21 completed, 11 unknown, 9 not yet recruiting, 8 recruiting. 22 Not applicable, 9 Phase 3, 5 Phase 2, 2 Phase 1.
Follow Rheumatic Heart Disease: new trials by email Literature Review of Rheumatic Heart Disease trials Research Report on Rheumatic Heart Disease
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Multi-country Evaluation of Early RHD in Children Across Africa for Vaccine Trial Readiness Rheumatic Heart Disease in Children | Not yet recruiting | Children's Hospital Medical Center, Cincinnati | 7500 | 2027-02-01 | 2026-08-27 | |
| Penicillin to Prevent Early Rheumatic Heart Disease in School-Aged Children Oral Penicillin V - Rheumatic Heart Disease in Children | Phase 3 | Not yet recruiting | Children's Hospital Medical Center, Cincinnati | 9622 | 2027-02-01 | 2026-09-03 |
| Testing a Registry-Based Strategy (ACT+) to Reduce Loss to Follow-Up in Rheumatic Heart Disease Screening in Uganda The ACT+ Strategy - Rheumatic Heart Disease | Not applicable | Not yet recruiting | Children's Hospital Medical Center, Cincinnati | 16 | 2026-12-01 | 2026-10-13 |
| ACT4RHD is an Open-label, Randomised, Adaptive Platform Trial to Evaluate Novel and Repurposed Clinical Interventions for Patients With Acute Rheumatic Fever and Carditis. ACT4RHD Seeks to Determine Whether These Interventions Reduce RHD Severity at 6 Months. Hydroxychloroquine (HCQ), No Hydroxychloroquine (HCQ), Prednisone or Prednisolone - Rheumatic Fever, Rheumatic Heart Disease in Children | Phase 3 | Not yet recruiting | Starship Child Health, Te Toka Tumai Auckland | 600 | 2026-12-01 | 2026-10-07 |
| Artificial Intelligence to Scale Early Rheumatic Heart Disease Detection AI assisted echocardiography - Rheumatic Heart Disease | Not applicable | Not yet recruiting | Children's Hospital Medical Center, Cincinnati | 62 | 2026-11-01 | 2026-10-16 |
| A Non-Inferiority Trial of Stopping Penicillin in Early Rheumatic Heart Disease: GOAL-Stop Secondary Prophylaxis - Rheumatic Heart Disease | Phase 3 | Recruiting | Children's Hospital Medical Center, Cincinnati | 922 | 2026-03-23 | 2026-06-22 |
| Clinical Trial Phase I/IIa to Evaluate the Safety and Immunogenicity of StreptInCor StrepIncor, Placebo - Rheumatic Heart Disease, Rheumatic Heart Disease in Children | Phase 1 / Phase 2 | Not yet recruiting | University of Sao Paulo General Hospital | 60 | 2025-10-01 | 2025-07-22 |
| Vitamin K Antagonist in Rheumatic Heart Disease Patients With Mechanical Heart Valves: Our Current Status Rheumatic Heart Disease | Not yet recruiting | Ahmed Hassan Rostom Ibrahim | 165 | 2025-09-01 | 2025-08-28 | |
| Korea VHD Echo Study: Surveillance of Aortic, Mitral & Tricuspid Patients - Insights From Real-world Practice Heart Valve Diseases, Aortic Valve Stenosis | Not yet recruiting | Yonsei University | 30000 | 2025-08-01 | 2025-07-16 | |
| Effectiveness of Edutainment-Based Interventions in Increasing Knowledge of Rheumatic Fever and Rheumatic Heart Disease Among School-Going Children in Nepal: Study Protocol for Colors to Save Hearts Quasi-Experimental Pretest-Posttest Study education material - Rheumatic Heart Disease | Not applicable | Not yet recruiting | Kathmandu Institute of Child Health | 2400 | 2025-07-28 | 2025-07-15 |
| Treating Severe Mitral Valve Annular or Valvular Calcification Using Shockwave Balloon SMARTWAVE SmartWave Lithotripsy balloon - Mitral Annulus Calcification, Rheumatic Heart Disease | Not applicable | Recruiting | Prince of Wales Hospital, Shatin, Hong Kong | 10 | 2025-03-08 | 2026-09-16 |
| School-based Program for the Prevention of Rheumatic Heart Disease in Endemic Regions School nurse program - Rheumatic Heart Disease in Children | Not applicable | Recruiting | Thomas Pilgrim | 6000 | 2024-12-15 | 2026-01-20 |
| Identifying Essential Elements of SAP Supports Case Management Supports - Rheumatic Heart Disease in Children, Heart Disease, Valvular | Not applicable | Completed | Children's Hospital Medical Center, Cincinnati | 335 | 2024-08-21 | 2026-05-28 |
| Comparison of Wire Assisted Percutaneous Balloon Mitral Valvulotomy With Standard Inoue Balloon Valvulotomy Percutaneous Balloon Mitral Valvulotomy - Rheumatic Heart Disease | Not applicable | Completed | Helse Stavanger HF | 20 | 2024-05-24 | 2024-06-20 |
| Accelerating Delivery of rheUmatic Heart Disease Preventive iNterventions in Northern Uganda ADUNU program for delivery of RHD care services - Rheumatic Heart Disease | Not applicable | Recruiting | Children's Hospital Medical Center, Cincinnati | 221 | 2024-05-01 | 2026-05-15 |
| Non-Expert Acquisition & Remote Expert Review of Screening Echocardiography Images From Child Health & AnteNatal Clinics SPLASH echocardiography screening - Rheumatic Heart Disease | Not applicable | Unknown | Menzies School of Health Research | 1500 | 2024-04-01 | 2024-03-18 |
| Gliflozins on HF in Regurgitant Rheumatic Heart SGLT2 inhibitor - Rheumatic Heart Disease, Heart Failure | Unknown | Assiut University | 150 | 2023-12-01 | 2023-10-30 | |
| GOALIE: Intramuscular vs. Enteral Penicillin Prophylaxis to Prevent Progression of Latent RHD Trial phenoxymethyl penicillin, intramuscular benzathine penicillin G (BPG) prophylaxis - Rheumatic Heart Disease | Phase 2 | Active not recruiting | Children's Hospital Medical Center, Cincinnati | 1004 | 2023-09-01 | 2026-10-19 |
| Measuring the Prevalence of Toxoplasmosis and Its Socio-economic Consequences Presence of Toxoplasma gondii IgG Antibodies - Toxoplasmosis, Rhd | Unknown | University of Zurich | 120 | 2023-06-26 | 2023-05-18 | |
| Rate Control Efficacy in Atrial Fibrillation With Rheumatic Mitral Stenosis: Lenient vs Strict Rate Control Strategies Rate control - Atrial Fibrillation, Rheumatic Mitral Stenosis | Not applicable | Unknown | University of Brawijaya | 100 | 2023-03-01 | 2024-05-10 |
Showing 20 of 55. Sign in to see all of them.
Mitral Valve Stenosis (7) · Rheumatic Fever (7) · Heart Valve Diseases (6) · Atrial Fibrillation (5) · Heart Diseases (3) · Heart Failure (3) · Aortic Valve Insufficiency (2) · Heart Defects, Congenital (2) · Mitral Valve Insufficiency (2) · Stroke (2) · Anemia, Sickle Cell (1) · Aneurysm (1) · Aortic Diseases (1) · Aortic Valve Stenosis (1)
Bacterial Infections (55) · Bacterial Infections and Mycoses (55) · Cardiovascular Diseases (55) · Gram-Positive Bacterial Infections (55) · Infections (55) · Streptococcal Infections (54) · Heart Diseases (52) · Rheumatic Fever (48) · Arthritis (7) · Connective Tissue Diseases (7) · Heart Valve Diseases (7) · Joint Diseases (7) · Musculoskeletal Diseases (7) · Skin and Connective Tissue Diseases (7) · Pathologic Processes (6)
Rivaroxaban (3) · Echocardiography (2) · Penicillin G (2) · Penicillin V (2) · Warfarin (2) · Aspirin (1) · Atorvastatin (1) · Cardiac Surgical Procedures (1) · Case Managers (1) · Control Groups (1) · Epinephrine (1) · Glutamine (1) · Heart Rate (1) · High-Throughput Nucleotide Sequencing (1) · Hydroxychloroquine (1)
Children's Hospital Medical Center, Cincinnati (12) · Insel Gruppe AG, University Hospital Bern (3) · Assiut University (2) · Population Health Research Institute (2) · Sun Yat-sen University (2) · Thomas Pilgrim (2) · University of Washington (2) · Ahmed Hassan Rostom Ibrahim (1) · Brigham and Women's Hospital (1) · Centre for Infectious Disease Research in Zambia (1) · Children's National Research Institute (1) · China Medical University Hospital (1) · Helse Nord-Trøndelag HF (1) · Helse Stavanger HF (1) · Kathmandu Institute of Child Health (1)
Uganda (15) · Nepal (8) · China (5) · Zambia (4) · Brazil (3) · Ethiopia (3) · Indonesia (3) · Egypt (2) · Nigeria (2) · Pakistan (2) · Rwanda (2) · Switzerland (2) · Australia (1) · Botswana (1) · Cameroon (1)
Andrea Z Beaton (4) · Andrea Beaton (3) · Jing-song Ou, MD,PhD (2) · Nona Sotoodehnia, MD, MPH (2) · Thomas Pilgrim, MD (2) · Ade Meidian Ambari, MD,FIHA (1) · Adrian VS Hill, DPhil DM (1) · Ahmed G Bakry, MD (1) · An Aldia Asrial, MD (1) · Andrea Beaton, MD (1) · Andrea Z Beaton, Dr (1) · Andrea Z Beaton, MD (1) · Andrew C Steer, FRACP PhD (1) · Ardian Rizal, MD, FIHA (1)
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R34HL143279 (2), 2023 (1), R21TW011108 (1), U01AI060579 (1)