03 |
| Thiamine Supplementation in Patients With Septic Shock Thiamine, Placebos - Septic Shock, Shock, Septic | Phase 1 | Withdrawn | The Cleveland Clinic | 2016-11-05 | 2019-03-15 | |
| Safety, Pharmacokinetics and Pharmacodynamics of BMS-936559 in Severe Sepsis BMS-936559, Placebo - Severe Sepsis, Septic Shock | Phase 1 | Terminated | Bristol-Myers Squibb | 35 | 2015-12-02 | 2017-09-15 |
| Cellular Immunotherapy for Septic Shock: A Phase I Trial Allogeneic mesenchymal stromal cells - Septic Shock | Phase 1 | Completed | Ottawa Hospital Research Institute | 9 | 2015-05-01 | 2018-10-31 |
| Anisodamine Critically Ill SeptIc Shock anisodamine - Septic Shock | Phase 1 / Phase 2 | Completed | Jinhua Central Hospital | 355 | 2015-04-01 | 2021-09-29 |
| Russian Clinical Trial of Mesenchymal Cells in Patients With Septic Shock and Severe Neutropenia Mesenchymal stromal cells, Standard therapy of septic shock - Septic Shock, Nonchemotherapy Drug-induced Neutropenia | Phase 1 / Phase 2 | Unknown | National Research Center for Hematology, Russia | 30 | 2012-12-01 | 2013-05-10 |
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Shock, Septic (31) · Sepsis (18) · Inflammation (3) · Acidosis, Lactic (1) · Acute Lung Injury (1) · Critical Illness (1) · Hyperphagia (1) · Hypotension (1) · Infections (1) · Lung Diseases (1) · Neutropenia (1) · Respiratory Distress Syndrome (1) · Shock (1) · Thiamine Deficiency (1)
Pathologic Processes (31) · Pathological Conditions, Signs and Symptoms (31) · Systemic Inflammatory Response Syndrome (31) · Infections (30) · Shock (30) · Inflammation (28) · Sepsis (13) · Respiratory Tract Diseases (3) · Lung Diseases (2) · Acid-Base Imbalance (1) · Acidosis (1) · Agranulocytosis (1) · Avitaminosis (1) · Cardiovascular Diseases (1) · Cytopenia (1)
Ascorbic Acid (3) · Bronchoscopy (3) · Meropenem (3) · Ventilators, Mechanical (3) · Thiamine (2) · 2-(phenylmethyl)-1-naphthol (1) · Acetylcarnitine (1) · Albumins (1) · Angiotensin II (1) · Apigenin (1) · BMS-936559 (1) · Carnitine (1) · Central Venous Catheters (1) · Exenatide (1) · Glucose (1)
King Abdul Aziz Specialist Hospital (3) · Jinhua Central Hospital (2) · Wake Forest University Health Sciences (2) · A.P.J. Vlaar (1) · Alberta Health Services, Calgary (1) · Amany Mousa Salama Muhammed (1) · Beth Israel Deaconess Medical Center (1) · Bristol-Myers Squibb (1) · Children's Hospital Medical Center, Cincinnati (1) · George Washington University (1) · John Basmaji (1) · Lithuanian University of Health Sciences (1) · Melbourne Health (1) · National Institutes of Health Clinical Center (CC) (1) · National Research Center for Hematology, Russia (1)
United States (12) · China (4) · Canada (3) · Saudi Arabia (3) · Australia (1) · Egypt (1) · Greece (1) · Lithuania (1) · Netherlands (1) · Russia (1) · Turkey (Türkiye) (1)
Alan E Jones, MD (2) · Alexander P Vlaar, MD, PhD, MBA (1) · Alpha Fowler, MD (1) · Anastasia Kotanidou, MD, PhD (1) · Anthony F Suffredini, M.D. (1) · Faheem W Guirgis, MD (1) · Gennady M. Galstyan, MD PhD (1) · George F Alvarez, MD (1) · Jennifer M. Kaplan, M.D., M.S. (1) · Jinesh Mehta, MD (1) · John Basmaji (1) · Lakhmir Chawla, MD (1) · Lauralyn McIntyre, MD (1)
PMID 23374652, PMID 24484547, PMID 25286986, PMID 26605292, PMID 26825368, PMID 28203424, PMID 28960096, PMID 30255316, PMID 30747773, PMID 31537565, PMID 33392541, PMID 33829305, PMID 34579741, PMID 35784641, PMID 38321529, PMID 38488429, PMID 39716214, PMID 40009025